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Intracellular function and new extracellular signaling pathways of CCN proteins and their common molecular base

Research Project

Project/Area Number 19H03817
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57010:Oral biological science-related
Research InstitutionOkayama University

Principal Investigator

Takigawa Masaharu  岡山大学, 医歯薬学域, 教授 (20112063)

Co-Investigator(Kenkyū-buntansha) 青山 絵理子  岡山大学, 医歯薬学域, 助教 (10432650)
星島 光博  岡山大学, 歯学部, 客員研究員 (30736567)
久保田 聡  岡山大学, 医歯薬学域, 教授 (90221936)
西田 崇  岡山大学, 医歯薬学域, 准教授 (30322233)
江口 傑徳  岡山大学, 医歯薬学域, 講師 (20457229)
大野 充昭  岡山大学, 医歯薬学域, 准教授 (60613156)
鈴木 守  大阪大学, 蛋白質研究所, 准教授 (40280507)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2021: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
KeywordsCCNタンパク質 / CCNファミリー / 軟骨細胞 / 結合分子 / 細胞外情報ネットワーク / 細胞外ベジクル / 細胞内機能 / イントラクリン / 核移行 / 軟骨 / 細胞外小胞 / 神経-筋接合部 / LRP4 / Rab14 / CCN2 / 神経栄養因子 / 結合因子 / エクソソーム / 立体構造
Outline of Research at the Start

CCNタンパク質(CCNs)は、再生医療の標的分子として期待されているが、その作用の分子基盤は未だ完全解明には至っていない。本研究では、細胞外分泌タンパク質とみなされていたCCNsが細胞内で新機能を果たすことと、CCNsが従来のタンパク質分泌機構に加え、細胞外小胞により結合分子と共に輸送され、標的細胞微小環境で協働作用するという新分泌~作用機構が存在することを証明する。また、上記の細胞内外機能を含めその多彩な作用は結合因子との協働作用であるとの仮説のもと、複数の結合分子との結合状態を解明すべく、代表分子CCN2の立体構造を解明してその分子基盤を確立し、それらの成果を臨床応用へ繋ぐ道を開く。

Outline of Final Research Achievements

In this study, we found the followings. (1) CCNs regulate differentiation of more various types of cells than the cell types previous known as CCN targets. In addition to the expanded repertoire of target cell types, CCN2 has, surprisingly, intracellular functions. CCN2 is associated with Rab14 on proteoglycan-containing vesicles during their transport from the Golgi apparatus to endosomes in chondrocytes. CCN2 is also transported into nuclei and acts as a transcriptional factor of alphaSMA gene, a maker of myofibroblasts. (2) In addition to autocrine/paracrine fashion, CCN proteins act through new signaling pathway: they are included into extracellular vesicles with various binding partners and transported to distant organs/tissues/cells, and then act together on target cells there. (3) To exert these new functions, CCNs also need to cooperate with specific binding factors. Determination of 3-dimensional structure of CCN-binding factor complex is ongoing toward medical application.

Academic Significance and Societal Importance of the Research Achievements

CCNタンパク質は細胞外に分泌されて細胞外マトリクス中で、細胞間を飛び交う様々な情報伝達物質に結合してそれらを貯留したり受容体への結合を介助することによりその多彩な作用を発揮するものと考えられ、いわば"シグナルコンダクター(指揮者)”であると定義されてきた。しかし、今回、その局在が細胞外ベジクルや細胞内にも拡がりその多彩な作用の範囲もさらに拡がり、CCNタンパク質自体を新たな分子群として再定義する必要がでてきたことの学術的意義は極めて大きい。また、このような従来なかった作用機構を有する新分子群は、新たな発想に基ずく革新的な医学応用に繋がる可能性を秘めておりその社会的意義も大きい。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (139 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (6 results) Journal Article (46 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 45 results,  Open Access: 23 results) Presentation (81 results) (of which Int'l Joint Research: 3 results,  Invited: 3 results) Book (2 results) Remarks (4 results)

  • [Int'l Joint Research] International CCN Society/University of Western Brittany(フランス)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Ain Shams University(エジプト)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Peking University(中国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] UCLA(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] International CCN Society(フランス)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] ハーバード大学/UCLA(米国)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] CCN Proteins (Cellular Communication Network Factors): Expanding Their Repertoire Toward a New Concept2023

    • Author(s)
      Takigawa Masaharu
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 1-10

    • DOI

      10.1007/978-1-0716-2744-0_1

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular fluorescence imaging for the evaluation of bioactivity of CCN family proteins2023

    • Author(s)
      Kawaki H, Kubota S, Takigawa M
    • Journal Title

      Methods of Molecular Biology

      Volume: 2582 Pages: 23-29

    • DOI

      10.1007/978-1-0716-2744-0_3

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocols for screening peptides binding to CCN family proteins and their extended utility2023

    • Author(s)
      Kubota S, Kawaki H, Takigawa M
    • Journal Title

      Methods of Molecular Biology

      Volume: 2582 Pages: 87-101

    • DOI

      10.1007/978-1-0716-2744-0_8

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of the Posttranscriptional Regulation of CCN Genes: Approach to Multiple Steps of CCN2 Gene Expression2023

    • Author(s)
      Kondo Seiji、Kubota Satoshi、Takigawa Masaharu
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 127-155

    • DOI

      10.1007/978-1-0716-2744-0_10

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Utilizing Public Molecular Biological Databases for CCN Family Research2023

    • Author(s)
      Kubota Satoshi
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 169-187

    • DOI

      10.1007/978-1-0716-2744-0_12

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression analysis of CCNs along with odontoblastic differentiation in vivo.2023

    • Author(s)
      Kawata K, Kubota S.
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 281-291

    • DOI

      10.1007/978-1-0716-2744-0_19

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mouse Models of Tumor Bone Metastasis and Invasion for Studying CCN Proteins.2023

    • Author(s)
      Shimo T, Okui T, Horie N, Yokozeki K, Takigawa M, Sasaki A.
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 343-353

    • DOI

      10.1007/978-1-0716-2744-0_24

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mouse Models of Tumor Bone Metastasis and Invasion for Studying CCN Proteins.2023

    • Author(s)
      Shimo T, Shimatani M, Tanimura A, Takigawa M.
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 295-308

    • DOI

      10.1007/978-1-0716-2744-0_20

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protocol for CRISPR/Cas Genome Editing for Investigating Cell Communication Network.2023

    • Author(s)
      Okusha Y, Eguchi T.
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 157-167

    • DOI

      10.1007/978-1-0716-2744-0_11

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Western Blot Protocols for Analysis of CCN Proteins and Fragments in Exosomes, Vesicle-Free Fractions, and Cells2023

    • Author(s)
      Ono Kisho、Okusha Yuka、Tran Manh Tien、Umemori Koki、Eguchi Takanori
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 39-57

    • DOI

      10.1007/978-1-0716-2744-0_5

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Do not overwork: cellular communication network factor 3 for life in cartilage2023

    • Author(s)
      Kubota Satoshi、Kawaki Harumi、Perbal Bernard、Takigawa Masaharu、Kawata Kazumi、Hattori Takako、Nishida Takashi
    • Journal Title

      Journal of Cell Communication and Signaling

      Volume: - Issue: 2 Pages: 353-359

    • DOI

      10.1007/s12079-023-00723-4

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elevated Expression of CCN3 in Articular Cartilage Induces Osteoarthritis in Hip Joints Irrespective of Age and Weight Bearing2022

    • Author(s)
      Hirose Kazuki、Kuwahara Miho、Nakata Eiji、Tetsunaga Tomonori、Yamada Kazuki、Saiga Kenta、Takigawa Masaharu、Ozaki Toshifumi、Kubota Satoshi、Hattori Takako
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 23 Pages: 15311-15311

    • DOI

      10.3390/ijms232315311

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Imaging of Molecular Interaction Between CCN Protein and Its Binding Partners: An In Situ Proximity Ligation Assay of Interaction Between CCN2 and Rab14 in Chondrocytes2022

    • Author(s)
      Hoshijima Mitsuhiro、Aoyama Eriko、Kamioka Hiroshi、Takigawa Masaharu
    • Journal Title

      Methods in Molecular Biology

      Volume: 2582 Pages: 31-37

    • DOI

      10.1007/978-1-0716-2744-0_4

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Molecular Interaction Between CCN Protein and Its Binding Partners: A Solid-Phase Binding Assay and Surface Plasmon Resonance2022

    • Author(s)
      Aoyama Eriko、Takigawa Masaharu
    • Journal Title

      Methods in Molecular Biology

      Volume: 2582 Pages: 77-86

    • DOI

      10.1007/978-1-0716-2744-0_7

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Evaluation of Meniscus Regenerative Effects of LIPUS-Induced CCN Proteins: Induction by LIPUS of CCN2 and Meniscus-Related Genes in Cultured Meniscus Cells and Meniscus Tissues2022

    • Author(s)
      Kamatsuki Yusuke、Aoyama Eriko、Furumatsu Takayuki、Ozaki Toshifumi、Takigawa Masaharu
    • Journal Title

      Methods in Molecular Biology

      Volume: 2582 Pages: 223-235

    • DOI

      10.1007/978-1-0716-2744-0_15

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Cell Biological Assays for Measuring Bone Remodeling Activities of CCN Proteins2022

    • Author(s)
      Nishida Takashi、Kubota Satoshi、Takigawa Masaharu
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 255-268

    • DOI

      10.1007/978-1-0716-2744-0_17

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Transfection, Spinfection, Exofection, and Luciferase Assays for Analysis of CCN Genes Expression Mechanism2022

    • Author(s)
      Eguchi Takanori、Lu Yanyin、Taha Eman A.、Okusha Yuka
    • Journal Title

      Methods Mol Biol.

