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Mechanism of Molecular Levarage

Research Project

Project/Area Number 19H03661
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionTokai University

Principal Investigator

Goto Shinya  東海大学, 医学部, 教授 (50225653)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2022: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Keywords血小板 / 膜糖蛋白 / コンピューター / 分子動力学 / インテグリン / 分子動力学計算 / GPIIb/IIIa / 細胞 / 膜糖蛋白GPIIb/IIIa / 活性化 / 血栓形成 / 高性能コンピューター / 血栓 / 細胞活性化 / 心筋梗塞 / コンピューターシミュレーション / 細胞機能
Outline of Research at the Start

活性化による血小板細胞の機能変化は膜糖タンパクGPIIb/IIIaの細胞外ドメインの高次構造変化による。細胞内ドメイン・細胞膜貫通ドメイン・細胞外ドメインを統合したGPIIb/IIIaモデルを、分子を構成する全ての原子と周囲の水分子の位置座標から作成する。血小板細胞活性化に伴う細胞内環境のわずかな変化がGPIIb/IIIaの細胞外ドメインの大きな構造変化を惹起するメカニズムとして「分子レバレッジ機構」の解明を目指す。

Outline of Final Research Achievements

The integrated model of Integrin αIIbβ3 (platelet GPIIb/IIIa) was developed by combining the extracellular domain adopted from crystal structure and the transmembrane and intracellular domain obtained by NMR. The trans-membrane domain was settled into the phosphatidylcholine (POPC) lipid bilayer model. The position coordinates and velocity vectors of all atoms and water molecules around them were calculated by molecular dynamic simulation with the use of CHARMM (Chemistry at HARvard Macromolecular Mechanics) force field in every 2 x 10-15 sec. By using this newly developed model. the relationship between dynamic structural changes in extra-cellular domain of integrin αIIbβ3 could be understood from the dynamic structural fluctuation in intra-cellular domain of integrin αIIbβ3.

Academic Significance and Societal Importance of the Research Achievements

細胞は外部環境に適応して生理機能を変化させる。細胞機能の変化は各種膜蛋白の細胞ガイドメインの構造に依存している。外部環境の変化による細胞内環境の微小変化が細胞外ドメインの構造と機能を大きく変化させるメカニズムを分子動力学計算にて物理卓的に解明するための方法の基盤を作成した。医学・生物学に広く応用可能な技術となる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (83 results)

All 2024 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (9 results) Journal Article (49 results) (of which Int'l Joint Research: 33 results,  Peer Reviewed: 45 results,  Open Access: 35 results) Presentation (19 results) (of which Int'l Joint Research: 5 results,  Invited: 10 results) Book (1 results) Patent(Industrial Property Rights) (5 results)

  • [Int'l Joint Research] Harvard University/Duke University(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Oxford University/The Thrombosis Research Institute(英国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] The University of Oxford/Thrombosis Research Institute(英国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Harvard University/Duke University(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] ハーバード大学(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ハーバード大学(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Thrombosis Research Institute(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Oxford University(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Harvard University(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Development of the Integrated Computer Simulation Model of the Intracellular, Transmembrane, and Extracellular Domain of Platelet Integrin αIIbβ3 (Platelet Membrane Glycoprotein: GPIIb?IIIa)2024

    • Author(s)
      Nakayama Masamitsu、Goto Shinichi、Goto Shinya
    • Journal Title

      TH Open

      Volume: 08 Issue: 01 Pages: e96-e105

    • DOI

      10.1055/a-2247-9438

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Detection of the Relationship between the Multi-Dimensional Data Sets of Serially Measured Blood Pressure and the Future Risk of Death in Healthy Elderly Japanese Population2023

    • Author(s)
      Nakayama Masamitsu、Goto Shinichi、Sakano Teppei、Goto Shinya
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 30 Issue: 8 Pages: 1002-1009

    • DOI

      10.5551/jat.63798

    • ISSN
      1340-3478, 1880-3873
    • Year and Date
      2023-08-01
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Asian perspective on the recently published practice guideline for acute coronary syndrome by ESC2023

    • Author(s)
      Torii Sho、Chiang Chern-En、Hong Soon Jun、Goto Shinichi、Huang Wei-Chun、Chan Mark Yan-Yee、Kajiya Takashi、Goto Shinya
    • Journal Title

