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Functional analysis of uterine cancer stem cell-associated protein SPARC and development of novel drugs targeting it

Research Project

Project/Area Number 19H03800
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 56040:Obstetrics and gynecology-related
Research InstitutionKyushu University

Principal Investigator

kato kiyoko  九州大学, 医学研究院, 教授 (10253527)

Co-Investigator(Kenkyū-buntansha) 片山 佳樹  九州大学, 工学研究院, 教授 (70284528)
森 健  九州大学, 工学研究院, 准教授 (70335785)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords子宮体癌 / 癌幹細胞 / SPARC / AKT / Aldoxorubicin / がん幹細胞 / SAPRC
Outline of Research at the Start

本研究では、secreted proteins acidic and rich in cysteine (以下SPARC)を「子宮体癌がん幹細胞関連蛋白」としてとらえ、1)その発現機構を脱メチル化の点から解析し、また活性化の分子機構をMMP3の点から検討するとともに、2)SPARCが腫瘍細胞や間質細胞などの周囲の微小環境へ及ぼす影響やその相互作用を明らかにする。また、3)SPARCがアルブミン結合蛋白である性質を利用し、SPARCを標的とするアルブミン結合薬剤を創薬し子宮体癌の新規治療法を開発する。

Outline of Final Research Achievements

We examined the function of SPARC, which is upregulated in uterine cancer stem cells. We showed that SPARC expression in endometrial cancer cells induces phosphorylation of AKT and epithelial-mesenchymal transition, and that SPARC activates fibroblasts in the presence of fibronectin. Furthermore, after confirming the binding and cellular uptake of SPARC to fluorescently labeled human serum albumin, we confirmed the growth inhibitory effect of albumin-bound doxorubicin, Aldoxorubicin, on SPARC-expressing uterine cancer cells in three-dimensional culture and in vivo. These results indicate that Aldoxorubicin is a potential therapeutic candidate for the treatment of SPARC-expressing uterine cancer in the future.

Academic Significance and Societal Importance of the Research Achievements

子宮体癌において、進行癌や再発・転移例は予後不良であり治療抵抗性のがんの克服が課題である。治療抵抗性の要因として、がん幹細胞の存在が言われており、がん幹細胞を標的とした新規治療法の開発が急務である。我々は幹細胞の同定法の一つであるSide-population細胞を分離する方法を用いて子宮体がん幹細胞の解析を行い、EMTが治療抵抗性の重要な因子であること、このEMTにはSPARCとfibronectinの共発現が関与していることを明らかにした。このSPARCやfibronectinを標的とした治療法が開発は悪性度の高い子宮体癌の予後改善に貢献でき社会的に意義がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (42 results)

All 2022 2021 2020 2019

All Journal Article (21 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 21 results,  Open Access: 12 results) Presentation (19 results) (of which Int'l Joint Research: 1 results,  Invited: 7 results) Book (2 results)

  • [Journal Article] Fibronectin mediates activation of stromal fibroblasts by SPARC in endometrial cancer cells2021

    • Author(s)
      Yoshida Sachiko、Asanoma Kazuo、Yagi Hiroshi、Onoyama Ichiro、Hori Emiko、Matsumura Yumiko、Okugawa Kaoru、Yahata Hideaki、Kato Kiyoko
    • Journal Title

      BMC Cancer

      Volume: 21 Issue: 1 Pages: 1-12

    • DOI

      10.1186/s12885-021-07875-9

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic outcomes and risk factors for recurrence after laser vaporization for cervical intraepithelial neoplasia: a single-center retrospective study2021

    • Author(s)
      Kodama Keisuke、Yahata Hideaki、Okugawa Kaoru、Tomonobe Hiroshi、Yasutake Nobuko、Yoshida Sachiko、Yagi Hiroshi、Yasunaga Masafumi、Ohgami Tatsuhiro、Onoyama Ichiro、Asanoma Kazuo、Hori Emiko、Shimokawa Mototsugu、Kato Kiyoko
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 4 Pages: 770-776

