Comprehensive sports science research to elucidate the key to extending healthy life expectancy in the Japanese

• Project/Area Number: 19H04008
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: Waseda University
• Principal Investigator: Muraoka Isao 早稲田大学, スポーツ科学学術院, 名誉教授 (80112712)
• Co-Investigator(Kenkyū-buntansha): 岡 浩一朗 早稲田大学, スポーツ科学学術院, 教授 (00318817) ; 澤田 亨 早稲田大学, スポーツ科学学術院, 教授 (00642290)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000); Fiscal Year 2023: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: スポーツ科学 / メカニズム / 疫学 / 横断研究 / 健康寿命 / 座位行動 / コホート研究 / 因果推論 / スポーツ疫学

Outline of Research at the Start

疫学研究によって身体不活動、座りすぎ、低体力などの健康寿命の延伸を阻害するリスク因子が特定されているが、リスク因子の背後に存在しているメカニズムの多くは不明なままである。これは、疫学研究によってリスク因子が特定されてきたものの、これまでの疫学研究では複数のリスク因子を対象とした網羅的な研究がなされてこなかったことや、リスク因子に関する詳細な測定が実施されていないことが原因と考えられる。そこで、本研究はリスク因子に関する網羅的で詳細な測定を実施する疫学研究によって、健康寿命の延伸を阻害しているさまざまなリスク因子の影響度や背後に存在しているメカニズムを明らかにする。

Outline of Final Research Achievements

We found that a combination of low cardiorespiratory fitness, muscle strength, visceral fat, and lower leg circumference is related to type 2 diabetes, and that cardiorespiratory fitness and maximum walking speed are related to knee osteoarthritis and lifestyle-related diseases. We also clarified the relationship between latent bradycardia and lifestyle-related diseases and confirmed the possibility that coffee intake is a preventive factor for sarcopenia. In addition, the relationship between SMMI and FFMI was clarified, and the usefulness of SMMI as a screening index for sarcopenia was revealed. In addition, we identified factors that determine resting oxidative stress in middle-aged and elderly people through genetic analysis, and published research results on the need for gene-based analysis, such as clarifying the relationship between age estimation methods based on DNA methylation and cardiopulmonary fitness.

Academic Significance and Societal Importance of the Research Achievements

超高齢社会の日本において健康寿命の延伸は社会存続のための重要な課題である。現在、身体活動不足や座りすぎなどの健康寿命の延伸を阻害するリスク因子が数多く報告されているがそれぞれの研究が報告しているリスク因子はさまざまであり、それぞれのリスク因子の影響度や、その背後に存在しているメカニズムについて不明な点が多い。健康寿命を延伸させるためのエビデンスに基づいた健康政策を立案するためには、健康寿命の延伸を阻害する影響力のあるリスク因子や、組み合わせたリスク因子の影響、個々のリスク因子が影響を与える年代や性別を明らかにすることが課題であり、本研究はこの課題にたいしていくつかのエビデンスを提供した。

