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Development of new therapeutoc strategy for high-risk chemotherapy-refractory neuroblastoma

Research Project

Project/Area Number 19H03598
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKanazawa University

Principal Investigator

Kinuya Seigo  金沢大学, 医学系, 教授 (20281024)

Co-Investigator(Kenkyū-buntansha) 萱野 大樹  金沢大学, 附属病院, 講師 (10547152)
小川 数馬  金沢大学, 新学術創成研究機構, 教授 (30347471)
村山 敏典  金沢大学, 附属病院, 教授 (30378765)
稲木 杏吏  金沢大学, 附属病院, 講師 (40645131)
若林 大志  金沢大学, 附属病院, 助教 (60622818)
今井 康人  金沢大学, 附属病院, 特任教授 (60720878)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Keywords内照射療法 / 内用療法 / 神経芽腫 / MIBG / 免疫チェックポイント阻害剤
Outline of Research at the Start

高リスク群化学療法不応性神経芽腫に対して、研究応募者施設では、大容量131I-MIBG内照射療法(以下、MIBG治療)を治療に組み込むことで、寛解導入可能であることを示してきたが、無効例、寛解後再発が多々経験される。高リスク群神経芽腫に対して、近年免疫チェックポイント阻害剤による免疫療法の可能性が報告されつつある。一方、外照射放射線治療において、死滅した癌細胞由来物質により惹起された宿主免疫応答効果が考慮されるようになってきた。本研究においては、神経芽腫治療においてMIBG治療と免疫療法の治療効果増強の可能性とその背景機序を動物における非臨床で検証し、将来の臨床応用に結びつけることを企図する。

Outline of Final Research Achievements

Accumulation of 131I-MIBG in the neuroblastoma cell lines, SK-N-SH and SK-N-F1, were determined to be the saturable active transport through upytake-1 mechanism on cells in contrast that in nonspecific cells depended on non-saturable uptake. Vmax of this mechanism on the cells was determined. Analysis by flow-cytometry revealed PD-L1 expression on SK-N-F1 cells but not on SK-N-SH cells. However, its expression after irradiation was controversially upregulated in SK-N-SH cells but not in SK-N-F1 cells. The combined use of internal radiation therapy and immune therapy may be valuable in the treatment of neuroblastoma patients.

Academic Significance and Societal Importance of the Research Achievements

高リスク群神経芽腫患者の生命予後はきわめて不良である。応募者の施設では、骨髄破壊的投与量による131I-MIBGと化学療法および治療後の骨髄移植を併用することにより、治療奏効率の厚情が得られることを示してきたが、いまだ十分な奏効率とは言えない状況である。本研究で、この治療方針に免疫治療を併用することにより、一層の奏効率が得られる可能性が見いだされた。また、臨床で本治療を先進医療B、医師主導治験として継続実施でき、本課題を臨床に持ち上げるための基盤作りができた。医療従事者被ばく低減に関わる検討によると、タングステンシールドの使用により大幅に線量低減が可能であることが示された。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (65 results)

All 2022 2021 2020 2019

All Journal Article (24 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 23 results,  Open Access: 15 results) Presentation (41 results) (of which Int'l Joint Research: 8 results,  Invited: 16 results)

  • [Journal Article] Prognostic factors for refractory pheochromocytoma and paraganglioma after 131 I-metaiodobenzylguanidine therapy2022

    • Author(s)
      Hiromasa T, Wakabayashi H, Kayano D, Inaki A, Watanabe S, Mori H, Akatani N, Yamase T, Kunita Y, Saito S, Kinuya S.
    • Journal Title

      Ann Nucl Med

      Volume: 36 Issue: 1 Pages: 61-69

    • DOI

      10.1007/s12149-021-01685-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phase I/II clinical trial of high-dose [131I] meta-iodobenzylguanidine therapy for high-risk neuroblastoma preceding single myeloablative chemotherapy and haematopoietic stem cell transplantation.2022

    • Author(s)
      Kuroda R, Wakabayashi H, Araki R, Inaki A, Nishimura R, Ikawa Y, Yoshimura K, Murayama T, Imai Y, Funasaka T, Wada T, Kinuya S.
    • Journal Title

