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Chiral amino acids in pathogenesis diabetic nephropathy/diabetic kidney disease and their perspectives for biomarker candidates

Research Project

Project/Area Number 19H03557
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionKanazawa University

Principal Investigator

Wada Takashi  金沢大学, その他部局等, その他 (40334784)

Co-Investigator(Kenkyū-buntansha) 古市 賢吾  金沢医科大学, 医学部, 教授 (50432125)
坂井 宣彦  金沢大学, 附属病院, 准教授 (60377421)
岩田 恭宜  金沢大学, 附属病院, 特任教授 (90432137)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords腎臓 / 糖尿病性腎症 / 糖尿病性腎臓病 / キラルアミノ酸 / バイオマーカー
Outline of Research at the Start

D体、L体を識別するキラルアミノ酸、ことにD-アミノ酸の生理的、疾病での役割は未だ不明である。糖尿病性腎症は透析導入原疾患第一位であり、その克服に向けて病態解明と予後を示すバイオマーカー確立は喫緊の課題である。本研究では、生命活動に必須なアミノ酸、ことにキラルアミノ酸に注目し、生体での生理的意義、糖尿病性腎症におけるキラルアミノ酸を介した病態解明、新規バイオマーカー開発を目指す。

Outline of Final Research Achievements

This study was aimed to determine D-amino acid (AA) profile and associated bacteria in patients with chronic kidney disease (CKD) with and without diabetes mellitus (DM). Detailed D-AA profile has not been studied in CKD patients with DM so far. We examined the chiral AA levels of salivary, stool, plasma, and urine and related bacteria in patients examined. 16S rRNA gene sequencing analysis of the oral and gut microbiota were also performed to determine bacterial species responsible for D-AA levels. Plasma D-alanine and D-serine levels were higher in patients with CKD than in healthy adults. In addition, plasma D-alanine levels were significantly higher in CKD patients with DM as compared to those without DM. D-alanine was produced by salivary Streptococcus, which positively correlated with plasma D-alanine levels. Collectively, D-alanine might be a biomarker candidate for CKD patients with DM.

Academic Significance and Societal Importance of the Research Achievements

糖尿病性腎臓病・糖尿病性腎症(腎症)は透析導入原疾患の第1位である。そのため、腎症の病態解明と病態を反映するバイオマーカー開発は重要な課題である。本研究の学術的な特色は、技術革新により分析可能となったキラルアミノ酸に着目し、1)腎症の病態の解明と病態・予後を反映するD-アミノ酸の同定と病態への役割の検討、2)特定のD-アミノ酸の産生微生物の同定、3)腎臨床・病理所見とD-アミノ酸の突合を行い、その分子機序、病態・予後など臨床的意義を反映することである。本研究はキラルアミノ酸により腎症の病態解明とバイオマーカー開発を目指すものであり、学術的意義ならびに社会的意義が深い。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (61 results)

All 2023 2022 2021 2020 2019 2018

All Journal Article (33 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 29 results,  Open Access: 31 results) Presentation (21 results) (of which Int'l Joint Research: 1 results,  Invited: 12 results) Book (7 results)

  • [Journal Article] Intra-brain and plasma levels of L-Serine are associated with cognitive status in patients with CKD. Kid Dis2023

    • Author(s)
      〇Iwata Y*, Nakade Y, Kinoshita M, Sabit H, Nakajima R, Furuichi K, Mita M, Nakane M, Sakai N, Kitajima S, Toyama T, Miyagawa T, Hara A, Shimizu M, Sato K, Oshima M, Nakagawa S, Yamamura Y, Ogura H, Koshino Y, Nakada M, Wada T.
    • Journal Title

      Kidney Dis (Basel) .

      Volume: 9 Issue: 2 Pages: 118-129

    • DOI

      10.1159/000527798

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intestinal Bacterial Translocation Contributes to Diabetic Kidney Disease.2022

    • Author(s)
      Linh HT, Iwata Y, Senda Y, Sakai-Takemori Y, Nakade Y, Oshima M, Nakagawa-Yoneda S, Ogura H, Sato K, Minami T, Kitajima S, Toyama T, Yamamura Y, Miyagawa T, Hara A, Shimizu M, Furuichi K, Sakai N, Yamada H, Asanuma K, Matsushima K, Wada T.
    • Journal Title

      J Am Soc Nephrol.

