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Elucidation of malignancy, peritoneal dissemination and spread mechanism of ovarian cancer by interaction with peritoneal mesothelium.

Research Project

Project/Area Number 19H03797
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionNagoya University

Principal Investigator

Kikkawa Fumitaka  名古屋大学, 医学系研究科, 招へい教員 (40224985)

Co-Investigator(Kenkyū-buntansha) 梶山 広明  名古屋大学, 医学系研究科, 教授 (00345886)
横井 暁  名古屋大学, 医学部附属病院, 助教 (30737135)
芳川 修久  名古屋大学, 医学部附属病院, 助教 (60804747)
鈴木 史朗  愛知県がんセンター(研究所), 婦人科部, 部長 (20612758)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords卵巣癌 / がん微小環境 / 細胞間相互作用 / 卵巣がん / 婦人科がん / エクソソーム / 中皮細胞 / マイクロRNA / 細胞外小胞 / exosome / ovarian cancer / miRNA / mesothelium
Outline of Research at the Start

これまで卵巣がんの微小環境に着目し、多くの報告を行ってきた。さらに近年、我々は卵巣がん細胞が放出するエクソソームの機能を、世界に先駆けて明らかにした。卵巣がん細胞が放出するエクソソームが中皮細胞と協力して、腹膜転移を促進させる機構を同定した。卵巣がん細胞はその微小環境において、がん細胞の自身の悪性化のみならず、周囲の種々の細胞とメッセージを送り合うことで、様々な生理機能を発揮させていることが明らかになったが、詳細は明らかにされていない。がん細胞とそれを取り巻く細胞間との情報伝達機構どのようなものがあるのか、これらの疑問を解明するためにエクソソームmiRNAを中心に研究する。

Outline of Final Research Achievements

The aim of this study was to elucidate new disease mechanisms by focusing on cell-cell interactions in the ovarian cancer tumor-microenvironment (TME), and to discover novel therapeutic targets for ovarian cancer patients. Throughout the three-year research period, we have elucidated the malignant mechanisms of refractory ovarian cancer from extremely multiple aspects. The research included metabolomic analysis, small RNA sequencing, therapeutic effects of vitamins, and the relationship with adipose tissue. All of the results are the whole new findings, which have been reported for the first time. The function of mesothelial cells in TME is still under investigation. Although this research grant is in its final year, we will continue to elucidate the functions of various cells in the ovarian cancer TME and leading to develop them for clinical applications such as diagnosis and treatment.

Academic Significance and Societal Importance of the Research Achievements

卵巣がんは、婦人科悪性腫瘍の中で最も予後不良ながん種であり、罹患率・死亡率ともに上昇の一途を辿っている。卵巣がん細胞は極めて腹膜播種を起こしやすく、診断時多くの症例で腹膜播種を伴っており、重要な予後因子の一つとなっている。また、腹膜播種に対する有効な治療法は現在も確立されているとはいえず、腹膜播種巣での分子生理機構もほとんど明らかにされていない。本研究はこうした卵巣がんの課題に対して、解決の糸口となり得る知見と考えている。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (51 results)

All 2022 2021 2020 2019

All Journal Article (37 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 37 results,  Open Access: 27 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Survival benefits of retroperitoneal lymphadenectomy for optimally-resected advanced ovarian high-grade serous carcinoma: a multi-institutional retrospective study2022

    • Author(s)
      Ikeda Yoshiki、Yoshihara Masato、Tamauchi Satoshi、Yokoi Akira、Yoshikawa Nobuhisa、Kajiyama Hiroaki
    • Journal Title

      Journal of Gynecologic Oncology

      Volume: 33 Issue: 4

    • DOI

      10.3802/jgo.2022.33.e40

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of platinum distribution to predict platinum resistance in ovarian cancer after platinum treatment in neoadjuvant chemotherapy2022

    • Author(s)
      Uno Kaname、Yoshikawa Nobuhisa、Tazaki Akira、Ohnuma Shoko、Kitami Kazuhisa、Iyoshi Shohei、Mogi Kazumasa、Yoshihara Masato、Koya Yoshihiro、Sugiyama Mai、Tamauchi Satoshi、Ikeda Yoshiki、Yokoi Akira、Kikkawa Fumitaka、Kato Masashi、Kajiyama Hiroaki
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 4513-4513