      Eur J Nucl Med Mol Imaging,

      Volume: in press Issue: 5 Pages: 1574-1583

    • DOI

      10.1007/s00259-021-05630-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Application of a tungsten apron for occupational radiation exposure in nursing care of children with neuroblastoma during 131 I-meta-iodo-benzyl-guanidine therapy2022

    • Author(s)
      Taniguchi Y, Wakabayashi H, Yoneyama H, Chen Z, Morino K, Otosaki A, Yamada M, Inaki A, Kayano D, Kinuya S.
    • Journal Title

      Sci Rep

      Volume: 12 Issue: 1 Pages: 47-47

    • DOI

      10.1038/s41598-021-03843-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of Radiohalogenated Osimertinib Derivatives as Imaging Probes for Companion Diagnostics of Osimertinib2022

    • Author(s)
      Mishiro K, Nishii R, Sawazaki I, Sofuku T, Fuchigami T, Sudo H, Effendi N, Makino A, Kiyono Y, Shiba K, Taki J, Kinuya S, Ogawa K.
    • Journal Title

      J Med Chem

      Volume: 65 Issue: 3 Pages: 1835-1847

    • DOI

      10.1021/acs.jmedchem.1c01211

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of the detecting capability between 123I-mIBG and post-therapeutic 131I-mIBG scintigraphy for curie scoring in patients with neuroblastoma after chemotherapy.2021

    • Author(s)
      Qiu ZL, Saito S, Kayano D, Wakabayashi H, Kinuya S.
    • Journal Title

      Ann Nucl Med

      Volume: 35 Issue: 6 Pages: 649-661

    • DOI

      10.1007/s12149-020-01569-1

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Manual on the proper use of sodium astatide ([211At]NaAt) injections in clinical trials for targeted alpha therapy (1st edition)2021

    • Author(s)
      Watabe Tadashi、Hosono Makoto、Kinuya Seigo、Yamada Takahiro、Yanagida Sachiko、Namba Masao、Nakamura Yoshihide
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 35 Issue: 7 Pages: 753-766

    • DOI

      10.1007/s12149-021-01619-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Report on Health Resource Use in Internal Radiation Therapy with <sup>131</sup>I-MIBG2021

    • Author(s)
      Kato K, Nakamura S, Matoba Y, Kinuya S.
    • Journal Title

      KAKUIGAKU

      Volume: 58 Issue: 1 Pages: 33-38

    • DOI

      10.18893/kakuigaku.tr.2103

    • NAID

      130008047398

    • ISSN
      2189-9932
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Radiation Protection Against Exposure from Patients Receiving <sup>131</sup>I-MIBG and Released from Radiation Treatment Room2021

    • Author(s)
      Inaki A, Wakabayashi H, Kayano D, Kinuya S.
    • Journal Title

      KAKUIGAKU

      Volume: 58 Issue: 1 Pages: 59-66

    • DOI

      10.18893/kakuigaku.tr.2106

    • NAID

      130008067995

    • ISSN
      2189-9932
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 68Ga- and 211At-Labeled RGD Peptides for Radiotheranostics with Multiradionuclides2021

    • Author(s)
      Ogawa K, Echigo H, Mishiro K, Hirata S, Washiyama K, Kitamura Y, Takahashi K, Shiba K, Kinuya S.
    • Journal Title

      Molecular Pharmaceutics

      Volume: 18(9) Issue: 9 Pages: 3553-3562

    • DOI

      10.1021/acs.molpharmaceut.1c00460

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An open-label, single-arm, multi-center, phase II clinical trial of single-dose [<sup>131</sup>I]meta-iodobenzylguanidine therapy for patients with refractory pheochromocytoma and paraganglioma.2021

    • Author(s)
      Inaki A, Shiga T, Tsushima Y, Jinguji M, Wakabayashi H, Kayano D, Akatani N, Yamase T, Kunita Y, Watanabe S, Hiromasa T, Mori H, Hirata K, Watanabe S, Higuchi T, Tomonaga H, Kinuya S.
    • Journal Title

      Ann Nucl Med.

