• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Anti-arteriosclerotic effects of exercise in CKD: The role of calciprotein particle

Research Project

Project/Area Number 19H03995
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionWaseda University (2020-2021)
University of Tsukuba (2019)

Principal Investigator

Seiji Maeda  早稲田大学, スポーツ科学学術院, 教授 (30282346)

Co-Investigator(Kenkyū-buntansha) 小崎 恵生  筑波大学, 体育系, 助教 (10900293)
黒尾 誠  自治医科大学, 医学部, 教授 (10716864)
山縣 邦弘  筑波大学, 医学医療系, 教授 (90312850)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
KeywordsCalciprotein particle / 動脈硬化 / 運動療法 / 骨格筋指数 / リン代謝 / 慢性腎臓病 / 心血管機能 / 血中CPP / 身体機能 / 身体活動 / 運動 / 有酸素性運動 / カルシプロテイン粒子 / 有酸素性運動トレーニング / 筋力 / 筋量 / 圧受容器反射
Outline of Research at the Start

中高齢慢性腎臓病患者における実践的な動脈硬化の予防・改善策の確立は本邦おいて喫緊の課題である。しかし、これまでに慢性腎臓病特有の病態(尿毒症や骨ミネラル代謝異常など)を有する中高齢慢性腎臓病患者において、有酸素性運動が動脈硬化の進行抑制に有効であるかは十分に検討されておらず、そのメカニズムも十分に解明されていない。そこで、本研究では「中高齢慢性腎臓病患者において有酸素性運動は動脈硬化度を低下させるか?」および「その一部のメカニズムにカルシプロテイン粒子が関与するか?」 という本研究の核心をなす学術的「問い」を明らかにすることを目的とする。

Outline of Final Research Achievements

Calciprotein particles (CPPs) are tiny mineral protein aggregates consisting of calcium phosphate and fetuin-A. Recent studies suggest that CPPs may contribute to the pathogenesis of chronic inflammation and arteriosclerosis. We hypothesized that habitual exercise decreased circulating CPP levels and conducted the following two trials; protocol 1 was an observational study to explore factors associated with circulating CPP levels and protocol 2 was an interventional study to determine the effect of a 2-month exercise intervention on circulating CPP levels. In the observational study, the skeletal muscle mass index was negatively correlated with the circulating CPP levels. In the interventional study, a 2-month exercise intervention did not affect circulating CPP levels. Although this is the first study to examine the habitual exercise on circulating CPP levels, further investigations are needed to conclude whether habitual exercise affects circulating CPP levels.

Academic Significance and Societal Importance of the Research Achievements

わが国において、中高齢CKD患者における実践的な動脈硬化の予防・改善策の確立は喫緊の課題である。そこで我々は、定期的な運動実践が新しい動脈硬化進行因子であるCPPの血中濃度に及ぼす影響を検討する観察研究と介入研究をそれぞれ行った。その結果、中高齢者における骨格筋指数が血中CPP濃度の規定因子となる可能性が明らかになった。さらに、中高齢者を対象に2か月間の運動介入が血中CPP濃度に及ぼす影響を世界で初めて検討した。本研究の成果は、血中CPP濃度の上昇を抑制するための運動介入プログラム開発の契機となり、慢性腎臓病患者における心血管疾患の予防に大きく貢献する可能性がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (37 results)

All 2022 2021 2020 2019

All Journal Article (11 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 11 results,  Open Access: 4 results) Presentation (26 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Sedentary behavior and cardiometabolic disease: Experimental evidence and mechanisms2022

    • Author(s)
      Kosaki Keisei、Maeda Seiji、Oka Koichiro
    • Journal Title

      Japanese Journal of Physical Fitness and Sports Medicine

      Volume: 71 Issue: 1 Pages: 147-155

    • DOI

      10.7600/jspfsm.71.147

    • NAID

      130008141471

    • ISSN
      0039-906X, 1881-4751
    • Year and Date
      2022-02-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of circulating calciprotein particle levels with skeletal muscle mass and strength in middle-aged and older adults2022

    • Author(s)
      Yoshioka Masaki、Kosaki Keisei、Matsui Masahiro、Okabe Naoya、Saito Chie、Yamagata Kunihiro、Kuro-O Makoto、Maeda Seiji
    • Journal Title