      Volume: 2582 Pages: 103-126

    • DOI

      10.1007/978-1-0716-2744-0_9

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comprehensive Method for Exosome Isolation and Proteome Analysis for Detection of CCN Factors in/on Exosomes2022

    • Author(s)
      Eguchi Takanori、Okusha Yuka、Lu Yanyin、Ono Kisho、Taha Eman A.、Fukuoka Shiro
    • Journal Title

      Methods in Molecular Biology

      Volume: 2582 Pages: 59-76

    • DOI

      10.1007/978-1-0716-2744-0_6

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] CCN Proteins: Cellular Communication Network Factors:Expanding their repertoire toward a new concept2022

    • Author(s)
      Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Cellular Fluorescence Imaging for The Evaluation of Bioactivity of CCN Family Proteins2022

    • Author(s)
      Harumi Kawaki, Satoshi Kubota, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Imaging of Molecular Interaction between CCN Protein and Its Binding Partners: An In Situ Proximity Ligation Assay of Interaction Between CCN2 and Rab14 in Chondrocytes2022

    • Author(s)
      Mitsuhiro Hoshijima, Eriko Aoyama, Hiroshi Kamioka, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Molecular Interaction between CCN Protein and Its Binding Partners: A Solid-Phase Binding Assay and Surface Plasmon Resonance2022

    • Author(s)
      Eriko Aoyama and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protocols for Screening Peptides Binding to CCN Family Proteins and their Extended Utility2022

    • Author(s)
      Satoshi Kubota, Harumi Kawaki and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analyses of the Post-transcriptional Regulation of CCN Genes-Approach to Multiple Steps of ccn2 Gene Expression-2022

    • Author(s)
      Seiji Kondo, Satoshi Kubota, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Evaluation of Meniscus Regenerative Effects of LIPUS-Induced CCN Proteins: Induction By LIPUS Of CCN2 and Meniscus-Related Genes in Cultured Meniscus Cells and Meniscus Tissues.2022

    • Author(s)
      Yusuke Kamatsuki, Eriko Aoyama, Takayuki Furumatsu, Toshifumi Ozaki, and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel Cell Biological Assays for Measuring Bone Remodeling Activities of CCN Proteins2022

    • Author(s)
      Takashi Nishida, Satoshi Kubota and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiogenesis Assays for The Analysis of CCN Proteins2022

    • Author(s)
      Tsuyoshi Shimo, Mari Shimatani, Akihiko Tanimura and Masaharu Takigawa
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mouse models of tumor bone metastasis and invasion for the studying CCN proteins2022

    • Author(s)
      Tsuyoshi Shimo, Tatsuo Okui, Naohiro Horie, Kenji Yokozeki, Masaharu Takigawa and Akira Sasaki
    • Journal Title

      Methods in Molecular Biology

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cellular communication network factor 3 in cartilage development and maintenance2021

    • Author(s)
      Kubota Satoshi、Kawaki Harumi、Perbal Bernard、Kawata Kazumi、Hattori Takako、Nishida Takashi
    • Journal Title

      Journal of Cell Communication and Signaling

      Volume: 15 Issue: 4 Pages: 533-543

    • DOI

      10.1007/s12079-021-00629-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of cellular communication network factor 2/connective tissue growth factor on tube formation by endothelial cells derived from human periodontal ligaments.2021

    • Author(s)
      Hiroko Takeuchi-Igarashi, Toshiaki Tachibana, Etsuko Murakashi, Satoshi Kubota, Yukihiro Numabe
    • Journal Title

      Archives of Oral Biology

      Volume: 132 Pages: 105279-105279

    • DOI

      10.1016/j.archoralbio.2021.105279

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RFX1‐mediated CCN3 induction that may support chondrocyte survival under starved conditions2021

    • Author(s)
      Mizukawa Tomomi、Nishida Takashi、Akashi Sho、Kawata Kazumi、Kikuchi Sumire、Kawaki Harumi、Takigawa Masaharu、Kamioka Hiroshi、Kubota Satoshi
    • Journal Title

      Journal of Cellular Physiology

      Volume: in press Issue: 10 Pages: 6884-6896

    • DOI

      10.1002/jcp.30348

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Angiotensin II on Chondrocyte Degeneration and Protection via Differential Usage of Angiotensin II Receptors2021

    • Author(s)
      Nishida Takashi、Akashi Sho、Takigawa Masaharu、Kubota Satoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 17 Pages: 9204-9204

    • DOI

      10.3390/ijms22179204

    • NAID

      120007147372

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bipartite regulation of cellular communication network factor 2 and fibroblast growth factor 1 genes by fibroblast growth factor 1 through histone deacetylase 1 and fork head box protein A12021

    • Author(s)
      Elseoudi Abdellatif、Nishida Takashi、Mizukawa Tomomi、Hattori Takako、Kawata Kazumi、Taha Eman A.、Takigawa Masaharu、Kubota Satoshi
    • Journal Title

      Journal of Cell Communication and Signaling

      Volume: 15 Issue: 1 Pages: 81-91

    • DOI

      10.1007/s12079-020-00600-4

    • NAID

      120007182886

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against Cancer.2020

    • Author(s)
      Okusha Y, Eguchi T, Tran MT, Sogawa C, Yoshida K, Itagaki M, Taha EA, Ono K, Aoyama E, Okamura H, Kozaki KI, Calderwood SK, Takigawa M, Okamoto K.
    • Journal Title

      Cancers (Basel).