      Volume: 36 Issue: 3 Pages: 267-278

    • DOI

      10.1007/s12149-021-01699-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Radiobrominated Tyrosine Kinase Inhibitor for EGFR with L858R/T790M Mutations in Lung Carcinoma2021

    • Author(s)
      Fawwaz M, Mishiro K, Nishii R, Makino A, Kiyono Y, Shiba K, Kinuya S, Ogawa K.
    • Journal Title

      Pharmaceuticals (Basel)

      Volume: 14 Issue: 3 Pages: 256-256

    • DOI

      10.3390/ph14030256

    • NAID

      120006994107

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] In vitro and in vivo evaluation of [125/123I]-2-[4-(2-iodophenyl)piperidino]cyclopentanol([125/123I]-OI5V) as a potential sigma-1 receptor ligand for SPECT.2021

    • Author(s)
      Taiki Shigeno, Takashi Kozaka, Yoji Kitamura, Kazuma Ogawa, Junichi Taki, Seigo Kinuya, Kazuhiro Shiba.
    • Journal Title

      Ann Nucl Med.

      Volume: 35 Issue: 2 Pages: 165-175

    • DOI

      10.1007/s12149-020-01552-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of Radiogallium-Labeled Peptides for Platelet-Derived Growth Factor Receptor β (PDGFR β) Imaging: Influence of Different Linkers2020

    • Author(s)
      Effendi N, Mishiro K, Shiba K, Kinuya S, Ogawa K.
    • Journal Title

      Molecules

      Volume: 26 Issue: 1 Pages: 41-41

    • DOI

      10.3390/molecules26010041

    • NAID

      120007185671

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnostic Use of Post-therapy 131 I-Meta-Iodobenzylguanidine Scintigraphy in Consolidation Therapy for Children with High-Risk Neuroblastoma2020

    • Author(s)
      Wakabayashi H, Kayano D, Inaki A, Araki R, Kuroda R, Akatani N, Yamase T, Watanabe S, Hiromasa T, Kunita Y, Mori H, Saito S, Ikawa Y, Fujiki T, Kinuya S.
    • Journal Title

      Diagnostics (Basel)

      Volume: 10 Issue: 9 Pages: 663-663

    • DOI

      10.3390/diagnostics10090663

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-dose 131I-mIBG as consolidation therapy in pediatric patients with relapsed neuroblastoma and ganglioneuroblastoma: the Japanese experience2020

    • Author(s)
      Wakabayashi Hiroshi、Kayano Daiki、Inaki Anri、Araki Raita、Kuroda Rie、Ikawa Yasuhiro、Fujiki Toshihiro、Akatani Norihito、Yamase Takafumi、Watanabe Satoru、Hiromasa Tomo、Kunita Yuji、Mori Hiroshi、Saito Shintaro、Nishimura Ryosei、Wada Taizo、Kinuya Seigo
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 34 Issue: 11 Pages: 840-846

    • DOI

      10.1007/s12149-020-01514-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreasing undesirable absorbed radiation to the intestine after administration of radium-223 dichloride for treatment of bone metastases2020

    • Author(s)
      Ogawa K, Higashi T, Mishiro K, Wakabayashi H, Shiba K, Odani A, Kinuya S.
    • Journal Title

      Sci Rep

      Volume: 10 Issue: 1 Pages: 11917-11917

    • DOI

      10.1038/s41598-020-68846-x

    • NAID

      120007185662

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis and Fundamental Evaluation of Radioiodinated Rociletinib (CO-1686) as a Probe to Lung Cancer with L858R/T790M Mutations of Epidermal Growth Factor Receptor (EGFR)2020

    • Author(s)
      Fawwaz M, Mishiro K, Nishii R, Sawazaki I, Shiba K, Kinuya S, Ogawa K.
    • Journal Title

      Molecules

      Volume: 25 Issue: 12 Pages: 2914-2914

    • DOI

      10.3390/molecules25122914

    • NAID

      120007185670

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Nationwide Survey on Avoidance of Targeted Radionuclide Therapy in Patients with Limited Activities of Daily Living and Those Undergoing Hemodialysis2020

    • Author(s)
      Mori H, Inaki A, Kayano D, Wakabayashi H, Hosono M, Higashi T, Oriuchi N, Abe K, Uchiyama M, Kinuya S.
    • Journal Title

      KAKUIGAKU

      Volume: 57 Issue: 1 Pages: 39-46

    • DOI

      10.18893/kakuigaku.oa.1902

    • NAID

      130007851903

    • ISSN
      2189-9932
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiation exposure in nurses during care of 131I-MIBG therapy for pediatric patients with high-risk neuroblastoma2020

