| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
We have been examining molecular mechanisms underlying neuronal degeneration and regeneration after nerve injury. In our gene screening we have identified several molecules associated with lipid dynamics. Our previous GPCR screening revealed several orphan receptors were expressed by glial cells in response to nerve injury. Recently those orphan GPCRs were deorphanized and found that some of them were associated with intercellular lipid signaling. In this study we have examined the functional significances of phosphatidylserine receptor GPR34, and found the GPR34 mediated signal is associated with neuropathic pain.
Nerve injury induced characteristic changes of membrane of injured neurons. The remodeling of lipid composition would be necessary for axon regeneration. Furthermore, lipid remodeling in glial cells was found to be critical for the changes of microglial morphology. We also found that the lipid mediated signaling is critical in phagocytosis by microglia and astrocyte.
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