    • DOI

      10.1038/s41598-022-08503-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aberrant activation of cell cycle-related kinases and the potential therapeutic impact of PLK1 or CHEK1 inhibition in uterine leiomyosarcoma2022

    • Author(s)
      Yoshida Kosuke、Yokoi Akira、Yamamoto Tomofumi、Hayashi Yusuke、Nakayama Jun、Yokoi Tsuyoshi、Yoshida Hiroshi、Kato Tomoyasu、Kajiyama Hiroaki、Yamamoto Yusuke
    • Journal Title

      Clinical Cancer Research

      Volume: - Issue: 10 Pages: 2147-2159

    • DOI

      10.1158/1078-0432.ccr-22-0100

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Is adjuvant chemotherapy necessary for young women with early-stage epithelial ovarian cancer who have undergone fertility-sparing surgery?: a multicenter retrospective analysis2022

    • Author(s)
      Ikeda Yoshiki、Yoshihara Masato、Yoshikawa Nobuhisa、Yokoi Akira、Tamauchi Satoshi、Nishino Kimihiro、Niimi Kaoru、Kajiyama Hiroaki
    • Journal Title

      BMC Women's Health

      Volume: 22 Issue: 1 Pages: 80-80

    • DOI

      10.1186/s12905-022-01642-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peritoneal restoration by repurposing vitamin D inhibits ovarian cancer dissemination via blockade of the TGF-β1/thrombospondin-1 axis2022

    • Author(s)
      Kitami Kazuhisa、Yoshihara Masato、Tamauchi Satoshi、Sugiyama Mai、Koya Yoshihiro、Yamakita Yoshihiko、Fujimoto Hiroki、Iyoshi Shohei、Uno Kaname、Mogi Kazumasa、Ikeda Yoshiki、Yokoi Akira、Yoshikawa Nobuhisa、Nishino Kimihiro、Niimi Kaoru、Nawa Akihiro、Enomoto Atsushi、Kajiyama Hiroaki
    • Journal Title

      Matrix Biology

      Volume: 109 Pages: 70-90

    • DOI

      10.1016/j.matbio.2022.03.003

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ChrXq27.3 miRNA cluster functions in cancer development2021

    • Author(s)
      Yoshida Kosuke、Yokoi Akira、Yamamoto Yusuke、Kajiyama Hiroaki
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 40 Issue: 1

    • DOI

      10.1186/s13046-021-01910-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significance of Concurrent Chemoradiotherapy as Primary Treatment in Patients with Metastatic Cervical Cancer2021

    • Author(s)
      Hattori Satomi、Yoshikawa Nobuhisa、Mogi Kazumasa、Yoshida Kosuke、Yoshihara Masato、Tamauchi Satoshi、Ikeda Yoshiki、Yokoi Akira、Nishino Kimihiro、Niimi Kaoru、Suzuki Shiro、Kajiyama Hiroaki
    • Journal Title

      Current Oncology

      Volume: 28 Issue: 3 Pages: 1663-1672

    • DOI

      10.3390/curroncol28030155

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Metabolome analysis reveals a diversity of cancer tissues in advanced epithelial ovarian cancer2021

    • Author(s)
      Yoshida Kosuke、Yoshikawa Nobuhisa、Kitami Kazuhisa、Tamauchi Satoshi、Ikeda Yoshiki、Yokoi Akira、Nishino Kimihiro、Niimi Kaoru、Kajiyama Hiroaki
    • Journal Title

      Cancer Cell International

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12935-021-02014-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is cystectomy an option as conservative surgery for young patients with borderline ovarian tumor? A multi‐institutional retrospective study2021

    • Author(s)
      Ikeda Yoshiki、Yoshihara Masato、Yoshikawa Nobuhisa、Tamauchi Satoshi、Yokoi Akira、Nishino Kimihiro、Niimi Kaoru、Kajiyama Hiroaki
    • Journal Title