      European Heart Journal: Acute Cardiovascular Care

      Volume: 13 Issue: 1 Pages: 162-164

    • DOI

      10.1093/ehjacc/zuad126

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] MRP1-Dependent Extracellular Release of Glutathione Induces Cardiomyocyte Ferroptosis After Ischemia-Reperfusion2023

    • Author(s)
      Genki Ichihara, Yoshinori Katsumata, Yuki Sugiura, Yuta Matsuoka, Rae Maeda, Jin Endo, Atsushi Anzai, Kohsuke Shirakawa, Hidenori Moriyama, Hiroki Kitakata, Takahiro Hiraide, Shinichi Goto, Seien Ko, Yuji Iwasawa, Kazuhisa Sugai, Kyohei Daigo, Shinya Goto, Kazuki Sato, Ken-Ichi Yamada, Makoto Suematsu, et al.
    • Journal Title

      Circulation Research

      Volume: 133 Issue: 10 Pages: 861-876

    • DOI

      10.1161/circresaha.123.323517

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acute pulmonary hypertension due to microthrombus formation following COVID-19 vaccination: a case report2023

    • Author(s)
      Nakagawa Akiko、Nakamura Norihito、Torii Sho、Goto Shinya
    • Journal Title

      European Heart Journal - Case Reports

      Volume: 7 Issue: 8

    • DOI

      10.1093/ehjcr/ytad353

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment of Cancer-Associated Thrombosis: Recent Advances, Unmet Needs, and Future Direction2023

    • Author(s)
      Wang Tzu-Fei、Khorana Alok A、Agnelli Giancarlo、Bloomfield Dan、Bonaca Marc P、B?ller Harry R、Connors Jean M、Goto Shinya、Jing Zhi-Cheng、Kakkar Ajay K、Khder Yasser、Raskob Gary E、Soff Gerald A、Verhamme Peter、Weitz Jeffrey I、Carrier Marc
    • Journal Title

      The Oncologist

      Volume: 28 Issue: 7 Pages: 555-564

    • DOI

      10.1093/oncolo/oyad116

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Statin Treatment and the Alterations in the Platelet Lipidome: What Is the Impact of Lipid Profile on Thrombosis?2023

    • Author(s)
      Goto Shinichi、Goto Shinya
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 123 Issue: 06 Pages: 573-575

    • DOI

      10.1055/a-2052-9650

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Healthcare Resource Utilization in Patients with Newly Diagnosed Atrial Fibrillation: A Global Analysis from the GARFIELD-AF Registry2023

    • Author(s)
      Mantovani LG, Cozzolino P, Ferrara P, Virdone S, Camm AJ, Verheugt FWA, Bassand JP, Turpie AGG, Hacke W, Kayani K, Goldhaber SG, Goto S, Pieper KS, Gersh BJ, Fox KAA,1 Haas S, Eickels M, Kakkar AK.
    • Journal Title

      Healthcare

      Volume: 11 Issue: 5 Pages: 638-65

    • DOI

      10.3390/healthcare11050638

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sustained Myocarditis Following Messenger RNA Vaccination against COVID-19: Relation to Neutralizing Antibody and Amelioration by Low-Dose Booster Vaccination.2023

    • Author(s)
      Miyazaki K, Fujii T, Mori K, Tamimoto R, Nagamatsu H, Murakami T, Cho Y, Goto S, Mori H.
    • Journal Title

      J Clin Med

      Volume: 12 Issue: 4 Pages: 1421-1421

    • DOI

      10.3390/jcm12041421

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 36-month clinical outcomes of patients with venous thromboembolism: GARFIELD-VTE.2022

    • Author(s)
      3.Turpie AGG, Farjat AE, Haas S, Ageno W, Weitz JI, Goldhaber SZ, Goto S, Angchaisuksirih S, Kayanii G, Lopes RD, Chiang CN, Gibbs H, Tsem E, Verhammenn P, Cate HT, Muntaner J, Schellong S, Bounameaux H, Prandoni P, Kakkar AK
    • Journal Title

      Thromb Res

      Volume: 222 Pages: 31-39

    • DOI

      10.1016/j.thromres.2022.11.016

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Empagliflozin in Patients with Chronic Kidney Disease.2022

    • Author(s)
      Herrington WG, Brenner S, Cheung AK, Liu ZH, Li J, Hooi LS, Liu W, Kadowaki T, Nangaku M, Levin A, Cherney D, Maggioni AP, Pontremoli R, Deo R, Goto S, Rossello X, Tuttle KR, Steubl D, Petrini M, Massey D, Eilbracht J, Brueckmann M, Landray MJ, Baigent C, Haynes R
    • Journal Title

      N Engl J Med

      Volume: 388 Issue: 2 Pages: 117-127

    • DOI

      10.1056/nejmoa2204233

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Characteristics of von Willebrand Factor Binding with Platelet Glycoprotein Ibα Mutants at Residue 233 Causing Various Biological Functions.2022

    • Author(s)
      Nakayama M, Goto S, and Goto S.
    • Journal Title

      TH-Open

      Volume: 06 Issue: 04 Pages: e421-e428

    • DOI

      10.1055/a-1937-9940

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Contributing Role of Mitochondrial Energy Metabolism on Platelet Adhesion, Activation and Thrombus Formation under Blood Flow Conditions. Platelet,2022

    • Author(s)
      Tamura N, Goto S, Yokota H, and Goto S
    • Journal Title

      Platelet

      Volume: in press Issue: 7 Pages: 1083-1089

    • DOI

      10.1080/09537104.2022.2046722

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term safety and efficacy of anacetrapib in patients with atherosclerotic vascular disease2022

    • Author(s)
      Sammons E, Hopewell JC, Chen F, Stevens W, Wallendszus K, Goodenough R, Lay M, Hill M, Macdonnell S, Fabbri G, Lucci D, Fajardo-Moser M, Brenner S, Hao D, Zhang H, Liu J, Wuhan B, Mosegaard S, Herrington W, Wanner C,Ertl G, Maggioni A, Barter P, Mihaylova B, Mitchel Y, Blaustein R, Goto S,
    • Journal Title

      European Heart Journal.

      Volume: 6 Issue: 14 Pages: 1416-1424

    • DOI

      10.1093/eurheartj/ehab863

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] GARFIELD-AF risk score for mortality, stroke and bleeding within 2 years in patients with atrial fibrillation2022

    • Author(s)
      ox KAA, Virdone S, Pieper KS, Bassand JP, Camm AJ, Fitzmaurice DA, Goldhaber SZ, Goto S, Haas S, Kayani G, Oto A, Misselwitz F, Piccini JP, Dalgaard F, Turpie AGG, Verheugt FW, Kakkar AK
    • Journal Title

      European Heart Journal - Quality of Care and Clinical Outcomes

      Volume: 8 Pages: 214-227

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Important Regulatory Roles of Erythrocytes on Platelet Adhesion to the von Willebrand Factor on the Wall Under Blood Flow Conditions.2021

    • Author(s)
      Tamura N, Shimizu K, Shiozaki S, Sugiyama K, Nakayama M, Goto S, Takagi S, Goto S.
    • Journal Title

      Thromb Haemost

      Volume: in press Issue: 06 Pages: 974-983

    • DOI

      10.1055/a-1677-9499

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Influence of Body Mass Index on Clinical Outcomes in Venous Thromboembolism: Insights from GARFIELD-VTE2021

    • Author(s)
      Weitz JI, Farjat AE, Ageno W, Turpie AG, Haas S, Goto S, Goldhaber SG, Angchaisuksiri P, Gibbs H, MacCallum P, Carrier M, Kayani G, Schellong S, Bounameaux H, Mantovani LG, Prandoni P, Kakkar AK
    • Journal Title

      J Thrombi Haemost

      Volume: 19 Issue: 12 Pages: 3031-3043

    • DOI

      10.1111/jth.15520

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Generalizability of the REDUCE-IT trial and cardiovascular outcomes associated with hypertriglyceridemia among patients potentially eligible for icosapent ethyl therapy: An analysis of the REduction of Atherothrombosis for Continued Health (REACH) registry.2021

    • Author(s)
      Picard F, Bhatt DL, Ducrocq G, Ohman EM, Goto S, Eagle KA, Wilson PWF, Smith SC Jr, Elbez Y, Steg PG
    • Journal Title

      Int J Cardiol.

