Epidemiological study of dementia related factors using metabolomics analysis in general Japanese men

• Project/Area Number: 19H03898
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Kadota Aya 滋賀医科大学, 医学部, 准教授 (60546068)
• Co-Investigator(Kenkyū-buntansha): 遠山 育夫 滋賀医科大学, 医学部, 理事 (20207533) ; 椎野 顯彦 滋賀医科大学, 神経難病研究センター, 准教授 (50215935) ; 三浦 克之 滋賀医科大学, 医学部, 教授 (90257452) ; 森野 勝太郎 滋賀医科大学, 医学部, 准教授 (90444447)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000); Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2019: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
• Keywords: 認知症 / 疫学研究 / メタボロミクス / メタボローム

Outline of Research at the Start

本申請課題はメタボロミクス分析を一般地域住民男性コホート研究で実施することにより、認知症の前段階である軽度の認知機能低下や脳体積萎縮に関与する代謝産物を網羅的に探索し、バイオマーカーを同定する。さらに、長期予後との関連を明らかにすることで、認知機能低下のメカニズム解明や予防法の提言を行う事を目的とする。より早期のスクリーニングや介入が可能となれば、本邦の認知症の一次予防に役立つ。

Outline of Final Research Achievements

This project is to identify metabolites associated with mild cognitive decline and brain volume atrophy, which are the pre-stages of dementia, in a general community male cohort study using metabolomics analysis, and to elucidate the mechanism of cognitive decline and preventive measures. We analyzed the relationships between the 442 metabolites in blood identified by metabolomics analysis and cognitive function and microcerebrovascular lesions evaluated by head MRI, and investigated the metabolic pathways involved in the pathology.
As a result, a statistically significant relationship was found between cognitive function and 51 metabolites, and in particular, they have a statistically significant relationship with short-term memory, verbal ability, and fluency. A statistically significant association was also observed between the number of microcerebrovascular lesions and 45 metabolites.

Academic Significance and Societal Importance of the Research Achievements

本研究により日本人一般地域住民男性において認知機能低下に関与する代謝物を明らかにする事ができた。また、認知機能に加えて、頭部MRI所見、頸動脈エコー所見と代謝物との関連分析を行った。これらの成果を合わせ、代謝物からみた認知機能低下のメカニズム解明、予防法に関する提言を行う。認知症患者ではなく、一般住民を対象とした認知機能と代謝物の検討は世界的に少ない。本研究の成果は、特に本邦の認知症の一次予防に役立つと考える。

Research Products

• [Journal Article] Relationship between Serum Irisin Levels and MRI-Measured Cerebral Small Vessel Disease in Japanese Men (2023)
  • Author(s): Moniruzzaman Mohammad、Kadota Aya、Hisamatsu Takashi、Segawa Hiroyoshi、Kondo Keiko、Torii Sayuki、Miyagawa Naoko、Fujiyoshi Akira、Yano Yuichiro、Watanabe Yoshiyuki、Shiino Akihiko、Nozaki Kazuhiko、Ueshima Hirotsugu、Miura Katsuyuki、on behalf of the SESSA Research Group
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Issue: 8 Pages: 1045-1056
  • DOI: 10.5551/jat.63824
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2023-08-01
  • Peer Reviewed
• [Journal Article] Differential Association of Serum n-3 Polyunsaturated Fatty Acids with Various Cerebrovascular Lesions in Japanese Men (2022)
  • Author(s): Kondo Keiko、Arima Hisatomi、Fujiyoshi Akira、Sekikawa Akira、Kadota Aya、Hisamatsu Takashi、Torii Sayuki、Shiino Akihiko、Morino Katsutaro、Miyagawa Naoko、Segawa Hiroyoshi、Watanabe Yoshiyuki、Maegawa Hiroshi、Nozaki Kazuhiko、Miura Katsuyuki、Ueshima Hirotsugu、for the SESSA Research Group
  • Journal Title: Cerebrovascular Diseases Volume: 51 Issue: 6 Pages: 774-780
  • DOI: 10.1159/000524243
  • Peer Reviewed
• [Journal Article] Alcohol drinking and brain morphometry in apparently healthy community-dwelling Japanese men (2021)
  • Author(s): Syaifullah AH, Shiino A, Fujiyoshi A, Kadota A, Kondo K, Ito T, Segawa H, Moniruzzaman M, Waki T, Miyagawa N, Tooyama I, Ueshima H, Miura K; SESSA Research Group.
  • Journal Title: Alcohol Volume: 90 Pages: 57-65
  • DOI: 10.1016/j.alcohol.2020.11.006
  • Peer Reviewed / Open Access
• [Journal Article] Seven-Day Pedometer-Assessed Step Counts and Brain Volume: A Population-Based Observational Study (2021)
  • Author(s): Moniruzzaman Mohammad、Kadota Aya、Shiino Akihiko、Fujiyoshi Akira、Ito Takahiro、Haidar Syaifullah Ali、Miyagawa Naoko、Kondo Keiko、Hisamatsu Takashi、Segawa Hiroyoshi、Tooyama Ikuo、Ueshima Hirotsugu、Miura Katsuyuki、_ _
  • Journal Title: Journal of Physical Activity and Health Volume: 18 Issue: 2 Pages: 157-164
  • DOI: 10.1123/jpah.2019-0659
  • Peer Reviewed