| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2019: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
To understand the pathogenesis of influenza virus infection, it is necessary to distinguish between the inflammatory response in the airway epithelial tissues in the early stages of infection and the excessive inflammatory response amplified secondarily by macrophages. We identified MxA as a sensor molecule that regulates the induction of inflammatory response from airway epithelial cells, and found that MxA suppressed human infection with avian influenza virus, suggesting that MxA is one of the molecular determinants of host range restriction for avian influenza virus. We also revealed that ASC speckles released extracellularly by the inflammatory response are transmitted cell-to-cell and induce an excessive inflammatory response (cytokinesis storm) even in uninfected cells.
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