• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Induction of low-frequency brain rhythms by static magnetic field exposure and changes in interconnectivity with related areas

Research Project

Project/Area Number 19H03977
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionHiroshima University

Principal Investigator

Kirimoto Hikari  広島大学, 医系科学研究科(保), 教授 (40406260)

Co-Investigator(Kenkyū-buntansha) 美馬 達哉  立命館大学, 先端総合学術研究科, 教授 (20324618)
渡邊 龍憲  広島大学, 医系科学研究科(保), 助教 (20868400)
緒方 勝也  国際医療福祉大学, 福岡薬学部, 教授 (50380613)
鈴木 誠  東京家政大学, 健康科学部, 教授 (80554302)
中川 慧  広島大学, 医系科学研究科(保), 助教 (10711070)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2021: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Keywords経頭蓋静磁場刺激 / 非侵襲的脳刺激 / リハビリテーション / 静磁場刺激 / 脳波 / 静磁場 / 脳律動 / 運動 / 感覚 / 背外側前頭前野 / ワーキングメモリ / 視覚認知課題 / 視空間認知
Outline of Research at the Start

近年,頭皮上にネオジム永久磁石を置くことにより,その静磁場が皮質の興奮性を抑制性に変化させる効果が認められようになった.この脳刺激法は,経頭蓋静磁場刺激(tSMS)と呼ばれ,新たなる非侵襲的脳刺激法として注目されている.本研究では健常被験者を対象とし,従来型の脳刺激法と比較して経済性,安全性,操作性において圧倒的に優れたtSMSの介入効果の安定性,及び刺激部位と関連のある領野との相互結合性(コネクティビティ)の変化の特性を明らかにする.

Outline of Final Research Achievements

Transcranial static magnetic field stimulation, like the preceding noninvasive brain stimulation (transcranial magnetic or current stimulation), has interventional effects not only on the primary sensorimotor cortex, but also on the supplementary motor cortex, the supramarginal gyrus, and the dorsolateral prefrontal cortex. I have confirmed that there is. In addition, it was clarified that there is a remote stimulus effect that affects the stimulus measurement and the excitability of the contralateral primary motor cortex. These results demonstrate that transcranial static magnetic field stimulation is an equivalent or partially superior tool to conventional noninvasive brain stimulation. In particular, static magnetic field stimulation, which is superior in terms of economy, safety, and operability compared to conventional brain stimulation methods, showed the possibility of becoming a useful noninvasive brain stimulation tool for home neurorehabilitation.

Academic Significance and Societal Importance of the Research Achievements

頭皮上にネオジム永久磁石を置くことにより,その静磁場が皮質の興奮性を抑制性に変化させる脳刺激法は,経頭蓋静磁場刺激と呼ばれている.2011年の最初の報告以来この10年間,tSMSは先行する非侵襲的脳刺激に加わるニューファミリーとしてのポジションを築いてきた.
本研究では,従来型の脳刺激法と比較して経済性,安全性,操作性において圧倒的に優れた静磁場刺激が,補足運動野,縁上回,背外側前頭前野などの広範囲な脳領域に対して介入効果を有することを明らかにした.静磁場刺激は将来的に在宅ニューロリハに有用な非侵襲的脳刺激ツールとなり得る可能性を示すことができたと考えている.

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (37 results)

All 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (13 results) (of which Int'l Joint Research: 6 results,  Peer Reviewed: 13 results,  Open Access: 13 results) Presentation (21 results) (of which Int'l Joint Research: 10 results,  Invited: 6 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] FENNSI Group/Hospital Nacional de Paraple’jicos/SESCAM(スペイン)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Event-related potentials evoked by skin puncture reflect activation of Aβ fibers: comparison with intraepidermal and transcutaneous electrical stimulations2021

    • Author(s)
      Shiroshita Yui、Kirimoto Hikari、Watanabe Tatsunori、Yunoki Keisuke、Sobue Ikuko
    • Journal Title

