Comprehensive epidemiological study on the actual condition and natural history of non-alcoholic fatty liver disease
| Project/Area Number |
19H03886
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 58020:Hygiene and public health-related: including laboratory approach
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| Research Institution | Hiroshima University |
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Principal Investigator |
Tanaka Junko 広島大学, 医系科学研究科(医), 教授 (70155266)
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| Co-Investigator(Kenkyū-buntansha) |
杉山 文 広島大学, 医系科学研究科(医), 助教 (50778280)
秋田 智之 広島大学, 医系科学研究科(医), 講師 (80609925)
大久 真幸 広島大学, 医系科学研究科(医), 助教 (20727250)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 非アルコール性脂肪性肝疾患 / NAFLD / NASH / 大規模コホート研究 / 自然史 / 数理疫学的モデル / 血清疫学研究 / 医療ビッグデータ / FIB4-index / 飲酒 / 医療ビックデータ / NDB / NAFLD/NASH |
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| Outline of Research at the Start |
本研究では一般集団におけるNAFLDの実態と自然史の解明を目的とし、①広島県健診受診者集団（年間3-3.5万人/年：計15-17.5万人、2013～2018年）、② 岩手県健診受診者集団（年間1.8-2.2万人/年：計9-11万人、2013～2018年）を対象に、次の４つを明らかにする。
１）非アルコール性脂肪性肝疾患（NAFLD）の実態把握：「非アルコール性」の再定義を含む
２）一般集団におけるFIB4-indexの分布と肝線維化指標としての有用性評価
３）数理疫学的モデル（マルコフモデル）による脂肪性肝疾患の肝病態予測推移
４）NAFLD患者のうち、重篤な肝疾患へと進行するNASH患者数の推計
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| Outline of Final Research Achievements |
This study aimed to understand the epidemiology and natural history of NAFLD by analyzing a database of 75,670 individuals with data on alcohol consumption and ultrasonography results from a large-scale health screening data (2008-2019). The results revealed the following findings: 1) There were no significant differences in the prevalence and incidence of fatty liver among different categories of alcohol consumption. 2) The distribution of a scoring system for liver fibrosis, FIB4-index, in the general population was greatly influenced by age factors. 3) By utilizing a Markov model to predict the progression of liver diseases, it was estimated that the cumulative incidence of fatty liver by the age of 70, starting from a normal liver at the age of 40, was approximately 30% for both men and women, while the cumulative incidence of NASH was around 1%. Therefore, it was considered imperative to improve lifestyle habits among middle-aged individuals to reduce future disease burden.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、大規模一般集団のデータ解析により、飲酒は脂肪肝有病・罹患頻度に有意に関連せず、肥満が最も影響が大きい独立した因子であることを示した。近年飲酒量や他の肝疾患の有無は問わない包括的な疾患概念・定義として提唱されているMetabolic dysfunction-associated fatty liver Disease （MAFLD）はより実態に合っていると考えられた。また、FIB4-indexは簡便性という利点はあるものの、一般集団に対する一次スクリーニングとしての肝線維化評価には適さない可能性を指摘した。数理疫学モデルにより、一般集団における脂肪性肝疾患の病態推移予測を明らかにした。
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Report
(5 results)
Research Products
(12 results)
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[Journal Article] Distribution of FIB-4 index in the general population -Analysis of 75,666 residents who underwent health checkups-2022
Author(s)
Aya SUGIYAMA, Akemi KURISU, Bunthen E, Serge OUOBA, Ko KO, Anvarjon RAKHIMOV, Tomoyuki AKITA, Takayuki HARAKAWA, Toru SAKO, Makoto KOSHIYAMA, Takashi KUMADA, Junko Tanaka
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Journal Title
BMC Gastroenterology
Volume: in press
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationship between drinking frequency and fatty liver prevalence or incidence in Japanese undergoing health checkup in 2008-20192021
Author(s)
Aya Sugiyama, Akemi Kurisu, Serge Ouoba, Bunthen E 1, Ko Ko, Anvarjon Rakhimov, Md Razeen Ashraf Hussain, Tomoyuki Akita, Takayuki Harakawa, Toru Sako, Makoto Koshiyama, Junko Tanaka
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Journal Title
Liver International
Volume: 41
Issue: 12
Pages: 2914-2923
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Prevalence of fatty liver and advanced fibrosis by using ultrasonography and FibroScan in a random sample of general population2021
Author(s)
Aya Sugiyama, Yuko Nagaoki, Megumi Mino, Hiroomi Kodama, Kanon Abe, Hirohito Imada, Serge OUOBA, Bunthen E, Ko Ko, Tomoyuki Akita, Toru Sako, Kazuaki Chayama, Junko Tanaka
Organizer
American Association for the Study of Liver Disease The Liver Meeting 2021（AASLD）
Related Report
Int'l Joint Research
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[Presentation] The relationship between the frequency of drinking and incidence of fatty liver in Japanese cohort undergoing health checkups during the period 2008-20192021
Author(s)
Aya SUGIYAMA, Akemi KURISU, Serge OUOBA, Bunthen E, Ko KO, Anvarjon RAKHIMOV, Md Razeen Ashraf HUSSAIN, Tomoyuki AKITA, Takayuki HARAKAWA, Toru SAKO, Makoto KOSHIYAMA, Junko TANAKA
Organizer
European Association for the Study of the Liver (EASL) Digital NAFLD Summit 2021
Related Report
Int'l Joint Research
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