      Volume: 340 Pages: 96-104

    • DOI

      10.1016/j.ijcard.2021.08.031

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reexamination of the Embolic Stroke of Undetermined Source Concept2021

    • Author(s)
      Albers GW, Bernstein R, Brachmann J, Camm AJ, Fromm P, Goto S, Granger CB, Hohnloser SH, Hylek E, Krieger D, Passman R, Pines JM, Kowey P
    • Journal Title

      Stroke

      Volume: 52 Issue: 8 Pages: 2715-2722

    • DOI

      10.1161/strokeaha.121.035208

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risks associated with discontinuation of oral anticoagulation in newly diagnosed patients with atrial fibrillation: Results from the GARFIELD-AF Registry2021

    • Author(s)
      Cools F, Johnson D, Camm AJ, Bassand J-P, Verheugt FWA, Yang S, Tsiatis A, Fitzmaurice DA, Goldhaber SZ, Kayani G, Goto S, Haas S, Misselwitz F, Turpie AGG, Fox KAA, Pieper KS, Kakkar AK
    • Journal Title

      J thromb Haemost

      Volume: 19 Issue: 9 Pages: 2322-2334

    • DOI

      10.1111/jth.15415

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influence of anemia on clinical outcomes in venous thromboembolism: Results from GARFIELD-VTE2021

    • Author(s)
      Goto S, Turpie AGG, Farjat AE, Weitz JI, Haas S, Ageno W, Goldhaber SZ, Angchaisuksiri P, Kayani G, MacCallum P, Schellong S, Bounameaux H, Mantovani LG, Prandoni P and Kakkar AK
    • Journal Title

      Thromb Res

      Volume: 203 Pages: 155-162

    • DOI

      10.1016/j.thromres.2021.05.007

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Bleeding and related mortality with NOACs and VKAs in newly diagnosed atrial fibrillation2021

    • Author(s)
      Bassand J-P, Virdone S, Badoz M, Verheugt FWA, Camm AJ, Cools F, Fox KAA, Goldhaber SZ, Goto S, Haas S, Hacke W, Kayani G, Misselwitz F, Pieper KS, Turpie AGG, van Eickels M and Kakkar AK
    • Journal Title

      Blood Advances.

      Volume: 5 Issue: 4 Pages: 1081-1091

    • DOI

      10.1182/bloodadvances.2020003560

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Computer Simulation of Platelet Adhesion around Stent Struts in the Presence and Absence of Tissue Defects around Them2021

    • Author(s)
      Kawamura Y, Tamura N, Goto S, and Goto S
    • Journal Title

      J Intervent Cardiol

      Volume: - Pages: 8880988-8880988

    • DOI

      10.1155/2021/8880988

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Venous thromboembolism in Asia and worldwide: Emerging insights from GARFIELD-VTE2021

    • Author(s)
      Angchaisuksiri P, Goto S, Farjat AE, Fryk H, Bang S-M, Chiang C-E, Jing Z-C, Kondo K, Sathar J and Tse E
    • Journal Title

      Thromb Res

      Volume: 201 Pages: 63-72

    • DOI

      10.1016/j.thromres.2021.02.024

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pregnancy-Associated Venous Thromboembolism: Insights from GARFIELD-VTE.2021

    • Author(s)
      Jerjes-Sanchez C, Rodriguez D, Farjat AE, Kayani G, MacCallum P, Lopes RD, Turpie AGG, Weitz JI, Haas S, Ageno W, Goto S, Goldhaber SZ, Angchaisuksiri P, Nielsen JD, Schellong S, Bounameaux H, Mantovani LG, Prandoni P, Kakkar AK
    • Journal Title

      TH-open

      Volume: 5 Issue: 01 Pages: e24-e34

    • DOI

      10.1055/s-0040-1722611

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Apixaban Versus Warfarin in Patients With Atrial Fibrillation and Left Ventricular Hypertrophy: Insights From the ARISTOTLE Trial2021

    • Author(s)
      Al-Khatib SM, Mulder H, Wojdyla D, Lopes RD, Wallentin L, Alexander JH, Hijazi Z, Goto S, Granger CB
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 14 Issue: 3

    • DOI

      10.1161/circep.120.009614

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New cardiovascular prevention guidelines: How to optimally manage dyslipidaemia and cardiovascular risk in 2021 in patients needing secondary prevention?2021

    • Author(s)
      Atar D, Jukema JW, Molemans B, Taub PR, Goto S, Mach F, CerezoOlmos C, Underberg J, Keech A, Tokglu L and Bonaca MP
    • Journal Title

