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Identification of Novel Molecular Targets and Drug Development by Genomic and Multilayer-Omics Analysis of Hereditary Cardiomyopathies

Research Project

Project/Area Number 19H03652
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionOsaka University

Principal Investigator

Asano Yoshihiro  大阪大学, 医学系研究科, 特任准教授(常勤) (60527670)

Co-Investigator(Kenkyū-buntansha) 宮下 洋平  大阪大学, 医学系研究科, 助教 (60816312)
木岡 秀隆  大阪大学, 医学系研究科, 助教 (70642099)
塚本 蔵  大阪大学, 生命機能研究科, 准教授 (80589151)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords心筋症 / ゲノムデータベース構築 / オミックス研究 / 創薬治療法開発 / 創薬開発 / ゲノム / オミックス / 創薬 / 新規治療薬開発 / 新規治療法開発
Outline of Research at the Start

遺伝性心筋症はさまざまな遺伝子の上に存在する多くの変異が原因に成り得ると考えられている。しかし十分明らかとはなっておらず、疾患の正確な分類とそれに対応する治療法の開発はまだ途上にある。独自に開発した遺伝性心筋症ゲノム変異データベースを用いて、そこから同定される遺伝性心筋症および心不全に関する5つの分子標的に対して、関連する類似変異の機能評価を行うともに、創薬研究の観点から新たな原因分子探索も行い、それらの生理活性の評価系を構築してそれに基づく心筋症治療薬創出研究基盤を構築する。

Outline of Final Research Achievements

For drug discovery research and development related to hereditary cardiomyopathy and heart failure, we have identified the cause of the disease, searched for novel molecular targets, and established a research platform for the creation of cardiomyopathy drugs based on a bioactivity evaluation system. In addition to developing an integrated database of clinical and genomic variant information, we identified that homozygous truncating pathogenic variants in the gene encoding Bcl-2 associated athanogene (BAG) co-chaperone 5 (BAG5) among five patients with inherited dilated cardiomyopathy. BAG5 acts as a nucleotide exchange factor for heat shock cognate 71 kDa protein (HSC70), activating HSC70-mediated protein folding. Bag5 mutant knock-in mice exhibited ventricular dilatation, arrhythmogenicity, and poor prognosis under catecholamine stimulation, recapitulating the human DCM phenotype, and administration of an AAV-BAG5 gene could fully ameliorate these DCM phenotypes.

Academic Significance and Societal Importance of the Research Achievements

心筋収縮機構および恒常性に関与する新規遺伝子の同定を行うため、次世代ゲノム解析技術(全エクソーム解析、全ゲノム解析、構造解析、横断オミックス解析)を応用し、疾患バリアントの同定を行い、新規心筋症原因遺伝子を同定した。結果をもとに新規創薬標的の分子探索を実施し、心臓特異的な疾患原因分子の病態機序に立脚した効率的な研究基盤を構築し、大規模計算リソースを用いた情報解析を実施した。その結果、疾患ゲノムバリアントデータベースを構築した。その他にも機能未知の心筋症分子探索から疾患機序を同定し、その機能評価を行い、治療標的として導出した。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (53 results)

All 2022 2021 2020 2019

All Journal Article (24 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 24 results,  Open Access: 16 results) Presentation (15 results) (of which Int'l Joint Research: 2 results,  Invited: 15 results) Book (10 results) Patent(Industrial Property Rights) (4 results) (of which Overseas: 2 results)

  • [Journal Article] Phospholamban p.Arg14del Cardiomyopathy: A Japanese Case Series2022

    • Author(s)
      Tabata Tomoka、Kuramoto Yuki、Ohtani Tomohito、Miyawaki Hiroshi、Miyashita Yohei、Sera Fusako、Kioka Hidetaka、Higo Shuichiro、Asano Yoshihiro、Hikoso Shungo、Sakata Yasushi
    • Journal Title