    • DOI

      10.1007/s10147-020-01848-x

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identification of genes associated with endometrial cell ageing2021

    • Author(s)
      Kawamura Teruhiko、Tomari Hiroyuki、Onoyama Ichiro、Araki Hiromitsu、Yasunaga Masafumi、Lin Cui、Kawamura Keiko、Yokota Natsuko、Yoshida Sachiko、Yagi Hiroshi、Asanoma Kazuo、Sonoda Kenzo、Egashira Katsuko、Ito Takashi、Kato Kiyoko
    • Journal Title

      Molecular Human Reproduction

      Volume: 27 Issue: 2 Pages: 1-12

    • DOI

      10.1093/molehr/gaaa078

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] YBX2 and cancer testis antigen 45 contribute to stemness, chemoresistance and a high degree of malignancy in human endometrial cancer2021

    • Author(s)
      Suzuki I, Yoshida S, Tabu K, Kusunoki S, Matsumura Y, Izumi H, Asanoma K, Yagi H, Onoyama I, Sonoda K, Kohno K, Taga T, Itakura A, Takeda S, Kato K
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 4220-4220

    • DOI

      10.1038/s41598-021-83200-5

    • NAID

      120007044568

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic impact of the subclassification of M llerian cancer stage IV in the FIGO 2014 staging system with a focus of extra-abdominal lymph node metastases2021

    • Author(s)
      Yasunaga Masafumi、Yahata Hideaki、Okugawa Kaoru、Hori Emiko、Kodama Keisuke、Yagi Hiroshi、Ohgami Tatsuhiro、Onoyama Ichiro、Asanoma Kazuo、Kato Kiyoko
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 7 Pages: 1330-1335

    • DOI

      10.1007/s10147-021-01908-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Endometrial endometrioid carcinoma, grade 1, is more aggressive in the elderly than in the young2021

    • Author(s)
      Hachisuga Kazuhisa、Ohishi Yoshihiro、Tomonobe Hiroshi、Yahata Hideaki、Kato Kiyoko、Oda Yoshinao
    • Journal Title

      Histopathology

      Volume: 79 Issue: 5 Pages: 708-719

    • DOI

      10.1111/his.14400

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts2021

    • Author(s)
      Yoshida Kanoko、Kusama Kazuya、Fukushima Yuta、Ohmaru-Nakanishi Takako、Kato Kiyoko、Tamura Kazuhiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 7 Pages: 3683-3683

    • DOI

      10.3390/ijms22073683

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Clinical Significance of Lymphovascular Space Invasion in Stage IA Endometrial Cancer2021

    • Author(s)
      Okugawa Kaoru、Yahata Hideaki、Hachisuga Kazuhisa、Tomonobe Hiroshi、Yasutake Nobuko、Kodama Keisuke、Kenjo Hironori、Yagi Hiroshi、Ohgami Tatsuhiro、Yasunaga Masafumi、Onoyama Ichiro、Asanoma Kazuo、Hori Emiko、Ohishi Yoshihiro、Oda Yoshinao、Kato Kiyoko
    • Journal Title

      Oncology

      Volume: 100 Issue: 4 Pages: 195-202

    • DOI

      10.1159/000521382

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hypersensitivity reaction to pegylated liposomal doxorubicin administration for Mullerian carcinoma in Japanese women2021

    • Author(s)
      Yamaguchi Shinichiro、Yahata Hideaki、Okugawa Kaoru、Kodama Keisuke、Yagi Hiroshi、Yasunaga Masafumi、Ohgami Tatsuhiro、Onoyama Ichiro、Asanoma Kazuo、Kato Kiyoko
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 47 Issue: 4 Pages: 1544-1548

    • DOI

      10.1111/jog.14680

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dual specificity phosphatase 6 plays a critical role in the maintenance of a cancer stem‐like cell phenotype in human endometrial cancer2020