      Volume: - Issue: 6 Pages: 1105-1119

    • DOI

      10.1681/asn.2021060843

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective Effect of D-Alanine Against Acute Kidney Injury.2022

    • Author(s)
      Iwata Y, Nakade Y, Kitajima S, Yoneda-Nakagawa S, Oshima M, Sakai N, Ogura H, Sato K, Toyama T, Yamamura Y, Miyagawa T,Yamazaki H, Hara A, Shimizu M, Furuichi K, Mita M, Hamase K, Tanaka T, Nishida M, Muramatsu W, Yamamoto H, Shichino S, Ueha S, Matsushima K, Wada T.
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 322 Issue: 6 Pages: F667-F679

    • DOI

      10.1152/ajprenal.00198.2021

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased levels of oral Streptococcus-derived D-alanine in patients with chronic kidney disease and diabetes mellitus.2022

    • Author(s)
      Nakade Y, Iwata Y*, Sakai N, Mita M, Nakane M, Hamase K, Suda W, Toyama T, Kitajima S, Hara A, Shimizu M, Ogushi C, Furuichi K, Koshino Y, Morita H, Hattori M, Wada T.
    • Journal Title

      Sci Rep

      Volume: 12 Issue: 1 Pages: 21773-21773

    • DOI

      10.1038/s41598-022-26175-1

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction in the magnitude of serum potassium elevation in combination therapy with esaxerenone (CS‐3150) and sodium‐glucose co‐transporter‐2 inhibitor in patients with diabetic kidney disease: Subanalysis of two phase 3 studies2022

    • Author(s)
      Shikata Kenichi、Ito Sadayoshi、Kashihara Naoki、Nangaku Masaomi、Wada Takashi、Okuda Yasuyuki、Sawanobori Tomoko、Sugimoto Kotaro
    • Journal Title

      Journal of Diabetes Investigation

      Volume: - Issue: 7 Pages: 1190-1202

    • DOI

      10.1111/jdi.13778

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cysteinylated albumin as a potential biomarker for the progression of kidney disease in patients with type 2 diabetes2021

    • Author(s)
      Imafuku T, Watanabe H, Oniki K, Yoshida A, Kato H, Nakano T, Tokumaru K, Fujita I, Arimura N, Maeda H, Sakamoto Y, Kondo N, Morita A, Saruwatari J, Tanaka M, Matsushita K, Wada T, Fukagawa M, Otagiri M, Fitzgerald ML, Jinnouchi H, Maruyama T.
    • Journal Title

      Diabetes Care

      Volume: 26 Issue: 6 Pages: e115-e117

    • DOI

      10.2337/dc20-3003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Carnitine/organic cation transporter 1 precipitates the progression of interstitial fibrosis through oxidative stress in diabetic nephropathy in mice2021

    • Author(s)
      Makiishi Shohei、Furuichi Kengo、Yamamura Yuta、Sako Keisuke、Shinozaki Yasuyuki、Toyama Tadashi、Kitajima Shinji、Iwata Yasunori、Sakai Norihiko、Shimizu Miho、Hirose-Sugiura Tomoko、Kaneko Shuichi、Kato Yukio、Wada Takashi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 9093-9093

    • DOI

      10.1038/s41598-021-88724-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum hemoglobin concentration and risk of renal function decline in early stages of diabetic kidney disease: a nationwide, biopsy-based cohort study2021

    • Author(s)
      Yamanouchi M,Furuichi K,Shimizu M,Toyama T,Yamamura Y,Oshima M,Kitajima S,Hara A,Iwata Y,Sakai N,Oba Y,Matsuoka S,Ikuma De,Mizuno H,Suwabe T,Hoshino J Sawa N,Yuzawa Y,Kitamura H,Suzuki Y,Sato H,Uesugi N,Ueda Y,Nishi S,Yokoyama H,Nishino T,Samejima K Kohagura K,Shibagaki Y,Makino H,Matsuo S,Ubara Y,Wada
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 37 Issue: 3 Pages: 489-497

    • DOI

      10.1093/ndt/gfab185

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Combined changes in albuminuria and kidney function and subsequent risk for kidney failure in type 2 diabetes2021

    • Author(s)
      Oshima Megumi、ToyaIwata Yasunori、et. al
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 9 Issue: 1 Pages: e002311-e002311