      Internal Medicine

      Volume: 61 Issue: 13 Pages: 1987-1993

    • DOI

      10.2169/internalmedicine.8594-21

    • NAID

      130008130223

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2022-07-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Loss-of-function mutations in the co-chaperone protein BAG5 cause dilated cardiomyopathy requiring heart transplantation2022

    • Author(s)
      Hakui Hideyuki、Kioka Hidetaka、Miyashita Yohei、Nishimura Shunsuke、Matsuoka Ken、Kato Hisakazu、Tsukamoto Osamu、(3人省略)、Saito Shigeyoshi、Ohta Kunio、Asanuma Hiroshi、Fu Hai Ying、Shinomiya Haruki、Yamada Noriaki、Ohtani Tomohito、Sawa Yoshiki、Kitakaze Masafumi、Takashima Seiji、Sakata Yasushi、Asano Yoshihiro
    • Journal Title

      Science Translational Medicine

      Volume: 14 Issue: 628

    • DOI

      10.1126/scitranslmed.abf3274

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-exome Sequencing Analysis of a Japanese Patient With Hyperinsulinemia and Liver Dysfunction2022

    • Author(s)
      Fujita Shingo、Horitani Emi、Miyashita Yohei、Fujita Yukari、Fukui Kenji、Kamada Yoshihiro、Mineo Ikuo、Asano Yoshihiro、Iwahashi Hiromi、Kozawa Junji、Shimomura Iichiro
    • Journal Title

      Journal of the Endocrine Society

      Volume: 6 Issue: 3

    • DOI

      10.1210/jendso/bvac008

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiac Fibroblasts Play Pathogenic Roles in Idiopathic Restrictive Cardiomyopathy2021

    • Author(s)
      Tsuru Hirofumi、Ishida Hidekazu、Narita Jun、Ishii Ryo、Suginobe Hidehiro、Ishii Yoichiro、Wang Renjie、Kogaki Shigetoyo、Taira Masaki、Ueno Takayoshi、Miyashita Yohei、Kioka Hidetaka、Asano Yoshihiro、Sawa Yoshiki、Ozono Keiichi
    • Journal Title

      Circulation Journal

      Volume: 85 Issue: 5 Pages: 677-686

    • DOI

      10.1253/circj.CJ-20-1008

    • NAID

      130008028981

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-04-23
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aberrant accumulation of TMEM43 accompanied by perturbed transmural gene expression in arrhythmogenic cardiomyopathy2021

    • Author(s)
      Shinomiya Haruki、Kato Hisakazu、・・・・・・・・Mashimo Tomoji、・・・・・・・・・・・・・・・・Sakata Yasushi、Asano Yoshihiro
    • Journal Title

      The FASEB Journal

      Volume: 35 Issue: 11

    • DOI

      10.1096/fj.202100800r

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recurrent de novo pathogenic variant of WASF1 in a Japanese patient with neurodevelopmental disorder with absent language and variable seizures2021

    • Author(s)
      Shimojima Yamamoto Keiko、Yanagishita Tomoe、Yamamoto Hisako、Miyamoto Yusaku、Nagata Miho、Ishihara Yasuki、Miyashita Yohei、Asano Yoshihiro、Sakata Yasushi、Yamamoto Toshiyuki
    • Journal Title

      Human Genome Variation

      Volume: 8 Issue: 1 Pages: 43-43

    • DOI

      10.1038/s41439-021-00176-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ASB2 is a novel E3 ligase of SMAD9 required for cardiogenesis2021

    • Author(s)
      Min Kyung-Duk、Asakura Masanori、Shirai Manabu、Yamazaki Satoru、Ito Shin、Fu Hai Ying、Asanuma Hiroshi、Asano Yoshihiro、Minamino Tetsuo、Takashima Seiji、Kitakaze Masafumi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 23056-23056

    • DOI

      10.1038/s41598-021-02390-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of Spatial Distribution of Spermatogenesis in Mouse Testes Using Creatine Chemical Exchange Saturation Transfer Imaging2021

    • Author(s)
      Takahashi Yusuke、Kioka Hidetaka、Fukuhara Shinichiro、Kuribayashi Sohei、Saito Shigeyoshi、Asano Yoshihiro、Takashima Seiji、Yoshioka Yoshichika、Sakata Yasushi
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 54 Issue: 5 Pages: 1457-1465

    • DOI

      10.1002/jmri.27734

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HECW2-related disorder in four Japanese patients2021

    • Author(s)
      Yanagishita T, Hirade T, Shimojima Yamamoto K, Funatsuka M, Miyamoto Y, Maeda M, Yanagi K, Kaname T, Nagata S, Nagata M, Ishihara Y, Miyashita Y, Asano Y, Sakata Y, Kosaki K, Yamamoto T
    • Journal Title

      Am Med Genet A

      Volume: 185 Issue: 10 Pages: 2895-2902

    • DOI

      10.1002/ajmg.a.62363

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cardio- and reno-protective effects of dipeptidyl peptidase III in diabetic mice2021

    • Author(s)
      Komeno M, Pang X, Shimizu A, Molla MR, Yasuda-Yamahara M, Kume S, Rahman NIA, Soh JEC, Nguyen LKC, Ahmat Amin MKB, Kokami N, Sato A, Asano Y, Maegawa H, Ogita H
    • Journal Title

      J Biol Chem

      Volume: 296 Pages: 100761-100761

    • DOI

      10.1016/j.jbc.2021.100761

    • NAID

      120007045058

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The CR9 element is a novel mechanical load‐responsive enhancer that regulates natriuretic peptide genes expression2021

    • Author(s)
      Miyashita Y, Tsukamoto O, Matsuoka K, Kamikubo K, Kuramoto Y, Fu HY, Tsubota T, Hasuike H, Takayama T, Ito H, Hitsumoto T, Okamoto C, Kioka H, Oya R, Shinomiya H, Hakui H, Shintani Y, Kato H, Kitakaze M, Sakata Y, Asano Y, Takashima S
    • Journal Title

      The FASEB Journal

      Volume: 35 Issue: 4

    • DOI

      10.1096/fj.202002111rr

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A recurrent de novo ZSWIM6 variant in a Japanese patient with severe neurodevelopmental delay and frequent vomiting2021

    • Author(s)
      Yanagishita Tomoe、Eto Kaoru、Yamamoto-Shimojima Keiko、Segawa Osamu、Nagata Miho、Ishihara Yasuki、Miyashita Yohei、Asano Yoshihiro、Sakata Yasushi、Nagata Satoru、Yamamoto Toshiyuki
    • Journal Title

      Human Genome Variation

      Volume: 8 Issue: 1

    • DOI

      10.1038/s41439-021-00148-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Visualization of Spatial Distribution of Spermatogenesis in Mouse Testes Using Creatine Chemical Exchange Saturation Transfer (CrCEST) Imaging.2021

    • Author(s)
      Takahashi Y, Kioka H, Saito S, Fukuhara S, Asano Y, Takashima S, Yoshioka Y, Sakata Y.
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: in-press

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Accurate Estimation of the Duration of Testicular Ischemia Using Creatine Chemical Exchange Saturation Transfer ( CrCEST ) Imaging2020

    • Author(s)
      Takahashi Yusuke、Kioka Hidetaka、Saito Shigeyoshi、Fukuhara Shinichiro、Asano Yoshihiro、Takashima Seiji、Yoshioka Yoshichika、Sakata Yasushi
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: 53 Issue: 5 Pages: 1559-1567

    • DOI

      10.1002/jmri.27456

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-Radioactive In Vitro Cardiac Myosin Light Chain Kinase Assays2020

    • Author(s)
      Kamikubo Kenta、Tsukamoto Osamu、Uyama-Saito Yuki、Oya Ryohei、Tsubota Tomoya、Fujino Noboru、Asano Yoshihiro、Kato Hisakazu、Matsuoka Ken、Takashima Seiji
    • Journal Title

      Journal of Visualized Experiments

      Volume: 160 Issue: 160 Pages: 1-1

    • DOI

      10.3791/61168

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases.2020

    • Author(s)
      Hayashi K, et al.
    • Journal Title

      Cardiovasc Res.

