| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
T cells develop in the thymus, where various stromal cells control the development and repertoire selection of immature T cells. Here we identified and characterized whole thymic stromal cells, including as yet uncharacterized cell types such as thymic mesenchymal cells. In particular, we found a novel subset of fibroblasts in the thymic medulla and revealed that these medullary fibroblasts play important roles in the induction of T cell self-tolerance (prevention of autoimmunity). The results of this study are expected to make a significant contribution to the understanding of the function of various types of fibroblasts in vivo as well as the etiology of autoimmune diseases.
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