    • DOI

      10.1136/bmjdrc-2021-002311

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two-year longitudinal trajectory patterns of albuminuria and subsequent rates of end-stage kidney disease and all-cause death: a nationwide cohort study of biopsy-proven diabetic kidney disease2021

    • Author(s)
      Yamanouchi Masayuki、Iwata Yasunori、et al.
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 9 Issue: 1 Pages: e002241-e002241

    • DOI

      10.1136/bmjdrc-2021-002241

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of the relationship between hemoglobin levels and renal interstitial fibrosis on long-term outcomes in type 2 diabetes with biopsy-proven diabetic nephropathy2021

    • Author(s)
      Shimizu Miho、Furuichi Kengo、Kitajima Shinji、Toyama Tadashi、Oshima Megumi、Ogura Hisayuki、Sato Koichi、Nakagawa Shiori、Yamamura Yuta、Miyagawa Taro、Hara Akinori、Iwata Yasunori、Sakai Norihiko、Kitagawa Kiyoki、Yoshimura Mitsuhiro、Yokoyama Hitoshi、Wada Takashi
    • Journal Title

      BMC Nephrology

      Volume: 22 Issue: 1 Pages: 319-319

    • DOI

      10.1186/s12882-021-02510-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of canagliflozin versus finerenone on cardiorenal outcomes: exploratory <i>post hoc</i> analyses from FIDELIO-DKD compared to reported CREDENCE results2021

    • Author(s)
      Agarwal Rajiv、Anker Stefan D、Filippatos Gerasimos、Pitt Bertram、Rossing Peter、Ruilope Luis M、Boletis John、Toto Robert、Umpierrez Guillermo E、Wanner Christoph、Wada Takashi、Scott Charlie、Joseph Amer、Ogbaa Ike、Roberts Luke、Scheerer Markus F、Bakris George L
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: gfab336 Issue: 7 Pages: 1261-1269

    • DOI

      10.1093/ndt/gfab336

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Significance of the Gut Microbiota in Acute Kidney Injury2021

    • Author(s)
      Kobayashi Taku、Iwata Yasunori、Nakade Yusuke、Wada Takashi
    • Journal Title

      Toxins

      Volume: 13 Issue: 6 Pages: 369-369

    • DOI

      10.3390/toxins13060369

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trajectories of kidney function in diabetes: a clinicopathological update2021

    • Author(s)
      Oshima Megumi、Shimizu Miho、Yamanouchi Masayuki、Toyama Tadashi、Hara Akinori、Furuichi Kengo、Wada Takashi
    • Journal Title

      Nature Reviews Nephrology

      Volume: 17 Issue: 11 Pages: 740-750

    • DOI

      10.1038/s41581-021-00462-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Circulating Biomarkers in Predicting Diabetic Kidney Disease Progression With Autoantibodies to Erythropoietin Receptor2021

    • Author(s)
      Oshima Megumi、Hara Akinori、Toyama Tadashi、Jun Min、Pollock Carol、Jardine Meg、Harrap Stephen、Poulter Neil、Cooper Mark E.、Woodward Mark、Chalmers John、Perkovic Vlado、Wong Muh Geot、Wada Takashi
    • Journal Title

      Kidney International Reports

      Volume: 6 Issue: 2 Pages: 284-295

    • DOI

      10.1016/j.ekir.2020.10.039

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nonproteinuric diabetic kidney disease.2020

    • Author(s)
      Yamanouchi M, Furuichi K, Hoshino J, Ubara Y, Wada T.
    • Journal Title

      Clin Exp Nephrol

      Volume: - Issue: 7 Pages: 573-581

    • DOI

      10.1007/s10157-020-01881-0

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinicopathological features of fast eGFR decliners among patients with diabetic nephropathy2020

    • Author(s)
      Furuichi Kengo、Shimizu Miho、Yamanouchi Masayuki、Hoshino Junichi、Sakai Norihiko、Iwata Yasunori、Toyama Tadashi、Kitajima Shinji、Hara Akinori、Wada Takashi et.al.
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 8 Issue: 1 Pages: e001157-e001157

    • DOI

      10.1136/bmjdrc-2019-001157

    • NAID

      120006892782

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Propagermanium administration for patients with type 2 diabetes and nephropathy: A randomized pilot trial2020

