Establishment of effective injury prevention programs for muscle strain

• Project/Area Number: 19H04005
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Juntendo University
• Principal Investigator: Miyamoto Naokazu 順天堂大学, スポーツ健康科学部, 先任准教授 (20420408)
• Co-Investigator(Kenkyū-buntansha): 福 典之 順天堂大学, スポーツ健康科学部, 先任准教授 (40392526)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2020: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000); Fiscal Year 2019: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 肉離れ / 骨格筋 / スティフネス / 予防 / 超音波 / エラストグラフィ / 筋膜 / 遺伝子多型 / 外傷予防 / 遺伝子 / 腱 / コラーゲン繊維 / 傷害予防

Outline of Research at the Start

スポーツの現場では様々な肉離れ予防策が実施されているが、肉離れ受傷を予防できていないのが現状である。これは、肉離れの受傷リスク因子が未解明であることが原因であると考えられる。そこで本研究では、「効果的な肉離れ予防の基本策」および「個々人の特徴に好適なカスタムメイド型予防策」を構築するための学術的基盤を創出することを目的とする。この目的を達成するために、まずは肉離れ好発部位における骨格筋や腱などの特徴を同定し、それらの特徴と肉離れ受傷との直接的関連性を検証することで「肉離れ受傷リスク因子」を解明する。また、その受傷リスク因子に影響を及ぼす遺伝要因を明らかにする。

Outline of Final Research Achievements

The purposes of the present study were to (A) elucidate the characteristics of muscles and sites prone to muscle strains, (B) examine the direct relationship between the characteristics of these prone sites and the occurrence of muscle strains, and (C) identify genetic polymorphisms that affect risk factors for muscle strain injuries. The results suggest that stiffness of the long head of the biceps femoris, assessed using ultrasound shear wave elastography, may be a risk factor for muscle strain injuries in the muscle.

Academic Significance and Societal Importance of the Research Achievements

従来、ハムストリングの筋力や柔軟性（関節可動域）が肉離れ受傷リスクとして評価・測定されているが、それらの評価ではなぜ大腿二頭筋に肉離れが好発するのか説明ができない。超音波剪断波エラストグラフィで個々の組織（筋）の特性を評価することによって、従来よりも高い精度で肉離れ受傷リスクを評価・検出できる可能性がある。

Research Products

• [Journal Article] Passive and active muscle elasticity of medial gastrocnemius is related to performance in sprinters (2022)
  • Author(s): Yamazaki Kazuhiko、Inoue Kakeru、Miyamoto Naokazu
  • Journal Title: European Journal of Applied Physiology Volume: 122 Issue: 2 Pages: 447-457
  • DOI: 10.1007/s00421-021-04848-5
  • Peer Reviewed
• [Journal Article] Passive Muscle Stiffness of Biceps Femoris is Acutely Reduced after Eccentric Knee Flexion (2022)
  • Author(s): Zhi Lei、Miyamoto Naokazu、Naito Hisashi
  • Journal Title: Journal of Sports Science and Medicine Volume: 21 Pages: 487-492
  • DOI: 10.52082/jssm.2022.487
  • Peer Reviewed
• [Journal Article] Site‐specific features of active muscle stiffness and proximal aponeurosis strain in biceps femoris long head (2021)
  • Author(s): Miyamoto Naokazu、Hirata Kosuke
  • Journal Title: Scandinavian Journal of Medicine & Science in Sports Volume: 31 Issue: 8 Pages: 1666-1673
  • DOI: 10.1111/sms.13973
  • Peer Reviewed
• [Journal Article] Characteristics of the Passive Muscle Stiffness of the Vastus Lateralis: A Feasibility Study to Assess Muscle Fibrosis (2021)
  • Author(s): Maeda A, Yamagishi M, Otsuka Y, Izumo T, Rogi T, Shibata H, Fukuda M, Arimitsu T, Yamada Y, Miyamoto N, Hashimoto T
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 18 Issue: 17 Pages: 8947-8947
  • DOI: 10.3390/ijerph18178947
  • Peer Reviewed / Open Access
• [Journal Article] No Association of Plantar Aponeurosis Stiffness with Medial Longitudinal Arch Stiffness (2021)
  • Author(s): Noro Hiroaki、Miyamoto Naokazu、Mitsukawa Naotoshi、Yanagiya Toshio
  • Journal Title: International Journal of Sports Medicine Volume: Online ahead of print Issue: 10 Pages: 945-949
  • DOI: 10.1055/a-1373-5734
  • Peer Reviewed
• [Journal Article] Female Athletes Genetically Susceptible to Fatigue Fracture Are Resistant to Muscle Injury (2021)
  • Author(s): Miyamoto-Mikami E, Kumagai H, Tanisawa K, Taga Y, Hirata K, Kikuchi N, Kamiya N, Kawakami R, Midorikawa T, Kawamura T, Kakigi R, Natsume T, Zempo H, Suzuki K, Kohmura Y, Mizuno K, Torii S, Sakamoto S, Oka K, Higuchi M, Naito H, Miyamoto N, Fuku N
  • Journal Title: Medicine & Science in Sports & Exercise Volume: Publish Ahead of Print Issue: 9 Pages: 0-0
  • DOI: 10.1249/mss.0000000000002658
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Association between medial gastrocnemius muscle-tendon unit architecture and ankle dorsiflexion range of motion with and without consideration of slack angle (2021)
  • Author(s): Hirata Kosuke、Kanehisa Hiroaki、Miyamoto Naokazu
  • Journal Title: PLOS ONE Volume: 16 Issue: 3 Pages: e0248125-e0248125
  • DOI: 10.1371/journal.pone.0248125
  • Peer Reviewed / Open Access
• [Journal Article] Non‐uniform distribution of passive muscle stiffness within hamstring (2020)
  • Author(s): Miyamoto Naokazu、Kimura Noriko、Hirata Kosuke
  • Journal Title: Scandinavian Journal of Medicine & Science in Sports Volume: 30 Issue: 9 Pages: 1729-1738
  • DOI: 10.1111/sms.13732
  • Peer Reviewed
• [Journal Article] eQTL variants in COL22A1 are associated with muscle injury in athletes (2020)
  • Author(s): Miyamoto-Mikami Eri、Kumagai Hiroshi、Kikuchi Naoki、Kamiya Nobuhiro、Miyamoto Naokazu、Fuku Noriyuki
  • Journal Title: Physiological Genomics Volume: 52 Issue: 12 Pages: 588-589
  • DOI: 10.1152/physiolgenomics.00115.2020
  • Peer Reviewed / Open Access
• [Journal Article] Moderate Associations of Muscle Elasticity of the Hamstring with Hip Joint Flexibility (2019)
  • Author(s): Miyamoto Naokazu、Hirata Kosuke
  • Journal Title: International Journal of Sports Medicine Volume: 40 Issue: 11 Pages: 717-724
  • DOI: 10.1055/a-0981-7282
  • Peer Reviewed
• [Remarks] 宮本直和研究室
  • URL: https://www.miyamotolab.net/