| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2023: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
Autistic-like behavioral abnormalities were observed in the pups of the maternal inflammation model, and analysis of the embryonic brain revealed a PTPδ microexon selection pattern in the cortex that was different from that of the control group. Although behavioral abnormalities were also observed in the pups of systemic lupus erythematosus model mice, no obvious difference was detected in PTPδ microexon selection in the prenatal brain compared to the control group. This suggests that prenatal brain inflammation caused by maternal inflammation leads to abnormal behavior and PTPδ microexon selection in the cerebral cortex, but that chronic inflammation results in behavioral abnormalities through a different mechanism.
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