    • Author(s)
      Hara Akinori、Shimizu Miho、Hamaguchi Erika、Kakuda Hirokazu、Ikeda Kenzo、Okumura Toshiya、Kitagawa Kiyoki、Koshino Yoshitaka、Kobayashi Motoo、Takasawa Kazuya、Hisada Yukimasa、Toyama Tadashi、Iwata Yasunori、Sakai Norihiko、Wada Takashi
    • Journal Title

      Endocrinology, Diabetes & Metabolism

      Volume: 3 Issue: 3

    • DOI

      10.1002/edm2.159

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of canagliflozin on anaemia in patients with type 2 diabetes and chronic kidney disease: a post-hoc analysis from the CREDENCE trial2020

    • Author(s)
      Oshima Megumi、Neuen Brendon L、Jardine Meg J、Bakris George、Edwards Robert、Levin Adeera、Mahaffey Kenneth W、Neal Bruce、Pollock Carol、Rosenthal Norman、Wada Takashi、Wheeler David C、Perkovic Vlado、Heerspink Hiddo J L
    • Journal Title

      The Lancet Diabetes & Endocrinology

      Volume: 8 Issue: 11 Pages: 903-914

    • DOI

      10.1016/s2213-8587(20)30300-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between anti-erythropoietin receptor autoantibodies and responsiveness to erythropoiesis-stimulating agents in patients on hemodialysis: a multi-center cross-sectional study.2020

    • Author(s)
      Hara A, Koshino Y, Kurokawa Y, Shinozaki Y, Miyake T, Kitajima S, Toyama T, Iwata Y, Sakai N, Shimizu M, Furuichi K, Nakamura H, Wada T.
    • Journal Title

      Clin Exp Nephrol

      Volume: 24 Issue: 1 Pages: 88-95

    • DOI

      10.1007/s10157-019-01787-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 細菌由来D-アミノ酸を介した新たな腎腸連関機序2020

    • Author(s)
      中出祐介・岩田恭宜・和田隆志
    • Journal Title

      D-アミノ酸学会誌

      Volume: 8 Pages: 1-8

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Association of renal arteriosclerosis and hypertension with renal and cardiovascular outcomes in Japanese type?2 diabetes patients with diabetic nephropathy2019

    • Author(s)
      Shimizu M, et al
    • Journal Title

      J Diabetes Investig

      Volume: 印刷中 Issue: 4 Pages: 1041-1049

    • DOI

      10.1111/jdi.12981

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of SGLT2 inhibitors on cardiovascular, renal and safety outcomes in patients with type 2 diabetes mellitus and chronic kidney disease: A systematic review and meta‐analysis2019

    • Author(s)
      Toyama Tadashi、Neuen Brendon L.、Jun Min、Ohkuma Toshiaki、Neal Bruce、Jardine Meg J.、Heerspink Hiddo L.、Wong Muh Geot、Ninomiya Toshiharu、Wada Takashi、Perkovic Vlado
    • Journal Title

      Diabetes, Obesity and Metabolism

      Volume: 21 Issue: 5 Pages: 1237-1250

    • DOI

      10.1111/dom.13648

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Amplified Association Between Blood Pressure and Albuminuria in Overweight Patients With Biopsy-Proven Hypertensive Nephrosclerosis2019

    • Author(s)
      Kohagura Kentaro、Furuichi Kengo、Kochi Masako、Shimizu Miho、Yuzawa Yukio、Hara Akinori、Toyama Tadashi、Kitamura Hiroshi、Suzuki Yoshiki、Sato Hiroshi、Uesugi Noriko、Ubara Yoshifumi、Hoshino Junichi、Hisano Satoshi、Ueda Yoshihiko、Nishi Shinichi、Wada Takashi et al.
    • Journal Title

      American Journal of Hypertension

      Volume: 32 Issue: 5 Pages: 486-491

    • DOI

      10.1093/ajh/hpz010

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonproteinuric Versus Proteinuric Phenotypes in Diabetic Kidney Disease: A Propensity Score-Matched Analysis of a Nationwide, Biopsy-Based Cohort Study.2019

    • Author(s)
      Yamanouchi M, Furuichi K, Hoshino J, Toyama T, Hara A, Shimizu M, Kinowaki K, Fujii T, Ohashi K, Yuzawa Y, Kitamura H, Suzuki Y, Sato H, Uesugi N, Hisano S, Ueda Y, Nishi S, Yokoyama H, Nishino T, Samejima K, Kohagura K, Shibagaki Y, Mise K, Makino H, Matsuo S, Ubara Y, Wada T.
    • Journal Title

