| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
We have so far found that premetastatic niche is formed before cancer metastasis. The premetastatic niche is an inflammation-like environment that mimics the tumor microenvironment and is triggered by the TLR4 endogenous ligand S100A8. In this study, we found that novel multivalent S100A8 inhibitory peptides inhibited tumor growth in a xenograft model, and that TLR4/MD-2 pathway via S100A8 may be involved in the onset of acute respiratory distress syndrome. These results suggested that the S100A8-TLR4/MD-2 pathway may serve as a promising molecular target not only for cancer but also for various S100A8-related diseases.
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