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Elucidation of early pathology of motor neuron diseases using disease specific iPSCs

Research Project

Project/Area Number 19H03576
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52020:Neurology-related
Research InstitutionAichi Medical University

Principal Investigator

Okada Yohei  愛知医科大学, 加齢医科学研究所, 教授 (30383714)

Co-Investigator(Kenkyū-buntansha) 伊藤 卓治  愛知医科大学, 加齢医科学研究所, 助教 (30794151)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Keywords疾患iPS細胞 / 運動ニューロン疾患 / 早期病態
Outline of Research at the Start

球脊髄性筋萎縮症(SBMA)は、30~50歳台の成人男性に発症する緩徐進行性の下位運動ニューロン変性疾患である。ポリグルタミン鎖の伸長した変異ARが、リガンドであるテストステロン依存的に凝集体を形成し、神経変性を誘導すると考えられてきた。一方で、変異AR凝集体によらない早期病態が示唆されており、またリュープロレリン(抗アンドロゲン療法)は発症早期の患者でのみ有効性が示されたことから、早期病態の解明と早期治療は必要不可欠である。本研究では、SBMA疾患iPS細胞による早期病態モデルを用いて同定した4つの分泌型神経ペプチドに着目し、SBMAの早期病態、神経・筋病態解明と新規治療標的の探索を行う。

Outline of Final Research Achievements

Spinal bulbar muscular atrophy (SBMA) is an adult-onset motor neuron degenerative disease. Previous analysis has shown the pathogenesis induced by mutant androgen receptor (AR) aggregates, however, recent analysis suggested pathology independent of mutant AR aggregates. Moreover, leuprorelin treatment has shown to be effective especially in patients in the early stage of the disease. In this study, we generated an early disease model using motor neurons derived from SBMA disease-specific iPSCs, and identified molecules that were involved in the early pathology of SBMA. Inhibitors of the identified molecules and their downstream molecules rescued the phenotype, suggesting that these molecules could be novel therapeutic targets of SBMA.

Academic Significance and Societal Importance of the Research Achievements

本研究により、SBMA疾患特異的iPS細胞を用いることで、SBMAの早期病態を再現し得る病態モデルを作成し、早期病態に関与する分子を同定することができた。また、これらの分子の病態への関与を解析することで、SBMAの早期病態の一部を解明し、新規治療標的を同定することができた。今後は、同定した分子を足がかりにSBMAの早期病態の詳細を解明するとともに、新規治療開発に向けた解析を進めていく予定である。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (57 results)

All 2022 2021 2020 2019 Other

All Journal Article (15 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (39 results) (of which Int'l Joint Research: 7 results,  Invited: 10 results) Remarks (3 results)

  • [Journal Article] The SYNGAP1 3'UTR variant in ALS patients causes aberrant SYNGAP1 splicing and dendritic spine loss by recruiting HNRNPK2022

    • Author(s)
      Yokoi S, Ito T, Sahashi K, Nakatochi M, Tohnai G, Nakamura R, Fujioka Y, Ishigaki S, Udagawa T, Izumi Y, Morita M, Kano O, Oda M, Sone T, Okano H, Atsuta N, Katsuno M, Okada Y*, Sobue G*
    • Journal Title

      Journal of Neuroscience

      Volume: 42 Issue: 47 Pages: 8881-8896

    • DOI

      10.1523/jneurosci.0455-22.2022

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SBMAの病態解明・治療開発研究2022

    • Author(s)
      岡田梨奈、岡田洋平
    • Journal Title

      生体の科学

      Volume: 73 Pages: 480-481

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Two distinct mechanisms of neuropathy in immunoglobulin light chain (AL) amyloidosis2021

    • Author(s)
      Koike H, Mouria N, Fukamia Y, Iijima M, Matsuo K, Yagi N, Saito A, Nakamura H, Takahashi K, Nakae Y, Okada Y, Tanaka F, Sobue G, Katsuno M
    • Journal Title

      Commun Biol.