      Diabetes Care

      Volume: - Issue: 5 Pages: 891-902

    • DOI

      10.2337/dc18-1320

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiome-derived phenyl sulfate contributes to albuminuria in diabetic kidney disease2019

    • Author(s)
      Kikuchi Koichi、Saigusa Daisuke、Kanemitsu Yoshitomi、Matsumoto Yotaro、Tsukamoto Hiroki、Abe Takaaki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1835-1835

    • DOI

      10.1038/s41467-019-09735-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The involvement of autotaxin in renal interstitial fibrosis through regulation of fibroblast functions and induction of vascular leakage.2019

    • Author(s)
      Sakai N, Bain G, Furuichi K, Iwata Y, Nakamura M, Hara A, Kitajima S, Sagara A, Miyake T, Toyama T, Sato K, Nakagawa S, Shimizu M, Kaneko S, Wada T.
    • Journal Title

      Sci Rep

      Volume: 9 Pages: 7414-7414

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The relationship between eGFR slope and subsequent risk of vascular outcomes and all-cause mortality in type 2 diabetes: the ADVANCE-ON study.2019

    • Author(s)
      Oshima M, Jun M, Ohkuma T, Toyama T, Wada T, Cooper ME, Hadjadj S, Hamet P, Harrap S, Mancia G, Marre M, Williams B, Chalmers J, Woodward M, Perkovic V, ADVANCE Collaborative Group.
    • Journal Title

      Diabetologia

      Volume: 62 Issue: 11 Pages: 1988-1997

    • DOI

      10.1007/s00125-019-4948-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Retinopathy progression and the risk of end-stage kidney disease: results from a longitudinal Japanese cohort of 232 patients with type 2 diabetes and biopsy-proven diabetic kidney disease2019

    • Author(s)
      Yamanouchi Masayuki、Mori Mikiro、Hoshino Junichi、Kinowaki Keiichi、Fujii Takeshi、Ohashi Kenichi、Furuichi Kengo、Wada Takashi、Ubara Yoshifumi
    • Journal Title

      BMJ Open Diabetes Research & Care

      Volume: 7 Issue: 1 Pages: e000726-e000726

    • DOI

      10.1136/bmjdrc-2019-000726

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] トピックスⅢ. Diabetic nephropathyとdiabetic kidney disease(腎臓)2019

    • Author(s)
      古市賢吾・和田隆志
    • Journal Title

      日本内科学会雑誌

      Volume: 108 Pages: 681-687

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] トピックスⅡ. DKDの病理学的特徴2019

    • Author(s)
      清水美保・和田隆志
    • Journal Title

      日本内科学会雑誌

      Volume: 108 Pages: 907-915

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] D-セリンと腎臓病2019

    • Author(s)
      中出祐介・岩田恭宜・和田隆志
    • Journal Title

      生化学

      Volume: 91 Pages: 349-354

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Erythropoietin signal protected HUVEC from high glucose induced injury2018

    • Author(s)
      Yasuda Haruka、Iwata Yasunori、Nakajima Satoshi、Furuichi Kengo、Miyake Taito、Sakai Norihiko、Kitajima Shinji、Toyama Tadashi、Shinozaki Yasuyuki、Sagara Akihiro、Miyagawa Taro、Hara Akinori、Shimizu Miho、Kamikawa Yasutaka、Sato Kouichi、Oshima Megumi、Yoneda-Nakagawa Shiori、Kaneko Shuichi、Wada Takashi
    • Journal Title

      Nephrology

      Volume: in press Issue: 7 Pages: 767-774

    • DOI

      10.1111/nep.13518

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] バイオマーカー開発と産学連携への期待2022

    • Author(s)
      和田隆志
    • Organizer
      日本医療検査科学会 第54回大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 腎病理に基づくDKDコホート解析2021

    • Author(s)
      清水美保・古市賢吾・和田隆志
    • Organizer
      第64回日本糖尿病学会年次学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 糖尿病性腎臓病における腎硬化症の側面2021

    • Author(s)
      清水美保・古市賢吾・和田隆志
    • Organizer
      第64回日本腎臓学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Strategies for anemia managementin diabetes and chronic kidney disease2021

    • Author(s)
      大島恵・和田隆志
    • Organizer
      第64回日本腎臓学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 糖尿病性腎臓病:病態と治療2021