      Volume: 0 Issue: 13 Pages: 0-0

    • DOI

      10.1093/cvr/cvaa010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] In vivo real‐time ATP imaging in zebrafish hearts reveals G0s2 induces ischemic tolerance2020

    • Author(s)
      Kioka Hidetaka、Kato Hisakazu、Fujita Takeshi、Asano Yoshihiro、Shintani Yasunori、Yamazaki Satoru、Tsukamoto Osamu、Imamura Hiromi、Kogo Mikihiko、Kitakaze Masafumi、Sakata Yasushi、Takashima Seiji
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 2 Pages: 2041-2054

    • DOI

      10.1096/fj.201901686r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of transmembrane protein 168 mutation in familial Brugada syndrome.2020

    • Author(s)
      Shimizu A, Zankov DP, Sato A, Komeno M, Toyoda F, Yamazaki S, Makita T, Noda T, Ikawa M, Asano Y, Miyashita Y, Takashima S, Morita H, Ishikawa T, Makita N, Hitosugi M, Matsuura H, Ohno S, Horie M, Ogita H.
    • Journal Title

      FASEB Journal

      Volume: 34 Issue: 5 Pages: 6399-6417

    • DOI

      10.1096/fj.201902991r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mutant KCNJ3 and KCNJ5 potassium channels as novel molecular targets in bradyarrhythmias and atrial fibrillation.2019

    • Author(s)
      Yamada N, Asano Y, Fujita M, Yamazaki S, Inanobe A, Matsuura N, Kobayashi H, Ohno S, Ebana Y, Tsukamoto O, Ishino S, Takuwa A, Kioka H, Yamashita T, Hashimoto N, Zankov DP, Shimizu A, Asakura M, Asanuma H, Kato H, Nishida Y, Miyashita Y, Shinomiya H, Naiki N, Hayashi K, Makiyama T, Ogita H, et al.
    • Journal Title

      Circulation

      Volume: In press Issue: 18 Pages: 2157-2169

    • DOI

      10.1161/circulationaha.118.036761

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of cardiac myosin light chain kinase gene mutation on development of dilated cardiomyopathy2019

    • Author(s)
      Hodatsu A, Fujino N, Uyama Y, Tsukamoto O, Imai-Okazaki A, Yamazaki S, Seguchi O, Konno T, Hayashi K, Kawashiri MA, Asano Y, Kitakaze M, Takashima S, Yamagishi M
    • Journal Title

      ESC Heart Fail

      Volume: 6 Issue: 2 Pages: 06-415

    • DOI

      10.1002/ehf2.12410

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Next-generation sequencing identifies contribution of both class I and II HLA genes on susceptibility of multiple sclerosis in Japanese2019

    • Author(s)
      Ogawa, Kotaro; Okuno, Tatsusada; Hosomichi, Kazuyoshi; Hosokawa, Akiko; Hirata, Jun; Suzuki, Ken; Sakaue, Saori; Kinoshita, Makoto; Asano, Yoshihiro; Miyamoto, Katsuichi
    • Journal Title

      Journal of neuroinflammation

      Volume: 16 Issue: 1 Pages: 162-162

    • DOI

      10.1186/s12974-019-1551-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A molecular triage process mediated by RING finger protein 126 and BCL2-associated athanogene 6 regulates degradation of G0/G1 switch gene 22019

    • Author(s)
      Kamikubo Kenta、Kato Hisakazu、Kioka Hidetaka、Yamazaki Satoru、Tsukamoto Osamu、Nishida Yuya、Asano Yoshihiro、Imamura Hiromi、Kawahara Hiroyuki、Shintani Yasunori、Takashima Seiji
    • Journal Title

      Journal of Biological Chemistry

      Volume: 294 Issue: 40 Pages: 14562-14573

    • DOI

      10.1074/jbc.ra119.008544

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Higd1a improves respiratory function in the models of mitochondrial disorder2019

