| Budget Amount *help |
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2023: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
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| Outline of Final Research Achievements |
Although an light-dark cycle (LD) is a primary zeitgerber for the circadian system, timed exercise could entrain circadian behavior rhythms under constant darkness (DD). In the present study, we investigate whether entrainment by scheduled exercise alters the internal temporal order of the behavioral circadian rhythms or clock gene expression in the central circadian pacemaker in the SCN, extra-SCN brains, and peripheral organs when mice are entrained to the scheduled exercise under DD as same as the mice uder entrained to an LD. We used adult male Per1-luc mice. The temporal order of behavioral circadian rhythms and the rhythms in the SCN and peripheral tissues but not in the arcuate nucleus were maintained in the mice entrained to the scheduled exercise and LD. The present findings reveal that the SCN entrains to daily exercise, and daily exercise reorganizes the internal temporal order of behavioral circadian rhythms and clock gene expression in the SCN and peripheral tissues.
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