| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Regulatory mechanism of the immune checkpoint LILRB4 expressed mainly on myeloid-lineage cells such as macrophages and dendritic cells has not been clarified yet. We successfully identified its physiological ligand as fibronectin (FN), more specifically its N-terminal 30 kDa domain (FN30). We also found that upon recognition of FN30 by LILRB4, this regulatory receptor could suppress FN-binding integrin signal as well as focal adhesion-related signal associated with cell adhesion. Our findings identify for the first time a unique regulator of cell-adhesion-related intracellular signal.
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