      PeerJ

      Volume: 9 Pages: e12250-e12250

    • DOI

      10.7717/peerj.12250

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Effect of Prior Knowledge of Color on Behavioral Responses and Event-Related Potentials During Go/No-go Task2021

    • Author(s)
      Kubo Nami、Watanabe Tatsunori、Chen Xiaoxiao、Matsumoto Takuya、Yunoki Keisuke、Kuwabara Takayuki、Kirimoto Hikari
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 1-11

    • DOI

      10.3389/fnhum.2021.674964

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transient Modulation of Working Memory Performance and Event-Related Potentials by Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex2021

    • Author(s)
      Chen Xiaoxiao、Watanabe Tatsunori、Kubo Nami、Yunoki Keisuke、Matsumoto Takuya、Kuwabara Takayuki、Sunagawa Toru、Date Shota、Mima Tatsuya、Kirimoto Hikari
    • Journal Title

      Brain Sciences

      Volume: 11 Issue: 6 Pages: 739-739

    • DOI

      10.3390/brainsci11060739

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of transcranial static magnetic stimulation over the primary motor cortex on local and network spontaneous electroencephalogram oscillations2021

    • Author(s)
      Shibata Sumiya、Watanabe Tatsunori、Yukawa Yoshihiro、Minakuchi Masatoshi、Shimomura Ryota、Ichimura Sachimori、Kirimoto Hikari、Mima Tatsuya
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1-7

    • DOI

      10.1038/s41598-021-87746-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Null Effect of Transcranial Static Magnetic Field Stimulation over the Dorsolateral Prefrontal Cortex on Behavioral Performance in a Go/NoGo Task2021

    • Author(s)
      Watanabe T, Kubo N, Chen X, Yunoki K,Matsumoto T, Kuwabara T, Sunagawa T, Date S, Mima T, Kirimoto H
    • Journal Title

      Brain Sciences

      Volume: 11(4) Issue: 4 Pages: 483-483

    • DOI

      10.3390/brainsci11040483

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Midfrontal theta as moderator between beta oscillations and precision control2021

    • Author(s)
      Watanabe Tatsunori、Mima Tatsuya、Shibata Sumiya、Kirimoto Hikari
    • Journal Title

      NeuroImage

      Volume: 235 Pages: 118022-118022

    • DOI

      10.1016/j.neuroimage.2021.118022

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Excitability of the Ipsilateral Primary Motor Cortex During Unilateral Goal-Directed Movement2021

    • Author(s)
      Matsumoto Takuya、Watanabe Tatsunori、Kuwabara Takayuki、Yunoki Keisuke、Chen Xiaoxiao、Kubo Nami、Kirimoto Hikari
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 1-10

    • DOI

      10.3389/fnhum.2021.617146

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Can Event-Related Potentials Evoked by Heel Lance Assess Pain Processing in Neonates? A Systematic Review2021

    • Author(s)
      Shiroshita Yui、Kirimoto Hikari、Ozawa Mio、Watanabe Tatsunori、Uematsu Hiroko、Yunoki Keisuke、Sobue Ikuko
    • Journal Title

      Children

      Volume: 8 Issue: 2 Pages: 58-58

    • DOI

      10.3390/children8020058

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of transcranial static magnetic fields stimulation over the supplementary motor area on anticipatory postural adjustments2020

    • Author(s)
      Daisuke Tsuru, Tatsunori Watanabea, Xiaoxiao Chen, Nami Kubo, Toru Sunagawa, Tatsuya Mima, Hikari Kirimoto
    • Journal Title

      Neuroscience Letters

      Volume: 723 Pages: 1-6

    • DOI

      10.1016/j.neulet.2020.134863

    • NAID

      120007002545

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of transcranial static magnetic stimulation on intracortical excitability in the contralateral primary motor cortex2020

    • Author(s)
      Sumiya Shibata, Tatsunori Watanabe, Yoshihiro Yukawa, Masatoshi Minakuchi, Ryota Shimomura, Tatsuya Mima
    • Journal Title

      Neuroscience Letters

      Volume: 723 Pages: 1-5

    • DOI

      10.1016/j.neulet.2020.134871

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnification of visual feedback modulates corticomuscular and intermuscular coherences differently in young and elderly adults2020

    • Author(s)
      Watanabe Tatsunori、Nojima Ippei、Mima Tatsuya、Sugiura Hideshi、Kirimoto Hikari
    • Journal Title

      NeuroImage

      Volume: 220 Pages: 117089-117089

    • DOI

      10.1016/j.neuroimage.2020.117089

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of static magnetic field stimulation on the accuracy of tachystoscopically presented line bisection.2020

    • Author(s)
      *Kirimoto, H., Watanabe, T., Kubo, N., Date, S., Sunagawa, T., Mima, T., Ogata, K., Nakazono, H., Tobimatsu, S., & Oliviero, A.
    • Journal Title

      Brain Sci.

      Volume: 10 Issue: 12 Pages: 1006-1006

    • DOI

      10.3390/brainsci10121006

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Change-Driven M100 Component in the Bilateral Secondary Somatosensory Cortex: A Magnetoencephalographic Study2018

    • Author(s)
      Yamashiro Koya、Sato Daisuke、Onishi Hideaki、Sugawara Kazuhiro、Otsuru Naofumi、Kirimoto Hikari、Nakazawa Sho、Yamazaki Yudai、Shirozu Hiroshi、Maruyama Atsuo
    • Journal Title

      Brain Topography

      Volume: 印刷中 Issue: 3 Pages: 435-444

    • DOI

      10.1007/s10548-018-0687-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Cutaneous stimulus registration and information processing differ during constant finger force and position2021

    • Author(s)
      Yunoki K, Watanabe T, Matsumoto T, Kuwabara T, Chen X, Ito K, Ishida H, Horinouchi T, Kirimoto H
    • Organizer
      The 2nd International Electronic Conference on Brain Sciences
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effect of piano playing experience on tapping synchronization to different sensory modalities2021

    • Author(s)
      Ito K, Watanabe T, Matsumoto T, Yunoki K, Chen X, Kubo N, Kuwabara T, Ishida H, Horinouchi T, Kirimoto H
    • Organizer
      The 2nd International Electronic Conference on Brain Sciences
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Repeated bout rate enhancement of finger tapping does not occur in musicians2021

    • Author(s)
      Ito K, Watanabe T, Yunoki K, Matsumoto T, Chen X, Kubo N, Kuwabara T, Ishida H, Horinouchi T, Kirimoto H
    • Organizer
      The 2nd International Electronic Conference on Brain Sciences
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンポジウム「脳疾患の作業療法と臨床神経生理」2021

    • Author(s)
      桐本 光(オーガナイザ)
    • Organizer
      第51回日本臨床神経生理学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 企画セミナ「神経生理学者がイタミに寄り添う時 」2021

    • Author(s)
      桐本 光(オーガナイザ)
    • Organizer
      第55回日本作業療法学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 静磁場暴露による脳機能の可塑的変化の誘導 ,シンポジウム 07 「脳科学のリハビリテーションへの応用」2021

    • Author(s)
      桐本 光
    • Organizer
      第23回日本薬物脳波学会・第37回日本脳電磁図トポグラフィ研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Transcranial static magnetic field stimulation over the supplementary motor area modulates function of anticipatory postural adjustments2020

    • Author(s)
      Kuwabara T, Watanabe T, Matsumoto T, Yunoki K, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      Federation of European neuroscience society
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Transcranial static magnetic stimulation over the temporal lobe induces plastic changes in the accuracy of tachystoscopically presented line bisection2020

    • Author(s)
      Yunoki K, Watanabe T, Matsumoto T, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      Federation of European neuroscience society
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of transcranial static magnetic field stimulation over the supplementary motor area on the function of anticipatory postural adjustments2020

    • Author(s)
      Kuwabara T, Watanabe T, Matsumoto T, Yunoki K, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      14th ICME International Conference on Complex Medical Engineering
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of transcranial static magnetic field stimulation on the accuracy of tachystoscopically presented line bisection2020

