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Development of a prediction system of systemic disease using AI technology based on oral flora.

Research Project

Project/Area Number 19H04032
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionShimane University

Principal Investigator

WADA Koichiro  島根大学, 学術研究院医学・看護学系, 教授 (90263467)

Co-Investigator(Kenkyū-buntansha) 中島 淳  横浜市立大学, 医学研究科, 教授 (30326037)
梅村 和夫  浜松医科大学, 医学部, 教授 (40232912)
田中 徹也  中国学園大学, 公私立大学の部局等, 教授(移行) (10346380)
岡本 貴行  島根大学, 学術研究院医学・看護学系, 准教授 (30378286)
結束 貴臣  横浜市立大学, 附属病院, 助教 (30738620)
臼田 春樹  島根大学, 学術研究院医学・看護学系, 助教 (30707667)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2019: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords口腔内フローラ / 全身疾患 / Artificial Intelligence / 予測システム / 臨床薬理学 / 薬理学 / 臨床薬理 / Artificial Intelligence / 臨床薬理学的アプローチ / リスク予測
Outline of Research at the Start

近年、健全な口腔環境の維持が健康寿命に関わる要因として注目されており、高病原性の全身疾患誘発性口腔細菌の保菌は健康寿命を短くする要因の一つと考えられている。しかしながら従来型の「特定高病原性細菌のみを検出する方法」では、全身疾患発症を的確に予測するのは困難であった。そこで本研究では、これまで蓄積したデータや臨床データを用いて各種データの重み付けを行い、数値化されたデータをAI によって解析し、現在の健康状態や将来的な全身疾患発症リスクの予測を行うシステムを作製する。このシステムの効果的な運用法を確立し、口腔フローラを用いた全身疾患発症リスクの予測と発症予防法の確立を目指す研究である。

Outline of Final Research Achievements

It is strongly suggested that the importance of the oral environment may be related to healthy longevity, and it is considered that the carrier of oral bacteria that may develop systemic diseases is an important factor that shortens healthy life expectancy. Therefore, we tried to develop a "prediction system of the onset of various systemic diseases using AI technology based on the oral flora ". The system we created can predict the risk of developing the disease in the future due to the pattern of oral bacterial flora. In fact, we could predict the onset of a disease using this system, it was possible to predict the disease onset by establishing more than 80%.
In order to develop a more complete system in near future, further improvements will be required to increase the prediction probability of the onset of systemic diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は「口腔内フローラを指標とした全身疾患発症リスク予測システムの確立」であり、システムという「形」を作製することは社会に還元できる成果を残すという点から重要であると考えられる。さらにこのシステムを効果的に運用することにより将来の全身疾患発症リスクを予測し発症予防に役立てることは、人々の健康維持にとってはかり知れない恩恵をもたらす可能性を秘めている。口腔細菌に起因する重度全身疾患発症を予測し、重度全身疾患の発症を予防することが可能になるとすれば、 多くの人々のQuality of life の低下や要介護者の増加を減らすことにつながり、社会的意義は大きいのではないかと考えている。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (46 results)

All 2021 2020 2019 Other

All Journal Article (20 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 18 results,  Open Access: 17 results) Presentation (23 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (2 results) Remarks (1 results)

  • [Journal Article] A prospective interventional trial on the effect of periodontal treatment on Fusobacterium nucleatum abundance in patients with colorectal tumours2021

    • Author(s)
      Yoshihara Tsutomu、Kioi Mitomu、Baba Junichi、Usuda Haruki、Kessoku Takaomi、Iwaki Michihiro、Takatsu Tomohiro、Misawa Noboru、Ashikari Keiichi、Matsuura Tetsuya、Fuyuki Akiko、Ohkubo Hidenori、Matsumoto Mitsuharu、Wada Koichiro、Nakajima Atsushi、Higurashi Takuma
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 23719-23719

    • DOI

      10.1038/s41598-021-03083-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endotoxins and Non-Alcoholic Fatty Liver Disease2021

    • Author(s)
      Kessoku T, Kobayashi T, Imajo K, Tanaka K, Yamamoto A, Takahashi K, Kasai Y, Ozaki A, Iwaki M, Nogami A, Honda Y, Ogawa Y, Kato S, Higurashi T, Hosono K, Yoneda M, Okamoto T, Usuda H, Wada K, Kobayashi N, Saito S, Nakajima A
    • Journal Title

      Frontiers in Endocrinology

      Volume: 12 Pages: 770986-770986

    • DOI

      10.3389/fendo.2021.770986

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Leaky Gut: Effect of Dietary Fiber and Fats on Microbiome and Intestinal Barrier2021

    • Author(s)
      Usuda Haruki、Okamoto Takayuki、Wada Koichiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 14 Pages: 7613-7613

    • DOI

      10.3390/ijms22147613

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Leaky Gut in Nonalcoholic Fatty Liver Disease: A Novel Therapeutic Target.2021

    • Author(s)
      Kessoku T, Kobayashi T, Tanaka K, Yamamoto A, Takahashi K, Iwaki M, Ozaki A, Kasai Y, Nogami A, Honda Y, Ogawa Y, Kato S, Imajo K, Higurashi T, Hosono K, Yoneda M, Usuda H, Wada K, Saito S, Nakajima A.
    • Journal Title

      Int J Mol Sci.

      Volume: 22 Issue: 15 Pages: 8161-8161

    • DOI

      10.3390/ijms22158161

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of <i>Bifidobacterium bifidum</i> G9-1 in improving quality of life in patients with chronic constipation: a prospective intervention study2021

    • Author(s)
      Fuyuki A, Higurashi T, Kessoku T, Ashikari K, Yoshihara T, Misawa N, Iwaki M, Kobayashi T, Ohkubo H, Yoneda M, Usuda H, Wada K, Nakajima A.
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 40 Issue: 2 Pages: 105-114

    • DOI

      10.12938/bmfh.2020-073

    • NAID

      130008026131

    • ISSN
      2186-3342
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Juvenile social defeat stress exposure favors in later onset of irritable bowel syndrome-like symptoms in male mice2021

    • Author(s)
      Matsumoto Kenjiro、Takata Kana、Yamada Daisuke、Usuda Haruki、Wada Koichiro、Tada Maaya、Mishima Yoshiyuki、Ishihara Shunji、Horie Syunji、Saitoh Akiyoshi、Kato Shinichi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 16276-16276

    • DOI

      10.1038/s41598-021-95916-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial connexin-integrin crosstalk in vascular inflammation2021

    • Author(s)
      Okamoto Takayuki、Park Eun Jeong、Kawamoto Eiji、Usuda Haruki、Wada Koichiro、Taguchi Akihiko、Shimaoka Motomu
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1867 Issue: 9 Pages: 166168-166168

    • DOI

      10.1016/j.bbadis.2021.166168

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The benefit of elobixibat in chronic constipation is associated with faecal deoxycholic acid but not effects of altered microbiota2020

    • Author(s)
      Misawa N、Higurashi T、Takatsu T、Iwaki M、Kobayashi T、Yoshihara T、Ashikari K、Kessoku T、Fuyuki A、Matsuura T、Ohkubo H、Usuda H、Wada K、Naritaka N、Takei H、Nittono H、Matsumoto M、Honda A、Nakajima A、Camilleri M
    • Journal Title

      Alimentary Pharmacology & Therapeutics

      Volume: 52 Issue: 5 Pages: 821-828

    • DOI

      10.1111/apt.15950

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Simulator-based pharmacological practice using iPad-Cloud system for medical education2020

    • Author(s)
      Wada Koichiro、Usuda Haruki、Tanaka Tetsuya、Okamoto Takayuki
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 155 Issue: 3 Pages: 185-186

    • DOI

      10.1254/fpj.19115

    • NAID

      130007839010

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Recombinant Human Soluble Thrombomodulin Suppresses Monocyte Adhesion by Reducing Lipopolysaccharide-Induced Endothelial Cellular Stiffening2020

    • Author(s)
      Okamoto Takayuki、Kawamoto Eiji、Usuda Haruki、Tanaka Tetsuya、Nikai Tetsuro、Asanuma Kunihiro、Suzuki Koji、Shimaoka Motomu、Wada Koichiro
    • Journal Title

      Cells

      Volume: 9 Issue: 8 Pages: 1811-1811

    • DOI

      10.3390/cells9081811

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rationale and design of a randomised, double-blind, placebo-controlled, parallel-group, investigator-initiated phase 2a study to investigate the efficacy and safety of elobixibat in combination with cholestyramine for non-alcoholic fatty liver disease.2020

    • Author(s)
      Kessoku T, Kobayashi T, Ozaki A, Iwaki M, Honda Y, Ogawa Y, Imajo K, Saigusa Y, Yamamoto K, Yamanaka T, Usuda H, Wada K, Yoneda M, Saito S, Nakajima A.
    • Journal Title

      BMJ Open.

      Volume: 10 Issue: 9 Pages: e037961-e037961

    • DOI

      10.1136/bmjopen-2020-037961

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differential expression of pro-inflammatory and pro-coagulant genes in endothelial cells induced by Porhyromonas gingivalis lipopolysaccharide, Escherichia coli lipopolysaccharide, and zymosan.2020

    • Author(s)
      Hossain KH, Okamoto T, Usuda H, Jahan I, Niibayashi T, Wada K.
    • Journal Title

      Shimane Journal of Medical Science

      Volume: 37 Pages: 123-132

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The protective effect of Bifidobacterium bifidum G9-1 against mucus degradation by Akkermansia muciniphila following small intestine injury caused by a proton pump inhibitor and aspirin.2020

    • Author(s)
      Yoshihara T, Oikawa Y, Kato T, Kessoku T, Kobayashi T, Kato S, Misawa N, Ashikari K, Fuyuki A, Ohkubo H, Higurashi T, Tateishi Y, Tanaka Y, Nakajima S, Ohno H, Wada K, Nakajima A.
    • Journal Title

      Gut Microbes.

      Volume: 11 Issue: 5 Pages: 1385-1404

    • DOI

      10.1080/19490976.2020.1758290

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiota composition associated with hepatic fibrosis in non-obese patients with non-alcoholic fatty liver disease.2020

    • Author(s)
      Iwaki M, Kessoku T, Ozaki A, Kasai Y, Kobayashi T, Nogami A, Honda Y, Ogawa Y, Imajo K, Yoneda M, Maeda A, Tanaka Y, Nakajima S, Ohno H, Usuda H, Kawanaka M, Kawaguchi T, Torimura T, Kage M, Hyogo H, Takahashi H, Eguchi Y, Aishima S, Wada K, Kobayashi N, Sumida Y, Saito S, Nakajima A.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: - Issue: 8 Pages: 2275-2284

    • DOI

      10.1111/jgh.15487

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lubiprostone in patients with non-alcoholic fatty liver disease: a randomised, double-blind, placebo-controlled, phase 2a trial.2020

    • Author(s)
      Kessoku T, Imajo K, Kobayashi T, Yoneda M, Kirikoshi H, Kubota K, Taguri M, Yamanaka T, Usuda H, Wada K, Kobayashi N, Saito S, Nakajima A.
    • Journal Title

      Lancet Gastroenterol Hepatol.

      Volume: 5 Issue: 11 Pages: 996-1007

    • DOI

      10.1016/s2468-1253(20)30216-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リーキーガット症候群(Leaky Gut Syndrome)と疾患 ー NASH発症との関連性を中心として ー2020

    • Author(s)
      和田孝一郎
    • Journal Title

      島根医学

      Volume: 40(3) Pages: 10-19

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: protocol of the PERION multicenter, two-arm, open-label, randomized trial2020

    • Author(s)
      Kamata Yohei、Kessoku Takaomi、Shimizu Tomoko、Kobayashi Takashi、Kurihashi Takeo、Sato Satsuki、Kuraji Syotaro、Aoyama Norio、Iwasaki Tomoyuki、Takashiba Shogo、Hamada Nobushiro、Kodama Toshiro、Tamura Toshiyuki、Ino Satoshi、Higurashi Takuma、Taguri Masataka、Yamanaka Takeharu、Yoneda Masato、Minabe Masato
    • Journal Title