      Volume: 12(4). Issue: 4 Pages: 881-881

    • DOI

      10.3390/cancers12040881

    • NAID

      120006860095

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Roles of Interaction between CCN2 and Rab14 in Aggrecan Production by Chondrocytes.2020

    • Author(s)
      Hoshijima M, Hattori T, Aoyama E, Nishida T, Kubota S, Kamioka H, Takigawa M.
    • Journal Title

      International Journal of Molecular

      Volume: 21 Issue: 8 Pages: 2769-2769

    • DOI

      10.3390/ijms21082769

    • NAID

      120006862789

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Triple knockdown of CDC37, HSP90-alpha, and HSP90-beta diminishes extracellular vesicles-driven malignancy events and macrophage M2 polarization in oral cancer.2020

    • Author(s)
      Ono K, Sogawa C, Kawai H, Tran MT, Taha EA, Lu Y, Oo MW, Okusha Y, Okamura H, Ibaragi S, Takigawa M, Kozaki K, Nagatsuka H, Sasaki A, Okamoto K, Calderwood SK, Eguchi T
    • Journal Title

      J Extracell Vesicles

      Volume: in press Issue: 1 Pages: 1769373-1769373

    • DOI

      10.1080/20013078.2020.1769373

    • NAID

      120006956812

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CTGF/CCN2 facilitates LRP4‐mediated formation of the embryonic neuromuscular junction2020

    • Author(s)
      Ohkawara Bisei、Kobayakawa Akinori、Kanbara Shunsuke、Hattori Takako、Kubota Satoshi、Ito Mikako、Masuda Akio、Takigawa Masaharu、Lyons Karen M、Ishiguro Naoki、Ohno Kinji
    • Journal Title

      EMBO reports

      Volume: 21 Issue: 8

    • DOI

      10.15252/embr.201948462

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of cellular communication network factor 2 (CCN2) in breast cancer cells via the cell-type dependent interplay between CCN2 and glycolysis2020

    • Author(s)
      Sho Akashi, Takashi Nishida, Tomomi Mizukawa, Kazumi Kawata, Masaharu Takigawa, Seiji Iida, Satoshi Kubota
    • Journal Title

      J Oral Biosci .

      Volume: 62 Issue: 3 Pages: 280-288

    • DOI

      10.1016/j.job.2020.07.001

    • NAID

      120007147394

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CCN3 (NOV) Drives Degradative Changes in Aging Articular Cartilage2020

    • Author(s)
      Kuwahara Miho、Kadoya Koichi、Kondo Sei、Fu Shanqi、Miyake Yoshiko、Ogo Ayako、Ono Mitsuaki、Furumatsu Takayuki、Nakata Eiji、Sasaki Takako、Minagi Shogo、Takigawa Masaharu、Kubota Satoshi、Hattori Takako
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 20 Pages: 7556-7556

    • DOI

      10.3390/ijms21207556

    • NAID

      120006900771

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Suppression of adipocyte differentiation by low-intensity pulsed ultrasound via inhibition of insulin signaling and promotion of CCN family protein 22020

    • Author(s)
      Nishida T, Nagao Y, Hashitani S, Yamanaka N, Takigawa M, Kubota S
    • Journal Title

      Journal of Cellular Biochemistry

      Volume: - Issue: 12 Pages: 29680-29680

    • DOI

      10.1002/jcb.29680

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antiparkinson Drug Benztropine Suppresses Tumor Growth, Circulating Tumor Cells, and Metastasis by Acting on SLC6A3/DAT and Reducing STAT3.2020

    • Author(s)
      Sogawa C, Eguchi T, Tran MT, Ishige M, Trin K, Okusha Y, Taha EA, Lu Y, Kawai H, Sogawa N, Takigawa M, Calderwood SK, Okamoto K, Kozaki KI.
    • Journal Title

      Cancers (Basel).

      Volume: 12(2). Issue: 2 Pages: 523-523

    • DOI

      10.3390/cancers12020523

    • NAID

      120006840778

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Selective Agonists of Nuclear Retinoic Acid Receptor Gamma Inhibit Growth of HCS-2/8 Chondrosarcoma Cells2019

    • Author(s)
      W. P. Shield, 3rd, A. Cellini, H. Tian, K. Wilson, Y. Dan, J. M. Abzug, S. Garcia, N. Moritani, I. Alferiev, M. Chorny, M. Takigawa, V. Y. Ng, M. Iwamoto.M. Enomoto-Iwamoto.
    • Journal Title

      J Orthop Res

      Volume: - Issue: 5 Pages: 1045-1051

    • DOI

      10.1002/jor.24555

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Jiadifenolide induces the expression of cellular communication network factor (CCN) genes, and CCN2 exhibits neurotrophic activity in neuronal precursor cells derived from human induced pluripotent stem cells2019

    • Author(s)
      Shoji Masaki, Ueda Masako, Nishioka Megumi, Minato Hiroki, Seki Masahide, Harada Kenichiubo Miwa, Fukuyama Yoshiyasu, Suzuki Yutaka, Aoyama Eriko, Takigawa Masaharu, Kuzuhara Takashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 519 Issue: 2 Pages: 309-315

    • DOI

      10.1016/j.bbrc.2019.09.003

    • NAID

      120006842045

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of matricellular CCN2 deposited by osteocytes in osteoclastogenesis and osteoblast differentiation2019

    • Author(s)
      Nishida T, Kubota S, Yokoi H, Mukoyama M, Takigawa M
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 10913-10913

    • DOI

      10.1038/s41598-019-47285-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A reporter system evaluates tumorigenesis, metastasis, β-catenin/MMP regulation, and druggability.2019