    • Author(s)
      Taniguchi Yuka、Wakabayashi Hiroshi、Inaki Anri、Kayano Daiki、Yamada Masako、Kinuya Seigo
    • Journal Title

      Annals of Nuclear Medicine

      Volume: 34 Issue: 6 Pages: 441-447

    • DOI

      10.1007/s12149-020-01466-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-dose 131I-metaiodobenzylguanidine therapy in patients with high-risk neuroblastoma in Japan.2020

    • Author(s)
      Kayano D, Wakabayashi H, Nakajima K, Kuroda R, Watanabe S, Inaki A, Toratani A, Akatani N, Yamase T, Kunita Y, Hiromasa T, Takata A, Mori H, Saito S, Araki R, Taki J, Kinuya S
    • Journal Title

      Ann Nucl Med

      Volume: 34 Issue: 6 Pages: 397-406

    • DOI

      10.1007/s12149-020-01460-z

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 希少がんに対する核医学治療:期待と本邦における課題2020

    • Author(s)
      絹谷清剛
    • Journal Title

      腫瘍内科

      Volume: 26 Pages: 449-456

    • NAID

      40022384683

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Utility of 123I-MIBG Standardized Uptake Value in Patients with Refractory Pheochromocytoma and Paraganglioma2019

    • Author(s)
      Wakabayashi H, Konishi T, Yoneyama H, Inaki A, Hiromasa T, Yamase T, Akatani N, Watanabe S, Mori H, Kayano D, Kinuya S
    • Journal Title

      Asia Ocean J Nucl Med Biol

      Volume: 7 Pages: 115-120

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A phase I clinical trial for [131I]meta-iodobenzylguanidine therapy in patients with refractory pheochromocytoma and paraganglioma.2019

    • Author(s)
      Wakabayashi H, Inaki A, Yoshimura K, Murayama T, Imai Y, Higuchi T, Jinguji M, Shiga T, Kinuya S.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 7625-7626

    • DOI

      10.1038/s41598-019-43880-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiotheranostics Coupled between an At-211-Labeled RGD Peptide and the Corresponding Radioiodine-Labeled RGD Peptide2019

    • Author(s)
      Ogawa Kazuma、Takeda Takuya、Mishiro Kenji、Toyoshima Atsushi、Shiba Kazuhiro、Yoshimura Takashi、Shinohara Atsushi、Kinuya Seigo、Odani Akira
    • Journal Title

      ACS Omega

      Volume: 4 Issue: 3 Pages: 4584-4591

    • DOI

      10.1021/acsomega.8b03679

    • NAID

      120007185656

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 核医学治療普及に求められること2022

    • Author(s)
      絹谷清剛
    • Organizer
      令和3年度第1回量子医療研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] I-131MIBG核医学治療:自験例を含めて2022

    • Author(s)
      稲木杏吏
    • Organizer
      第35回JCRミッドウィンターセミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 核医学治療 ー theranostics2021

    • Author(s)
      絹谷清剛
    • Organizer
      第94回日本内分泌学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 国内で治療用核種を作ろう2021

    • Author(s)
      絹谷清剛
    • Organizer
      日本放射線腫瘍学会第34回学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 核医学治療を担う人材育成をするのは今2021

    • Author(s)
      絹谷清剛
    • Organizer
      第61回日本学術総会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 核医学治療 放射能でがんが治るんです2021

    • Author(s)
      絹谷清剛
    • Organizer
      第61回日本学術総会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Radiopharmaceutical theranostics in Japan2021

    • Author(s)
      絹谷清剛
    • Organizer
      2nd ZIRNET
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] アルファ線治療でがんが治る?2021

    • Author(s)
      絹谷清剛
    • Organizer
      第3回日本放射線安全管理学会・日本保健物理学会合同大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Adverse Prognostic factors in patients refractory pheochromocytoma and paraganglioma after (131) I-metaiodobenzylguanidine therapy.2021

    • Author(s)
      Hiromasa T, Wakabayashi H, Kayano D, Inaki A, Watanabe S, Mori H, Akatani N, Yamase T, Kunita Y, Saito S, Kinuya S.
    • Organizer
      EANM 2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Efficacy of I-131 MIBG therapy in the patients with neuroblastoma.2021