      Trials

      Volume: 21 Issue: 1 Pages: 291-291

    • DOI

      10.1186/s13063-020-4201-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Up-Regulated MicroRNA-27b Promotes Adipocyte Differentiation via Induction of Acyl-CoA Thioesterase 2 Expression2019

    • Author(s)
      Murata Yuka、Yamashiro Takashi、Kessoku Takaomi、Jahan Israt、Usuda Haruki、Tanaka Tetsuya、Okamoto Takayuki、Nakajima Atsushi、Wada Koichiro
    • Journal Title

      BioMed Research International

      Volume: 2019 Pages: 1-9

    • DOI

      10.1155/2019/2916243

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular Mechanism of Matrine from Sophora alopecuroides in the Reversing Effect of Multi-Anticancer Drug Resistance in K562/ADR Cells2019

    • Author(s)
      Chen Zhi、Nishimura Nobuhiro、Okamoto Takayuki、Wada Koichiro、Naora Kohji
    • Journal Title

      BioMed Research International

      Volume: 2019 Pages: 1-10

    • DOI

      10.1155/2019/1269532

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] リコモジュリンが血管内皮細胞の硬さに及ぼす影響の解析2019

    • Author(s)
      岡本貴行、川本英嗣、臼田春樹、田中徹也、本田剛一、和田孝一郎、島岡要
    • Journal Title

      Shock

      Volume: 34 Pages: 29-29

    • Related Report
      2019 Annual Research Report
  • [Presentation] 消化管粘膜透過性と多臓器連関: 創薬の対象としてのLeaky Gut Syndrome2021

    • Author(s)
      和田 孝一郎、臼田 春樹、岡本 貴行、新林 友美
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 炎症・免疫反応の多臓器連関: 消化管・口腔粘膜からはじまる全身疾患2021

    • Author(s)
      和田 孝一郎
    • Organizer
      第5回 黒潮カンファレンス 異分野融合創薬研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] miR-199a-3p と miR-126-3p は HIF-1α を標的として脂肪細分化を促進する2021

    • Author(s)
      Jahan Israt、岡本 貴行、臼田 春樹、田中 徹也、中島 淳、和田 孝一郎
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 口腔内細菌の保菌と好酸球性食道炎の関連性についての検討2021

    • Author(s)
      臼田 春樹、新林 友美、岡本 貴行、和田 孝一郎
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 細胞外環境の硬さによる血管内皮細胞の機能変化の解析2021

    • Author(s)
      岡本 貴行、臼田 春樹、和田 孝一郎
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 好酸球性食道炎患者における高病原性口腔内細菌の保菌および口腔内細菌叢についての基礎的検討2021

    • Author(s)
      臼田 春樹、新林 友美、岡本 貴行、和田 孝一郎
    • Organizer
      第74回日本薬理学会西南部会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 細胞接着基質の硬さがVEGF誘導性の血管内皮細胞の遺伝子発現に及ぼす影響2021

    • Author(s)
      岡本貴行, 松尾映里, 松尾映里, 伊藤温志, 川本英嗣, 川本英嗣, 臼田春樹, 和田孝一郎, 島岡要, 高尾仁二, 島本亮
    • Organizer
      第 43回日本血栓止血学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 口腔内細菌の保菌と好酸球性食道炎の関連性についての基礎的検討2021

    • Author(s)
      臼田春樹、新林友美、岡本貴行、和田孝一郎
    • Organizer
      第5回 黒潮カンファレンス 異分野融合創薬研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 細胞外環境の硬さが誘導する血管内皮細胞の遺伝子発現の解析2021

    • Author(s)
      岡本貴行、臼田春樹、和田孝一郎
    • Organizer
      第5回 黒潮カンファレンス 異分野融合創薬研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 食物繊維の欠乏が炎症性腸疾患に及ぼす影響に関する基礎的検討.2021

    • Author(s)
      臼田 春樹、神田 翔磨、岡本 貴行、和田 孝一郎.
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] リコモジュリンによる血管内皮細胞の硬化抑制とその役割.2021

    • Author(s)
      岡本 貴行、臼田 春樹、田中 徹也、和田 孝一郎.
    • Organizer
      第94回日本薬理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 島根県住民における口腔内高病原性細菌の保菌状況:性別・地域・細菌種について2019

    • Author(s)
      臼田春樹、岡本貴行、和田孝一郎、富永一道、渡邊 公人.
    • Organizer
      第4回 黒潮カンファレンス異分野融合創薬研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 腸粘膜バリア機能の破綻を診断しうる新規診試薬の確立.2019

    • Author(s)
      臼田春樹、新林友美、Kazi Helal Hossain、Israt Jahan、田中徹也、岡本貴行、和田孝一郎.
    • Organizer
      第135回日本薬理学会近畿部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Increased levels of bile acid in feces plays an important role in pathophysiology of non-alcoholic steatohepatitis.2019

    • Author(s)
      Kessoku T., Kobayashi T., Imajo K., Wada K., et al.
    • Organizer
      International Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficacy, safety, and tolerability of lubiprostone for the treatment of non-alcoholic fatty liver disease: The LUBIPRONE, double-blind, randomized, placebo-controlled, phase II study.2019

    • Author(s)
      Kessoku T., Imajyo K., Ogawa Y., Wada K., et al.
    • Organizer
      International Liver Congress / 54th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Streptococcus mutansの保菌は好酸球性食道炎の有病率と相関する2019

    • Author(s)
      臼田春樹、新林友美、田中徹也、岡本貴行、和田孝一郎
    • Organizer
      第72回日本薬理学会 西南部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞外環境の硬さとマクロファージの炎症性分化2019

    • Author(s)
      岡本貴行、臼田春樹、田中徹也、和田孝一郎
    • Organizer
      第72回日本薬理学会 西南部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラットの胎生期および新生児期におけるマスト細胞関連遺伝子の発現解析2019

    • Author(s)
      田中徹也、新林友美、臼田春樹、岡本貴行、和田孝一郎
    • Organizer
      第72回日本薬理学会 西南部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 軟らかい細胞外環境はマクロファージの炎症性分化を抑制する2019

    • Author(s)
      岡本貴行、臼田春樹、田中徹也、和田孝一郎
    • Organizer
      第4回 黒潮カンファレンス異分野融合創薬研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ラットの胎生期および新生児期におけるマスト細胞の発生2019

    • Author(s)
      田中徹也、新林友美、臼田春樹、岡本貴行、和田孝一郎
    • Organizer
      第4回 黒潮カンファレンス異分野融合創薬研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 血管内皮細胞の硬さ制御における YAP の役割2019

    • Author(s)
      岡本貴行、臼田春樹、田中徹也、川本英嗣、島岡要、和田孝一郎
    • Organizer
      第41回日本血栓止血学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞外環境の硬さとマクロファージの炎症性分化2019

    • Author(s)
      岡本貴行、臼田春樹、田中徹也、和田孝一郎
    • Organizer
      第27回日本血管生物医学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞外環境の硬さ依存的なマクロファージの分化傾向の解析2019

    • Author(s)
      岡本 貴行、臼田 春樹、田中 徹也、和田 孝一郎
    • Organizer
      第40回 日本臨床薬理学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Book] 「う蝕病原性細菌と脳卒中」 ヒト常在細菌叢と生理機能・全身疾患(落合邦康 監修) III: 第七章2020

    • Author(s)
      和田孝一郎、臼田春樹、岡本貴行、外村和也、田中篤太郎、梅村和夫.
    • Publisher
      シーエムシー出版
    • ISBN
      9784781315195
    • Related Report
      2020 Annual Research Report
  • [Book] 「歯周病と非アルコール性脂肪肝炎」 ヒト常在細菌叢と生理機能・全身疾患 (落合邦康 監修)III: 第十二章2020

    • Author(s)
      和田孝一郎、結束貴臣、小川祐二、今城健人、米田正人、中島淳.
    • Publisher
      シーエムシー出版
    • ISBN
      9784781315195
    • Related Report
      2020 Annual Research Report
  • [Remarks] 島根大学医学部薬理学講座

    • URL

      https://www.med.shimane-u.ac.jp/pharmacology/

    • Related Report
      2020 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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