| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2020: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
We elucidated the molecular mechanism of the onset of palladium allergy. In vitro culture condition, we found that when antigen-presenting cells were added with a palladium solution, MHC class I expression was reduced and re-expressed on the antigen-presenting cells. It was also found that the antigenic peptide was changed in the process of expression reduction and recovery of MHC class I, and was replaced with a peptide that should not be normally expressed. Furthermore, it was clarified that allergic antigens are expressed and allergic T cells are activated by antigen-peptide substitution with palladium.
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