      Hypertension Research

      Volume: 45 Issue: 5 Pages: 900-910

    • DOI

      10.1038/s41440-022-00870-y

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Physical Activity, Sedentary Behavior, And Skeletal Muscle Strength In Patients With Chronic Kidney Disease: An Isotemporal Substitution Approach2021

    • Author(s)
      Yoshioka Masaki、Kosaki Keisei、Matsui Masahiro、Takahashi Kanako、Shibata Ai、Oka Koichiro、Kuro-o Makoto、Saito Chie、Yamagata Kunihiro、Maeda Seiji
    • Journal Title

      Physical Therapy

      Volume: - Issue: 7

    • DOI

      10.1093/ptj/pzab101

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Renal hemodynamics across the adult lifespan: Relevance of flow pulsatility to chronic kidney disease2021

    • Author(s)
      Kosaki Keisei、Tarumi Takashi、Sugawara Jun、Tanahashi Koichiro、Kumagai Hiroshi、Matsui Masahiro、Sugaya Takeshi、Osuka Yosuke、Tanaka Kiyoji、Kuro-o Makoto、Saito Chie、Yamagata Kunihiro、Maeda Seiji
    • Journal Title

      Experimental Gerontology

      Volume: 152 Pages: 111459-111459

    • DOI

      10.1016/j.exger.2021.111459

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sedentary behavior and estimated nephron number in middle-aged and older adults with or without chronic kidney disease2021

    • Author(s)
      Kosaki Keisei、Takahashi Kanako、Matsui Masahiro、Yoshioka Masaki、Mori Shoya、Nishitani Natsumi、Shibata Ai、Saito Chie、Kuro-o Makoto、Yamagata Kunihiro、Oka Koichiro、Maeda Seiji
    • Journal Title

      Experimental Gerontology

      Volume: 154 Pages: 111531-111531

    • DOI

      10.1016/j.exger.2021.111531

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Replacing sedentary time for physical activity on bone density in patients with chronic kidney disease2021

    • Author(s)
      Yoshioka Masaki、Kosaki Keisei、Matsui Masahiro、Shibata Ai、Oka Koichiro、Kuro-o Makoto、Saito Chie、Yamagata Kunihiro、Maeda Seiji
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: 39 Issue: 6 Pages: 1091-1100

    • DOI

      10.1007/s00774-021-01255-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Circulating fibroblast growth factor 21 links hemodynamics with kidney function in middle-aged and older adults: A mediation analysis2021

    • Author(s)
      Matsui Masahiro、Kosaki Keisei、Kuro-o Makoto、Saito Chie、Yamagata Kunihiro、Maeda Seiji
    • Journal Title

      Hypertension Research

      Volume: 45 Issue: 1 Pages: 125-134

    • DOI

      10.1038/s41440-021-00782-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Sedentary behaviour, physical activity, and renal function in older adults: isotemporal substitution modelling2020

    • Author(s)
      Kosaki Keisei、Tanahashi Koichiro、Matsui Masahiro、Akazawa Nobuhiko、Osuka Yosuke、Tanaka Kiyoji、Dunstan David W.、Owen Neville、Shibata Ai、Oka Koichiro、Maeda Seiji
    • Journal Title

      BMC Nephrology

      Volume: 21 Issue: 1 Pages: 211-211

    • DOI

      10.1186/s12882-020-01869-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High Salt Diet Impacts the Risk of Sarcopenia Associated with Reduction of Skeletal Muscle Performance in the Japanese Population.2020

    • Author(s)
      Yoshida Y, Kosaki K, Sugasawa T, Matsui M, Yoshioka M, Aoki K, Kuji T, Mizuno R, Kuro-O M, Yamagata K, Maeda S, Takekoshi K.
    • Journal Title

      Nutrients

      Volume: 12 Issue: 11 Pages: 3474-3474

    • DOI

      10.3390/nu12113474

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between physical activity and circulating fibroblast growth factor 21 in middle-aged and older adults2020

    • Author(s)
      Matsui Masahiro、Kosaki Keisei、Tanahashi Koichiro、Akazawa Nobuhiko、Osuka Yosuke、Tanaka Kiyoji、Kuro-o Makoto、Maeda Seiji
    • Journal Title

      Experimental Gerontology

      Volume: 141 Pages: 111081-111081

    • DOI

      10.1016/j.exger.2020.111081

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Increased fibroblast growth factor-21 in chronic kidney disease is a trade-off between survival benefit and blood pressure dysregulation2019

    • Author(s)
      Nakano Toshihiro、Shiizaki Kazuhiro、Miura Yutaka、Matsui Masahiro、Kosaki Keisei、Mori Shoya、Yamagata Kunihiro、Maeda Seiji、Kishi Takuya、Usui Naoki、Yoshida Masahide、Onaka Tatsushi、Mizukami Hiroaki、Kaneda Ruri、Karasawa Kazunori、Nitta Kosaku、Kurosu Hiroshi、Kuro-o Makoto
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 19247-19247

    • DOI

      10.1038/s41598-019-55643-4

    • NAID

      120007132925

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Association between cardiorespiratory fitness and baroreflex sensitivity in middle-aged and older adults2021

    • Author(s)
      Shoya Mori, Takashi Tarumi, Keisei Kosaki, Masahiro Matsui, Masaki Yoshioka, Jun Sugawara, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Seiji Maeda
    • Organizer
      ACSM’s 68th Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Baroreflex Sensitivity Assessment: How Many Sit-Stand Maneuvers to Evaluate Cardiovascular Disease Risk?2021

    • Author(s)
      Shaya Mori, Takashi Tarumi, Keisei Kosaki, Masahiro Matsui, Masaki Yoshioka, Jun Sugawara, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Seiji Maeda
    • Organizer
      Experimental Biology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Circulating fibroblast growth factor 21, renal function, and aortic hemodynamics in middle-aged and older adults: a mediation analysis2021

    • Author(s)
      Masahiro Matsui, Keisei Kosaki, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Seiji Maeda
    • Organizer
      Experimental Biology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 保存期CKD患者の座位行動および身体活動と血中炎症性マーカーの関連性:Isotemporal substitution modelを用いた検討2021

    • Author(s)
      保田 梨沙, 小﨑 恵生, 松井 公宏, 吉岡 将輝, 柴田 愛, 斎藤 知栄, 黒尾 誠, 山縣 邦弘, 岡 浩一朗, 前田 清司
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中高齢者における下肢の筋力および機能と腎内血行動態の関連性2021

    • Author(s)
      西谷 菜津美, 小﨑 恵生, 松井 公宏, 吉岡 将輝, 森 翔也, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 中高齢CKD患者における座位行動および身体活動と男性更年期障害の関連性:Isotemporal substitution modelを用いた検討2021

    • Author(s)
      吉岡 将輝, 小﨑 恵生, 野間 駿太, 松井 公宏, 黒尾 誠, 柴田 愛, 斎藤 知栄, 山縣 邦弘, 岡 浩一朗, 前田 清司
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 一般成人における座位行動と脳血流変動の関連性2021

    • Author(s)
      森 翔也, 小﨑 恵生, 松井 公宏, 吉岡 将輝, 樽味 孝, 菅原 順, 柴田 愛, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 岡 浩一朗, 前田 清司
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 保存期CKD患者の身体活動および座位行動に関するエビデンス2021

    • Author(s)
      小﨑 恵生, 岡 浩一朗, 前田 清司
    • Organizer
      第11回日本腎臓リハビリテーション学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 慢性腎臓病患者における精神的健康度と身体機能の関連性2021

    • Author(s)
      松井 公宏, 小﨑 恵生, 吉岡 将輝, 森 翔也, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第11回日本腎臓リハビリテーション学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 保存期慢性腎臓病患者における強度別の身体活動量と生体電気インピーダンス法による位相角の関連性2021

    • Author(s)
      森 貴史, 小﨑 恵生, 松井 公宏, 吉岡 将輝, 黒尾 誠, 岡 浩一朗, 柴田 愛, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第11回日本腎臓リハビリテーション学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 中高齢者における身体の柔軟性と腎臓の機能および血行動態の関連性2021

    • Author(s)
      西谷 菜津美, 小﨑 恵生, 松井 公宏, 吉岡 将輝, 森 翔也, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第11回日本腎臓リハビリテーション学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 保存期慢性腎臓病男性における強度別の身体活動時間とAging Males' Symptomsスコアの関連性2021

    • Author(s)
      吉岡 将輝, 野間 駿太, 小﨑 恵生, 松井 公宏, 柴田 愛, 岡 浩一朗, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第22回日本健康支援学会年次学術大会・第8回日本介護予防・健康づくり学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 中高齢慢性腎臓病患者における身体活動量と血中炎症性マーカーの関連性2021

    • Author(s)
      保田 梨沙, 松井 公宏, 小﨑 恵生, 吉岡 将輝, 柴田 愛, 岡 浩一朗, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第22回日本健康支援学会年次学術大会・第8回日本介護予防・健康づくり学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 一般成人における有酸素性運動能力と腎臓の血流拍動性成分の関連性2021

    • Author(s)
      都甲 尚寛, 森 翔也, 小﨑 恵生, 松井 公宏, 樽味 孝, 菅原 順, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第22回日本健康支援学会年次学術大会・第8回日本介護予防・健康づくり学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Association between circulating FGF21 levels and physical activity in abdominal obese adults2020

    • Author(s)
      Masahiro Matsui, Keisei Kosaki, Koichiro Tanahashi, Nobuhiko Akazawa, Yosuke Osuka, Kiyoji Tanaka, Makoto Kuro-o, Seiji Maeda
    • Organizer
      ACSM’s 67th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sedentary behavior, physical activity and bone mineral density in CKD patients: An isotemporal substitution approach2020

    • Author(s)
      Masaki Yoshioka, Keisei Kosaki, Masahiro Matsui, Kanako Takahashi, Ai Shibata, Koichiro Oka, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Seiji Maeda
    • Organizer
      ACSM’s 67th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Sedentary behavior, physical activity, and baroreflex sensitivity in middle-aged and older adults2020

    • Author(s)
      Shoya Mori, Keisei Kosaki, Masahiro Matsui, Kanako Takahashi, Masaki Yoshioka, Takashi Tarumi, Jun Sugawara, Ai Shibata, Koichiro Oka, Makoto Kuro-o, Chie Saito, Kunihiro Yamagata, Seiji Maeda
    • Organizer
      ACSM’s 67th Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 一般成人における柔軟性と腎内血管抵抗指数の関連性2020

    • Author(s)
      西谷 菜津美, 小﨑 恵生, 松井 公宏, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 中高齢者慢性腎臓病患者における血中Cortisol/DHEAS比と骨格筋量指数の関連性2020

    • Author(s)
      森 貴史, 小﨑 恵生, 松井 公宏, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田清司
    • Organizer
      第7回日本サルコペニア・フレイル学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 高塩食によるサルコペニアのリスクの増加2020

    • Author(s)
      吉田 保子, 小﨑 恵生, 菅澤 威仁, 松井 公宏, 吉岡 将輝, 時野谷 勝幸, 黒尾 誠, 山縣 邦弘, 前田 清司, 竹越 一博
    • Organizer
      第7回日本サルコペニア・フレイル学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 中高齢者における血漿CPP値と筋力・筋量の関連性2019

    • Author(s)
      岡部 直哉, 小崎 恵生, 松井 公宏, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司.
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中高齢CKD患者における身体活動と身体機能の関連性2019

    • Author(s)
      吉岡 将輝, 小崎 恵生, 松井 公宏, 小崎 奏子, 柴田 愛, 岡 浩一朗, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中高齢CKD患者における身体機能と圧受容器反射感受性との関連性2019

    • Author(s)
      森 翔也, 小崎 恵生, 松井 公宏, 樽味 孝, 菅原 順, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 中高齢者における身体機能及びNephron indexの関連2019

    • Author(s)
      小崎 奏子, 小崎 恵生, 松井 公宏, 黒尾 誠, 斎藤 知栄, 山縣 邦弘, 前田 清司.
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Objectively-assessed sedentary behavior, physical activity, and renal function in Japanese middle-aged and older adults2019

    • Author(s)
      Keisei Kosaki, Koichiro Tanahashi, Masahiro Matsui, Nobuhiko Akazawa, Yosuke Osuka, Kiyoji Tanaka, David Dunstan, Neville Owen, Ai Shibata, Koichiro Oka, Seiji Maeda
    • Organizer
      2019 ASICS SMA Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between aerobic fitness and nephron index in middle-aged and older adults2019

    • Author(s)
      Kanako Takahashi, Keisei Kosaki, Koichiro Tanahashi, Yosuke Osuka, Kiyoji Tanaka, Makoto Kuro-o, Seiji Maeda.
    • Organizer
      2019 ASICS SMA Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi