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Development of optical bone clearing technique and elucidation of pathophysiology of bone metabolic disorders focusing on neural-vascular network

Research Project

Project/Area Number 19H03777
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56020:Orthopedics-related
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Sato Shingo  東京医科歯科大学, 医学部附属病院, 講師 (40462220)

Co-Investigator(Kenkyū-buntansha) 越智 広樹  国立障害者リハビリテーションセンター(研究所), 研究所 運動機能系障害研究部, 研究員 (30582283)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords整形外科 / 組織透明化技術 / 骨代謝 / 臓器間ネットワーク
Outline of Research at the Start

本研究は、筋骨格系の透明化技術や3次元イメージングといった最先端技術を駆使し、筋骨格系の多様な細胞どうしの相互作用を、これまであまり着目されてこなかった「神経-血管ネットワーク」との相関という新たな観点から明らかにするものである。また、メカニカルストレスの変化や骨代謝異常疾患の進行が、筋骨格系の神経-血管ネットワークに与える影響を明らかにすることで、神経-血管ネットワークによる筋骨格系の恒常性維持機構の解明を目指す。

Outline of Final Research Achievements

In this study, we succeeded in visualizing the neural-vascular network in musculoskeletal tissues by using cutting-edge technologies such as optical bone clearing technique and 3D imaging. We also developed an original method to quantify the amount of nerves or blood vessels based on the obtained 3D analysis data. Furthermore, we clarified the effect of mechanical stress on the maintenance of homeostasis of musculoskeletal tissues from the viewpoint of neural-vascular network, and applied our optical bone clearing technique to the pathological analysis of various bone metabolic disorders.

Academic Significance and Societal Importance of the Research Achievements

不動性骨粗鬆症、閉経後骨粗鬆症、骨折、がんの骨転移などの筋骨格系疾患の病態解析に、研究代表者らが開発した骨透明化技術を応用し、これらの疾患における神経-血管ネットワークの病態生理学的意義を明らかにできれば、神経・血管系を標的とした筋骨格系疾患の新たな治療法の開発に繋がることが期待される。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (24 results)

All 2021 2020 2019

All Journal Article (12 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 9 results,  Open Access: 8 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Mechanical load regulates bone growth via periosteal Osteocrin2021

    • Author(s)
      Watanabe-Takano H., Ochi H., Chiba A., Matsuo A., Kanai Y., Fukuhara S., Ito N., Sako K., Miyazaki T., Tainaka K., Harada I., Sato S., Sawada Y., Minamino N., Takeda S., Ueda H.R., Yasoda A., Mochizuki N.
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 2 Pages: 109380-109380

    • DOI

      10.1016/j.celrep.2021.109380

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A novel PAI-1 inhibitor prevents ageing-related muscle fiber atrophy.2021

    • Author(s)
      Aihemaiti A, Yamamoto N, Piao J, Oyaizu T, Ochi H, Sato S, Okawa A, Miyata T, Tsuji K, Ezura Y, Asou Y.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 534 Pages: 849-856

    • DOI

      10.1016/j.bbrc.2020.10.089

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cyclin-Dependent Kinase 1 Is Essential for Muscle Regeneration and Overload Muscle Fiber Hypertrophy2020

    • Author(s)
      Kobayashi Yutaka、Tanaka Tomoyuki、Mulati Mieradilli、Ochi Hiroki、Sato Shingo、Kaldis Philipp、Yoshii Toshitaka、Okawa Atsushi、Inose Hiroyuki
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 8 Pages: 1-14

    • DOI

      10.3389/fcell.2020.564581

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of a Novel MAN1A1-ROS1 Fusion Gene Through mRNA-based Screening for Tyrosine Kinase Gene Aberrations in a Patient with Leiomyosarcoma2020

    • Author(s)
      Suehara Y, Kohsaka S, Hayashi T, Akaike K, Kurisaki-Arakawa A, Sato S, Kobayashi E, Mizuno S, Ueno T, Morii T, Okuma T, Kurihara T, Hasegawa N, Sano K, Sasa K, Okubo T, Kim Y, Mano H, Saito T
    • Journal Title

      Clin Orthop Relat Res

      Volume: - Issue: 4 Pages: 838-852

    • DOI

      10.1097/corr.0000000000001548

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incidence of atypical femoral fractures in the treatment of bone metastasis: An alert report2020

    • Author(s)
      Kaku Takumi、Oh Yoto、Sato Shingo、Koyanagi Hirotaka、Hirai Takashi、Yuasa Masato、Yoshii Toshitaka、Nakagawa Tsuyoshi、Miyake Satoshi、Okawa Atsushi
    • Journal Title

      Journal of Bone Oncology

      Volume: 23 Pages: 100301-100301

    • DOI

      10.1016/j.jbo.2020.100301

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Surgical stabilization of spinal metastasis in diffuse idiopathic skeletal hyperostosis (“Mets-on-DISH”)2020

    • Author(s)
      Kawabata Atsuyuki、Hirai Takashi、Tohara Ryo、Yuasa Masato、Inose Hiroyuki、Koyanagi Hirotaka、Sato Shingo、Utagawa Kurando、Hashimoto Jun、Okawa Atsushi、Yoshii Toshitaka
    • Journal Title

      Medicine

      Volume: 99 Issue: 22 Pages: e20397-e20397

    • DOI

      10.1097/md.0000000000020397

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ひとりじゃない、チームで行う骨転移診療2020

    • Author(s)
      佐藤信吾
    • Journal Title

      Bone Joint Nerve

      Volume: 10 Pages: 397-403

    • Related Report
      2020 Annual Research Report
  • [Journal Article] The long noncoding RNA Crnde regulates osteoblast proliferation through the Wnt/β-catenin signaling pathway in mice.2020

    • Author(s)
      Mieradili Mulati,Toshitaka Yoshii, Atsushi Okawa, Hiroyuki Inose
    • Journal Title

      Bone

      Volume: 130 Pages: 115076-115076

    • DOI

      10.1016/j.bone.2019.115076

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The L-type amino acid transporter LAT1 inhibits osteoclastogenesis and maintains bone homeostasis through the mTORC1 pathway2019

    • Author(s)
      Ozaki Kakeru、Yamada Takanori、Horie Tetsuhiro、Ishizaki Atsushi、Hiraiwa Manami、Iezaki Takashi、Park Gyujin、Fukasawa Kazuya、Kamada Hikari、Tokumura Kazuya、Motono Mei、Kaneda Katsuyuki、Ogawa Kazuma、Ochi Hiroki、Sato Shingo、Kobayashi Yasuhiro、Shi Yun-Bo、Taylor Peter M.、Hinoi Eiichi
    • Journal Title

      Science Signaling

      Volume: 12 Issue: 589 Pages: 589-589

    • DOI

      10.1126/scisignal.aaw3921

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pericytes as a Source of Osteogenic Cells in Bone Fracture Healing2019

    • Author(s)
      Supakul Sopak、Yao Kenta、Ochi Hiroki、Shimada Tomohito、Hashimoto Kyoko、Sunamura Satoko、Mabuchi Yo、Tanaka Miwa、Akazawa Chihiro、Nakamura Takuro、Okawa Atsushi、Takeda Shu、Sato Shingo
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 20 Issue: 5 Pages: 1079-1079

    • DOI

      10.3390/ijms20051079

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 骨転移とマイクロRNA2019

    • Author(s)
      佐藤信吾
    • Journal Title

      BIO Clinica

      Volume: 34 Pages: 28-32

    • Related Report
      2019 Annual Research Report
  • [Journal Article] ペリサイト(血管周皮細胞)は多分化能を有し骨折治癒に貢献する2019

    • Author(s)
      佐藤信吾
    • Journal Title

      臨床雑誌整形外科

      Volume: 70 Pages: 788-788

    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨透明化技術の開発による骨内神経の3次元構造の可視化と除神経による骨恒常性変化の観察2021

    • Author(s)
      佐藤信吾、秦宇英、歌川蔵人、越智広樹、大川淳
    • Organizer
      第39回日本骨代謝学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 骨を透明にする技術の開発と宇宙実験への応用2021

    • Author(s)
      佐藤信吾、秦宇英、歌川蔵人、越智広樹、砂村聡子、海野愛子、三宅智、大川淳
    • Organizer
      第19回関東骨軟部腫瘍の基礎を語る会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Early diagnosis and early treatment for bone metastasis by in-hospital multi-disciplinary treatment approach2021

    • Author(s)
      7.Shingo Sato, Hirotaka Koyanagi, Takashi Hirai, Masato Yuasa, Satoshi Miyake, Atsushi Okawa
    • Organizer
      Asia Pacific Musculoskeletal Tumor Society (APMSTS) 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 多職種協働でがんロコモを防ぐ ~がん患者が最後まで「動ける」を目指した緩和ケアの実践~.2020

    • Author(s)
      佐藤信吾、酒井朋子、岡安健、野里洵子、入山哲次、高橋萌々子、岡梨津子、本松裕子、三宅智
    • Organizer
      緩和・支持・心のケア合同学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] デノスマブが支える運動器の健康 ~直ちに骨を守る行動を!~2020

    • Author(s)
      佐藤信吾
    • Organizer
      第60回関東整形災害外科学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] TES施行後、隣接椎体の骨転移による歩行障害が出現し、その治療に難渋した症例2020

    • Author(s)
      佐藤信吾、平井高志、吉井俊貴、小柳広高、阿江啓介、湯浅将人、三宅智、大川淳
    • Organizer
      第53回日本整形外科学会骨軟部腫瘍学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 緩和ケアにおける整形外科医の意義を考える ~がん患者が最後まで「動ける」を目指した緩和ケアの実践~2020

    • Author(s)
      佐藤信吾、小柳広高、平井高志、湯浅将人、酒井朋子、三宅智、大川淳
    • Organizer
      第53回日本整形外科学会骨軟部腫瘍学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 骨転移キャンサーボードで示すがん診療における整形外科医の存在意義2020

    • Author(s)
      佐藤信吾、小柳広高、平井高志、湯浅将人、本橋正隆、大川淳
    • Organizer
      第69回東日本整形災害外科学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 骨転移におけるがん細胞と骨の細胞とのコミュニケーション2020

    • Author(s)
      佐藤信吾、橋本恭子、越智広樹、大川淳、三宅智
    • Organizer
      第125回日本解剖学会総会・全国学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 骨細胞の長鎖ノンコーディングRNAによる骨代謝制御機構の解明2019

    • Author(s)
      佐藤信吾、荒井誠、越智広樹、砂村聡子、竹田秀、大川淳
    • Organizer
      第34回日本整形外科学会基礎学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ペリサイト(血管周皮細胞)は多分化能を有し骨折治癒に貢献する2019

    • Author(s)
      佐藤信吾、Supakul Sopak、八尾健太、越智広樹、橋本恭子、砂村聡子、竹田秀、大川淳
    • Organizer
      第37回日本骨代謝学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Book] チーム医療のためのがんロコモハンドブック2021

    • Author(s)
      佐藤信吾(共同執筆)
    • Total Pages
      535
    • Publisher
      総合医学社
    • Related Report
      2021 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

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