      Volume: 421 Pages: 117305-117305

    • DOI

      10.1016/j.jns.2020.117305

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective suppression of polyglutamine-expanded protein by lipid nanoparticle-delivered siRNA targeting CAG expansions in the mouse CNS.2021

    • Author(s)
      Hirunagi T, Sahashi K, Tachikawa K, Leu AI, Nguyen M, Mukthavaram R, Karmali PP, Chivukula P, Tohnai G, Iida M, Onodera K, Ohyama M, Okada Y, Okano H, Katsuno M.
    • Journal Title

      Mol Ther Nucleic Acids.

      Volume: 24 Pages: 1-10

    • DOI

      10.1016/j.omtn.2021.02.007

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of a Human Neuromuscular Tissue-on-a-Chip Model on a 24-Well-Plate-Format Compartmentalized Microfluidic Device2021

    • Author(s)
      Yamamoto K, Yamaoka N, Imaizumi Y, Nagashima T, Furutani T, Ito T, Okada Y, Honda H, Shimizu K
    • Journal Title

      Lab on a Chip

      Volume: 21 Issue: 10 Pages: 1897-1907

    • DOI

      10.1039/d1lc00048a

    • NAID

      120007169522

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antiparkinsonian drugs as potent contributors to nocturnal sleep in patients with Parkinson's disease.2021

    • Author(s)
      Taguchi S, Koide H, Oiwa H, Hayashi M, Ogawa K, Ito C, Nakashima K, Yuasa T, Yasumoto A, Ando H, Fujikake A, Fukuoka T, Tokui K, Izumi M, Tsunoda Y, Kawagashira Y, Okada Y, Niwa JI, Doyu M.
    • Journal Title

      PLoS One.

      Volume: 16 Issue: 7 Pages: e0255274-e0255274

    • DOI

      10.1371/journal.pone.0255274

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.2020

    • Author(s)
      Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi N, Yokoi D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Kanai K, Hattori N, Morita M, Taniguchi A, Kano O, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okada Y, Nagasaki M, Sobue G. et al.,
    • Journal Title

      Commun Biol.

      Volume: 23 Issue: 1 Pages: 526-526

    • DOI

      10.1038/s42003-020-01251-2

    • NAID

      120007178464

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] n vitro model of human skeletal muscle tissues with contractility fabricated by immortalized human myogenic cells.2020

    • Author(s)
      Nagashima T, Hadiwidjaja S, Ohsumi S, Murata A, Hisada T, Kato R, Okada Y, Honda H, Shimizu K
    • Journal Title

      Adv Biosyst.

      Volume: 11 Issue: 11

    • DOI

      10.1002/adbi.202000121

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modulation of oxygen tension, acidosis, and cell density is crucial for neural differentiation of human induced pluripotent stem cells.2020

    • Author(s)
      Okada R, Onodera K, Ito T, Doyu M, Okano HJ, Okada Y
    • Journal Title

      Neurosci. Res.

      Volume: - Pages: 30043-2

    • DOI

      10.1016/j.neures.2020.01.015

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unveiling synapse pathology in spinal bulbar muscular atrophy by genome-wide transcriptome analysis of purified motor neurons derived from disease specific iPSCs2020

    • Author(s)
      Onodera K, Shimojo D, Ishihara Y, Yano M, Miya F, Banno H, Kuzumaki N, Ito T, Okada R, Ohyama M, Yoshida M, Tsunoda T, Katsuno M, Doyu M, Sobue G, Okano H, Okada Y
    • Journal Title

      Mol. Brain

      Volume: 13 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s13041-020-0561-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Open-Chamber Co-Culture Microdevices for Single-Cell Analysis of Skeletal Muscle Myotubes and Motor Neurons with Neuromuscular Junctions2019

    • Author(s)
      Nao Yamaoka、Shimizu Kazunori、Yu Imaizumi、Takuji Ito、Yohei Okada、Hiroyuki Honda
    • Journal Title

      BioChip Journal

      Volume: in press Issue: 2 Pages: 127-132

    • DOI

      10.1007/s13206-018-3202-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant axon branching via Fos-B dysregulation in FUS-ALS motor neurons.2019

    • Author(s)
      Akiyama T, Suzuki N, Ishikawa M, Fujimori K, Sone T, Kawada J, Funayama R, Fujishima F, Mitsuzawa S, Ikeda K, Ono H, Shijo T, Osana S, Shirota M, Nakagawa T, et al.
    • Journal Title

      EBioMedicine

      Volume: 45 Pages: 362-378

    • DOI

      10.1016/j.ebiom.2019.06.013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Src inhibition attenuates polyglutamine-mediated neuromuscular degeneration in spinal and bulbar muscular atrophy2019

    • Author(s)
      Iida M, Sahashi K, Kondo N, Nakatsuji H, Tohnai G, Tsutsumi Y, Noda S, Murakami A, Onodera K, Okada Y, Nakatochi M, Okabe Y, Shimizu S, Mizuno M, Adachi H, Okano H, Sobue G, Katsuno M
    • Journal Title

      Nat. Commun.

      Volume: 10 Pages: 4262-4262

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tandem paired nicking promotes precise genome editing with scarce interference by p532019

    • Author(s)
      Hyodo T, Rahman ML, Karnan S, Ito T, Toyoda A, Ota A, Wahiduzzaman M, Tsuzuki S, Okada Y, Hosokawa Y, Konishi H.
    • Journal Title

      Cell Rep.

      Volume: 30 Issue: 4 Pages: 1195-1207

    • DOI

      10.1016/j.celrep.2019.12.064

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 疾患特異的iPS細胞を用いた神経変性疾患の病態解析と新規治療法開発2019

    • Author(s)
      岡田洋平
    • Journal Title

      臨床雑誌内科

      Volume: 123 Pages: 1315-1319

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] iPS細胞を用いたSBMAの病態解明、治療開発研究2022

    • Author(s)
      岡田洋平
    • Organizer
      SBMAの会 2022年度医療セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた神経疾患の病態解明と治療戦略2022

    • Author(s)
      岡田洋平
    • Organizer
      第62回日本定位・機能神経外科学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2022

    • Author(s)
      小野寺一成, 下門大祐, Bruno De Araujo Herculano1, 石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid Muhammad Irfanur, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央,岡野栄之,岡田洋平
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in ALS2022

    • Author(s)
      大岩康太郎, 渡邊征爾, 小野寺一成, 井口洋, 岡田洋平, 勝野雅央, 山中 宏二
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第33回日本末梢神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第33回日本末梢神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Bulk differentiation of iPSCs into contractible muscles for muscular disease modeling2022

    • Author(s)
      Rashid MI, Ito T, Miya F, Shimojo D, Arimoto K, Onodera K, Okada R, Nagashima T, Yamamoto K, Khatun Z, Okano H, Sakurai H, Shimizu K, Doyu M, Okada Y
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 疾患iPS細胞由来神経・筋共培養モデルを用いた運動ニューロン疾患の非細胞自律的神経変性を担う分子病態の解明2022

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、小野寺一成、岡田梨奈、下門大祐、田中智史、勝野雅央、祖父江元、道勇学、岡野栄之、岡田洋平
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Establishment of a more efficient disease model for ALS using feeder-free disease specific iPSCs2022

    • Author(s)
      Khatun Z, Onodera K, Yamaguchi S, Okada R, Ito T, Rashid MI, Inoue H, Aoki M, Okano H, Doyu M, Okada Y
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 疾患特異的iPS細胞を用いた球脊髄性筋萎縮症(SBMA)の早期病態解明と治療開発2022

    • Author(s)
      小野寺一成、下門大祐、石原康晴、太田明伸、Muhammad Irfanur Rashid、伊藤卓治、岡田梨奈、細川好孝、道勇学、祖父江元、勝野雅央、岡野栄之、岡田洋平
    • Organizer
      第22回日本再生医療学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 疾患特異的iPS細胞を用いた運動ニューロン疾患の病態解明と治療開発2021

    • Author(s)
      岡田洋平
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 病態に基づいた神経疾患の再生戦略2021

    • Author(s)
      岡田洋平
    • Organizer
      浜松医科大学尖端医学シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 疾患特異的iPS細胞を用いた神経・筋病態の解明2021

    • Author(s)
      岡田洋平
    • Organizer
      第60回日本臨床検査医学会東海・北陸支部総会、第344回日本臨床化学会東海・北陸支部例会 連合大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Elucidating early pathophysiology of spinal-bulbar muscular atrophy using disease-specific iPSCs2021

    • Author(s)
      小野寺一成, 下門大祐, de Ara?jo Herculano B,石原康晴, 依田真由子, 太田明伸, 矢野真人, 宮冬樹, Rashid MI, 伊藤卓治, 岡田梨奈, 角田達彦, 細川好孝, 道勇学, 祖父江元, 勝野雅央, 岡野栄之, 岡田 洋平
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] SynGAP variant from ALS cohort causes spine abnormality by excessive recruitment of FUS and hnRNPK2021

    • Author(s)
      横井聡, 伊藤卓治, 佐橋健太郎, 中村亮一, 石垣診祐, 熱田直樹, 勝野雅央, 岡田 洋平, 祖父江元
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 脳卒中患者における自律神経機能と病状との関連2021

    • Author(s)
      中島 康自, 小出 弘文, 林 未久, 伊藤 千弘, 湯淺 知子, 安本 明弘, 安藤 宏明, 田口 宗太郎, 藤掛 彰史, 福岡 敬晃, 徳井 啓介, 川頭 祐一, 岡田 洋平, 丹羽 淳一, 道勇 学
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Allele selective suppression of mutant polyQ protein by LNP-delivered siRNA targeting CAG expansions2021

    • Author(s)
      蛭薙智紀, 佐橋健太郎, 立川潔, Leu A, Nguyen M, Mukthavaram R, Karmali P, Chivukula P, 藤内玄規, 飯田円, 小野寺一成, 大山学, 岡田 洋平, 岡野栄之, 勝野雅央
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The effects of g-secretase inhibitor on differentiation of iPSC-derived neurons2021

    • Author(s)
      福井ナナミ、伊藤卓治、杉山香織、岡田梨奈、小野寺一成、Zohora Khatun、道勇学、岡田洋平
    • Organizer
      第44回日本神経科学大会 CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
  • [Presentation] Establishment of hiPSC-derived functional neuromuscular models for the analysis of neuromuscular diseases2021

    • Author(s)
      伊藤卓治、ラシッド ムハンマド イルファヌール、田中智史、下門大祐、岡野栄之、道勇学、岡田洋平
    • Organizer
      ヒトiPS細胞由来運動ニューロンと骨格筋を用いた機能的神経筋共培養モデルの構築、第44回日本神経科学大会 CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
  • [Presentation] Efficient, reproducible, and functional differentiation of human induced pluripotent stem cells (iPSCs) into skeletal muscles for muscular disease modeling.2021

    • Author(s)
      Rashid MI, Ito T, Shimojo D, Khatun Z, Sakurai H, Shimizu K, Doyu M, Okada Y.
    • Organizer
      PACTALS 2021 NAGOYA
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidating early pathophysiology of Spinal-bulbar muscular atrophy using diseasespecific iPSCs.2021

    • Author(s)
      Onodera K, Shimojo D, de Ara?jo Herculano B, Ishihara Y, Yoda M, Ota A, Rashid MI, Ito T, Okada R, Hosokawa Y, Doyu M, Sobue G, Katsuno M, Okano H, Okada Y
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Establishment of iPSC-derived neuromuscular co-culture model for the analysis of non-cell autonomous neurodegeneration in motor neuron diseases2021

    • Author(s)
      Ito T, Rashid MI, Tanaka S, Shimojo D, Okano H, Doyu M, Okada Y.
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficient, reproducible and functional differentiation of human iPSCs into skeletal muscles for muscular disease modeling.2021

    • Author(s)
      Rashid MI, Ito T, Shimojo D, Khatun Z, Sakurai H, Shimizu K, Doyu M, Okada Y.
    • Organizer
      ISSCR/JSRM 2021 Tokyo International Symposium, Tokyo
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 疾患iPS細胞を用いた運動ニューロン疾患の病態解明と治療開発2020

    • Author(s)
      岡田洋平
    • Organizer
      第19回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 末梢神経障害の機能再建におけるヒトiPS細胞の可能性と問題点2020

    • Author(s)
      岡田洋平
    • Organizer
      第31回日本末梢神経学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 疾患特異的iPS細胞を用いた神経・筋病態の解明2020

    • Author(s)
      岡田洋平
    • Organizer
      第6回日本筋学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Drug screening for early pathology of SBMA using disease specific iPSCs and novel biomarkers2020

    • Author(s)
      エルクラノ ブルーノ、小野寺一成、伊藤卓治、下門大祐、岡田梨奈、勝野雅央、道勇学、祖父江元、岡野栄之、岡田洋平
    • Organizer
      第19回日本再生医療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 疾患iPS細胞による神経・筋共培養を活用した神経変性疾患の病態解析2020

    • Author(s)
      伊藤卓治、小野寺一成、下門大祐、田中智史、岡田梨奈、ラシッド ムハンマド イルファヌール、道勇学、岡野栄之、岡田洋平
    • Organizer
      第19回日本再生医療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Efficient and reproducible skeletal muscle differentiation from iPSCs for muscular diseases modeling2020

    • Author(s)
      ラシッド ムハンマド イルファヌール、伊藤卓治、小野寺一成、道勇学、岡田洋平
    • Organizer
      第19回日本再生医療学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Elucidation of early pathophysiology of spinal-bulbar muscular atrophy using disease- specific iPSCs.2020

    • Author(s)
      Onodera K, Shimojo D,Yoda M, Ishihara Y, Ota A, Yano M, Miya F, Rashid MI, Ito T, Okada R, Tsunodna T, Hosokawa Y, Doyu M,Katsuno M, Okano H, Sobue G, Okada Y.
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Pathophysiological analysis of spinal and bulbar muscular atrophy using disease-specific iPSCs.2019

    • Author(s)
      Onodera K, Shimojo D, Yoda M, Ishihara Y, Ito T, Okada R, Doyu M, Katsuno M, Okano H, Sobue G, Okada Y
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] FUS depletion induces spine abnormality and SynGAP depletion in hiPSC-derived motor neuron.2019

    • Author(s)
      Yokoi S, Ito T, Sahashi K, Ishigaki S, Katsuno M, Okada Y, Sobue G.
    • Organizer
      第60回日本神経学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The effects of hypoxia on differentiation and maturation of human induced pluripotent stem cell-derived neural progenitors.2019

    • Author(s)
      Okada Y, Okada R, Li J, Onodera K, Ito T, Okano HJ, Doyu M
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Reconstruction of motor function in peripheral nerves by transplanatation of human iPSC-derived motor neuron progenitors.2019

    • Author(s)
      Niwa S, Saeki M, Shinkai H, Kurimoto S, Hirata H, Doyu M, Okada Y
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Elucidation of non-cell autonomous neurodegeneration in spinal and bulbar muscular atrophy using iPSC-derived neuromuscular models.2019

    • Author(s)
      Ito T, Tanaka S, Shimojo D, Doyu M, Okano H, Okada Y
    • Organizer
      ISSCR 2019 Annual Meeting, LosAngeles
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iPS細胞を用いた神経疾患研究2019

    • Author(s)
      岡田洋平
    • Organizer
      SBMAの会 第8回医療セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いたNMJ形成②2019

    • Author(s)
      岡田洋平
    • Organizer
      AMED再生医療実現拠点ネットワークプログラム「疾患特異的iPS細胞の利活用促進・難病研究加速プログラム」研究拠点I疾患別ミーティング
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Remarks] 愛知医科大学加齢医科学研究所 神経iPS細胞研究部門

    • URL

      https://okadalab-hp.com/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 愛知医科大学医学部内科学講座(神経内科)

    • URL

      https://www.aichi-med-u.ac.jp/su06/su0607/su060703/02.html

    • Related Report
      2021 Annual Research Report
  • [Remarks] 愛知医科大学 神経内科

    • URL

      https://www.aichi-med-u.ac.jp/su06/su0607/su060703/02.html

    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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