      International Journal of Gynecology & Obstetrics

      Volume: 157 Issue: 2 Pages: 437-443

    • DOI

      10.1002/ijgo.13844

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD63-mediated cloaking of VEGF in small extracellular vesicles contributes to anti-VEGF therapy resistance2021

    • Author(s)
      Ma Shaolin、Mangala S、Hu W、Bayaktar E、Yokoi A、Hu W、Pradeep S、Lee S、Piehowski PD.、Villar-Prados A、Wu S.、McGuire M.、Lara Olivia D.、Rodriguez C、LaFargue Christopher J.、Jennings B.、Rodland D.、Liu Tao、Kundra V、Ram Prahlad T.、Ramakrishnan Sundaram、Lopez Gabriel、Coleman RL.、Sood AK.
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 7 Pages: 109549-109549

    • DOI

      10.1016/j.celrep.2021.109549

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exosomes and extracellular vesicles: Rethinking the essential values in cancer biology2021

    • Author(s)
      Yokoi Akira、Ochiya Takahiro
    • Journal Title

      Seminars in Cancer Biology

      Volume: 74 Pages: 79-91

    • DOI

      10.1016/j.semcancer.2021.03.032

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adjuvant taxane plus platinum chemotherapy for stage I ovarian clear cell carcinoma with complete surgical staging: are more than three cycles necessary?2021

    • Author(s)
      Ukai Mayu、Suzuki Shiro、Yoshihara Masato、Yokoi Akira、Yoshikawa Nobuhisa、Kajiyama Hiroaki、Kikkawa Fumitaka
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 27 Issue: 3 Pages: 609-618

    • DOI

      10.1007/s10147-021-02075-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular microRNA profiling for prognostic prediction in patients with high‐grade serous ovarian carcinoma2021

    • Author(s)
      Yoshida Kosuke、Yokoi Akira、Matsuzaki Juntaro、Kato Tomoyasu、Ochiya Takahiro、Kajiyama Hiroaki、Yamamoto Yusuke
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 12 Pages: 4977-4986

    • DOI

      10.1111/cas.15154

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical effects of cervical conization with positive margins in cervical cancer2021

    • Author(s)
      Nagao Yukari、Yokoi Akira、Yoshida Kosuke、Sumi Masanori、Yoshihara Masato、Tamauchi Satoshi、Ikeda Yoshiki、Yoshikawa Nobuhisa、Nishino Kimihiro、Niimi Kaoru、Kajiyama Hiroaki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-02635-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Heat Shock Protein 105 as an Immunotherapeutic Target for Patients With Cervical Cancer2021

    • Author(s)
      NOSAKA KAZUTO、SUZUKI SHIRO、YOSHIKAWA TOSHIAKI、SHIMOMURA MANAMI、KITAMI KAZUHISA、YOSHIDA KOSUKE、YOSHIHARA MASATO、KIKKAWA FUMITAKA、NAKATSURA TETSUYA、KAJIYAMA HIROAKI
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 10 Pages: 4741-4751

    • DOI

      10.21873/anticanres.15289

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preclinical Verification of the Efficacy and Safety of Aqueous Plasma for Ovarian Cancer Therapy2021

    • Author(s)
      Nakamura Kae、Yoshikawa Nobuhisa、Mizuno Yuko、Ito Miwa、Tanaka Hiromasa、Mizuno Masaaki、Toyokuni Shinya、Hori Masaru、Kikkawa Fumitaka、Kajiyama Hiroaki
    • Journal Title

      Cancers

      Volume: 13 Issue: 5 Pages: 1141-1141

    • DOI

      10.3390/cancers13051141

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term post-recurrence survival outcomes in young women receiving fertility-sparing surgery for epithelial ovarian cancer2021

    • Author(s)
      Shigeyama Munehisa、Yoshihara Masato、Kitami Kazuhisa、Mogi Kazumasa、Uno Kaname、Iyoshi Shohei、Tano Sho、Yoshikawa Nobuhisa、Kajiyama Hiroaki
    • Journal Title

      European Journal of Obstetrics & Gynecology and Reproductive Biology

      Volume: 267 Pages: 221-225

    • DOI

      10.1016/j.ejogrb.2021.11.015

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A large-scale multi-institutional study evaluating prognostic aspects of positive ascites cytology and effects of therapeutic interventions in epithelial ovarian cancer2021

    • Author(s)
      Yoshihara Masato、Emoto Ryo、Kitami Kazuhisa、Iyoshi Shohei、Uno Kaname、Mogi Kazumasa、Tano Sho、Yoshikawa Nobuhisa、Matsui Shigeyuki、Kajiyama Hiroaki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 15154-15154

    • DOI

      10.1038/s41598-021-93718-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Achievement of live birth after overcoming two gynecological malignancies treated with radical trachelectomy and medroxyprogesterone acetate therapy2021

    • Author(s)
      Tamauchi Satoshi、Moriyama Yoshinori、Suzuki Shiro、Ikeda Yoshiki、Yoshikawa Nobuhisa、Kajiyama Hiroaki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 47 Issue: 11 Pages: 4101-4105

    • DOI

      10.1111/jog.15001

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vitamin D improves pulmonary function in a rat model for congenital diaphragmatic hernia2021

    • Author(s)
      Ito Yumiko、Tsuda Hiroyuki、Imai Kenji、Miki Rika、Miura Mayo、Tachi Asuka、Tano Sho、Hirako-Takamura Shima、Moriyama Yoshinori、Ushida Takafumi、Kobayashi Tomoko、Sumigama Seiji、Kajiyama Hiroaki、Kikkawa Fumitaka、Kotani Tomomi
    • Journal Title

      Archives of Biochemistry and Biophysics

      Volume: 700 Pages: 108769-108769

    • DOI

      10.1016/j.abb.2021.108769

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reduced response to controlled ovarian stimulation after radical trachelectomy: A pitfall of fertility‐sparing surgery for cervical cancer2021

    • Author(s)
      Tamauchi Satoshi、Kajiyama Hiroaki、Osuka Satoko、Moriyama Yoshinori、Yoshihara Masato、Kikkawa Fumitaka
    • Journal Title

      International Journal of Gynecology & Obstetrics

      Volume: ー Issue: 1 Pages: 162-168

    • DOI

      10.1002/ijgo.13529

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression of the chrXq27.3 miRNA cluster in recurrent ovarian clear cell carcinoma and its impact on cisplatin resistance2021

    • Author(s)
      Yoshida Kosuke、Yokoi Akira、Sugiyama Mai、Oda Shingo、Kitami Kazuhisa、Tamauchi Satoshi、Ikeda Yoshiki、Yoshikawa Nobuhisa、Nishino Kimihiro、Niimi Kaoru、Suzuki Shiro、Kikkawa Fumitaka、Yokoi Tsuyoshi、Kajiyama Hiroaki
    • Journal Title

      Oncogene

      Volume: 40 Issue: 7 Pages: 1255-1268

    • DOI

      10.1038/s41388-020-01595-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extracellular miRNAs as Predictive Biomarkers for Glypican-3-Derived Peptide Vaccine Therapy Response in Ovarian Clear Cell Carcinoma2021

    • Author(s)
      Ukai Mayu、Yokoi Akira、Yoshida Kosuke、Suzuki Shiro、Shibata Kiyosumi、Kikkawa Fumitaka、Nakatsura Tetsuya、Kajiyama Hiroaki
    • Journal Title

      Cancers

      Volume: 13 Issue: 3 Pages: 550-550

    • DOI

      10.3390/cancers13030550

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ovarian cancer-associated mesothelial cells induce acquired platinum-resistance in peritoneal metastasis via the FN1/Akt signaling pathway.2020

    • Author(s)
      Yoshihara M, Kajiyama H, Yokoi A, Sugiyama M, Koya Y, Yamakita Y, Liu W, Nakamura K, Moriyama Y, Yasui H, Suzuki S, Yamamoto Y, Ricciardelli C, Nawa A, Shibata K, Kikkawa F
    • Journal Title