    • Author(s)
      Nagao Takemasa、Shintani Yasunori、Hayashi Takaharu、Kioka Hidetaka、Kato Hisakazu、Nishida Yuya、Yamazaki Satoru、Tsukamoto Osamu、Yashirogi Shohei、Yazawa Issei、Asano Yoshihiro、Shinzawa‐Itoh Kyoko、Imamura Hiromi、Suzuki Takeo、Suzuki Tsutomu、Goto Yu‐ichi、Takashima Seiji
    • Journal Title

      The FASEB Journal

      Volume: 34 Issue: 1 Pages: 1859-1871

    • DOI

      10.1096/fj.201800389r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] AST-120, an Adsorbent of Uremic Toxins, Improves the Pathophysiology of Heart Failure in Conscious Dogs.2019

    • Author(s)
      Asanuma H, Chung H, Ito S, Min KD, Ihara M, Takahama H, Funayama M, Imazu M, Fukuda H, Ogai A, Asano Y, Minamino T, Takashima S, Morita T, Sugimachi M, Asakura M, Kitakaze M.
    • Journal Title

      Cardiovasc Drugs Ther.

      Volume: 33 Issue: 3 Pages: 277-286

    • DOI

      10.1007/s10557-019-06875-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] シンポジウム「心不全ゲノム医療の最前線」 疾患ゲノム解析による心不全の層別化とゲノム医療への応用2021

    • Author(s)
      朝野仁裕
    • Organizer
      第25回日本心不全学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 臨床・かかりつけ医セッション 心不全の原因を知り、治療へつなぐ情報の入手2021

    • Author(s)
      朝野仁裕
    • Organizer
      第69回日本心臓病学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] シンポジウム-2:遺伝子治療開発の最前線 遺伝性心筋症に対する新たな遺伝子治療法の開発2021

    • Author(s)
      朝野仁裕
    • Organizer
      第34回 日本動物細胞工学会2021年度大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] シンポジウム6:心筋症の分子機序 臨床にとどける心筋症のゲノム研究2021

    • Author(s)
      朝野仁裕
    • Organizer
      第7回日本心筋症研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 心筋症の臨床遺伝子診断とバリアントデータベースの利用による新規病態解明2020

    • Author(s)
      朝野仁裕
    • Organizer
      第 6 回日本心筋症研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 臨床にとどける心筋症のゲノム研究2020

    • Author(s)
      朝野仁裕
    • Organizer
      第24回日本心不全学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Development of Gene Therapy for Hereditary Cardiomyopathy2020

    • Author(s)
      Yoshihiro Asano
    • Organizer
      第24回日本心不全学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Identification of Novel Genes for Cardiomyopathies, Elucidation of Pathogenesis, and Development of New Therapeutic Strategies for Genomic Medicine2020

    • Author(s)
      Yoshihiro Asano
    • Organizer
      The 85th Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Elucidation of the Mechanism of KACh Channelopathy -New Stratification of the Disease, and Development of Treatment2020

    • Author(s)
      Yoshihiro Asano
    • Organizer
      The 85th Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Application of Genome Analysis and Information to Diagnosis and Treatment of Cardiomyopathy2020

    • Author(s)
      Yoshihiro Asano
    • Organizer
      The 85th Annual Scientific Meeting of the Japanese Circulation Society
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 臨床における心筋症ゲノム解析研究2020

    • Author(s)
      朝野仁裕
    • Organizer
      第7回日本心筋症研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Genome Analysis and Genomic Medicine in Cardiomyopathy2020

    • Author(s)
      Yoshihiro Asano
    • Organizer
      第84回日本循環器学会学術集会(開催延期)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Genomic medicine in sinus bradycardia and a strategy for development of a novel targeted therapy2019

    • Author(s)
      Yoshihiro Asano
    • Organizer
      2019 XXIII ISHR WORLD CONGRESS(国際心臓研究会世界大会)Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cardiomyopathies: genetic causes and precision medicine2019

    • Author(s)
      Yoshihiro Asano
    • Organizer
      ESC CONGRESS 2019(欧州心臓病学会年会)Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 心筋症の遺伝子診断における問題点と解決策2019

    • Author(s)
      朝野仁裕
    • Organizer
      第23回日本心不全学会学術集会、シンポジウム14「心筋症と遺伝子診断」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Book] 月刊心臓(公益財団法人 日本心臓財団)HEART's Selection 拡張型心筋症の精密医療  5.拡張型心筋症をゲノムで層別化する2021

    • Author(s)
      朝野仁裕
    • Publisher
      日本医学出版
    • Related Report
      2021 Annual Research Report
  • [Book] 循環器内科 核膜蛋白の変異によってひき起こされる不整脈原性心筋症の新たな分子機序2021

    • Author(s)
      四宮春輝, 朝野仁裕
    • Publisher
      科学評論社
    • Related Report
      2021 Annual Research Report
  • [Book] ゲノム・オミックス解析2021

    • Author(s)
      朝野仁裕
    • Publisher
      科学評論社
    • Related Report
      2020 Annual Research Report
  • [Book] 月刊心臓 HEART's Selection 拡張型心筋症の精密医療 拡張型心筋症をゲノムで層別化する2021

    • Author(s)
      朝野仁裕
    • Publisher
      日本心臓財団・日本循環器学会(日本医学出版)
    • Related Report
      2020 Annual Research Report
  • [Book] CARDIAC PRACTICE 循環器疾患のPrecision Medicine トピック 不整脈Precision Medicineへ向けた試み2020

    • Author(s)
      朝野仁裕
    • Publisher
      メディカルレビュー社
    • Related Report
      2020 Annual Research Report
  • [Book] 新心臓病学 第7章心筋疾患・心膜疾患 不整脈原性右室心筋症2020

    • Author(s)
      朝野仁裕
    • Publisher
      文光堂
    • Related Report
      2019 Annual Research Report
  • [Book] CARDIAC PRACTICE 循環器疾患のPrecision Medicine 不整脈Precision Medicineへ向けた試み2020

    • Author(s)
      朝野仁裕
    • Publisher
      メディカルレビュー社
    • Related Report
      2019 Annual Research Report
  • [Book] 医学のあゆみ 遺伝性心血管疾患のすべて 遺伝性徐脈性不整脈におけるゲノム医療へのアプローチ2019

    • Author(s)
      朝野仁裕
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2019 Annual Research Report
  • [Book] 月刊心臓 HEART's Selection 心臓病に挑むゲノム医療2019

    • Author(s)
      朝野仁裕
    • Publisher
      日本心臓財団・日本循環器学会(日本医学出版)
    • Related Report
      2019 Annual Research Report
  • [Book] 月刊心臓 心不全層別化に向けた疾患ゲノム解析2019

    • Author(s)
      朝野仁裕
    • Publisher
      日本心臓財団・日本循環器学会(日本医学出版)
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 遺伝性徐脈性不整脈治療薬2020

    • Inventor(s)
      朝野仁裕、高島成 二、山田憲明、山下 徹
    • Industrial Property Rights Holder
      朝野仁裕、高島成 二、山田憲明、山下 徹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 心不全感受性エンハンサーを含む遺伝子治療用ベクター2020

    • Inventor(s)
      朝野仁裕、高島成 二、松岡研、塚本 蔵、木岡秀隆
    • Industrial Property Rights Holder
      朝野仁裕、高島成 二、松岡研、塚本 蔵、木岡秀隆
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-206823
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] 遺伝性徐脈性不整脈治療薬2019

    • Inventor(s)
      朝野仁裕、高島成二、山田憲明、山下徹
    • Industrial Property Rights Holder
      朝野仁裕、高島成二、山田憲明、山下徹
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 心不全感受性エンハンサーを含む遺伝子治療用ベクター2019

    • Inventor(s)
      朝野仁裕、高島成二、松岡研、塚本蔵、木岡秀隆
    • Industrial Property Rights Holder
      朝野仁裕、高島成二、松岡研、塚本蔵、木岡秀隆
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-206823
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2025-01-30  

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