    • Author(s)
      和田隆志
    • Organizer
      日本内科学会 第80回東海支部主催生涯教育講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎臓病:腎病理に基づく現状と課題2021

    • Author(s)
      清水美保・和田隆志
    • Organizer
      第36回日本糖尿病合併症学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 糖尿病性腎臓病の病態を反映する腎病理とバイオマーカー2021

    • Author(s)
      清水美保・古市賢吾・和田隆志
    • Organizer
      第51回日本腎臓学会西部学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 腎腸連関と腎臓病2021

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Organizer
      第51回日本腎臓学会西部学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 重度尿蛋白を伴う糖尿病例に対するLDLアフェレシス2021

    • Author(s)
      原章規・遠山直志・和田隆志
    • Organizer
      第42回日本アフェレシス学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 糖尿病合併CKDの腎病理2021

    • Author(s)
      清水美保・和田隆志
    • Organizer
      第32回日本糖尿病性腎症研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The gut-kidney axis in diabetic kidney disease2020

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 糖尿病例における腎病変―病態と治療―2020

    • Author(s)
      和田隆志
    • Organizer
      日本糖尿病学会 中国四国地方会第58回総会(WEB開催)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 慢性腎臓病と糖尿病性腎臓病:病態と最新治療2020

    • Author(s)
      和田隆志
    • Organizer
      第65回日本透析医学会学術集会・総会(WEB開催)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎臓病・腎硬化症の診療2020

    • Author(s)
      和田隆志
    • Organizer
      2020年度日本内科学会生涯教育講演会 Bセッション(第2回)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 糖尿病例に見られる腎病理の多様性2019

    • Author(s)
      古市賢吾・和田隆志
    • Organizer
      第62回日本糖尿病学会年次学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎臓病/糖尿病性腎症の病理と病態2019

    • Author(s)
      和田隆志・清水美保・遠山直志・湯澤由紀夫・乳原善文・古市賢吾
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 細菌叢と腎臓を繋ぐD-アミノ酸2019

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Organizer
      第62回日本腎臓学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 腎腸連関機構の解明とその制御2019

    • Author(s)
      和田隆志
    • Organizer
      第40回日本炎症・再生医学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎症・糖尿病性腎臓病の病理と臨床病態2019

    • Author(s)
      和田隆志
    • Organizer
      第2回日本法医病理学会学術全国集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 腎症の先進医療:高度蛋白尿に対するアフェレシス療法2019

    • Author(s)
      原章規・和田隆志
    • Organizer
      第34回日本糖尿病合併症学会・第25回日本糖尿病眼学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Chiral Science Seminar (C03)2019

    • Author(s)
      Takashi Wada
    • Organizer
      The 4th International Conference of D-Amino Acid Research(IDAR2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 糖尿病性腎臓病の病態と治療2021

    • Author(s)
      清水美保・和田隆志
    • Total Pages
      270
    • Publisher
      中外医学社
    • Related Report
      2021 Annual Research Report
  • [Book] 糖尿病性腎臓病の病態と治療2021

    • Author(s)
      遠山直志・清水美保・古市賢吾・和田隆志
    • Total Pages
      270
    • Publisher
      中外医学社
    • Related Report
      2021 Annual Research Report
  • [Book] 糖尿病性腎臓病の病態と治療2021

    • Author(s)
      大島恵・遠山直志・和田隆志
    • Total Pages
      270
    • Publisher
      中外医学社
    • Related Report
      2021 Annual Research Report
  • [Book] 腎臓内科Controversy2021

    • Author(s)
      遠山直志・大島恵・清水美保・和田隆志
    • Total Pages
      308
    • Publisher
      中外医学社
    • Related Report
      2021 Annual Research Report
  • [Book] 腎臓内科Controversy2021

    • Author(s)
      清水美保・遠山直志・和田隆志
    • Total Pages
      308
    • Publisher
      中外医学社
    • Related Report
      2021 Annual Research Report
  • [Book] ヒトマイクロバイオーム Vol.22020

    • Author(s)
      岩田恭宜・中出祐介・和田隆志
    • Total Pages
      624
    • Publisher
      エヌ・ティー・エス
    • ISBN
      9784860436599
    • Related Report
      2020 Annual Research Report
  • [Book] 改訂第9版 内科学書 Vol.32019

    • Author(s)
      和田隆志・古市賢吾・清水美保
    • Total Pages
      3000
    • Publisher
      中山書店
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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