      Int J Cancer

      Volume: 146 Issue: 8 Pages: 2268-2280

    • DOI

      10.1002/ijc.32854

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sarcopenia as a Predictor of Survival Among Patients With Organ Metastatic Cervical Cancer2020

    • Author(s)
      Yoshikawa Nobuhisa、Shirakawa Akira、Yoshida Kosuke、Tamauchi Satoshi、Suzuki Shiro、Kikkawa Fumitaka、Kajiyama Hiroaki
    • Journal Title

      Nutrition in Clinical Practice

      Volume: - Issue: 6 Pages: 1041-1046

    • DOI

      10.1002/ncp.10482

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Survival after Anticancer Treatment of Terminally Ill Patients with Ovarian Carcinoma2020

    • Author(s)
      Kajiyama Hiroaki、Suzuki Shiro、Shimbo Akiko、Utsumi Fumi、Yoshikawa Nobuhisa、Kikkawa Fumitaka
    • Journal Title

      Journal of Palliative Medicine

      Volume: 23 Issue: 8 Pages: 1060-1065

    • DOI

      10.1089/jpm.2019.0456

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filopodia play an important role in the trans-mesothelial migration of ovarian cancer cells2020

    • Author(s)
      Masato Yoshihara, Yoshihiko Yamakita, Hiroaki Kajiyama, Takeshi Sengae,Yoshihiro Koya, Mamoru Yamashita, Akihiro Nawa, Fumitaka Kikkawa
    • Journal Title

      Experimental Cell Research

      Volume: 392 Issue: 2 Pages: 112011-112011

    • DOI

      10.1016/j.yexcr.2020.112011

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microphthalmia-Associated Transcription Factor-Dependent Melanoma Cell Adhesion Molecule Activation Promotes Peritoneal Metastasis of Ovarian Cancer2020

    • Author(s)
      Kitami Kazuhisa、Yoshihara Masato、Koya Yoshihiro、Sugiyama Mai、Iyoshi Shohei、Uno Kaname、Mogi Kazumasa、Tano Sho、Fujimoto Hiroki、Nawa Akihiro、Kikkawa Fumitaka、Kajiyama Hiroaki
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 24 Pages: 9776-9776

    • DOI

      10.3390/ijms21249776

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The impact of systematic retroperitoneal lymphadenectomy on long-term oncologic outcome of women with advanced ovarian clear-cell carcinoma2020

    • Author(s)
      Kajiyama Hiroaki、Suzuki Shiro、Yoshikawa Nobuhisa、Tamauchi Satoshi、Shibata Kiyosumi、Kikkawa Fumitaka
    • Journal Title

      Journal of Gynecologic Oncology

      Volume: 31 Issue: 4

    • DOI

      10.3802/jgo.2020.31.e47

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of uterus‐preserving surgery on Stage I primary mucinous epithelial ovarian carcinoma: A multi‐institutional study with propensity score‐weighted analysis2020

    • Author(s)
      Yoshihara Masato、Kajiyama Hiroaki、Tamauchi Satoshi、Iyoshi Shohei、Yokoi Akira、Suzuki Shiro、Kawai Michiyasu、Nagasaka Tetsuro、Takahashi Kunihiko、Matsui Shigeyuki、Kikkawa Fumitaka
    • Journal Title

      International Journal of Gynecology & Obstetrics

      Volume: 150 Issue: 2 Pages: 177-183

    • DOI

      10.1002/ijgo.13244

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Preoperative Prognostic Nutritional Index for the Prediction of Outcomes in Patients with Early-Stage Ovarian Clear Cell Carcinoma2020

    • Author(s)
      Yoshikawa Nobuhisa、Yoshida Kosuke、Tamauchi Satoshi、Ikeda Yoshiki、Nishino Kimihiro、Niimi Kaoru、Suzuki Shiro、Kikkawa Fumitaka、Kajiyama Hiroaki
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 7135-7135

    • DOI

      10.1038/s41598-020-64171-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of a patient‐derived xenograft model and cell line of malignant transformation of mature cystic teratoma of the ovary2020

    • Author(s)
      Tamauchi Satoshi、Suzuki Shiro、Xuboya Chang、Yoshihara Masato、Yoshida Kosuke、Ikeda Yoshiki、Yoshikawa Nobuhisa、Kajiyama Hiroaki、Kikkawa Fumitaka
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 47 Issue: 2 Pages: 713-719

    • DOI

      10.1111/jog.14596

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Complete Response of Recurrent Small Cell Carcinoma of the Uterine Cervix to Paclitaxel, Carboplatin, and Bevacizumab Combination Therapy2020

    • Author(s)
      Nakao Yuri、Tamauchi Satoshi、Yoshikawa Nobuhisa、Suzuki Shiro、Kajiyama Hiroaki、Kikkawa Fumitaka
    • Journal Title

      Case Reports in Oncology

      Volume: 13 Issue: 1 Pages: 373-378

    • DOI

      10.1159/000506446

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CCL2 secreted from cancer-associated mesothelial cells promotes peritoneal metastasis of ovarian cancer cells through the P38-MAPK pathway2020

    • Author(s)
      Hiroaki Yasui, Hiroaki Kajiyama, Satoshi Tamauchi, Shiro Suzuki, Yang Peng, Nobuhisa Yoshikawa, Mai Sugiyama, Kae Nakamura, Fumitaka Kikkawa
    • Journal Title

      Clinical & Experimental Metastasis

      Volume: 37 Pages: 145-158

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Unique miRNA profiling of squamous cell carcinoma arising from ovarian mature teratoma: comprehensive miRNA sequence analysis of its molecular background2019

    • Author(s)
      Yoshida Kosuke、Yokoi Akira、Kagawa Takumi、Oda Shingo、Hattori Satomi、Tamauchi Satoshi、Ikeda Yoshiki、Yoshikawa Nobuhisa、Nishino Kimihiro、Utsumi Fumi、Niimi Kaoru、Suzuki Shiro、Shibata Kiyosumi、Kajiyama Hiroaki、Yokoi Tsuyoshi、Kikkawa Fumitaka
    • Journal Title

      Carcinogenesis

      Volume: 40 Pages: 1435-1444

    • DOI

      10.1093/carcin/bgz135

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of connective tissue growth factor as a prognostic indicator and its possible involvement in the aggressive properties of epithelial ovarian carcinoma2019

    • Author(s)
      Shimbo Akiko、Kajiyama Hiroaki、Tamauchi Satoshi、Yoshikawa Nobuhisa、Ikeda Yoshiki、Nishino Kimihiro、Suzuki Shiro、Niimi Kaoru、Sakata Jun、Kikkawa Fumitaka
    • Journal Title

      Oncology Reports

      Volume: 42(6) Pages: 2323-2332

    • DOI

      10.3892/or.2019.7352

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Interleukin?33 expression in ovarian cancer and its possible suppression of peritoneal carcinomatosis2019

    • Author(s)
      Sekiya Atsushi、Suzuki Shiro、Tanaka Ayako、Hattori Satomi、Shimizu Yusuke、Yoshikawa Nobuhisa、Koya Yoshihiro、Kajiyama Hiroaki、Kikkawa Fumitaka
    • Journal Title

      International Journal of Oncology

      Volume: - Pages: 755-765

    • DOI

      10.3892/ijo.2019.4845

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 卵巣がんにおける脂肪系幹細胞由来small extracellular vesiclesの抗腫瘍効果2021

    • Author(s)
      横井 暁, 吉田 康将, 宇野 枢, 梶山 広明
    • Organizer
      日本癌学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 細胞外循環型マイクロRNAによる新しいバイオマーカー戦略2021

    • Author(s)
      横井 暁
    • Organizer
      日本婦人科がん検診学会総会・学術講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 卵巣がん細胞外小胞の機能解析と臨床応用へ向けた基盤研究2021

    • Author(s)
      横井 暁
    • Organizer
      第63回日本婦人科腫瘍学会学術講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 進行卵巣癌におけるNotchシグナルを介した腫瘍内細胞極性の解明と標的化(英語)2020

    • Author(s)
      吉原 雅人, 杉山 麻衣, 小屋 美博, 伊吉 祥平, 北見 和久, 宇野 枢, 茂木 一将, 田野 翔, 玉内 学志, 横井 暁, 芳川 修久, 那波 明宏, 梶山 広明
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 活性型ビタミンDは腹膜の中皮間葉転換を阻害し、卵巣癌腹膜播種を抑制する(英語)2020

    • Author(s)
      北見 和久, 吉原 雅人, 杉山 麻衣, 小屋 美博, 伊吉 祥平, 宇野 枢, 茂木 一将, 玉内 学志, 横井 暁, 芳川 修久, 那波 明宏, 梶山 広明
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 卵巣癌の腹膜播種における腹膜中皮と脂肪組織の影響(英語)2020

    • Author(s)
      茂木 一将, 吉原 雅人, 北見 和久, 伊吉 祥平, 宇野 枢, 田野 翔, 杉山 麻衣, 小屋 美博, 玉内 学志, 横井 暁, 芳川 修久, 那波 明宏, 梶山 広明
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 卵巣明細胞癌におけるchrXq27.3 miRNAクラスターの転移・再発への役割(英語)2020

    • Author(s)
      吉田 康将, 横井 暁, 吉原 雅人, 玉内 学志, 芳川 修久, 西野 公博, 新美 薫, 吉川 史隆, 梶山 広明
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 隣接細胞間コミュニケーションによる卵巣癌腹膜播種微小環境の形成2020

    • Author(s)
      杉山 麻衣, 梶山 広明, 吉原 雅人, 小屋 美博, 横井 暁, 山下 守, 那波 明宏, 吉川 史隆
    • Organizer
      第72回日本産科婦人科学会学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Identification of cancer specific miRNA in squamous cell carcinoma arising from mature teratoma of ovary using next-generation sequencing.2019

    • Author(s)
      Yoshida K, Yokoi A, Ikeda Y, Yoshikawa N, Nishino K, Niimi K, Suzuki S, Kajiyama H, Kikkawa F
    • Organizer
      第71 回日本産科婦人科学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A novel mechanism of cancer evolution and acquired diversity of epithelial ovarian cancer in the peritoneal ecosystem2019

    • Author(s)
      Yoshihara M, Kajiyama H, Sugiyama M, Koya Y, Yamakita Y, Yokoi A, Nawa A, Kikkawa F
    • Organizer
      Annual Congress of the Japan Society of Obstetrics and Gynecology
    • Related Report
      2019 Annual Research Report
  • [Presentation] 早期の卵巣明細胞癌における予後因子としての好中球リンパ球比および血小板リンパ球比の検討2019

    • Author(s)
      吉田康将,芳川修久,白川 晶,玉内学志,池田芳紀,西野公博,新美 薫,鈴木史朗,梶山広明,吉川史隆
    • Organizer
      第61回日本婦人科腫瘍学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Identification of unique miRNA profiling in squamous cell carcinoma arising from mature teratoma of ovary2019

    • Author(s)
      Yoshida K, Yokoi A, Tamauchi S, Yoshihara M, Yoshikawa N, Nishino K, Niimi K, Suzuki S, Kajiyama H, Kikkawa F
    • Organizer
      第78 回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Carcinoma-associated mesothelial cells as a novel therapeutic target in epithelial ovarian cancer2019

    • Author(s)
      Yoshihara M, Kajiyama H, Sugiyama M, Koya Y, Yokoi A, Iyoshi S, Kikkawa F
    • Organizer
      Annual meeting of the Japanese Cancer Association
    • Related Report
      2019 Annual Research Report
  • [Presentation] Comprehensive miRNA sequencing of squamous cell caricinoma arising from ovarian mature teratoma2019

    • Author(s)
      Yoshida K, Yokoi A, Tamauchi S, Ikeda Y, Yoshikawa N, Nishino K, Niimi K, Suzuki S, Kajiyama H, Kikkawa F
    • Organizer
      21st European Congress on Gynaecological Oncology (ESGO)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2023-01-30  

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