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Basic research on the construction of a database of diversity lung nodules and the development of a self-learning diagnostic imaging support system

Research Project

Project/Area Number 19H03599
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionGifu University

Principal Investigator

Fujita Hiroshi  岐阜大学, 工学部, 特任教授・名誉教授 (10124033)

Co-Investigator(Kenkyū-buntansha) 西尾 瑞穂  神戸大学, 医学部附属病院, 特定助教 (50581998)
村松 千左子  滋賀大学, データサイエンス学部, 准教授 (80509422)
八上 全弘  京都大学, 医学研究科, 特定講師 (70580108)
坂本 亮  京都大学, 医学研究科, 特定助教 (50741930)
富樫 かおり  京都大学, 医学研究科, 教授 (90135484)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Keywords計算機支援画像診断 / 深層学習 / 画像データベース / 胸部CT画像 / 導入後学習 / 胸部画像 / 自己学習
Outline of Research at the Start

本研究では,敵対的生成ネットワーク(GAN)モデルを用いた医用画像データベースの構築と,生成画像データによる自己学習型画像診断支援システムの開発を行う.具体的には,胸部CT画像を対象とし,特定の画像所見を持つという条件を満たした肺結節画像の生成法の開発を行い,また,生成データ及び新規ラベル無データを用いた追加学習法の検討を行う.成果として,画像診断精度の向上,及び生成データと学習モデルの公開による本研究分野の発展への貢献が期待される.

Outline of Final Research Achievements

As basic research on the construction of a computer-assisted image diagnosis (so-called AI-CAD) system equipped with AI, a solution to the lack of medical image data necessary for learning to obtain a deep learning (deep learning) type AI model with high accuracy. Basic research on (1) research on the possibility of generating three-dimensional CT images of lung nodules, (2) research on the effectiveness of research results, (3) research on pursuit of realism, and (4) continuous learning (post-marketing learning) was mainly carried out. As a result, it was shown that it is possible to form a realistic lung nodule image that is effective in a certain range based on the Generative Adversarial Networks (GAN technique). In addition, new findings were obtained by simulation study for the three update methods for continuous learning.

Academic Significance and Societal Importance of the Research Achievements

医用画像診断を目的としたディープラーニング搭載の最新のコンピュータ支援診断(いわゆるAI-CAD)システムの構築に対して,モデル学習時に最も障害となる医療画像データ不足があり,これはAI-CADシステムの精度向上を阻む一要因である.本研究で開発した画像生成技術によってそれを補うことにより,システムの精度向上の一躍を担う可能性が示され,さらに継続学習に対して得られた新たな成果により,本研究領域において学術的にはもちろん,すでに実用化が始まりつつあるシステムの性能向上に向けても,本知見は少なからず寄与できるであろう.

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (54 results)

All 2022 2021 2020 2019

All Journal Article (17 results) (of which Peer Reviewed: 9 results,  Open Access: 4 results) Presentation (37 results) (of which Int'l Joint Research: 5 results,  Invited: 26 results)

  • [Journal Article] Deep learning model for the automatic classification of COVID-19 pneumonia, non-COVID-19 pneumonia, and the healthy: A multi-center retrospective study2022

    • Author(s)
      Mizuho Nishio, Daigo Kobayashi, Eiko Nishioka, Hidetoshi Matsuo, Yasuyo Urase, Koji Onoue, Reiichi Ishikura, Yuri Kitamura, Eiro Sakai, Masaru Tomita, Akihiro Hamanaka, Takamichi Murakami
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 8214-8214

    • DOI

      10.1038/s41598-022-11990-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Investigation on continual training of computer-aided diagnosis systems by semi-supervised learning2022

    • Author(s)
      Muramamatsu Chisako、Nishio Mizuho、Oiwa Mikinao、Yakami Masahiro、Kubo Takeshi、Fujita Hiroshi
    • Journal Title

      Proc. of IMIP 2022: 2022 4th International Conference on Intelligent Medicine and Image Processing

      Volume: - Pages: 58-62

    • DOI

      10.1145/3524086.3524095

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 医用画像読影支援システムに対する導入後学習の検討2022

    • Author(s)
      村松千左子,西尾瑞穂,八上全弘,久保 武,大岩幹直,藤田広志
    • Journal Title

      IEICE Technical Report (電子情報通信学会・信学技報)

      Volume: MI2021-58 Pages: 55-58

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 臨床応用編②:歯科における画像診断領域へのAI応用2022

    • Author(s)
      藤田広志
    • Journal Title

      補綴臨床

      Volume: 55 Pages: 7-22

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 医用画像AI-CADにおける継続学習2022

    • Author(s)
      藤田広志,村松千左子
    • Journal Title

      INNERVISION

      Volume: 37

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Development of Deep Learning Model for COVID-19 Pneumonia in Chest X-ray Images2021

    • Author(s)
      西尾 瑞穂, 小林 大悟, 松尾 秀俊, 西岡 瑛子, 浦瀬 靖代, 尾上 宏治, 石藏 礼一, 村上 卓道
    • Journal Title

      Medical Imaging and Information Sciences

      Volume: 38 Issue: 2 Pages: 53-56

    • DOI

      10.11318/mii.38.53

    • NAID

      130008062567

    • ISSN
      0910-1543, 1880-4977
    • Year and Date
      2021-07-06
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AI-powered Diagnostic Medical Imaging Changes the Medical Field:Overview and Future Prospects for AI-based Image Diagnosis : "Third Eye" to Help Doctors2021

    • Author(s)
      藤田広志
    • Journal Title

      情報処理

      Volume: 62 Issue: 2 Pages: e1-e8

    • DOI

      10.20729/00208914

    • NAID

      170000184247

    • Year and Date
      2021-01-15
    • Related Report
      2020 Annual Research Report
  • [Journal Article] Lung Cancer Segmentation With Transfer Learning: Usefulness of a Pretrained Model Constructed From an Artificial Dataset Generated Using a Generative Adversarial Network2021

    • Author(s)
      Nishio Mizuho、Fujimoto Koji、Matsuo Hidetoshi、Muramatsu Chisako、Sakamoto Ryo、Fujita Hiroshi
    • Journal Title

      Frontiers in Artificial Intelligence

      Volume: 4 Pages: 694815-694815

    • DOI

      10.3389/frai.2021.694815

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 基礎編:AI技術の最新動向と医用画像診断領域への応用2021

    • Author(s)
      藤田広志
    • Journal Title

      補綴臨床

      Volume: 54 Pages: 484-508

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 臨床応用編①:医科における画像診断領域へのAI応用2021

    • Author(s)
      藤田広志
    • Journal Title

      補綴臨床

      Volume: 54 Pages: 637-650

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Homology-Based Image Processing for Automatic Classification of Histopathological Images of Lung Tissue2021

    • Author(s)
      Nishio Mizuho、Nishio Mari、Jimbo Naoe、Nakane Kazuaki
    • Journal Title

      Cancers

      Volume: 13 Issue: 6 Pages: 1192-1192

    • DOI

      10.3390/cancers13061192

    • NAID

      120007026364

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attribute-guided image generation of three-dimensional computed tomography images of lung nodules using a generative adversarial network2020

    • Author(s)
      Nishio Mizuho、Muramatsu Chisako、Noguchi Shunjiro、Nakai Hirotsugu、Fujimoto Koji、Sakamoto Ryo、Fujita Hiroshi
    • Journal Title

      Computers in Biology and Medicine

      Volume: 126 Pages: 104032-104032

    • DOI

      10.1016/j.compbiomed.2020.104032

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 第3次AIブーム・ディープラーニング時代における医用画像診断の最近の話題2020

    • Author(s)
      藤田広志
    • Journal Title

      画像応用技術専門委員会 研究会報告

      Volume: 35 Pages: 1-10

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Lung segmentation on chest X‐ray images in patients with severe abnormal findings using deep learning2020

    • Author(s)
      Nishio Mizuho、Fujimoto Koji、Togashi Kaori
    • Journal Title

      International Journal of Imaging Systems and Technology

      Volume: 31 Issue: 2 Pages: 1002-1008

    • DOI

      10.1002/ima.22528

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Automatic classification between COVID-19 pneumonia, non-COVID-19 pneumonia, and the healthy on chest X-ray image: combination of data augmentation methods2020

    • Author(s)
      Nishio Mizuho、Noguchi Shunjiro、Matsuo Hidetoshi、Murakami Takamichi
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 17532-17532

    • DOI

      10.1038/s41598-020-74539-2

    • NAID

      120006938932

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improving breast mass classification by shared data with domain transformation using a generative adversarial network2020

    • Author(s)
      Muramatsu Chisako、Nishio Mizuho、Goto Takuma、Oiwa Mikinao、Morita Takako、Yakami Masahiro、Kubo Takeshi、Togashi Kaori、Fujita Hiroshi
    • Journal Title