    • Author(s)
      Kayano D
    • Organizer
      18th Asian Oceanian Congress of Radiology
    • Related Report
      2021 Annual Research Report
  • [Presentation] Comparisons of detectability between whole-body MRI and I-123/131 mIBG images in patients with metastatic pheochromocytoma and paragangliom2021

    • Author(s)
      Mori H, Wakabayashi H , Saito S, Nakajima K, Hiromasa T, Watanabe S, Yamase T, Yoshida K, Gabata T, Kinuya S.
    • Organizer
      SNMMI 2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] A Phase I/II Clinical Trial for High-dose 131I-meta- iodobenzylguanidine Therapy for High-risk Neuroblastoma Preceding Single Myeloablative Chemotherapy and Hematopoietic Stem Cell Transplantation2021

    • Author(s)
      Wakabayashi H, Kuroda R, Araki R, Inaki A, Nishimura R, Ikawa Y, Yoshimura K, Murayma T, Imai Y, Funasaka T, Wada T, Kinuya S
    • Organizer
      EANM 2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Overall survival and Prognostic factors in Relapsed High-risk Neuroblastoma following High-dose 131I-meta-iodobenzylguanidine Therapy2021

    • Author(s)
      Wakabayashi H, Kuroda R, Inaki A, Kayano D, Kinuya S
    • Organizer
      2021 anual general meeting of ARCCNM
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effect of Using Tungsten Apron for Occupational Radiation Exposure in Nurses during Care of 131I-mIBG Therapy for Children with High-risk Neuroblastoma2021

    • Author(s)
      Wakabayashi H, Taniguchi Y, Yamada M, Morino K, Otosaki A, Inaki, Kayano D, Watanabe S, Hiromasa T, Mori H, Yamase T, Kunita Y, Saito S, Kinuya S
    • Organizer
      SNMMI 2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 高リスク群神経芽腫に対するI-131MIBG治療に ついて2021

    • Author(s)
      稲木杏吏
    • Organizer
      第53回北陸小児癌症例検討会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] これからの核医学治療 MIBG治療のこれまで、 これから2021

    • Author(s)
      萱野大樹
    • Organizer
      第61回日本核医学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] High-dose 131I-metaiodobenzylguanidine therapy in patients with high-risk neuroblastoma in Japan2021

    • Author(s)
      萱野大樹
    • Organizer
      第61回日本核医学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 祝!ライアット 褐色細胞腫に対するMIBG 治 療;当院の経験から2021

    • Author(s)
      萱野大樹
    • Organizer
      第8回腫瘍核医学診断治療セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] I-131-MIBG治療におけるタングステンエプロンの職業被はく防護効果2021

    • Author(s)
      谷口由華、乙崎亜希子、森野 啓、山田雅子、萱野大樹、若林 大志
    • Organizer
      第61回日本核医学 会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 131I-MIBG治療における看護師の職業被ばく2021

    • Author(s)
      谷口由華、萱野大樹、若林大志
    • Organizer
      第2回標的アイソトープ治療線量評価 研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 難治性褐色細胞腫および傍神経節腫における131I-mIBG 治 療後の予後因子の検討2021

    • Author(s)
      廣正 智、若林大志、萱野大樹、稲木杏吏、渡辺 悟、森 博 史、赤谷憲一、山瀬喬史、國田優志、齊藤晋太郎、絹谷清剛
    • Organizer
      第61回日本核医学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] PPGL転移病変に関するDWIBSとI-123/131 mIBGシンググラフィの初期検討2021

    • Author(s)
      森 博史、若林大志、齊藤晋太郎、中嶋憲一、廣正 智、渡辺 悟、山瀬喬史、吉田耕太郎、蒲田敏文、絹谷清剛
    • Organizer
      第80回日本放射線学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effectiveness of high-dose I-131MIBG as consolidation therapy for the patients with high-risk neuroblastoma2020

    • Author(s)
      Inaki A, Wakabayashi H, Watanabe S, Yamase T, Kunita Y, Hiromasa T, Akatani N, Saitou S, Kayano D, Kinuya S.
    • Organizer
      European Association of Nuclear Medicine
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiation ExposuretoNurses during Care of131I-MIBG Therapy for Paediatric Patients with High-risk Neuroblastoma2020