    • Author(s)
      Sogawa C, Eguchi T, Okusha Y, Ono K, Ohyama K, Iizuka M, Kawasaki R, Hamada Y, Takigawa M, Sogawa N, Okamoto K, and Kozaki K.
    • Journal Title

      Tissue Engineering Part A

      Volume: in press Issue: 19-20 Pages: 1413-1425

    • DOI

      10.1089/ten.tea.2018.0348

    • NAID

      120006788780

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Possible reparative effect of low-intensity pulsed ultrasound (LIPUS) on injured meniscus.2019

    • Author(s)
      Kamatsuki, Y, Aoyama, E., Furimatsu, T., Miyazawa, S., Maehara, A., Yamanaka, N., Nishida, T., Kubota, S., Ozaki, T., Takigawa, M
    • Journal Title

      J. Cell Commun. Signal.

      Volume: 13 Issue: 2 Pages: 193-207

    • DOI

      10.1007/s12079-018-0496-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] S-アデノシルメチオニンは軟骨細胞のポリアミン合成および成長因子遺伝子発現を介して分化を促進する2023

    • Author(s)
      ホアンディン ロック、青山絵理子、日浅未来、表 弘志、久保田聡、窪木拓男、滝川正春
    • Organizer
      第35回日本軟骨代謝学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] CCN2とGDF5やそのレセプターとの結合が軟骨細胞へ及ぼす影響の検討2023

    • Author(s)
      東原直裕、青山絵理子、古松毅之、久保田聡、尾﨑敏文、滝川正春
    • Organizer
      第35回日本軟骨代謝学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 軟骨細胞におけるCCN2由来環状RNAの探索とその機能2023

    • Author(s)
      加藤壮真、河田かずみ、水川朋美、西田 崇、久保田聡
    • Organizer
      第35回日本軟骨代謝学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] CCN6のBMP2とRANKLとの結合を介したEMT及び破骨細胞形成に対する抑制作用2022

    • Author(s)
      芳地浩彰、西田 崇、滝川正春、久保田聡:
    • Organizer
      第40回日本骨代謝学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 変形性関節症とCCN3発現の相関2022

    • Author(s)
      廣瀬一樹、服部高子、桑原実穂、滝川正春、中田英二、鉄永智紀、山田和希、佐藤嘉洋、小浦 卓、尾崎敏文、久保田聡
    • Organizer
      第40回日本骨代謝学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] GDF5とCCN2との結合が軟骨細胞に及ぼす影響の検討2022

    • Author(s)
      東原直裕、青山絵理子、古松毅之、久保田聡、尾﨑敏文、滝川正春
    • Organizer
      第13回日本CCNファミリー研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] S-adenosylmethionine can promote polyamine production and growth factor genes expression thereby regulating chondrocytic differentiation2022

    • Author(s)
      Hoang Dinh, L., Aoyama, E., Hiasa, M, Omote, H., Kubota, S., Kuboki, T., Takigawa, M.
    • Organizer
      第13回日本CCNファミリー研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] メトホルミンの軟骨細胞におけるlong non-coding RNA, UCA1およびCCN2の発現制御と代謝における意義2022

    • Author(s)
      近藤 星、 服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺翔太、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第13回日本CCNファミリー研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 軟骨細胞におけるCCN2由来環状RNAの発現とその機能の探索2022

    • Author(s)
      加藤壮真、河田かずみ、西田 崇、水川朋美、飯田征二、久保田聡
    • Organizer
      第13回日本CCNファミリー研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 廣瀬一樹、服部高子、桑原実穂、滝川正春、久保田聡:CCN3の関節軟骨における発現は、年齢、荷重の有無に関わらず変形性関節症と相関する-股関節を用いた研究-2022

    • Author(s)
      廣瀬一樹、服部高子、桑原実穂、滝川正春、久保田聡
    • Organizer
      第13回日本CCNファミリー研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 口腔がん細胞の上皮間葉転換に与えるCCN6の抑制作用2022

    • Author(s)
      芳地浩彰、西田 崇、滝川正春、久保田聡
    • Organizer
      第13回日本CCNファミリー研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 線維化を制御するPU.1発現に対する核移行したCCN2の作用2022

    • Author(s)
      西田 崇、滝川正春、久保田聡
    • Organizer
      第64回 歯科基礎医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Intragellar transport protein 88による象牙芽前駆細胞増殖制御機構2022

    • Author(s)
      河田かずみ、青山絵理子、久保田聡
    • Organizer
      第64回 歯科基礎医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] CCN6はSmad1/5/8のリン酸化を阻害してBMP2促進性の口腔がん細胞の上皮間葉転換を抑制する2022

    • Author(s)
      芳地浩彰、西田 崇、滝川正春、久保田聡
    • Organizer
      第64回 歯科基礎医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] S-アデノシルメチオニンはポリアミン産生だけでなく増殖因子の遺伝子発現を促進することによって軟骨細胞分化を促進する2022

    • Author(s)
      ホアンディン ロック、青山絵理子、久保田聡、窪木拓男、滝川正春
    • Organizer
      第64回 歯科基礎医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 軟骨細胞におけるCCN2由来環状RNAの発現2022

    • Author(s)
      加藤壮真、河田かずみ、西田 崇、久保田聡
    • Organizer
      第64回 歯科基礎医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 線維化を制御するPU.1とCCN2発現に対するCCN2のイントラクリン作用2022