Research Products

• [Int'l Joint Research] Hungarian University of Sports Science(ハンガリー)
• [Int'l Joint Research] University of California Los Angeles(米国)
• [Journal Article] Associations between cardiorespiratory fitness and lifestyle‐related factors with <scp>DNA</scp> methylation‐based ageing clocks in older men: <scp>WASEDA</scp>'S Health Study (2023)
  • Author(s): Kawamura Takuji、Radak Zsolt、Tabata Hiroki、Nakamura Nobuhiro、Kawakami Ryoko・・・・Jokai Matyas、Torma Ferenc、Kim Hyeon‐Ki、Miyachi Motohiko、Torii Suguru、Suzuki Katsuhiko、Ishii Kaori、Sakamoto Shizuo、Oka Koichiro、Higuchi Mitsuru、Muraoka Isao、McGreevy Kristen M.、Horvath Steve、Tanisawa Kumpei
  • Journal Title: Aging Cell Volume: 23 Issue: 1
  • DOI: 10.1111/acel.13960
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Coffee consumption and skeletal muscle mass: WASEDA’S Health Study (2022)
  • Author(s): Kawakami Ryoko、Tanisawa Kumpei、Ito Tomoko、Usui Chiyoko、Ishii Kaori、Muraoka Isao、Suzuki Katsuhiko、Sakamoto Shizuo、Higuchi Mitsuru、Oka Koichiro
  • Journal Title: British Journal of Nutrition Volume: - Issue: 1 Pages: 1-10
  • DOI: 10.1017/s0007114522003099
  • Peer Reviewed / Open Access
• [Journal Article] Fat-Free Mass Index as a Surrogate Marker of Appendicular Skeletal Muscle Mass Index for Low Muscle Mass Screening in Sarcopenia (2022)
  • Author(s): Kawakami Ryoko、Tanisawa Kumpei、Ito Tomoko、Usui Chiyoko、Miyachi Motohiko、Torii Suguru、Midorikawa Taishi、Ishii Kaori、Muraoka Isao、Suzuki Katsuhiko、Sakamoto Shizuo、Higuchi Mitsuru、Oka Koichiro
  • Journal Title: Journal of the American Medical Directors Association Volume: 23 Issue: 12 Pages: 1955-1961
  • DOI: 10.1016/j.jamda.2022.08.016
  • Peer Reviewed / Open Access
• [Journal Article] The combination of cardiorespiratory fitness and muscular fitness, and prevalence of diabetes mellitus in middle-aged and older men: WASEDA'S Health Study (2022)
  • Author(s): Wang D, Sawada SS, Tabata H, Kawakami R, Ito T, Tanisawa K, Higuchi M, Ishii K, Oka K, Suzuki K, Sakamoto S
  • Journal Title: BMC Public Health Volume: 22(1) Issue: 1 Pages: 626-626
  • DOI: 10.1186/s12889-022-12971-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Determinants of Resting Oxidative Stress in Middle-Aged and Elderly Men and Women: WASEDA'S Health Study (2021)
  • Author(s): Kawamura T, Tanisawa K, Kawakami R, Usui C, Ito T, Tabata H, Nakamura N, Kurosawa S, Choi W, Ma S, Radak Z, Sawada SS, Suzuki K, Ishii K, Sakamoto S, Oka K, Higuchi M, Muraoka I
  • Journal Title: Oxid Med Cell Longev Volume: - Issue: 1 Pages: 5566880-5566880
  • DOI: 10.1155/2021/5566880
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cut‐offs for calf circumference as a screening tool for low muscle mass: WASEDA'S Health Study (2020)
  • Author(s): Kawakami Ryoko、Miyachi Motohiko、Sawada Susumu S.、Torii Suguru、Midorikawa Taishi、Tanisawa Kumpei、Ito Tomoko、Usui Chiyoko、Ishii Kaori、Suzuki Katsuhiko、Sakamoto Shizuo、Higuchi Mitsuru、Muraoka Isao、Oka Koichiro
  • Journal Title: Geriatrics & Gerontology International Volume: 20 Issue: 10 Pages: 943-950
  • DOI: 10.1111/ggi.14025
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Visceral fat and cardiorespiratory fitness with prevalence of pre-diabetes/diabetes mellitus among middle-aged and elderly Japanese people: WASEDA’S Health Study (2020)
  • Author(s): Usui Chiyoko、Kawakami Ryoko、Tanisawa Kumpei、Ito Tomoko、Tabata Hiroki、Iizuka Satoshi、Kawamura Takuji、Midorikawa Taishi、Sawada Susumu S.、Torii Suguru、Sakamoto Shizuo、Suzuki Katsuhiko、Ishii Kaori、Oka Koichiro、Muraoka Isao、Higuchi Mitsuru
  • Journal Title: PLOS ONE Volume: 15 Issue: 10 Pages: 0241018-0241018
  • DOI: 10.1371/journal.pone.0241018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] 最大歩行速度と生活習慣病有病率の関係：横断研究－WASEDA’S Health Study－ (2020)
  • Author(s): 佐藤孝太朗、澤田亨、王棟、郡山さくら、田端宏樹、谷澤薫平、川上諒子、伊藤智子、薄井澄誉子、石井香織、鈴木克彦、樋口満、岡浩一朗、坂本静男
  • Organizer: 第39回日本臨床運動療法学会
• [Presentation] Walking speed and prevalence of lifestyle-related diseases in adults WASEDA'S Health Study (2020)
  • Author(s): Sato K, Sawada S , Wang D, Koriyama S, Tabata H, Tanisawa K, Kawakami R, Ito T, Usui C, Ishii K, Suzuki K, Higuchi M, Oka K, Sakamoto S
  • Organizer: 25th Anniversary Congress European College of Sport Science
  • Int'l Joint Research
• [Presentation] Cardiorespiratory fitness and muscle strength with the prevalence of diabetes: WASEDA’S Health Study (2020)
  • Author(s): Wang D, Sawada SS, Ito T, Gando Y, Fukushi T, Fujie R, Kurita S, Oka K, Sakamoto S, Higuchi M
  • Organizer: 67th American College of Sports Medicine Annual Meeting
  • Int'l Joint Research
• [Presentation] 全身持久力と下腿周の組合せと糖尿病有病率の関係：WASEDA'S Health Study (2020)
  • Author(s): 王棟、澤田亨、佐藤孝太郎、郡山さくら、田端宏樹３、谷澤薫平、川上諒子、石井香織、鈴木克彦、樋口満、岡浩一朗、坂本静男
  • Organizer: 第39回日本臨床運動療法学会
• [Presentation] Cardiorespiratory fitness and calf circumference with the prevalence of diabetes: WASEDA’S Health Study (2020)
  • Author(s): Wang D, Sawada S, Sato K, Koriyama S, Tabata H, Tanisawa K, Kawakami R, Suzuki K, Higuchi M, Ishii K, Oka K, Sakamoto S
  • Organizer: 25th Anniversary Congress European College of Sport Science
  • Int'l Joint Research
• [Presentation] Parasympathetic nervous regulation and prevalence of lifestyle-related diseases in Japanese: WASEDA'S Health Study. (2019)
  • Author(s): Konishi M, Sawada SS, Kawakami R, Tanisawa K, Tabata H, Nakamura N, Kim HK, Ito T, Higuchi M, Suzuki K, Torii S, Lee IM, Blair SN, Oka K, Sakamoto S.
  • Organizer: 66th ACSM annual meeting
• [Presentation] Cardiorespiratory fitness and prevalence of lifestyle-related diseases in Japanese men and women: WASEDA'S Health Study. (2019)
  • Author(s): Sawada SS, Kawakami R, Tanisawa K, Tabata H, Nakamura N, Kim HK, Konishi M, Ito T, Usui C, Midorikawa T, Higuchi M, Suzuki K, Torii S, Lee IM, Blair SN, Muraoka I, Ishii K, Oka K, Sakamoto S.
  • Organizer: 66th ACSM annual meeting
• [Presentation] Prevalence of knee osteoarthritis and cardiorespiratory fitness and in Japanese men and women: WASEDA'S Health Study. (2019)
  • Author(s): Iizuka S, Sawada SS, Kawakami R, Tanisawa K, Tabata H, Nakamura N, Kim HK, Konishi M, Ito T, Usui C, Midorikawa T, Higuchi M, Suzuki K, Sakamoto S, Ishii K, Oka K, Torii S.
  • Organizer: ECSS Congress Prague 2019
• [Presentation] 全身持久力と脚伸展パワーの組合せと糖尿病有病率の関係：WASEDA'S Health Study． (2019)
  • Author(s): 澤田亨、王棟、田端宏樹、谷澤薫平、川上諒子、石井香織、鈴木克彦、樋口満、岡浩一朗、坂本静男．
  • Organizer: 第74回日本体力医学会
• [Presentation] 中高年男女における最大脂質酸化量の規定要因の検討－WASEDA’S Health Study－． (2019)
  • Author(s): 田端宏樹、谷澤薫平、小西真幸、伊藤智子、川上諒子、薄井澄誉子、石井香織、緑川泰史、鳥居俊、澤田亨、鈴木克彦、岡浩一朗、樋口満、坂本静男．
  • Organizer: 第74回日本体力医学会
• [Presentation] 日本人中高齢者における全身持久力および内臓脂肪と糖尿病有病率の関係：WASEDA’S Health Study． (2019)
  • Author(s): 薄井澄誉子、川上諒子、谷澤薫平、田端宏樹、伊藤智子、飯塚哲司、河村拓史、緑川泰史、澤田亨、鳥居俊、坂本静男、鈴木克彦、石井香織、岡浩一朗、樋口満．
  • Organizer: 第74回日本体力医学会
• [Remarks] 早稲田大学校友を対象とした健康づくり研究 WASEDA'S Health Study
  • URL: https://wasedas-health-study.jp/survey/
• [Remarks] WASEDA'S Health Study
  • URL: https://wasedaalumni.jp/value/wasedas-health-study.html
• [Remarks] スポーツ疫学研究室
  • URL: https://sites.google.com/site/sssawadalab/
• [Remarks] 早稲田大学校友を対象とした健康づくり研究 WASEDA'S Health Stduy
  • URL: https://wasedas-health-study.jp/survey/
• [Remarks] 早稲田大学校友を対象とした健康づくり研究
  • URL: http://www.waseda.jp/prj-whs/index.html