      Computers in Biology and Medicine

      Volume: 119 Pages: 103698-103698

    • DOI

      10.1016/j.compbiomed.2020.103698

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AI-based computer-aided diagnosis (AI-CAD)2020

    • Author(s)
      Fujita H
    • Journal Title

      Radiological Physics and Technology

      Volume: 13 Issue: 1 Pages: 6-19

    • DOI

      10.1007/s12194-019-00552-4

    • Related Report
      2019 Annual Research Report
  • [Presentation] 機械学習とホモロジー法の肺疾患への応用2022

    • Author(s)
      西尾瑞穂
    • Organizer
      明治大学MIMS共同研究集会「AIを用いた医療画像解析の現状と課題」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Generation of three-dimensional CT images of lung nodules using deep learning2022

    • Author(s)
      Takaaki Matsunaga, Mizuho Nishio, Hidetoshi Matsuo, Aki Miyazaki, Atsushi Kono, Ryo Sakamoto, Chisako Muramatsu, Hiroshi Fujita, Takamichi Murakami
    • Organizer
      第 81 回日本医学放射線学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] AI for diagnostic imaging of chest2022

    • Author(s)
      Mizuho Nishio
    • Organizer
      第 81 回日本医学放射線学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 医用画像読影支援システムに対する導入後学習の検討2022

    • Author(s)
      村松千左子,西尾瑞穂,八上全弘,久保武,大岩幹直,藤田広志
    • Organizer
      電子情報通信学会医用画像研究会(MI研)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Investigation on continual training of computer-aided diagnosis systems by semi-supervised learning2022

    • Author(s)
      Muramatsu C, Nishio M, Oiwa M, Yakami M, Kubo T, Fujita H
    • Organizer
      4th International Conference on Intelligent Medicine and Image Processing (IMIP)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] システム導入後の継続学習に関する研究の現状2022

    • Author(s)
      村松千左子
    • Organizer
      日本放射線技術学会総会学術大会.JIRA Workshop 臨床導入後のAI搭載医療機器アップデートに関する課題
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Current status of AI support in medical imaging and diagnosis2022

    • Author(s)
      H.Fujita
    • Organizer
      2022 INTERNATIONAL WORKSHOP ON ADVANCED IMAGE TECHNOLOGY (IWAIT)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AIを導入したディープラーニング型CAD(AI-CAD)の新潮流と検診へのインパクト2022

    • Author(s)
      藤田広志
    • Organizer
      第29回 日本CT検診学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Deep-learning-based Image Super Resolution for Super High-resolution Computed Tomography2021

    • Author(s)
      Mizuho Nishio, Yamagishi Yosuke, Matsuo Hidetoshi, Kagawa Kiyosumi, Negi Noriyuki, Kono Atsushi, Murakami Takamichi
    • Organizer
      第 80 回日本医学放射線学会総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 肺がんの治療薬選択に役立つ画像と AI について2021

    • Author(s)
      西尾瑞穂
    • Organizer
      第8回 放射線セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Deep Learningの肺結節への応用2021

    • Author(s)
      西尾瑞穂
    • Organizer
      第13回呼吸機能イメージング研究会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 医療AIの現状と歯科画像領域への応用2021

    • Author(s)
      藤田広志
    • Organizer
      日本デジタル歯科学会第12回学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Current status of AI applications for medical image diagnosis2021

    • Author(s)
      Hiroshi Fujita
    • Organizer
      2021 13th International Conference on Digital Image Processing (ICDIP 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AI画像診断の現状,課題,将来2021

    • Author(s)
      藤田広志
    • Organizer
      メディカルAI学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 人工知能(AI)の医療応用について2021

    • Author(s)
      藤田広志
    • Organizer
      第45回 日本頭頚部癌学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 医療画像AIの最近の動向2021

    • Author(s)
      藤田広志
    • Organizer
      日本歯科人工知能(AI)第3回研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 複数臓器の自動領域抽出に関する継続学習の初期的検討2021

    • Author(s)
      西村彼方,周 向栄,原 武史,藤田広志
    • Organizer
      2021年度第35回 日本生体医工学会東海支部大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] AI-CADの現状と将来について2021

    • Author(s)
      藤田広志
    • Organizer
      NVIDIA医療AIウェビナー:医療AIの社会実装への加速 - 多様化する医療機器ソリューションへの提案
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 深層学習を用いた低線量CTのノイズ除去と肺結節の生成2021