    • Author(s)
      西田 崇、滝川正春、久保田聡
    • Organizer
      第95回日本生化学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] C型レクチン受容体CD302による骨芽細胞の接着制御機構の解明2022

    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第95回日本生化学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 軟骨組織の加齢変性におけるCCN3の機能2022

    • Author(s)
      桑原実穂、近藤 星、Fu Shanqi、大野充昭、古松毅之、中田英二、滝川正春、服部高子、久保田聡
    • Organizer
      第95回日本生化学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] S-アデノシルメチオニンによるポリアミン産生および成長因子発現を介した軟骨細胞分化の制御2022

    • Author(s)
      Hoang, L., Aoyama, E., Hiasa, M., Omote, H., Kubota, S., Kuboki, T., Takigawa, M.
    • Organizer
      第95回日本生化学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] C型レクチン受容体CD302は骨芽細胞の接着および遊走における正も制御因子である2022

    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第45回日本分子生物学会 日本生物物理学会 共催
    • Related Report
      2022 Annual Research Report
  • [Presentation] 軟骨細胞におけるメトホルミンによるlong non-coding RNA, UCA1およびCCN2の発現制御2022

    • Author(s)
      近藤 星、 服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺翔太、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第45回日本分子生物学会 日本生物物理学会 共催
    • Related Report
      2022 Annual Research Report
  • [Presentation] 口腔がん細胞の上皮間葉転換に与えるCCN6とBMP2の作用2022

    • Author(s)
      芳地浩彰、西田 崇、滝川正春、久保田聡
    • Organizer
      第43回岡山歯学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 軟骨代謝研究の過去40年と将来展望2022

    • Author(s)
      滝川 正春
    • Organizer
      第34回日本軟骨代謝学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 軟骨細胞における転写因子RFX1を介したCCN3の発現制御機構とその役割2022

    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池菫、川木晴美、滝川正春、上岡寛、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 変形性股関節症とCCN3発現の相関2022

    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、久保田聡、尾崎敏文
    • Organizer
      第34回日本軟骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 軟骨細胞におけるGDF5とCCN2との結合の意義2022

    • Author(s)
      東原直裕、青山絵理子、古松毅之、久保田聡、尾崎敏文、滝川正春
    • Organizer
      第34回日本軟骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メトホルミンによる非コードRNA誘導と軟骨細胞分化促進作用2022

    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、薬師寺 翔太、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第34回日本軟骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 軟骨細胞におけるCCN2、CCN3とPDGFRLの生物学的作用におけるHippo pathwayの関与2021

    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メトホルミンの軟骨細胞におけるUCA1誘導をともなった分化促進作用2021

    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 骨芽細胞におけるCD302の発現と機能2021

    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メトホルミンのUCA1誘導および軟骨細胞分化促進作用2021

    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 軟骨細胞におけるRFX1を介したCCN3の発現制御機構の解明2021

    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] C型レクチン様受容体CD302の骨芽細胞における発現と機能2021

    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 変形性肩関節症とCCN3発現上昇の相関について2021

    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、久保田聡、尾崎敏文
    • Organizer
      第36回日本整形外科学会基礎学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CCN3は関節軟骨の加齢性変性を促進する2021

    • Author(s)
      桑原実穂、武内聡子、近藤 星、Fu Shanqi, 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
    • Organizer
      第39回日本骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 変形性肩関節症モデルとしてのCCN3過剰発現マウス2021

    • Author(s)
      廣瀬一樹、中田英二、服部高子、鉄永智紀、山田和希、佐藤嘉洋、桑原実穂、滝川正春、 久保田聡、尾崎敏文
    • Organizer
      第39回日本骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CCN6の破骨細胞形成における阻害作用2021

    • Author(s)
      西田 崇、芳地浩彰、青山絵理子、滝川正春、久保田聡
    • Organizer
      第39回日本骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] S-adenosylmethionine positively modulates differentiation in chondrocytes via polyamine biosynthesis2021

    • Author(s)
      Hoang Dinh, L., Aoyama, E., Kubota, S., Kuboki, T., Takigawa, M.
    • Organizer
      第39回日本骨代謝学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 軟骨細解糖阻害剤NaFの線維化抑制効果とCCNファミリー遺伝子の関与2021

    • Author(s)
      水川朋美、西田 崇、明石 翔、堀 彩花、高柴正悟、上岡 寛、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CCN2、CCN3とPDGFRLの軟骨細胞における生物学的作用へのHippo pathwayの関与2021

    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第62回日本生化学会 中国・四国支部例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Cellular Communication Network factor 6 (CCN6)のEMT 及び破骨細胞形成に対する抑制作用2021

    • Author(s)
      芳地浩彰、西田 崇、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 成体神経筋接合部でのCCNファミリーの役割2021

    • Author(s)
      大河原美静、服部高子、久保田聡、伊藤美佳子、増田章男、滝川正春、Karen M. Lyons、大野欽司
    • Organizer
      第12回日本CCNファミリー研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] メトホルミンの軟骨細胞分化促進作用におけるUCA1とCCN2の役割2021

    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Chondrocyte differentiation is positively regulated by S-adenosyl- methionine via polyamine biosynthesis2021

    • Author(s)
      Hoang Dinh, L., Aoyama, E., Kubota, S., Kuboki, T., Takigawa, M.
    • Organizer
      第12回日本CCNファミリー研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 軟骨細胞でのRFX1によるCCNファミリータンパク質3遺伝子制御メカニズム2021

    • Author(s)
      水川朋美、西田 崇、明石 翔、河田かずみ、菊池 菫、川木晴美、滝川正春、上岡 寛、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] CCN2、CCN3とPDGFRLの軟骨細胞への作用におけるHippo pathwayの関与2021

    • Author(s)
      河田かずみ、青山絵理子、滝川正春、久保田聡
    • Organizer
      第12回日本CCNファミリー研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] non-coding RNAを介したメトホルミンの抗線維化作用の解析2021

    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第75回日本口腔科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 軟骨細胞老化促進因子としてのCCN32021

    • Author(s)
      桑原実穂、武内聡子、近藤 星、Fu Shanqi, 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
    • Organizer
      第33回日本軟骨代謝学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 軟骨細胞における解糖系によるCCN3遺伝子発現制御メカニズム2021

    • Author(s)
      水川朋美、西田 崇、明石 翔、上岡 寛、滝川正春、久保田聡
    • Organizer
      第33回日本軟骨代謝学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Regulation of CCN3 gene expression by glycolytic activity in chondrocytes2020

    • Author(s)
      Mizukawa, T., Nishida, T., Akashi, S., Kamioka, H., Takigawa, M., Kubota, S.
    • Organizer
      The 9th International Orthodontic Congress (9th IOC)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mechanism of enhancement by S-adenosylmethionine (SAM) on chondrocyte proliferation and differentiation: possible involvement of polyamine synthesis2020

    • Author(s)
      Tanai, A., Aoyama, E., Kubota, S., Takigawa, M.
    • Organizer
      第61回日本生化学会 中国・四国支部例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 軟骨細胞での解糖活性によるCCN3遺伝子の発現調節2020

    • Author(s)
      水川朋美、西田 崇、明石 翔、掘 綾花、高柴正悟、上岡 寛、滝川正春、久保田聡
    • Organizer
      第61回日本生化学会 中国・四国支部例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] S-アデノシルメチオニンによるポリアミン合成促進を介した軟骨細胞の分化促進作用2020

    • Author(s)
      棚井あいり、青山絵理子、久保田聡、滝川正春
    • Organizer
      第52回日本結合組織学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effect of melatonin on rhythmic gene expression in human articular chondrocytes2020

    • Author(s)
      Fu, S., Kuwahara, M., Uchida, Y., Hyashi, D., Shimomura, Y., Takagaki, A., Nishida, T., Nakata, E., Furumatsu, T., Kondo, S., Maruyama, Y., Hattori, A., Kubota, S., Hattori, T.
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] CCN2の核移行による線維化の制御2020

    • Author(s)
      西田 崇、滝川正春、久保田聡
    • Organizer
      第62回歯科基礎医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] S-アデノシルメチオニンはポリアミン合成経路を介して軟骨細胞の増殖および基質合成を促進する2020

    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第62回歯科基礎医学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] フッ素イオンによるCCNファミリー遺伝子の制御を介した歯肉線維化抑制効果の検証2020

    • Author(s)
      水川朋美、西田 崇、上岡 寛、久保田聡
    • Organizer
      第79回日本矯正歯科学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 軟骨細胞におけるエネルギー代謝不全時でのCCN3増産システムの解明2020

    • Author(s)
      水川朋美、西田 崇、明石 翔、上岡 寛、滝川正春、久保田聡
    • Organizer
      第38回日本骨代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] LIPUSによる脂肪細胞分化の抑制と骨芽細胞分化への影響2020

    • Author(s)
      西田 崇、滝川正春、久保田聡
    • Organizer
      第38回日本骨代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effect of melatonin on rhythmic gene expression in human articular cartilage2020

    • Author(s)
      Fu, S., Kuwahara, M., Uchida, Y., Kondo, S., Hyashi, D., Shimomura, Y., Takagaki, A., Nishida, T., Maruyama, Y., Ikegami, M., Hattori, A., Kubota, S., Hattori, T.
    • Organizer
      第38回日本骨代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] non-coding RNAを介したメトホルミンの抗線維化作用の解析2020

    • Author(s)
      近藤 星、服部高子、桑原実穂、Fu Shanqi、西田 崇、吉岡洋祐、森谷徳文、飯田征二、滝川正春、久保田聡
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 軟骨組織におけるCCN3の老化促進作用2020

    • Author(s)
      桑原実穂、 近藤 星、Fu Shanqi、大野充昭、古松毅之、中田英二、皆木省吾、滝川正春、久保田聡、服部高子
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Role of CCN2 produced by osteocytes in bone remodeling2019

    • Author(s)
      Nishida, T., Kubota, S., Yokoi, H., Mukoyama, M., Takigawa, M.
    • Organizer
      The 10th International Workshop of CCN Family of Genes
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Long noncoding RNAs that regulate CCN22019

    • Author(s)
      Kubota, S., Ishikawa, T., Mizukawa, T., Kondo, S., El-Seoudi, A., Nishida, T., Hattori, T., Kawata, K., Furumatsu, T., Takarada, T., Ono, M., Takigawa, M.
    • Organizer
      The 10th International Workshop of CCN Family of Genes
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 低出力性パルス超音波(LIPUS)による脂肪細胞分化の抑制機構の解明2019

    • Author(s)
      西田 崇、長尾有里香、橋谷智子、山中信康、滝川正春、久保田聡
    • Organizer
      第11回日本CCNファミリー研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 癌抑制遺伝子PDGFRLはCCN2、CCN3による軟骨細胞増殖と分化の制御を抑制する2019

    • Author(s)
      河田かずみ、久保田聡、滝川正春
    • Organizer
      第11回日本CCNファミリー研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 破骨細胞に対する低周波超音波パルスの分化抑制作用とその機序の解明2019

    • Author(s)
      青山絵理子、久保田聡、山中信康、滝川正春
    • Organizer
      第11回日本CCNファミリー研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Tsukushiと脳疾患発症の連関2019

    • Author(s)
      太田訓正、青山絵理子、Shah Adil Ishtiyaq Ahmad、Mohammad Badrul Anam、伊藤尚文、久保田聡、滝川正春
    • Organizer
      第11回日本CCNファミリー研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低出力超音波パルス刺激による破骨細胞前駆細胞のアポトーシス誘導とそのメカニズム2019

    • Author(s)
      青山絵理子、久保田聡、山中信康、滝川正春
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低出力性パルス超音波(LIPUS)による脂肪細胞分化の多面的抑制機構2019

    • Author(s)
      西田 崇、長尾有里香、橋谷智子、山中信康、滝川正春、久保田聡
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 低出力パルス超音波(LIPUS)の半月板修復効果とその作用機序 -CCN2/CTGFの関与2019

    • Author(s)
      青山絵理子、久保田聡、滝川正春
    • Organizer
      第61回歯科基礎医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 脂肪細胞分化に対する低出力パルス超音波(LIPUS)の抑制メカニズムの解明2019

    • Author(s)
      橋谷智子、西田 崇、長尾有里香、滝川正春、久保田聡
    • Organizer
      第61回歯科基礎医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 癌抑制遺伝子PDGFRLはCCN2、CCN3のデコイ受容体として軟骨細胞増殖と分化を制御する2019

    • Author(s)
      河田かずみ、久保田聡、滝川正春
    • Organizer
      第37回日本骨代謝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Angiotensin IIによる軟骨変性作用とそのCCN2による制御機構2019

    • Author(s)
      西田 崇、滝川正春、久保田聡
    • Organizer
      第37回日本骨代謝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Circadian production of melatonin in cartilage infuluences chondrocyte rhythmic gene expression2019

    • Author(s)
      Fu, S., Kuwahara, M., Uchida, Y., Kondo, S., Nishida, T., Ikegame, M., Kubota, S., Hattori, T.
    • Organizer
      第37回日本骨代謝学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 軟骨細胞は加齢にともなってCCN3を高発現し、その過剰発現は軟骨加齢を促進する2019

    • Author(s)
      桑原実穂、武内聡子、近藤 星、Fu, S., 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
    • Organizer
      第42回日本分子生物学学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 軟骨細胞の分化過程におけるCCN2の発現変動の意義2019

    • Author(s)
      村瀬友里香、青山絵理子、鈴木康弘、佐々木朗、久保田聡、佐藤靖史、滝川正春
    • Organizer
      第42回日本分子生物学学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] CCN2、CCN3による軟骨細胞増殖と分化の制御を抑制する癌抑制遺伝子PDGFRL2019

    • Author(s)
      河田かずみ、久保田聡、滝川正春
    • Organizer
      第40回岡山歯学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] フッ素イオンによるCCNファミリー遺伝子の制御2019

    • Author(s)
      水川朋美、西田 崇、明石 翔、堀 彩花、高柴正悟、上岡 寛、滝川正春、久保田聡
    • Organizer
      第40回岡山歯学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] CCN3は軟骨細胞の加齢に伴い発現上昇し、過剰発現は軟骨加齢を促進する2019

    • Author(s)
      桑原実穂、武内聡子、近藤 星、Fu Shanqi, 大野充昭、古松毅之、中田英二、滝川正春、久保田聡、服部高子
    • Organizer
      第40回岡山歯学会
    • Related Report
      2019 Annual Research Report
  • [Book] CCN Proteins: Methods and Protocols, 2nd Edition2023

    • Author(s)
      Takigawa Masaharu
    • Total Pages
      430
    • Publisher
      Spriger-Nature
    • Related Report
      2022 Annual Research Report
  • [Book] CCN Proteins-Methods and Protocols, 2nd Edition2022

    • Author(s)
      Takigawa M
    • Publisher
      Springer-Nature
    • Related Report
      2021 Annual Research Report
  • [Remarks] 岡山大学歯学部先端領域研究センター

    • Related Report
      2022 Annual Research Report
  • [Remarks] 岡山大学歯学部先端領域研究センター ARCOCS

    • URL

      http://www.dent.okayama-u.ac.jp/arcocs/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 岡山大学歯学部 ARCOCS

    • URL

      http://www.dent.okayama-u.ac.jp/arcocs/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 岡山大学歯学部先端領域研究センター ARCOCS

    • URL

      http://www.dent.okayama-u.ac.jp/arcocs/

    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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