| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
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| Outline of Final Research Achievements |
We hypothesized that cardiomyocyte-specific DNA damage response play a role in cell cycle exit of cardiomyocyte after birth. To test this hypothesis, we tried to develop a system that could reproducibly and controllably induce DNA damage in myocardial cells and non-myocardial cells using genetic engineering techniques. However, we were unable to develop a system with sufficient reproducibility.
On the other hand, through the observations made during the course of the initial research plan, we discovered that the SWI/SNF complex controls the division and proliferation of myocardial cells to the opposite direction in an ATPase subunit-specific manner. We are convinced that this chromatin remodeling complex ATPase subunit-specific regulation of DNA damage response and gene regulation is involved in the mechanism by which cardiomyocytes exit the cell cycle after birth.
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