    • Author(s)
      Yunoki K, Watanabe T, Matsumoto T, Kuwabara T, Kubo N, Chen X, Mima T, Kirimoto H
    • Organizer
      14th ICME International Conference on Complex Medical Engineering
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 静磁場刺激の臨床応用への可能性 ,ワークショップ「経頭蓋電気刺激と脳深部刺激の現状と課題」2020

    • Author(s)
      桐本 光
    • Organizer
      日本臨床神経生理学会学術大会第50回記念大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 経頭蓋磁気刺激が運動前野または背外側前頭前野に及ぼす影響の検討2019

    • Author(s)
      久保南実,鶴大輔,陳瀟瀟,桐本光
    • Organizer
      第49回日本臨床神経生理学会(福島)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 補足運動野に対する経頭蓋静磁場刺激が先行随伴性姿勢調節に及ぼす影響2019

    • Author(s)
      鶴大輔,陳瀟瀟,久保南実,桐本光
    • Organizer
      第49回日本臨床神経生理学会(福島)
    • Related Report
      2019 Annual Research Report
  • [Presentation] The effect of transcranial static magnetic field stimulation over the premotor cortex or dorsolateral prefrontal cortex on reaction time2019

    • Author(s)
      Kubo N, Tsuru D, XiaoXiao Chin, Watanabe T, Mima T, Kirimoto H
    • Organizer
      National Oscillation Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The effects of transcranial static magnetic field stimulation over the supplementary motor area on the function of anticipatory postural adjustments2019

    • Author(s)
      Tsuru D, Kubo N, XiaoXiao Chin, Watanabe T, Mima T, Kirimoto H
    • Organizer
      National Oscillation Conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 運動前野または背外側前頭前野に対する経頭蓋静磁場刺激の介入効果を検討するための予備的研究2019

    • Author(s)
      久保南実,鶴大輔,陳瀟瀟,桐本光
    • Organizer
      第24回日本基礎理学療法学会学術大会(新潟)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 補足運動野に対する経頭蓋静磁場刺激が先行随伴性姿勢調節に及ぼす影響2019

    • Author(s)
      鶴大輔,陳瀟瀟,久保南実,桐本光
    • Organizer
      第24回日本基礎理学療法学会学術大会(新潟)
    • Related Report
      2019 Annual Research Report
  • [Presentation] 運動課題の目的の明確性の違いが同側一次運動野皮質内抑制機能およびそのラテラリティに及ぼす影響2019

    • Author(s)
      松本 卓也,桑原貴之,桐本 光
    • Organizer
      第24回日本基礎理学療法学会学術大会(新潟)
    • Related Report
      2019 Annual Research Report
  • [Presentation] シンポジウム 作業療法に関する応用研究の最先端2019

    • Author(s)
      桐本 光
    • Organizer
      第53回日本作業療法学会(博多)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 合同シンポジウム「ロボットリハビリテーションによる上肢機能障害への挑戦」静磁場暴露による半球間抑制のモジュレーション2019

    • Author(s)
      桐本 光,緒方勝也,美馬達哉
    • Organizer
      第3回日本リハビリテーション医学会 秋季学術集会(静岡)
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Influence of static magnetic field stimulation on the accuracy of tachystoscopically presented line bisection2019

    • Author(s)
      Kirimoto H, Mima T, Ogata K, Nakazono H, Tsuru D, Kubo N, Chin X, Tobimatsu S
    • Organizer
      Neuroscience, Chicago
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] 日本の作業療法発達史-萌芽期の軌跡を尋ねてー2021

    • Author(s)
      桐本 光他;矢谷玲子,福田恵美子,藤井浩美編
    • Total Pages
      372
    • Publisher
      CBR
    • ISBN
      9784908083587
    • Related Report
      2021 Annual Research Report
  • [Remarks] 広島大学大学院 医系科学研究院 感覚運動神経科学教室

    • URL

      https://sites.google.com/view/sensorimotor/%E3%83%9B%E3%83%BC%E3%83%A0?authuser=0

    • Related Report
      2020 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi