| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
DNA methylation, one of the regulatory mechanisms of epigenetic gene expression, plays important roles in various biological phenomena. In this study, we aimed to elucidate the DNA methylation mechanism that regulates osteoblast differentiation at the molecular level and to develop an innovative method to induce bone formation. We performed integrated analysis of DNA methylation and gene expression in various mesenchymal cells and identified DNA methylation genes that regulate osteoblast differentiation. In addition, we successfully screened for DNA methylation inhibitors that promote bone formation. This study would contribute to the development of novel technology for efficient bone regeneration targeting DNA methylation and its social implementation.
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