    • Author(s)
      Wakabayashi H
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 診療用放射線の安全管理体制にかかる医療法施行規則改正について2020

    • Author(s)
      稲木杏吏
    • Organizer
      第20回日本核医学会春季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 悪性褐色細胞腫及びパラガングリオーマにおけるI-131MIBG治療について2020

    • Author(s)
      稲木杏吏
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] THERANOSTICS 核医学診療科と放射線治療科の連携 I-131 MIBG治療と外照射治療の連携2020

    • Author(s)
      萱野大樹
    • Organizer
      日本放射線腫瘍学会第33回学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 放射能でがんを治す - 核医学治療をご存じですか?2020

    • Author(s)
      絹谷清剛
    • Organizer
      がん治療法、あなたの選択のために プレシジョン医療と核医学診療がつくる未来
    • Related Report
      2020 Annual Research Report
  • [Presentation] RI内用療法(本邦におけるトピック)2020

    • Author(s)
      絹谷清剛
    • Organizer
      第20回日本核医学会春季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 核医学治療をしましょう!2020

    • Author(s)
      絹谷清剛
    • Organizer
      第79回日本医学放射線学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Precision Nuclear Medicine ~ 核医学治療2020

    • Author(s)
      絹谷清剛
    • Organizer
      第25回東海腫瘍核医学研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Long-term outcomes after high-dose I-131 MIBG therapy for high-risk neuroblastoma: a Japanese single-institution experience2019

    • Author(s)
      Kayano D, Wakabayashi H, Inaki A, Toratani A, Akatani N, Yamase T, Kunita Y, Watanabe S, Takata A, Hiromasa T, Mori H, Saito S, Nguyen TN, Kinuya S
    • Organizer
      European Association of Nuclear Medicine 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Theranostics in Japan2019

    • Author(s)
      Kinuya S
    • Organizer
      5th Theranostics World Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Future direction of precision nuclear medicine2019

    • Author(s)
      Kinuya S
    • Organizer
      2019 Annual Congress of Korean Society of Nuclear Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Theranostics in Japan2019

    • Author(s)
      Kinuya S
    • Organizer
      International Conference on Radiopharmaceutical Therapy 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A diagnostic use of post-therapy 131I-MIBG scintigraphy in pediatric patients with high-risk neuroblastoma2019

    • Author(s)
      Wakabayashi H, Kayano D, Inaki A, Araki R, Maeba H, Kuroda R, Akatani N, Yamase T, Watanabe S, Hiromasa T, Nguyen TN, Kinuya S
    • Organizer
      European Association of Nuclear Medicine 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A New Therapeutic Use of High-dose131I-MIBG Therapy as Consolidation Therapy in Pediatric Patients with High-risk Neuroblastoma: The Japanese experience2019

    • Author(s)
      Wakabayashi H, Kayano D, Inaki A, Araki R, Maeba H, Kuroda R, Akatani N, Yamase T, Watanabe S, Hiromasa T, Nishimura R, Yachie A, Kinuya S
    • Organizer
      Annual meeting of the Society of Nuclear Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 先進医療Bとして実施した難治性褐色細胞腫に対するI-131 MIBG内照射療法の第1相試験2019

    • Author(s)
      萱野大樹、若林大志、稲木杏吏、村山敏典、神宮司メグミ、樋口徹也、志賀 哲、絹谷清剛
    • Organizer
      第92回日本内分泌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 高リスク神経芽腫に対する大量I-131 MIBG治療後の長期経過観察2019

    • Author(s)
      萱野大樹、若林大志、稲木杏吏、虎谷文音、赤谷憲一、山瀬喬史、Nguyen Thi Nhung、絹谷清剛
    • Organizer
      第59回日本核医学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 短寿命α線核種によるがん治療2019

    • Author(s)
      絹谷清剛
    • Organizer
      現代の研究・教育・社会に相応しい放射線・放射性核種等の安全利用検討会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 高リスク神経芽腫に対する大量131I-MIBG地固め療法2019

    • Author(s)
      若林大志、萱野大樹、稲木杏吏、荒木来太、前馬秀明、黒田梨絵、赤谷憲一、山瀬蕎史、渡辺 悟、國田優志、絹谷清剛
    • Organizer
      第59回日本核医学会学術総会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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