    • Author(s)
      西尾瑞穂
    • Organizer
      第28回日本CT検診学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Cutting edge of AI in medical imaging support: An introduction2021

    • Author(s)
      H.Fujita
    • Organizer
      International Workshop on Advanced Image Technology 2021 (IWAIT 2021)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Cutting edge of AI support in medical image diagnosis2020

    • Author(s)
      H.Fujita
    • Organizer
      Satellite event of 2020 PMU International Conference on Industrial Revolution 4.0 in Computing, Mobility, and Manufacturing (CMM 2020, Dec. 8-10), Virtual Mini-Workshop on Artificial Intelligence
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 多重解像度処理を用いたホモロジー法による肺病理組織画像の自動鑑別2020

    • Author(s)
      西尾瑞穂, 西尾真理, 神保直江
    • Organizer
      明治大学MIMS共同研究集会「AIを用いた医療画像解析の現状と課題」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 第3次AIブーム・ディープラーニング時代における医用画像診断の最近の話題2020

    • Author(s)
      藤田広志
    • Organizer
      公益社団法人 精密工学会 画像応用技術専門委員会2020年度第4回研究会(テーマ:人センシング,サービス工学)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] AI・ディープラーニングを用いた画像支援診断への取り組みの最前線2020

    • Author(s)
      藤田広志
    • Organizer
      第58回 日本癌治療学会学術集会スポンサードシンポジウム8:~AI を用いた画像診断技術と肺癌診療の未来~
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] unpaired の学習データと構造保存損失を利用した深層学習によるMR・CT画像変換2020

    • Author(s)
      西尾瑞穂
    • Organizer
      第48回日本磁気共鳴医学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Medical AI × CAD :ディープラーニングの基礎から社会実装まで2020

    • Author(s)
      藤田広志
    • Organizer
      ウェビナー@スイート(Webinar Suite) 第1回 医療革新セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 医用画像診断における最近のAI/ディープラーニングの話題2020

    • Author(s)
      藤田広志
    • Organizer
      電子情報通信学会 基礎・境界ソサイエティ,システムと信号サブソサイエティ主催・第33回 回路とシステムワークショップ
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Fundamentals of deep learning in medical image diagnosis2020

    • Author(s)
      H.Fujita
    • Organizer
      2020 12th International Conference on Digital Image Processing
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 放射線科画像診断における機械学習・深層学習の活用:その現状と未来2020

    • Author(s)
      西尾瑞穂
    • Organizer
      日本医療情報学会関西支部 2020年度 第1回 講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] The Ultimate Guide to AI in Medical Imaging2020

    • Author(s)
      H.Fujita
    • Organizer
      6th International Conference on Computing and Artificial Intelligence (ICCAI 2020) & 2nd International Conference on Intelligent Medicine and Image Processing (IMIP 2020)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] AI・ディープラーニング時代における医用画像支援診断の新潮流2020

    • Author(s)
      藤田広志
    • Organizer
      第2回日本メディカルAI学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The state-of-the-art of AI-aided diagnosis in medical imaging2019

    • Author(s)
      H.Fujita
    • Organizer
      中華民国放射線医学会主催 AI in medical imaging 講演会(Changhua Christian Hospital)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The state-of-the-art of AI-aided diagnosis in medical imaging2019

    • Author(s)
      H.Fujita
    • Organizer
      中華民国放射線医学会主催 AI in medical imaging 講演会(台大醫院國際会議中心)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] The state-of-the-art of AI-aided diagnosis in medical imaging2019

    • Author(s)
      H.Fujita
    • Organizer
      2019 4th International Conference on Biomedical Signal and Image Processing (ICBIP 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 深層学習を利用した疑似結節陰影画像の生成手法の検討2019

    • Author(s)
      後藤拓真, 村松千左子, 西尾瑞穂, 八上全弘, 富樫かおり, 藤田広志
    • Organizer
      医用画像情報学会令和元年度春季大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Improvement of nodule classification using domain-transformed chest X-ray images2019

    • Author(s)
      C.Muramatsu, T.Goto, M.Nishio, M.Yakami, K.Togashi, and H.Fujita
    • Organizer
      105th RSNA Scientific Assembly and Annual Meeting (RSNA 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Generative adversarial networkを用いた肺結節の3次元CT画像の生成2019

    • Author(s)
      西尾瑞穂, 野口峻二郎, 尾上宏治, 子安 翔, 八上全弘, 村松千左子, 藤田広志, 富樫かおり
    • Organizer
      第38回日本医用画像工学会大会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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