    • Author(s)
      Kato Masaya、Onoyama Ichiro、Yoshida Sachiko、Cui Lin、Kawamura Keiko、Kodama Keisuke、Hori Emiko、Matsumura Yumiko、Yagi Hiroshi、Asanoma Kazuo、Yahata Hideaki、Itakura Atsuo、Takeda Satoru、Kato Kiyoko
    • Journal Title

      International Journal of Cancer

      Volume: - Issue: 7 Pages: 1987-1999

    • DOI

      10.1002/ijc.32965

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Contribution of senescence in human endometrial stromal cells during proliferative phase to embryo receptivity2020

    • Author(s)
      Tomari H, Kawamura T, Asanoma K, Egashira K, Kawamura K, Honjo K, Nagata Y, Kato K
    • Journal Title

      Biology of Reproduction

      Volume: - Issue: 1 Pages: 104-113

    • DOI

      10.1093/biolre/ioaa044

    • NAID

      120007044566

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Safety evaluation of abdominal trachelectomy in patients with cervical tumors >2 cm: a single-institution, retrospective analysis.2020

    • Author(s)
      Kaoru Okugawa, Hideaki Yahata, Kenzo Sonoda, Tatsuhiro Ohgami, Masafumi Yasunaga, Eisuke Kaneki, Kiyoko Kato.
    • Journal Title

      Journal of Gynecologic Oncology

      Volume: 31 Issue: 4 Pages: 1-10

    • DOI

      10.3802/jgo.2020.31.e41

    • NAID

      120007044540

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Is Adjuvant Therapy Necessary for Patients with Intermediate-Risk Cervical Cancer after Open Radical Hysterectomy?2020

    • Author(s)
      Yahata Hideaki、Sonoda Kenzo、Inoue Shusaku、Yasutake Nobuko、Kodama Keisuke、Yagi Hiroshi、Yasunaga Masafumi、Ohgami Tatsuhiro、Onoyama Ichiro、Kaneki Eisuke、Okugawa Kaoru、Asanoma Kazuo、Kato Kiyoko
    • Journal Title

      Oncology

      Volume: 98 Issue: 12 Pages: 853-858

    • DOI

      10.1159/000508569

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of adjuvant chemotherapy after abdominal trachelectomy for cervical cancer: a single-institution experience2020

    • Author(s)
      Okugawa Kaoru、Yahata Hideaki、Sonoda Kenzo、Kodama Keisuke、Yagi Hiroshi、Ohgami Tatsuhiro、Yasunaga Masafumi、Onoyama Ichiro、Kaneki Eisuke、Asanoma Kazuo、Kobayashi Hiroaki、Kato Kiyoko
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 26 Issue: 1 Pages: 216-224

    • DOI

      10.1007/s10147-020-01778-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonlinear Optics with Near-Infrared Excitation Enable Real-Time Quantitative Diagnosis of Human Cervical Cancers2020

    • Author(s)
      Matsui Takahiro、Tamoto Ryo、Iwasa Akio、Mimura Masafumi、Taniguchi Seiji、Hasegawa Tetsuo、Sudo Takao、Mizuno Hiroki、Kikuta Junichi、Onoyama Ichiro、Okugawa Kaoru、Shiomi Mayu、Matsuzaki Shinya、Morii Eiichi、Kimura Tadashi、Kato Kiyoko、Kiyota Yasujiro、Ishii Masaru
    • Journal Title

      Cancer Research

      Volume: 80 Issue: 17 Pages: 3745-3754

    • DOI

      10.1158/0008-5472.can-20-0348

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia2020

    • Author(s)
      Kato Masaya、Onoyama Ichiro、Kawakami Minoru、Yoshida Sachiko、Kawamura Keiko、Kodama Keisuke、Hori Emiko、Cui Lin、Matsumura Yumiko、Yagi Hiroshi、Asanoma Kazuo、Yahata Hideaki、Itakura Atsuo、Takeda Satoru、Kato Kiyoko
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 11 Pages: 0241482-0241482

    • DOI

      10.1371/journal.pone.0241482

    • NAID

      120007044541

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Re-evaluation of preoperative endometrial smears for the cytodiagnosis of uterine leiomyosarcoma.2020

    • Author(s)
      Kenzo Sonoda, Miwako Nogami, Keisuke Kodama, Yoshinao Oda, Kiyoko Kato.
    • Journal Title

      European Journal of Gynaecological Oncology

      Volume: 41 Issue: 2 Pages: 167-170

    • DOI

      10.31083/j.ejgo.2020.02.4950

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Retrospective analysis of treatment and prognosis for uterine leiomyosarcoma: 10‐year experience of a single institute2020

    • Author(s)
      Kodama Keisuke、Sonoda Kenzo、Kijima Masako、Yamaguchi Shinichiro、Yagi Hiroshi、Yasunaga Masafumi、Ohgami Tatsuhiro、Onoyama Ichiro、Kaneki Eisuke、Okugawa Kaoru、Yahata Hideaki、Ohishi Yoshihiro、Oda Yoshinao、Kato Kiyoko
    • Journal Title

      Asia-Pacific Journal of Clinical Oncology

      Volume: 16 Issue: 2 Pages: 63-67

    • DOI

      10.1111/ajco.13286

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutual suppression between BHLHE40/BHLHE41 and the MIR301B-MIR130B cluster is involved in epithelial-to-mesenchymal transition of endometrial cancer cells2019

    • Author(s)
      Asanoma K, Hori E, Yoshida S, Yagi H, Onoyama I, Kodama K, Yasunaga M, Ohgami T, Kaneki E, Okugawa K, Yahata H, Kato K,
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 45 Pages: 4640-4654

    • DOI

      10.18632/oncotarget.27061

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Survey of the desire to have children and engage in sexual activity after trachelectomy among young Japanese women with early-stage cervical cancer.2019

    • Author(s)
      3.Yahata H, Sonoda K, Okugawa K, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Asanoma K, Kato K.
    • Journal Title

      J Obstet Gynaecol Res.

      Volume: 45 Issue: 11 Pages: 2255-2259

    • DOI

      10.1111/jog.14099

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gα13-mediated LATS1 down-regulation contributes to epithelial-mesenchymal transition in ovarian cancer2019

    • Author(s)
      Yagi Hiroshi、Onoyama Ichiro、Asanoma Kazuo、Hori Emiko、Yasunaga Masafumi、Kodama Keisuke、Kijima Masako、Ohgami Tatsuhiro、Kaneki Eisuke、Okugawa Kaoru、Yahata Hideaki、Kato Kiyoko
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 12 Pages: 13683-13694

    • DOI

      10.1096/fj.201901278r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 産婦人科医療の新しい展開2022

    • Author(s)
      加藤 聖子
    • Organizer
      宮崎市郡産婦人科医会学術講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 時代に対応した働き方改革:病院における新しい男女共同参画を目指して2022

    • Author(s)
      加藤 聖子
    • Organizer
      日本医療マネジメント学会第14回宮崎県支部学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] パネルディスカッション; 産婦人科における総排泄腔遺残症の管理2021

    • Author(s)
      加藤 聖子
    • Organizer
      第121回日本外科学会定期学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 産婦人科における性分化疾患の治療2021

    • Author(s)
      加藤 聖子
    • Organizer
      第20回思春期診療研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Downregulation of 5-hydroxymethylcytosine is associated with the progression of cervical intraepithelial neoplasia2021

    • Author(s)
      Onoyama I, Kato M, Kawakami M, Kodama K, Yagi H, Asanoma K, Kato K
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 産婦人科医療の新しい展開2021

    • Author(s)
      加藤 聖子
    • Organizer
      令和3年度富山県産科婦人科学会 第4回 例会・特別講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 産婦人科における性分化疾患の治療2021

    • Author(s)
      加藤 聖子
    • Organizer
      第71回愛媛県産婦人科医会学術集談会・第37回愛媛県産婦人科医会臨床集談会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 女性ヘルスケアと高血圧2021

    • Author(s)
      加藤 聖子
    • Organizer
      第41回日本妊娠高血圧学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 早期子宮頸癌におけるセンチネルノードナビゲーション手術の長期予後2021

    • Author(s)
      矢幡 秀昭, 川上 穣, 蜂須賀 一寿, 安武 伸子, 小玉 敬亮, 八木 裕史, 大神 達寛, 安永 昌史, 小野山 一郎, 奥川 馨, 淺野間 和夫, 加藤 聖子
    • Organizer
      第59回日本癌治療学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 論文不正について2021

    • Author(s)
      加藤 聖子
    • Organizer
      第73回日本産科婦人科学会学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] International Session Poster 5 Cervical Cancer/CIN/SIL 3(Group 5); No adjuvant therapy for intermediate-risk group of cervical cancer after radical hysterectomy2019

    • Author(s)
      Yahata H, Inoue S, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Kato K
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] International Session Workshop 5 Oncology 2 Ovarian Cancer 1(Group 5); GEP oncogene induces epithelial-mesenchymal transition in ovarian cancer through LATS1 proteolysis2019

    • Author(s)
      Yahata H, Inoue S, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ohgami T, Onoyama I, Kaneki E, Okugawa K, Kato K
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] International Session Poster 30 Endometrial Cancer 2(Group 30); Mutual regulation between MIR301B-MIR130B and BHLHE40-BHLHE41 is involved in epithelial-to-mesenchymal transition of uterine endometrial cancer cells2019

    • Author(s)
      Asanoma K, Yagi H, Onoyama I, Sonoda K, Kato K
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] International Session Poster 31 Endometrial Cancer 3(Group 31); FRZB, Wnt inhibitor, functions as a tumor suppressor gene at early stage of carcinogenesis in endometrial cancer2019

    • Author(s)
      Onoyama I, Yasunaga M, Kodama K, Inoue S, Yamaguchi S, Yagi H , Ohgami T, Kaneki E, Okugawa K, Asanoma K, Yahata H, Kato K
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] International Session Poster 32 Cervical Cancer/CIN/SIL 4(Group 32); Retrospective evaluation of cervical laser vaporization for cervical intraepithelial neoplasia in our institution2019

    • Author(s)
      Kodama K, Kijima M , Inoue S, Yamaguchi S, Yagi H, Yasunaga M, Tatsuhiro , Onoyama I, Kaneki K, Okugawa K, Yahata H, Kato K
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] International Session Workshop 6 Oncology 3 Cervical Cancer/CIN/SIL2(Group 6); Safety evaluation of abdominal trachelectomy in patients with cervical cancer with tumors 2 cm:A single-institution, retrospective analysis2019

    • Author(s)
      Okugawa K, Inoue S, Kodama K, Yamaguchi S, Kenjo H, Yagi H, Ohgami T, Yasunaga M, Onoyama I, Kaneki E, Yahata H, Kato K
    • Organizer
      第71回日本産科婦人科学会学術講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 卵巣癌の進展におけるGα13シグナルの役割2019

    • Author(s)
      八木 裕史, 小玉 敬亮, 小野山 一郎, 淺野間 和夫, 加藤 聖子
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 女性の一生を診る2019

    • Author(s)
      加藤 聖子
    • Organizer
      第34回日本女性医学学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Is adjuvant therapy necessary for cervical cancer patients with intermediate risk factors after radical hysterectomy?2019

    • Author(s)
      Yahata H, Inoue S, Kijima M, Yamaguchi S, Yagi H, Yasunaga M, Ogami T, Onoyama I, Kaneki E, Okugawa K, Asanoma K, Kato K
    • Organizer
      The 26thAsia and Oceania Federation of Obstetrics and Gynaecology Congress (AOFOG)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] Molecular Diagnosis and Targeting for Gynecologic Malignancy2021

    • Author(s)
      Hiroshi Yagi, Kiyoko Kato
    • Total Pages
      165
    • Publisher
      Springer Nature
    • Related Report
      2021 Annual Research Report
  • [Book] 女性ヘルスケア2019

    • Author(s)
      加藤聖子、藤井知行
    • Total Pages
      384
    • Publisher
      中山書店
    • ISBN
      9784521747668
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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