      Atherosclerosis

      Volume: 319 Pages: 51-61

    • DOI

      10.1016/j.atherosclerosis.2020.12.013

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Provoked versus unprovoked venous thromboembolism: Findings from GARFIELD‐VTE2021

    • Author(s)
      Ageno W, Farjat A, Haas S, Weitz JI, Goldhaber SZ, Turpie AG, Goto S, Angchaisuksiri P, Dalsgaard Nielsen J and Kayani G
    • Journal Title

      Research and Practice in Thrombosis and Haemostasis

      Volume: 5 Issue: 2 Pages: 326-341

    • DOI

      10.1002/rth2.12482

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparative effectiveness of oral anticoagulants in everyday practice: GARFIELD-AF registry.2020

    • Author(s)
      Camm AJ, Fox KAA, Virdone S, Bassand JP, Fitzmaurice DA, Berchuck SJ, Gersh BJ, Goldhaber SZ, Goto S, Haas S, Misselwitz F, Pieper KS, Turpie AGG, Verheugt FWA, Cappato R, Kakkar AJness of oral anticoagulants in everyday practice: GARFIELD-AF registry
    • Journal Title

      Heart

      Volume: 107 Issue: 12 Pages: 962-970

    • DOI

      10.1136/heartjnl-2020-318420

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The East Asian Paradox: An Updated Position Statement on the Challenges to the Current Antithrombotic Strategy in Patients with Cardiovascular Disease2020

    • Author(s)
      Kim HK, Tantry US, Smith SCJr, o Jeong MH, Park SJ, Kim MH, Lim DS, Shin ES, Park DW, Huo Y, Chen SL, Bo Z, Goto S, Kimura T, Yasuda S, Chen WJ, Chan M, Aradi D, Geisler T, Gorog DA, Sibbing D, Lip GYH, Angiolillo DJ, Gurbel PA, Jeong YH
    • Journal Title

      Thromb Haemost,

      Volume: 6 Issue: 04 Pages: 1416-1424

    • DOI

      10.1055/s-0040-1718729

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Do baseline characteristics and treatments account for geographical disparities in the outcomes of patients with newly diagnosed atrial fibrillation? The prospective GARFIELD-AF registry.2020

    • Author(s)
      Camm AJ, Cools F, Virdone S, Bassand JP, Fitzmaurice DA, Arthur Fox KA, Goldhaber SZ, Goto S, Haas S, Mantovani LG, Kayani G, Grierson Turpie AG, Antoon Verheugt FW, Kakkar AK
    • Journal Title

      J Am Coll Cardiol,

      Volume: 76 Issue: 12 Pages: 1425-1436

    • DOI

      10.1016/j.jacc.2020.07.045

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Variability of PT-INR Values Measured by Point of Care Devices of INRatio/INRatio2, CoaguChek XS and Standard Laboratory Method. -A cross-sectional study-,2020

    • Author(s)
      Komatsu C, Iseki H, Goto S, and Goto S
    • Journal Title

      Arc Med Sch

      Volume: in press

    • DOI

      10.5114/aoms.2020.99165

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GARFIELD-AF: a worldwide prospective registry of patients with atrial fibrillation at risk of stroke2020

    • Author(s)
      Bassand J-P, Apenteng PN, Atar D, Camm AJ, Cools F, Corbalan R, Fitzmaurice DA, Fox KAA, Goto S, Haas S, Hacke W, Jerjes-Sanchez C, Koretsune Y, Heuzey J-YL, Sawhney JPS, Oh S, Cate Vt, Verheugt FWA, Kayani G, Pieper KS, Kakkar AK
    • Journal Title

      Future Cardiology

      Volume: 17 Issue: 1 Pages: 19-38

    • DOI

      10.2217/fca-2020-0014

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Outcomes Associated With Oral Anticoagulants Plus Antiplatelets in Patients With Newly Diagnosed Atrial Fibrillation2020

    • Author(s)
      Fox KAA, Velentgas, Camm AJ, Bassand JP, Fitzmaurice DA, Gersh BJ, Goldhaber SZ, Goto S, Haas S, Misselwitz F, Pieper KS, Turpie AGG, Verheugt FWA, Dabrowski E, Luo K, Gibbs L and Kakkar AK.
    • Journal Title

      JAMA Network Open

      Volume: 3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Caffeinated Beverages Intake, Dyspnea with Ticagrelor and Cardiovascular Outcomes: Insights from PEGASUS-TIMI 54 trial2020

    • Author(s)
      Furtado RHM, Venkateswaran RV, Nicolau JC, Gurmu Y, Bhatt DL, Storey RF, Steg PG, Magnani G, Goto S, Dellborg M, Kamensky G, Isaza D, Aylward P, Johanson P, Bonaca MP.
    • Journal Title

      J Am Heart Assoc,

      Volume: - Issue: 10

    • DOI

      10.1161/jaha.119.015785

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] No Significant Relationship Between Ticagrelor and Sleep Apnea in Large, Randomized, Blinded Trials2020

    • Author(s)
      Sabatine MS, Hiatt WR, Goto S, Johnston SC, Bonaca MP, Steg PG, Bhatt DL, Cannon CP, Andersson M, Wallentin L.
    • Journal Title

      JACC Cardiovasc Interv.

      Volume: 13 Issue: 8 Pages: 1012-1014

    • DOI

      10.1016/j.jcin.2020.02.009

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prior stroke and transient ischemic attack as risk factors for subsequent stroke in atrial fibrillationpatients: A report from the GARFIELD-AF registry.2020

    • Author(s)
      Hacke W, Bassand JP, Virdone S, Camm AJ, Fitzmaurice DA, Fox KA, Goldhaber SZ, Goto S, Haas S, Kayani G, Mantovani LG, Misselwitz F, Pieper KS, Turpie AG, van Eickels M, Verheugt FW, Kakkar AK
    • Journal Title

      Int J Stroke

      Volume: 15 Issue: 3 Pages: 308-317

    • DOI

      10.1177/1747493019891516

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] New artificial intelligence prediction model using serial prothrombin time international normalized ratio measurements in atrial fibrillation patients on vitamin K antagonists: GARFIELD-AF2019

    • Author(s)
      Goto Shinichi、Goto Shinya、Pieper Karen S、Bassand Jean-Pierre、Camm Alan John、Fitzmaurice David A、Goldhaber Samuel Z、Haas Sylvia、Parkhomenko Alexander、Oto Ali、Misselwitz Frank、Turpie Alexander G G、Verheugt Freek W A、Fox Keith A A、Gersh Bernard J、Kakkar Ajay K
    • Journal Title

      European Heart Journal - Cardiovascular Pharmacotherapy

      Volume: in press Issue: 5 Pages: 301-309

    • DOI

      10.1093/ehjcvp/pvz076

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Searching for Atrial Fibrillation Poststroke2019

    • Author(s)
      Schnabel Renate B., Goto Shinya、et al
    • Journal Title

      Circulation

      Volume: 140 Issue: 22 Pages: 1834-1850

    • DOI

      10.1161/circulationaha.119.040267

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Ticagrelor in patients with diabetes and stable coronary artery disease with a history of previous percutaneous coronary intervention (THEMIS-PCI): a phase 3, placebo-controlled, randomised trial2019

    • Author(s)
      Bhatt Deepak L、Shinya Goto, et al.
    • Journal Title

      The Lancet

      Volume: 394 Issue: 10204 Pages: 1169-1180

    • DOI

      10.1016/s0140-6736(19)31887-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Potential different impact of inhibition of thrombin function and thrombin generation rate for the growth of thrombi formed at site of endothelial injury under blood flow condition2019

    • Author(s)
      Ayabe Kengo、Goto Shinichi、Oka Hideki、Yabushita Hiroto、Nakayama Masamitsu、Tomita Aiko、Hasebe Terumitsu、Yokota Hideo、Takagi Shu、Goto Shinya
    • Journal Title

      Thrombosis Research

      Volume: 179 Pages: 121-127

    • DOI

      10.1016/j.thromres.2019.05.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ST-segment elevation myocardial infarction2019

    • Author(s)
      Vogel Birgit、Claessen Bimmer E.、Arnold Suzanne V.、Chan Danny、Cohen David J.、Giannitsis Evangelos、Gibson C. Michael、Goto Shinya、Katus Hugo A.、Kerneis Mathieu、Kimura Takeshi、Kunadian Vijay、Pinto Duane S.、Shiomi Hiroki、Spertus John A.、Steg P. Gabriel、Mehran Roxana
    • Journal Title

      Nature Reviews Disease Primers

      Volume: 5 Issue: 1

    • DOI

      10.1038/s41572-019-0090-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Dapagliflozin on Heart Failure and Mortality in Type 2 Diabetes Mellitus.2019

    • Author(s)
      Kato ET, Silverman MG, Mosenzon O, Zelniker TA, Cahn A, Furtado RHM, Kuder J, Murphy SA, Bhatt DL, Leiter LA, McGuire DK, Wilding JPH, Bonaca MP, Ruff CT, Desai AS, Goto S, Johansson PA, Gause-Nilsson I, Johanson P, Langkilde AM, Raz I, Sabatine MS, Wiviott SD.
    • Journal Title

      Circulation

      Volume: in press Issue: 22 Pages: 115-124

    • DOI

      10.1161/circulationaha.119.040130

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation2019

    • Author(s)
      Corbalan Ramon、Shinya Goto, et al.
    • Journal Title

      JAMA Cardiology

      Volume: 4 Issue: 6 Pages: 526-526

    • DOI

      10.1001/jamacardio.2018.4729

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dual antiplatelet therapy using cilostazol for secondary prevention in patients with high-risk ischaemic stroke in Japan: a multicentre, open-label, randomised controlled trial2019

    • Author(s)
      Toyoda Kazunori、Shinya Goto, et al.
    • Journal Title

      The Lancet Neurology

      Volume: 18 Issue: 6 Pages: 539-548

    • DOI

      10.1016/s1474-4422(19)30148-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Early Risks of Death, Stroke/Systemic Embolism, and Major Bleeding in Patients With Newly Diagnosed Atrial Fibrillation.2019

    • Author(s)
      Bassand JP, Virdone S, Goldhaber SZ, Camm AJ, Fitzmaurice DA, Fox KAA, Goto S, Haas S, Hacke W, Kayani G2, Mantovani LG10, Misselwitz F, Pieper KS2, Turpie AGG, van Eickels M, Verheugt FWA, Kakkar AK
    • Journal Title

      Circulation

      Volume: 139 Issue: 6 Pages: 787-798

    • DOI

      10.1161/circulationaha.118.035012

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prediction of binding characteristics between von Willebrand factor and platelet glycoprotein Ibα with various mutations by molecular dynamic simulation2019

    • Author(s)
      S. Goto, H. Oka, K. Ayabe, H. Yabushita, M. Nakayama, T. Hasebe, H. Yokota, S. Takagi, M. Sano, and A. Tomita
    • Journal Title

      Thrombosis Research

      Volume: Vol. 184 Pages: 129-135

    • DOI

      10.1016/j.thromres.2019.10.022

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Global Trial or Local One?2019

    • Author(s)
      Goto Shinya
    • Journal Title

      Circulation

      Volume: 140 Issue: 23 Pages: 1878-1880

    • DOI

      10.1161/circulationaha.119.043629

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Letter by Goto and Goto Regarding Article, "Fully Automated Echocardiogram Interpretation in Clinical Practice: Feasibility and Diagnostic Accuracy"2019

    • Author(s)
      Goto S and Goto S
    • Journal Title

      Circulation

      Volume: 139 Issue: 13 Pages: 1646-1647

    • DOI

      10.1161/circulationaha.118.038451

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 第XI因子阻害剤の現状と今後の展開2024

    • Author(s)
      後藤信哉
    • Organizer
      第271回日本循環器学会地方会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Antithrombotic Therapy in Cardiology2023

    • Author(s)
      Shinya Goto
    • Organizer
      45th Japanese Society of Thrombosis and Haemostsis
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 高性能コンピューターを用いた個別最適化医療2022

    • Author(s)
      後藤信哉
    • Organizer
      第56回日本成人病学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Medical Therapy after ISCHEMIA trial2022

    • Author(s)
      後藤信哉
    • Organizer
      第68回日本循環器学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 心房細動における血栓塞栓の発症機序と危険因子2022

    • Author(s)
      後藤信哉
    • Organizer
      第68回日本循環器学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Do we have to care about "specific" antiplatelet drug after DAPT period?2022

    • Author(s)
      後藤信哉
    • Organizer
      第68回日本循環器学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The Effect Of CSL112 (Apolipoprotein A-I [Human]) On Cholesterol Efflux Capacity: A Cross-Study Comparison2021

    • Author(s)
      Bo Zheng, Shinya Goto, Regina Clementi, John Feaster, Danielle Duffy, Penelope Dalitz, Jolanta Airey, John Roberts1 Serge Korjian, C. Michael Gibson
    • Organizer
      ACC2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 循環器内科における高性能コンピューターの利用2021

    • Author(s)
      後藤信哉
    • Organizer
      第37回 日本臨床化学会関東支部例会プログラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Artificial intelligence (AI) to detect non-ischemic cardiomyopathy2021

    • Author(s)
      Shinya Goto
    • Organizer
      APSTH2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新しい抗血栓薬2021

    • Author(s)
      後藤信哉
    • Organizer
      第53回日本動脈硬化学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Platelet Hyperactivity in Diabetes Mellitus -Are Platelets “Sticker?”2020

    • Author(s)
      Shinya Goto
    • Organizer
      JCS 2020 Kyoto
    • Related Report
      2020 Annual Research Report
  • [Presentation] Exploring the Best Antiplatelet Regimen after PCI in East Asia and Globally2020

    • Author(s)
      Shinya Goto
    • Organizer
      JCS 2020 Kyoto
    • Related Report
      2020 Annual Research Report
  • [Presentation] Discussion regarding “A Prospective, Randomized, Endpoint Study Exploring Platelet Response to Half-Dose Prasugrel and Ticagrelor in Patients with the ACS: HOPE-TAILOR Study2020

    • Author(s)
      Shinya Goto
    • Organizer
      JCS 2020 Kyoto
    • Related Report
      2020 Annual Research Report
  • [Presentation] 人の脳とコンピューターの本質的な相違から今後の AI 技術を考える2019

    • Author(s)
      Shinya Goto
    • Organizer
      第28回日本コンピューター外科学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] バイオマーカーセットとコンピューターによる臨床イベント予測技術2019

    • Author(s)
      後藤信哉
    • Organizer
      第60回日本脈管学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 担がん患者の血栓塞栓症治療2019

    • Author(s)
      後藤信哉
    • Organizer
      第60回日本脈管学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Lipid lowering drugs in the elderly: anything different?2019

    • Author(s)
      Shinya Goto
    • Organizer
      ESC2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Is There an Ethnic Difference in the Risk of Bleeding Complications with the Use of Antithrombotic Agents2019

    • Author(s)
      Shinya Goto
    • Organizer
      ISTH 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Computer Simulation of Platelet Adhesion and Thrombus Formation2019

    • Author(s)
      Shinya Goto
    • Organizer
      6th International Conference on Computational and Mathematical Biomedical Engineering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] New Insights Into Metabolic Syndrome2021

    • Author(s)
      Shinya Goto: Editor Takada A.
    • Total Pages
      230
    • Publisher
      IntechOpen
    • ISBN
      9781839684562
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 予後予測システム、予後予測プログラム作成装置、予後予測装置、予後予測方法および予後予測プログラム2021

    • Inventor(s)
      後藤信哉、後藤信一
    • Industrial Property Rights Holder
      学校法人東海大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Acquisition Date
      2023
    • Related Report
      2023 Annual Research Report
  • [Patent(Industrial Property Rights)] フォンヴィルブランド因子と血小板との結合を阻害するための医薬組成物2021

    • Inventor(s)
      後藤信哉、平山令明、中山正光、後藤信一
    • Industrial Property Rights Holder
      学校法人東海大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-191728
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 予測システム、予測装置、および予測プログラム2021

    • Inventor(s)
      坂野哲平、後藤信哉、後藤信一、中山正光
    • Industrial Property Rights Holder
      株式会社アルム、学校法人東海大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-075064
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 予後予測システム、予後予測プログラム作成装置、予後予測装置、予後予測方法及び予後予測プログラム2019

    • Inventor(s)
      後藤信哉、後藤信一
    • Industrial Property Rights Holder
      学校法人東海大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2022
    • Related Report
      2022 Annual Research Report
  • [Patent(Industrial Property Rights)] 血液凝固剤投薬治療における予後イベント予測2019

    • Inventor(s)
      後藤信哉、後藤信一
    • Industrial Property Rights Holder
      学校法人東海大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-038948
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2025-01-30  

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