Mechanisms of leukemogenesis by HTLV-1 and development of novel therapies

• Project/Area Number: 19H03689
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: Kumamoto University
• Principal Investigator: Matsuoka Masao 熊本大学, 大学院生命科学研究部(医), 教授 (10244138)
• Co-Investigator(Kenkyū-buntansha): 安永 純一朗 京都大学, ウイルス・再生医科学研究所, 講師 (40362404)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: HTLV-1 / 成人T細胞白血病 / HBZ / ウイルス発がん / HTLV-I / 成人T 細胞白血病 / Tax

Outline of Research at the Start

我々はHTLV-1がコードするHTLV-1 bZIP factor（HBZ）の発がん、炎症惹起機構を明らかにし、その病態における重要性を明らかにしてきた。またHBZタンパク質だけでなくHBZ RNAも機能を有することを解明してきた。本研究ではHBZによる宿主エピゲノム変化、発がん機構における分子機構の解析を進めHTLV-1による発がん機構を明らかにする。また、、HBZを標的としたワクチン開発研究を行い発症予防法、新規免疫治療法の開発に繋げることを目的とする。

Outline of Final Research Achievements

We studied mechanism how HTLV-1 bZIP factor (HBZ) causes diseases like adult T-cell leukemia (ATL). Loss of IL-6 increased pathogenesis by HBZ. As mechanisms, loss of IL-6 promotes differentiation of HBZ expressing T cells to regulatory T cells, and increases IL-10 production. IL-10 promotes T-cell proliferation in the presence of HBZ. HBZ interacts with STAT1, 3, resulting in enhanced proliferation of T cells. We identified mechanisms why HBZ RNA is mainly localized in the nucleus, and found it as a common phenomenon in retroviruses. We also analyze epigenetic changes induced by HBZ protein and RNA, and found that increased TAp73 promotes oncogenesis by metabolic changes.

Academic Significance and Societal Importance of the Research Achievements

HTLV-1感染者は本邦に多くATL発症は社会的問題となっている。本研究はHTLV-1による新たな発がん機構を明らかにし、今後の治療法開発を進める上で有用な情報を提供した。また、HBZ mRNAがタンパク質をコードするだけでなくRNA自身も機能を有することを世界に先駆けて明らかにしたが、その機構をさらに解明し、レトロウイルスアンチセンス鎖に共通する性質であることを示したことは今後のレトロウイルス研究に大きな貢献が期待できる。

Research Products

• [Int'l Joint Research] Imperial College London(英国)
• [Int'l Joint Research] Ohio State University(米国)
• [Journal Article] HTLV-1 bZIP factor-induced reprogramming of lactate metabolism and epigenetic status promote leukemic cell expansion. (2023)
  • Author(s): Toyoda K, Yasunaga JI, Shichijo T, Arima Y, Tsujita K, Tanaka A, Salah T, Zhang W, Hussein O, Sonoda M, Watanabe M, Kurita D, Nakashima K, Yamada K, Miyoshi H, Ohshima K and Matsuoka M
  • Journal Title: Blood Cancer Discovery Volume: in press Issue: 5 Pages: 374-393
  • DOI: 10.1158/2643-3230.bcd-22-0139
  • Peer Reviewed
• [Journal Article] HTLV-1 bZIP factor impairs DNA mismatch repair system (2023)
  • Author(s): Sakurada-Aono Maki、Sakamoto Takashi、Kobayashi Masayuki、Takiuchi Yoko、Iwai Fumie、Tada Kohei、Sasanuma Hiroyuki、Hirabayashi Shigeki、Murakawa Yasuhiro、Shirakawa Kotaro、Sakamoto Chihiro、Shindo Keisuke、Yasunaga Jun-ichirou、Matsuoka Masao、Pommier Yves、Takeda Shunichi、Takaori-Kondo Akifumi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 657 Pages: 43-49
  • DOI: 10.1016/j.bbrc.2023.03.049
  • Peer Reviewed
• [Journal Article] Pseudo-progression of adult T-cell leukemia-lymphoma after cord blood transplantation (2022)
  • Author(s): Fuji Shigeo、Yasunaga Jun-ichirou、Watanabe Eri、Matsuoka Masao、Uchimaru Kaoru、Ishikawa Jun
  • Journal Title: Haematologica Volume: 107 Issue: 11 Pages: 2756-2759
  • DOI: 10.3324/haematol.2022.281175
  • Peer Reviewed / Open Access
• [Journal Article] Beneficial impact of first‐line mogamulizumab‐containing chemotherapy in adult T‐cell leukaemia‐lymphoma (2022)
  • Author(s): Shichijo Takafumi、Nosaka Kisato、Tatetsu Hiro、Higuchi Yusuke、Endo Shinya、Inoue Yoshitaka、Toyoda Kosuke、Kikukawa Yoshitaka、Kawakita Toshiro、Yasunaga Jun‐ichirou、Matsuoka Masao
  • Journal Title: British Journal of Haematology Volume: 198 Issue: 6 Pages: 983-987
  • DOI: 10.1111/bjh.18281
  • Peer Reviewed / Open Access
• [Journal Article] Predictive impact of soluble interleukin‐2 receptor and number of extranodal sites for identification of patients at very high risk of CNS relapse in diffuse large B‐cell lymphoma (2022)
  • Author(s): Shichijo Takafumi、Tatetsu Hiro、Nosaka Kisato、Higuchi Yusuke、Kikukawa Yoshitaka、Inoue Yoshitaka、Toyoda Kosuke、Yasunaga Jun‐ichirou、Matsuoka Masao
  • Journal Title: eJHaem Volume: - Issue: 2 Pages: 385-393
  • DOI: 10.1002/jha2.393
  • Peer Reviewed / Open Access
• [Journal Article] Whole-genome landscape of adult T-cell leukemia/lymphoma (2022)
  • Author(s): Kogure Y, Kameda T, Koya J, Yoshimitsu M, Nosaka K, Yasunaga JI, Imaizumi Y, Watanabe M, Saito Y, Okada A, Kakiuchi N, Nannya Y,Kitanaka A, Hidaka M, Nakano N, Utsunomiya A, Sica RA, Acuna-Villaorduna A, Janakiram M, Shah U, Shibata T, Takeuchi K, Ogawa S, Ye BH, Shimoda K, Kataoka K（他20名、26番目）
  • Journal Title: Blood Volume: 139 Issue: 7 Pages: 967-982
  • DOI: 10.1182/blood.2021013568
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] HTLV-1 activates YAP via NF-κB/p65 to promote oncogenesis. (2022)
  • Author(s): Zhao T, Wang Z, Fang J, Cheng W, Zhang Y, Huang J, Xu L, Gou H, Zeng L, Jin Z, Matsuoka M
  • Journal Title: Proc Natl Acad Sci USA Volume: 119 Issue: 9
  • DOI: 10.1073/pnas.2115316119
  • Peer Reviewed
• [Journal Article] Targeting vulnerabilities of adult T-cell leukemia (2022)
  • Author(s): Matsuoka Masao
  • Journal Title: Blood Volume: 139 Issue: 10 Pages: 1435-1435
  • DOI: 10.1182/blood.2021014879
  • Peer Reviewed
• [Journal Article] Functional and Pathogenic Roles of Retroviral Antisense Transcripts (2022)
  • Author(s): Toyoda Kosuke、Matsuoka Masao
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 875211-875211
  • DOI: 10.3389/fimmu.2022.875211
  • Peer Reviewed
• [Journal Article] M-Sec induced by HTLV-1 mediates an efficient viral transmission (2021)
  • Author(s): Hiyoshi M, Takahashi N, Eltalkhawy YM, Noyori O, Lotfi S, Panaampon J, Okada S, Tanaka Y, Ueno T, Fujisawa JI, Sato Y, Suzuki T, Hasegawa H, Tokunaga M, Satou Y, Yasunaga JI, Matsuoka M, Utsunomiya A, Suzu S
  • Journal Title: PLoS Pathog Volume: 17 Issue: 11 Pages: e1010126-e1010126
  • DOI: 10.1371/journal.ppat.1010126
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prevention of acute graft-versus-host disease in adult T-cell leukemia?lymphoma patients who received mogamulizumab before allogeneic hematopoietic cell transplantation (2021)
  • Author(s): Inoue Yoshitaka、Nishimura Nao、Murai Masayuki、Matsumoto Miho、Watanabe Miho、Yamada Asami、Izaki Mikiko、Nosaka Kisato、Matsuoka Masao
  • Journal Title: International Journal of Hematology Volume: 115 Issue: 3 Pages: 435-439
  • DOI: 10.1007/s12185-021-03250-3
  • Peer Reviewed
• [Journal Article] Human retroviral antisense mRNAs are retained in the nuclei of infected cells for viral persistence. (2021)
  • Author(s): Ma G, Yasunaga JI, Shimura K, Takemoto K, Watanabe M, Amano M, Nakata H, Liu B, Zuo X, Matsuoka M.
  • Journal Title: Proc Natl Acad Sci USA. Volume: 118 Issue: 17
  • DOI: 10.1073/pnas.2014783118
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Genome wide association study of HTLV-1 associated myelopathy/tropical spastic paraparesis in the Japanese population (2021)
  • Author(s): Penova Marina et al.
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 118 Issue: 11
  • DOI: 10.1073/pnas.2004199118
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adult T‐cell leukemia‐lymphoma as a viral disease: Subtypes based on viral aspects (2021)
  • Author(s): Nosaka Kisato、Matsuoka Masao
  • Journal Title: Cancer Science Volume: 112 Issue: 5 Pages: 1688-1694
  • DOI: 10.1111/cas.14869
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The noncanonical role of EZH2 in cancer (2021)
  • Author(s): Huang Jinhua、Gou Hongwei、Yao Jia、Yi Kaining、Jin Zhigang、Matsuoka Masao、Zhao Tiejun
  • Journal Title: Cancer Science Volume: 112 Issue: 4 Pages: 1376-1382
  • DOI: 10.1111/cas.14840
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In vivo dynamics and adaptation of HTLV-1-infected clones under different clinical conditions (2021)
  • Author(s): Izaki Mikiko、Yasunaga Jun-ichirou、Nosaka Kisato、Sugata Kenji、Utsunomiya Hayato、Suehiro Youko、Shichijo Takafumi、Yamada Asami、Sugawara Yasuhiko、Hibi Taizo、Inomata Yukihiro、Akari Hirofumi、Melamed Anat、Bangham Charles、Matsuoka Masao
  • Journal Title: PLOS Pathogens Volume: 17 Issue: 2 Pages: e1009271-e1009271
  • DOI: 10.1371/journal.ppat.1009271
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Systematic clustering algorithm for chromatin accessibility data and its application to hematopoietic cells (2020)
  • Author(s): Tanaka Azusa、Ishitsuka Yasuhiro、Ohta Hiroki、Fujimoto Akihiro、Yasunaga Jun-ichirou、Matsuoka Masao
  • Journal Title: PLOS Computational Biology Volume: 16 Issue: 11 Pages: e1008422-e1008422
  • DOI: 10.1371/journal.pcbi.1008422
  • Peer Reviewed / Open Access
• [Journal Article] Frequent horizontal and mother-to-child transmission may contribute to high prevalence of STLV-1 infection in Japanese macaques (2020)
  • Author(s): Murata Megumi、Yasunaga Jun-ichirou、Washizaki Ayaka、Seki Yohei、Kuramitsu Madoka、Tan Wei Keat、Hu Anna、Okuma Kazu、Hamaguchi Isao、Mizukami Takuo、Matsuoka Masao、Akari Hirofumi
  • Journal Title: Retrovirology Volume: 17 Issue: 1 Pages: 1-10
  • DOI: 10.1186/s12977-020-00525-1
  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1 induces T cell malignancy and inflammation by viral antisense factor-mediated modulation of the cytokine signaling (2020)
  • Author(s): Higuchi Yusuke、Yasunaga Jun-ichirou、Mitagami Yu、Tsukamoto Hirotake、Nakashima Kazutaka、Ohshima Koichi、Matsuoka Masao
  • Journal Title: Proceedings of the National Academy of Sciences Volume: 117 Issue: 24 Pages: 13740-13749
  • DOI: 10.1073/pnas.1922884117
  • Peer Reviewed / Open Access
• [Journal Article] IL-2/IL-2 Receptor Pathway Plays a Crucial Role in the Growth and Malignant Transformation of HTLV-1-Infected T Cells to Develop Adult T-Cell Leukemia. (2020)
  • Author(s): Maeda M, Tanabe-Shibuya J, Miyazato P, Masutani H, Yasunaga JI, Usami K, Shimizu A, Matsuoka M.
  • Journal Title: Frontiers in Microbiology Volume: 11 Pages: 356-356
  • DOI: 10.3389/fmicb.2020.00356
  • NAID: 120006936325
  • Peer Reviewed / Open Access
• [Journal Article] HTLV-1 bZIP factor: the key viral gene for pathogenesis. (2020)
  • Author(s): Matsuoka M, Mesnard JM.
  • Journal Title: Retroviology Volume: 17 Issue: 1 Pages: 2-2
  • DOI: 10.1186/s12977-020-0511-0
  • NAID: 120006796414
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Regulation of Latency in the Human T Cell Leukemia Virus, HTLV-1. (2019)
  • Author(s): Bangham CRM, Miura M, Kulkarni A, Matsuoka M.
  • Journal Title: Annu Rev Virol, Volume: 6 Issue: 1 Pages: 365-385
  • DOI: 10.1146/annurev-virology-092818-015501
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pentosan Polysulfate Demonstrates Anti-human T-Cell Leukemia Virus Type 1 ActivitiesIn VitroandIn Vivo (2019)
  • Author(s): Ma Guangyong、Yasunaga Jun-ichirou、Ohshima Koichi、Matsumoto Tadashi、Matsuoka Masao
  • Journal Title: Journal of Virology Volume: 93 Issue: 16
  • DOI: 10.1128/jvi.00413-19
  • Peer Reviewed / Open Access
• [Journal Article] 40 years of the human T-cell leukemia virus: past, present, and future (2019)
  • Author(s): Tagaya Yutaka、Matsuoka Masao、Gallo Robert
  • Journal Title: F1000Research Volume: 8 Pages: 228-228
  • DOI: 10.12688/f1000research.17479.1
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] HTLV-1感染とATL発症機構 (2022)
  • Author(s): 8.松岡雅雄
  • Organizer: 第44回日本造血・免疫細胞療法学会
  • Invited
• [Presentation] HTLV-1 bZIP factorが誘導するTAp73は，MCT1・MCT4双方の発現を介してがん代謝の乳酸排泄を促進する (2022)
  • Author(s): 豊田 康祐、安永 純一朗、田中 梓、栗田 大輔、渡辺 美穂、七條 敬文、三好 寛明、大島 孝一、松岡 雅雄
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] HTLV-1 bZIP factorタンパク質の細胞内局在変動と病原性における役割 (2022)
  • Author(s): 張 文怡、安永 純一朗、七條 敬文、栗田 大輔、松岡 雅雄
  • Organizer: 第81回日本癌学会学術総会
• [Presentation] Evaluation of the risk of HTLV-1-associated diseases by analyzing immune responses and proviral load (2022)
  • Author(s): 山田 麻美、安永 純一朗、砂川 純也、中岡 慎治、岩見 真吾、木暮 泰寛、伊藤 勇太、片岡 圭亮、中川 正法、岩永 正子、内丸 薫、宇都宮 與、高 起良、渡邉 俊樹、野坂 生郷、松岡 雅雄
  • Organizer: 第84回日本血液学会学術集会
• [Presentation] Monocyte/macrophage-like subpopulation in adult T-cell leukemia cells identified by mass cytometry (2022)
  • Author(s): 渡辺 美穂、安永 純一朗、野坂 生郷、松岡 雅雄
  • Organizer: 第84回日本血液学会学術集会
• [Presentation] Impact of mogamulizumab-containing chemotherapy on survival in newly diagnosed aggressive ATL (2022)
  • Author(s): 七條 敬文、野坂 生郷、立津 央、樋口 悠介、遠藤 慎也、井上 明威、豊田 康祐、菊川 佳敬、河北 敏郎、安永 純一朗、松岡 雅雄
  • Organizer: 第84回日本血液学会学術集会
• [Presentation] HTLV-1プロウイルス内部に存在するオープンクロマチン領域による新たなウイルス複製制御機構 (2022)
  • Author(s): 園田 未祐、安永 純一朗、野坂 生郷、田中 梓、松岡 雅雄
  • Organizer: 第69回日本ウイルス学会学術集会
• [Presentation] The Role of CD38 in Multiple Myeloma Cell Biology (2021)
  • Author(s): Kawano Y, Kushima S, Hata H, Matsuoka M.
  • Organizer: 63th ASH Annual Meeting & Exposition:
  • Int'l Joint Research
• [Presentation] HBZ Protein and RNA Dysregulate PRC2-TP73 Epigenetic Circuits to Contribute to the Warburg Effect (2021)
  • Author(s): 豊田康祐, 安永純一朗, 有馬勇一郎, 田中梓, 辻田賢一, 渡辺美穂, 園田未祐, 七條敬文, 松岡雅雄
  • Organizer: 第12回JSH国際シンポジウム
• [Presentation] Dynamics of HTLV-1 infected cell clones and the influence of host immune response (2021)
  • Author(s): 井崎幹子, 安永純一朗, 野坂生郷, 宇都宮勇人, 末廣陽子, 七條敬文, 山田麻美, 松岡雅雄
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] HBZタンパク質とRNAはEZH2の抑制を介してTP73の発現を誘導しWarburg効果に貢献する (2021)
  • Author(s): 豊田康祐, 安永純一朗, 有馬勇一郎, 田中梓, 辻田賢一, 渡辺美穂, 園田未祐, 七條敬文, 松岡雅雄
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] 宿主抗レトロウイルス因子に対する不適応がATL発がんに寄与する (2021)
  • Author(s): 七條敬文, 安永純一朗, 高起良, 野坂生郷, 松岡 雅雄
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] In vivo loss of PD-1 accelerates neoplastic and inflammatory diseases induced by HTLV-1 bZIP factor (2021)
  • Author(s): 園田未祐, 安永純一朗, 樋口悠介, 井上明威, 野坂生郷, 大島孝一, 松岡雅雄
  • Organizer: 第83回日本血液学会学術集会
• [Presentation] Maladaptation of HTLV-1 to host and its association with its pathogenesis (2021)
  • Author(s): 七條敬文, 安永純一朗, 渡辺美穂, 豊田康祐, 野坂生郷, 松岡 雅雄
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Evaluation of risk of HTLV-1-associated diseases by analyzing the host immune responses (2021)
  • Author(s): 山田麻美, 安永純一朗, 野坂生郷, 松岡雅雄
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] Association between heterogeneity in HTLV-1-infected cells and disease status analyzed at single cell level (2021)
  • Author(s): 渡辺美穂, 安永純一朗, 野坂生郷, 松岡雅雄
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] HTLV-1の病原性発現機構：これまでの軌跡と将来への展望 (2021)
  • Author(s): 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] 一過性HTLV1-Tax発現はT細胞早期活性化機構を模倣する (2021)
  • Author(s): 栗田大輔, 安永純一朗, 田中梓, 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] HTLV-1感染細胞クローンの生体内動態と宿主免疫の役割 (2021)
  • Author(s): 井崎幹子, 安永純一朗, 野坂生郷, 宇都宮勇人, 末廣陽子, 菅田謙治, 七條敬文, 山田麻美, Anat Melamed,Charles Bangham, 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] HBZタンパク質とRNAは異なる作用機序でTP73を誘導しATL細胞のWarburg効果に寄与する (2021)
  • Author(s): 豊田康祐, 安永純一朗, 有馬勇一郎, 田中梓, 辻田賢一, 渡辺美穂, 園田未祐, 七條敬文, 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] HTLV-1のAPOBEC3Gに対する進化不適応と病原性との関連 (2021)
  • Author(s): 七條敬文, 安永純一朗, 大西 知帆, 渡辺美穂, 豊田康祐, 高起良, 明里宏文, 野坂生郷, 松岡 雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] 宿主免疫応答とプロウイルス量によるHTLV-1関連疾患発症リスク群の同定 (2021)
  • Author(s): 山田麻美, 安永純一朗, 野坂生郷, 中川正法, 岩見真吾, 砂川純也, 中岡慎治, 木暮泰寛, 片岡圭亮, 岩永正子, 内丸薫, 宇都宮與, 高起良, 渡邊俊樹, 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] 単一細胞マスサイトメトリーにより明らかとなったATL細胞の多様性 (2021)
  • Author(s): 渡辺美穂, 安永純一朗, 野坂生郷, 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] Single chain antibodyを用いたHBZタンパク質の機能解析 (2021)
  • Author(s): 上野満徳, 安永純一朗, 福田夏希, 佐藤卓史, 森岡弘志, 野坂生郷, 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] PD-1 の抑制は HTLV-1 bZIP factor の病原性を促進する (2021)
  • Author(s): 園田未祐, 安永純一朗, 七條敬文, 豊田康祐, 樋口悠介, 井上明威, 野坂生郷, 村田めぐみ, 明里宏文, 中嶋一貴, 大島孝一, 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] クローナリティの証明が困難であり確定診断に苦慮したATL症例 (2021)
  • Author(s): 中村貴久, 安永純一朗, 横尾貴保, 高島光徳, 川上史, 樋口悠介, 立津央, 野坂生郷, 加留部謙之輔, 三上芳喜, 松岡雅雄
  • Organizer: 第7回日本HTLV-1学会学術集会
• [Presentation] HTLV-1 bZIP factor（HBZ）タンパク質とmRNAは異なる作用機序でTP73を誘導し，Warburg効果に寄与する (2021)
  • Author(s): 豊田康祐, 安永純一朗, 松岡雅雄
  • Organizer: 第68回日本ウイルス学会学術集会
• [Presentation] Critical roles of HBZ in HTLV-1 pathogenesis. (2019)
  • Author(s): Masao Matsuoka
  • Organizer: 19th International Conference on Human Retrovirology HTLV and Related Viruses
  • Int'l Joint Research / Invited
• [Presentation] How Human T-cell Leukemia Virus Type 1 Causes Diseases. (2019)
  • Author(s): Masao Matsuoka
  • Organizer: Ohio State University Distinguished Research Award in Retrovirology
  • Invited
• [Presentation] ヒトT細胞白血病ウイルス１型 up-to-date (2019)
  • Author(s): 松岡 雅雄
  • Organizer: 第67回日本輸血・細胞治療学会
  • Invited
• [Presentation] HTLV-1 Dysregulates IL-6 and IL-10-JAK/STAT Signaling and Induces Leukemia/Lymphoma CD4+T-Cell with Regulatory T-Cell-like Signatures. (2019)
  • Author(s): Yusuke Higuchi, Jun-ichirou Yasunaga, Yu Mitagami, Koichi Ohshima, Masao Matsuoka.
  • Organizer: The 61st American Society of Hematology Annual Meeting and Exposition
• [Presentation] レトロウイルスがコードするアンチセンスRNAの核局在はウイルスの持続感染に関与する (2019)
  • Author(s): 安永純一朗、松岡雅雄
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] Epigenetic alterations by transient expression of HTLV-1 Tax in ATL cell (2019)
  • Author(s): 栗田大輔、安永純一朗、田中梓、松岡雅雄
  • Organizer: 第81回日本血液学会
• [Presentation] IL-10-JAK-STAT signaling pathway is involved in inflammation and oncogenesis induced by HTLV-1 bZIP factor (2019)
  • Author(s): 樋口悠介、安永純一朗、三田上悠、大島孝一、松岡雅雄
  • Organizer: 第81回日本血液学会