Clarification of mechanism of gastric tumorigenesis based on cancer stratification and development of novel therapeutic strategy

• Project/Area Number: 19H03726
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Chiba University
• Principal Investigator: Kaneda Atsushi 千葉大学, 大学院医学研究院, 教授 (10313024)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000); Fiscal Year 2019: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
• Keywords: 胃癌 / エピゲノム / Epstein-Barrウイルス / がん

Outline of Research at the Start

本申請ではエピゲノム特性を用いた胃癌症例層別化に基づいて、胃癌サブタイプの発癌分子基盤を解明することを目的とした研究を行う。2019年度はInfiniumビーズアレイを用いて臨床胃癌標本におけるDNAメチル化の網羅的解析を行い胃癌症例をサブタイプに層別化する。2020年度以降は重要なドライバー変異候補及び活性化シグナルを、shRNAライブラリーを用いた網羅的ノックダウン解析により同定し、また胃上皮細胞へのin vitroエピゲノム異常誘導モデルを用いて胃発癌に重要な役割を持つエピゲノム変異を同定する。胃癌サブタイプの発癌分子機構を解明し、その分子特性に基づいた薬剤候補を同定する。

Outline of Final Research Achievements

In this study, clinical gastric cancer specimens and in vitro models were used to stratify gastric cancer cases based on epigenome characteristics. In particular, for gastric cancer subtypes exhibiting hypermethylation such as EBV gastric cancer and MSI gastric cancer, we elucidated the molecular mechanism of carcinogenesis, identified epigenomic changes important for carcinogenesis, and identified the molecular mechanism that induces the epigenome changes. By applying the molecular properties of the gastric cancer subtypes, we identified promising seed compounds with effective anticancer activity and proceeded with the synthesis of new compounds that could target regions with epigenomic aberrations.

Academic Significance and Societal Importance of the Research Achievements

胃癌は本邦で毎年10万人以上が罹患し約5万人が命を落とす重要疾患であり、その本態としての発癌分子基盤を解明することは予後を改善するための喫緊の課題である。本研究では、臨床胃癌標本および細胞培養実験により、特にEBV胃癌やMSI胃癌と呼ばれるDNA高メチル化を呈する胃癌サブタイプに対して、エピゲノム異常による全く新たな胃発癌分子機構を同定し、またそのエピゲノム異常を誘導する分子機序を同定した。さらに同定した分子特性を応用し、有効な抗がん作用を有する化合物を同定するなど、新たな薬剤治療戦略の基盤を築いた。

Research Products

• [Int'l Joint Research] Duke-NUS Medical School/Genome Institute of Singapore/Cancer Science Institute of Singapore(シンガポール)
• [Int'l Joint Research] Duke-NUS/Genome Institute of Singapore/Cancer Science Institute of Singapore(シンガポール)
• [Int'l Joint Research] Yonsei Cancer Center,(韓国)
• [Int'l Joint Research] Duke-NUS Medical School/Cancer Science Institute of Singapore/Genome Institute of Singapore(シンガポール)
• [Journal Article] A Point Mutation R122C in RUNX3 Promotes the Expansion of Isthmus Stem Cells and Inhibits Their Differentiation in the Stomach (2022)
  • Author(s): 4.Douchi D, Yamamura A, Matsuo J, Lee J-W, Nuttonmanit N, Melissa Lim YH, Suda K, Shimura M, Chen S, Pang S, Kohu K, Kaneko M, Kiyonari H, Kaneda A, Yoshida H, Taniuchi I, Osato M, Yang H, Unno M, Bok-Yan So J, Yeoh KG, Huey Chuang LS, Bae S-C, Ito Y
  • Journal Title: Cellular and Molecular Gastroenterology and Hepatology Volume: 13 Issue: 5 Pages: 1317-1345
  • DOI: 10.1016/j.jcmgh.2022.01.010
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] ARID1A loss-of-function induces CpG island methylator phenotype (2022)
  • Author(s): Yamada Harumi、Takeshima Hideyuki、Fujiki Ryoji、Yamashita Satoshi、Sekine Shigeki、Ando Takayuki、Hattori Naoko、Okabe Atsushi、Yoshikawa Takaki、Obama Kazutaka、Katai Hitoshi、Kaneda Atsushi、Ushijima Toshikazu
  • Journal Title: Cancer Letters Volume: 532 Pages: 215587-215587
  • DOI: 10.1016/j.canlet.2022.215587
  • Peer Reviewed / Open Access
• [Journal Article] Transcriptional dysregulation by aberrant enhancer activation and rewiring in cancer (2021)
  • Author(s): Okabe Atsushi、Kaneda Atsushi
  • Journal Title: Cancer Science Volume: 112 Issue: 6 Pages: 2081-2088
  • DOI: 10.1111/cas.14884
  • Peer Reviewed / Open Access
• [Journal Article] Activation of EHF via STAT3 phosphorylation by LMP2A in Epstein‐Barr virus‐positive gastric cancer (2021)
  • Author(s): Li Wenzhe、Okabe Atsushi、Usui Genki、Fukuyo Masaki、Matsusaka Keisuke、Rahmutulla Bahityar、Mano Yasunobu、Hoshii Takayuki、Funata Sayaka、Hiura Nobuhiro、Fukayama Masashi、Tan Patrick、Ushiku Tetsuo、Kaneda Atsushi
  • Journal Title: Cancer Science Volume: 112 Issue: 8 Pages: 3349-3362
  • DOI: 10.1111/cas.14978
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Virus?host interactions in carcinogenesis of Epstein-Barr virus-associated gastric carcinoma: Potential roles of lost ARID1A expression in its early stage (2021)
  • Author(s): Abe Hiroyuki、Kunita Akiko、Otake Yuya、Kanda Teru、Kaneda Atsushi、Ushiku Tetsuo、Fukayama Masashi
  • Journal Title: PLOS ONE Volume: 16 Issue: 9 Pages: e0256440-e0256440
  • DOI: 10.1371/journal.pone.0256440
  • Peer Reviewed / Open Access
• [Journal Article] Genetic alterations in squamous cell lung cancer associated with idiopathic pulmonary fibrosis (2021)
  • Author(s): Hata Atsushi、Nakajima Takahiro、Matsusaka Keisuke、Fukuyo Masaki、Nakayama Manabu、Morimoto Junichi、Ito Yuki、Yamamoto Takayoshi、Sakairi Yuichi、Rahmutulla Bahityar、Ota Satoshi、Wada Hironobu、Suzuki Hidemi、Iwata Takekazu、Matsubara Hisahiro、Ohara Osamu、Yoshino Ichiro、Kaneda Atsushi
  • Journal Title: International Journal of Cancer Volume: - Issue: 12 Pages: 3008-3018
  • DOI: 10.1002/ijc.33499
  • Peer Reviewed
• [Journal Article] Identification of AR-V7 downstream genes commonly targeted by AR/AR-V7 and specifically targeted by AR-V7 in castration resistant prostate cancer (2021)
  • Author(s): Sugiura Masahiro、Sato Hiroaki、Okabe Atsushi、Fukuyo Masaki、Mano Yasunobu、Shinohara Ken-ichi、Rahmutulla Bahityar、Higuchi Kosuke、Maimaiti Maihulan、Kanesaka Manato、Imamura Yusuke、Furihata Tomomi、Sakamoto Shinichi、Komiya Akira、Anzai Naohiko、Kanai Yoshikatsu、Luo Jun、Ichikawa Tomohiko、Kaneda Atsushi
  • Journal Title: Translational Oncology Volume: 14 Issue: 1 Pages: 100915-100915
  • DOI: 10.1016/j.tranon.2020.100915
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Epigenetic modifications in prostate cancer (2020)
  • Author(s): Sugiura Masahiro、Sato Hiroaki、Kanesaka Manato、Imamura Yusuke、Sakamoto Shinichi、Ichikawa Tomohiko、Kaneda Atsushi
  • Journal Title: International Journal of Urology Volume: 28 Issue: 2 Pages: 140-149
  • DOI: 10.1111/iju.14406
  • Peer Reviewed
• [Journal Article] Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma (2020)
  • Author(s): Okabe Atsushi, Huang Kie Kyon, Matsusaka Keisuke, Fukuyo Masaki, Xing Manjie, Ong Xuewen, Hoshii Takayuki, Usui Genki, Seki Motoaki, Mano Yasunobu, Rahmutulla Bahityar, Kanda Teru, Suzuki Takayoshi, Rha Sun Young, Ushiku Tetsuo, Fukayama Masashi, Tan Patrick, Kaneda Atsushi
  • Journal Title: Nature Genetics Volume: 52 Issue: 9 Pages: 919-930
  • DOI: 10.1038/s41588-020-0665-7
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Differential gene analysis during the development of obliterative bronchiolitis in a murine orthotopic lung transplantation model: A comprehensive transcriptome-based analysis (2020)
  • Author(s): Hata A、Suzuki H、Nakajima T、Fujiwara T、Shiina Y、Kaiho T、Toyoda T、Inage T、Ito T、Sakairi Y、Tamura H、Wada H、Yamada Y、Chiyo M、Matsusaka K、Fukuyo M、Shinohara K、Itoga S、Motohashi S、Matsushita K、Kaneda A、Yoshino I
  • Journal Title: PLOS ONE Volume: 15 Issue: 5 Pages: 0232884-0232884
  • DOI: 10.1371/journal.pone.0232884
  • Peer Reviewed / Open Access
• [Journal Article] High expression of CXCL14 is a biomarker of lung adenocarcinoma with micropapillary pattern (2020)
  • Author(s): Sata Yuki, Nakajima Takahiro, Fukuyo Masaki, Matsusaka Keisuke, Hata Atsushi, Morimoto Junichi, Rahmutulla Bahityar, Ito Yuki, Suzuki Hidemi, Yoshino Ichiro, Kaneda Atsushi
  • Journal Title: Cancer Science Volume: 111 Issue: 7 Pages: 2588-2597
  • DOI: 10.1111/cas.14456
  • Peer Reviewed / Open Access
• [Journal Article] Higher methylation subtype of malignant melanoma and its correlation with thicker progression and worse prognosis (2020)
  • Author(s): Yamamoto Yosuke、Matsusaka Keisuke、Fukuyo Masaki、Rahmutulla Bahityar、Matsue Hiroyuki、Kaneda Atsushi
  • Journal Title: Cancer Medicine Volume: 9 Issue: 19 Pages: 7194-7204
  • DOI: 10.1002/cam4.3127
  • Peer Reviewed / Open Access
• [Journal Article] Epstein‐Barr virus positive gastric cancer involves enhancer activation through ATF3 (2020)
  • Author(s): Asakawa Yuta、Okabe Atsushi、Fukuyo Masaki、Li Wenzhe、Ikeda Eriko、Mano Yasunobu、Funata Sayaka、Namba Hiroe、Fujii Takahiro、Kita Kazuko、Matsusaka Keisuke、Kaneda Atsushi
  • Journal Title: Cancer Science Volume: 00 Issue: 5 Pages: 1-11
  • DOI: 10.1111/cas.14370
  • Peer Reviewed / Open Access
• [Journal Article] Stratification of HPV-associated and HPV-negative oropharyngeal squamous cell carcinomas based on DNA methylation epigenotypes. (2020)
  • Author(s): Nakagawa T, Matsusaka K, Misawa K, Ota S, Fukuyo M, Rahmutulla B, Kunii N, Sakurai D, Hanazawa T, Matsubara H, Okamoto Y, Kaneda A
  • Journal Title: Int J Cancer. Volume: 146 Issue: 9 Pages: 2460-2474
  • DOI: 10.1002/ijc.32890
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Establishment of epigenetic markers to predict irradiation efficacy against oropharyngeal cancer. (2020)
  • Author(s): Kurokawa T, Nakagawa T, Matsusaka K, Fukuyo M, Mima M, Misawa K, Rahmutulla B, Ikeda JI, Hanazawa T, Okamoto Y, Kaneda A
  • Journal Title: Cancer Sci. Volume: 111 Issue: 4 Pages: 1407-1416
  • DOI: 10.1111/cas.14338
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A low DNA methylation epigenotype in lung squamous cell carcinoma and its association with idiopathic pulmonary fibrosis and poorer prognosis. (2020)
  • Author(s): Hata A, Nakajima T, Matsusaka K, Fukuyo M, Morimoto J, Yamamoto T, Sakairi Y, Rahmutulla B, Ota S, Wada H, Suzuki H, Matsubara H, Yoshino I, Kaneda A.
  • Journal Title: Int J Cancer Volume: 146 Issue: 2 Pages: 388-399
  • DOI: 10.1002/ijc.32532
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Thirty years of Epstein-Barr virus-associated gastric carcinoma. (2020)
  • Author(s): Fukayama M, Abe H, Kunita A, Shinozaki-Ushiku A, Matsusaka K, Ushiku T, Kaneda A.
  • Journal Title: Virchows Arch Volume: 476 Issue: 3 Pages: 353-365
  • DOI: 10.1007/s00428-019-02724-4
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Post-transcriptional regulation of BRG1 by FIRΔexon2 in gastric cancer (2020)
  • Author(s): Ailiken Guzhanuer、Kitamura Kouichi、Hoshino Tyuji、Satoh Mamoru、Tanaka Nobuko、Minamoto Toshinari、Rahmutulla Bahityar、Kobayashi Sohei、Kano Masayuki、Tanaka Tomoaki、Kaneda Atsushi、Nomura Fumio、Matsubara Hisahiro、Matsushita Kazuyuki
  • Journal Title: Oncogenesis Volume: 9 Issue: 2 Pages: 26-26
  • DOI: 10.1038/s41389-020-0205-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Integrated Paired-end Enhancer Profiling and Whole-Genome Sequencing Reveals Recurrent CCNE1 and IGF2 Enhancer Hijacking in Primary Gastric Adenocarcinoma. (2019)
  • Author(s): Ooi WF, Nargund AM, Lim KJ, Zhang S, Xing M, Mandoli A, Lim JQ, Ho SWT, Guo Y, Yao X, Lin JS, Nandi T, Xu C, Ong X, Lee M, Tan ALK, Lam YN, Teo JX, Kaneda A, White KP, Lim WK, Rozen SG, Teh BT, Li S, Skanderup AJ, Tan P.
  • Journal Title: Gut Volume: epub Issue: 6 Pages: 1039-1052
  • DOI: 10.1136/gutjnl-2018-317612
  • Peer Reviewed / Int'l Joint Research
• [Presentation] ウイルス感染に襲撃されるホスト細胞のエピゲノム (2021)
  • Author(s): 金田篤志
  • Organizer: 第1回日本耳鼻咽喉科免疫アレルギー感染症学会
  • Invited
• [Presentation] Epigenomic and transcriptional rewiring by oncovirus infection (2021)
  • Author(s): Atsushi Kaneda
  • Organizer: 80th Annual Meeting of Japan Cancer Association
  • Int'l Joint Research / Invited
• [Presentation] Analyses of gastric cancer risk in a cohort of 4,257 asymptomatic population and accumulated DNA methylation (2021)
  • Author(s): Genki Usui, Keisuke matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Eiji Sakai, Tetsuo Ushiku, Atsushi Kaneda
  • Organizer: 80th Annual Meeting of Japan Cancer Association
  • Int'l Joint Research
• [Presentation] Tissue-wide analysis of chromatin structural aberrations induced by oncovirus infection (2021)
  • Author(s): Atsushi Okabe, Takahiro Fjii, Harue Mizokami, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Patrick Tan, Atsushi Kaneda
  • Organizer: 80th Annual Meeting of Japan Cancer Association
  • Int'l Joint Research
• [Presentation] Heterochromatin disruption and chromatin structural rewiring induced by Epstein-Barr virus infection in gastric adenocarcinoma (2021)
  • Author(s): Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Takayuki Hoshii, Teru Kanda, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda
  • Organizer: 19th International Symposium on Epstein-Barr Virus and associated diseases
  • Int'l Joint Research
• [Presentation] Activation of EHF and Wnt signaling via STAT3 phosphorylation by LMP2A in Epstein-Barr virus-positive gastric cancer (2021)
  • Author(s): Atsushi Kaneda, Wenzhe Li, Atsushi Okabe, Genki Usui, Masaki Fukuyo, Keisuke Matsusaka, Bahityar Rahmutulla Nawai, Yasunobu Mano, Sayaka Funata, Takayuki Hoshii, Tetsuo Ushiku, Patrick Tan, Masashi Fukayama
  • Organizer: 第32回日本消化器癌発生学会
• [Presentation] 無症候検診コホートを対象とした胃発癌リスク因子の探索と胃粘膜に蓄積したDNAメチル化の解析 (2021)
  • Author(s): 臼井源紀，松坂恵介，福世真樹, ラヒムトラ バハテヤリ, 酒井英嗣, 郡司俊秋, 松橋信行, 森川鉄平, 牛久哲男, 金田篤志
  • Organizer: 第32回日本消化器癌発生学会
• [Presentation] Viral genome rewires heterochromatin and enhancers of host genome to induce tumorigenesis. (2020)
  • Author(s): Kaneda A
  • Organizer: The 79th Annual Meeting of the Japan Cancer Association.
  • Int'l Joint Research / Invited
• [Presentation] Epstein-Barr ウイルスはヘテロクロマチンを破綻させて癌原遺伝子を活性化するエピ変異原である (2020)
  • Author(s): 金田篤志
  • Organizer: 日本環境変異原学会第49回大会
  • Invited
• [Presentation] ヘテロクロマチン領域の異常活性化による胃癌発癌 (2020)
  • Author(s): 金田篤志、岡部篤史、福世真樹、松坂恵介、深山正久
  • Organizer: 第16回消化管学会
  • Invited
• [Presentation] ウイルス感染がもたらす固有のエピゲノム異常と消化管腫瘍サブタイプの同定 (2020)
  • Author(s): 金田篤志
  • Organizer: 日本消化器癌発生学会第６回理事長直轄プロジェクト
  • Invited
• [Presentation] Driver epi-mutations of gastric cancer induced by Epstein-Barr virus infection (2020)
  • Author(s): Atsushi Kaneda
  • Organizer: 22nd International Conference on Emerging Infectious Diseases in the Pacific Rim.
  • Int'l Joint Research / Invited
• [Presentation] Dynamic epigenomic activation and inactivation by pathogen in gastric carcinogenesis. (2019)
  • Author(s): Atsushi Kaneda.
  • Organizer: USC Seminar
  • Int'l Joint Research / Invited
• [Presentation] Epigenomic activation and inactivation in gastric epithelial cells induced by pathogen (2019)
  • Author(s): Atsushi Kaneda
  • Organizer: CSCB Seminar
  • Int'l Joint Research / Invited
• [Presentation] Epstein-Barrウイルス感染がもたらすヘテロクロマチンリプログラミングによる癌遺伝子の活性化 (2019)
  • Author(s): 岡部篤史、松坂恵介、福世真樹、南波宏枝、舩田さやか、金田篤志．
  • Organizer: 第13回日本エピジェネティクス研究会年会
• [Presentation] H3K4メチル基転移酵素の触媒作用非依存的な転写制御． (2019)
  • Author(s): 星居孝之、金田篤志、Scott Armstrong
  • Organizer: 第13回日本エピジェネティクス研究会年会
• [Presentation] JAG1活性化細胞と正常細胞の共培養モデルを用いたRas/Raf誘導性早期細胞老化機構の解析 (2019)
  • Author(s): 眞野恭伸、福世真樹、岡部篤史、松坂恵介、山本遼太、油谷浩幸、金田篤志．
  • Organizer: 第13回日本エピジェネティクス研究会年会
• [Presentation] Oncogene activation through enhancer activation after Epstein-Barr virus infection in gastric epithelial cells. (2019)
  • Author(s): Li Wenzhe、岡部篤史、松坂恵介、福世真樹、Rahmutulla B、金田篤志．
  • Organizer: 第13回日本エピジェネティクス研究会年会
• [Presentation] ゲノム修飾情報の異常による発癌と癌層別化. (2019)
  • Author(s): 金田篤志
  • Organizer: 第32回モロシヌス研究会
  • Invited
• [Presentation] Epstein-Barrウイルスが誘導するDNA異常メチル化の分子機序の同定. (2019)
  • Author(s): 松坂恵介、岡部篤史、南波宏枝、船田さやか、深山正久、金田篤志
  • Organizer: 第16回EBウイルス研究会
• [Presentation] EBウイルス陽性腫瘍において共通するエピゲノム活性化変化 (2019)
  • Author(s): 藤井貴大、岡部篤史、松坂恵介、福世真樹、バハテヤリ・ラヒムトラ、金田篤志．
  • Organizer: 第10回東日本研究医養成コンソーシアム
• [Presentation] Induction of epigenomic aberrations in epithelial cells by infection of pathogen. (2019)
  • Author(s): Atsushi Kaneda.
  • Organizer: 1st Chiba University - University of Toronto Workshop.
  • Int'l Joint Research / Invited
• [Presentation] Chromatin reprogramming via interaction between host genome and EBV during gastric tumorigenesis. (2019)
  • Author(s): Atsushi Kaneda.
  • Organizer: 第78回日本癌学会学術総会.
  • Int'l Joint Research / Invited
• [Presentation] EBV infection induces domain structural changes which lead to oncogenic activation. (2019)
  • Author(s): Okabe A, Matsusaka K, Fukuyo M, Rahmutulla B, Tan P, Kaneda A.
  • Organizer: 第78回日本癌学会学術総会.
  • Int'l Joint Research
• [Presentation] Alteration of histone modification and chromatin structure in HPV related head and neck squamous cell carcinoma. (2019)
  • Author(s): Mima M, Okabe A, Nakagawa T, Kurokawa T, Fukuyo M, Rahmutulla B, Matsusaka K, Misawa K, Mineta H, Kaneda A.
  • Organizer: 第78回日本癌学会学術総会.
• [Presentation] 背景胃粘膜におけるDNA異常メチル化の蓄積と胃癌発症リスク因子の探索． (2019)
  • Author(s): 臼井源紀、松坂恵介、牛久哲男、森川鉄平、金田篤志．
  • Organizer: 第5回がんゲノム・エピゲノム研究会.
• [Presentation] ヘテロクロマチン領域の異常活性化による胃癌発癌． (2019)
  • Author(s): 金田篤志、岡部篤史、松坂恵介、深山正久
  • Organizer: 第30回日本消化器癌発生学会総会
• [Presentation] 消化管腫瘍におけるエピゲノム異常とウイルス感染によるその誘導の解明. (2019)
  • Author(s): 金田篤志
  • Organizer: 第30回日本消化器癌発生学会総会
  • Invited
• [Presentation] Epstein-Barrウイルス感染が誘導する胃上皮細胞におけるメチル化誘導因子の同定． (2019)
  • Author(s): 小形武広、舩田さやか、松坂恵介、岡部篤史、金田篤志．
  • Organizer: 第30回日本消化器癌発生学会総会
• [Presentation] TP53野生型高メチル化胃癌におけるゲノム・エピゲノム異常． (2019)
  • Author(s): 松坂恵介、眞野恭伸、福世真樹、浦辺雅之、Bahityar Rahmutulla、瀬戸泰之、深山正久、金田篤志．
  • Organizer: 第30回日本消化器癌発生学会総会
• [Presentation] HPV関連頭頸部扁平上皮癌のヒストン修飾・クロマチン構造解析 (2019)
  • Author(s): 美馬勝人, 岡部篤史, 中川拓也, 黒川友哉, 近藤悟, 福世真樹, Bahityar Rahmutulla, 松坂恵介, 三澤清, 峯田周幸, 金田篤志
  • Organizer: 第30回日本消化器癌発生学会総会
• [Presentation] 背景胃粘膜におけるDNA異常メチル化の蓄積と胃癌発症リスク因子の探索. (2019)
  • Author(s): 臼井源紀，松坂恵介，福世真樹, 篠崎智大, 郡司俊秋, 松橋信行, 森川鉄平，牛久哲男, 金田篤志．
  • Organizer: 第30回日本消化器癌発生学会総会
• [Presentation] Infection of pathogens induces extensive epigenomic alterations including aberrant three-dimension chromatin interaction in gastric tumorigenesis. (2019)
  • Author(s): Atsushi Kaneda.
  • Organizer: 第42回日本分子生物学会
  • Int'l Joint Research / Invited
• [Presentation] Epstein-Barrウイルス感染がもたらすヘテロクロマチンリプログラミングによる癌遺伝子の活性化 (2019)
  • Author(s): Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla1, Patrick Tan, Atsushi Kaneda.
  • Organizer: 第42回日本分子生物学会
• [Presentation] 共培養システムを用いたJAG1-Notchシグナルの活性化が及ぼす老化誘導機構の解析 (2019)
  • Author(s): 眞野恭伸、福世真樹、岡部篤史、松坂恵介、山中遼太、油谷浩幸、金田篤志.
  • Organizer: 第42回日本分子生物学会
• [Presentation] Epstein-Barrウイルス感染が誘導するメチル化誘導因子の同定 (2019)
  • Author(s): 小形武広、舩田さやか、松坂恵介、岡部篤史、金田篤志
  • Organizer: 第42回日本分子生物学会
• [Presentation] 癌ウイルス感染がもたらすヘテロクロマチン領域の破綻と異常活性化による胃癌発癌. (2019)
  • Author(s): 金田篤志
  • Organizer: 第37回染色体ワークショップ
  • Invited
• [Presentation] Oncogene activation through enhancer activation after Epstein-Barr virus infection in gastric cancer. (2019)
  • Author(s): Wenzhe Li, Atsushi Okabe, Keisuke Matsusaka, Rahmutulla Bahityar, Masaki Fukuyo, Atsushi Kaneda.
  • Organizer: 第42回日本分子生物学会
• [Book] ウイルスがホスト細胞のヘテロクロマチンを活性化し発がんさせる (2021)
  • Author(s): 岡部篤史、金田篤志
  • Total Pages: 4
  • Publisher: 羊土社
• [Book] エピジェネティクスの疾患 (2020)
  • Author(s): 金田篤志
  • Total Pages: 2
  • Publisher: 朝倉書店
• [Book] がんのエピゲノム異常 (2020)
  • Author(s): 佐藤広明、金田篤志
  • Total Pages: 6
  • Publisher: 医歯薬出版
• [Book] 遺伝子医学 (2019)
  • Author(s): 金田篤志、松坂恵介、岡部篤史、中川拓也、畑敦、杉浦正洋
  • Total Pages: 7
  • Publisher: メディカル ドゥ
• [Book] 医学のあゆみ (2019)
  • Author(s): 佐藤広明、金田篤志
  • Total Pages: 6
  • Publisher: 医歯薬出版
• [Remarks] 分子腫瘍学 - 千葉大学大学院医学研究院・医学部
  • URL: https://www.m.chiba-u.ac.jp/class/moloncol/
• [Remarks] 分子腫瘍学 - 千葉大学大学院医学研究院・医学部
  • URL: https://www.m.chiba-u.ac.jp/class/moloncol/news.html
• [Remarks] 分子腫瘍学HP - 千葉大学大学院医学研究院
  • URL: https://www.m.chiba-u.ac.jp/class/moloncol/