Investigation of molecular pathways linking aberrant glucose metabolism and mitotic process in colorectal cancer and its application to development of cancer therapy
Project/Area Number |
19H03727
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Review Section |
Basic Section 55020:Digestive surgery-related
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Research Institution | Kanazawa University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
宮下 知治 金沢医科大学, 医学部, 准教授 (30397210)
WONG W・R 金沢大学, ナノ生命科学研究所, 教授 (30464035)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Project Status |
Completed (Fiscal Year 2021)
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Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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Keywords | 大腸がん / 糖代謝改変 / 細胞核分裂 |
Outline of Research at the Start |
細胞の異常な糖エネルギー代謝(代謝改変)と際限のない細胞分裂の繰りかえしは、がん増殖の最たる特性(悪性形質)である。これまでは、この代謝改変と細胞分裂は別々の悪性形質として研究されてきた。本研究は大腸がんを対象にして、両者の悪性形質に共通して作用する細胞のしくみ(分子経路)を究明する。そして、得られる結果をもとに、効果的ながん治療法の開発を目的とする。
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Outline of Final Research Achievements |
Aberrant glycolysis (metabolic reprograming) and unlimited cellular mitosis are the major malignant phenotypes that promote cancer proliferation. We previously identified glycogen synthase kinase (GSK)3β as a distinct tumor-promoting enzyme. This study found the biological mechanisms by which GSK3β participates in both malignant phenotypes in colorectal cancer (CRC). These results clarified that GSK3β facilitates CRC progression via interconnecting the metabolic reprograming and cellular mitosis.
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Academic Significance and Societal Importance of the Research Achievements |
これまでは、がんの代謝改変と細胞分裂は別々の悪性形質として研究されてきた。本研究は、大腸がんでGSK3βが両者の悪性形質を結びつけて増殖を促進することを解明した。このようなGSK3βを指標とする大腸がん増殖のしくみは、本酵素を標的とするがん治療法開発の基盤を強化する。
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Phosphorylation of hTERT at threonine 249 is a novel tumor biomarker of aggressive cancer with poor prognosis in multiple organs2022
Author(s)
Matsuda Y, Yamashita T, Ye J, Yasukawa M, Yamakawa K, Mukai Y, Machitani M, Daigo Y, Miyagi Y, Yokose T, Oshima T, Ito H, Morinaga S, Kishida T, Minamoto T, Yamada S, Takei J, Kaneko MK, Kojima M, Kaneko S, Masaki T, Hirata M, Haba R, Kontani K, Kanaji N, Miyatake N, Okano K, Kato Y, Masutomi K
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Journal Title
J Pathol
Volume: 257
Issue: 2
Pages: 172-185
DOI
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Peer Reviewed / Open Access
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[Journal Article] Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum2020
Author(s)
Nakanishi, H. Sawada, T. Kaizaki, Y. Ota, R. Suzuki, H. Yamamoto, E. Aoki, H. Eizuka, M. Hasatani, K. Takahashi, N. Inagaki, S. Ebi, M. Kato, H. Kubota, E. Kataoka, H. Takahashi, S. Tokino, T. Minamoto, T. Sugai, T. Sasaki, Y.
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Journal Title
PLoS One
Volume: 15
Issue: 2
Pages: e0229262-e0229262
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma2020
Author(s)
Dilireba Bolidong, Takahiro Domoto, Masahiro Uehara, Hemragul Sabit, Tomoyuki Okumura, Yoshio Endo, Mitsutoshi Nakada, Itasu Ninomiya, Tomoharu Miyashita, Richard W Wong, Toshinari Minamoto
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Journal Title
Scientific Reports
Volume: 10
Issue: 1
Pages: 11807-11807
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Anti-FIRΔexon2, a splicing variant form of PUF60, auto-antibody is detected in the sera of esophageal squamous cell carcinoma.2019
Author(s)
Kobayashi S, Hiwasa T, Ishige T, Rahmutulla B, Kano M, Hoshino T, Minamoto T, Shimada H, Nomura F, Matsubara H, Matsushita K.
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Journal Title
Cancer Sci.
Volume: 4
Issue: 6
Pages: 1-10
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Integrated genetic and epigenetic analysis of cancer-related genes in non-ampullary duodenal adenomas and mucosal adenocarcinomas2020
Author(s)
Takeshi Sawada, Ryosuke Ota, Sho Tsuyama, Takashi Yao, Yasushi Sasaki, Hiromu Suzuki, Yasuharu Kaizaki, Kenkei Hasatani, Eiichiro Yamamoto, Hiroyoshi Nakanishi, Shigetsugu Tsuji, Naohiro Yoshida, Hisashi Doyama, Eiji Kubota, Hiromi Kataoka, Toshinari Minamoto
Organizer
Digestive Disease Week (DDW) 2020
Related Report
Int'l Joint Research
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[Presentation] Glycogen synthase kinase-3β is a new therapeutic target in soft tissue sarcoma: a basic research.2019
Author(s)
Kensaku Abe, Norio Yamamoto, Takahiro Domoto, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Higuchi, Yuta Taniguchi, Hirotaka Yonezawa, Yoshihiro Araki, Toshinari Minamoto, Hiroyuki Tsuchiya.
Organizer
American Academy of Orthopaedic Surgeons (AAOS) Annual Meeting 2019
Related Report
Int'l Joint Research
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[Presentation] 非乳頭十二指腸腫瘍におけるDNAメチル化解析.2019
Author(s)
澤田 武, 太田亮介, 鈴木 拓, 津山 翔, 八尾隆史, 中西宏佳, 山本英一郎, 久保田英嗣, 片岡洋望, 佐々木泰史, 源 利成.
Organizer
第78回日本癌学会学術総会
Related Report
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[Presentation] Methylation analysis of non-ampullary duodenal precancerous lesions.2019
Author(s)
Ryosuke Ota, Takeshi Sawada, Hiromu Suzuki, Sho Tsuyama, Takashi Yao, Eiichiro Yamamoto, Hiroyoshi Nakanishi, Shigetsugu Tsuji, Naohiro Yoshida, Hisashi Doyama, Hiroshi Minato, Kenkei Hasatani, Yasuharu Kaizaki, Eiji Kubota, Hiromi Kataoka, Yasushi Sasaki, Toshinari Minamoto.
Organizer
27th United European Gastroenterology (UEG) Week 2019
Related Report
Int'l Joint Research
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[Presentation] 十二指腸非乳頭部腫瘍における遺伝子メチル化と変異解析.2019
Author(s)
澤田 武, 太田亮介, 鈴木 拓, 津山 翔, 八尾隆史, 中西宏佳, 波佐谷兼慶, 海崎泰治, 吉田尚弘, 辻 重継, 土山寿志, 湊 宏, 山本英一郎, 久保田英嗣, 片岡洋望, 佐々木泰史, 源 利成.
Organizer
第30回日本消化器癌発生学会総会
Related Report