| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
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| Outline of Final Research Achievements |
To determine the contribution of the ‘efference copy’ of motor commands to motor control in normal conditions and during motor disorders, we aimed to establish techniques for recording and manipulating the ' efference copy' pathways in non-human primates. First, we attempted to inhibit the neural pathway transmitting 'efference copy' from the corticospinal tract to the lateral reticular nucleus with the chemogenetic tools but failed to show significant behavioural and electrophysiological changes. Therefore, we further recorded the neural activity in the motor-related areas that are the source of motor commands and conducted a detailed behavioural analysis using torque perturbation, which showed neural activity related to preparation for motor responses. These findings have promoted further research to clarify the cortico-cerebellar interaction and their function with regard to 'efference copy' for the preparation of motor responses.
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