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Effect of exercise and nutritional intervention on genetic risk score in sarcopenic obesity patients

Research Project

Project/Area Number 19H04039
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionRitsumeikan University

Principal Investigator

Sanada Kiyoshi  立命館大学, スポーツ健康科学部, 教授 (50421227)

Co-Investigator(Kenkyū-buntansha) 家光 素行  立命館大学, スポーツ健康科学部, 教授 (90375460)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywordsサルコペニア / 肥満 / 遺伝子多型 / 運動処方 / 栄養処方
Outline of Research at the Start

これまでのBMI,ウエスト/ヒップ比,およびその他の肥満フェノタイプに関する網羅的なゲノムワイド関連研究では,300を超える一塩基多型が同定され,複数の遺伝要因を統合した肥満リスクスコアと身体活動や食習慣との関連が報告されている.しかし現在のところサルコペニア肥満関連遺伝子多型について網羅的に解析し,同定された関連遺伝子多型によるリスクをスコア化した報告は国内外で認められない.
本研究は,サルコペニア肥満関連遺伝子多型を網羅的に複数同定するとともに,遺伝的な保有リスクをスコア化し,サルコペニア肥満の遺伝リスクスコアごとに,運動および食事療法による改善効果がどの程度得られるのかについて検証する.

Outline of Final Research Achievements

In this study, we conducted a literature review on the prevention of sarcopenia and its genetic effects due to exercise, a cross-sectional study on the relationship between depression and physical activity in obese subjects with sarcopenia, and a study on sarcopenia and atherosclerosis-related indices in middle-aged and elderly women. Interaction with iron intake, exercise intervention for sarcopenic obesity was conducted. To summarize the relationships between sarcopenia-related genes and muscle mass and muscle function, they can be classified into (1) genes related to physical strength, (2) genes related to skeletal muscle metabolism, and (3) genes related to inflammation. Sarcopenic obesity showed depressive symptoms when the amount of daily activity was low. In addition, continuous aqua exercise can be expected to reduce body fat.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果は、サルコペニア肥満者の運動療法に活用することができる。特にACEやACTN3遺伝子多型の保有者は体力の向上を、VDRやIGF-1遺伝子多型の保有者は、筋量の維持・増加と運動機能の向上を、CRP遺伝子多型の保有者は、炎症反応抑制のための腹部肥満の予防などが求められると考えられる。また、高齢女性においては、家事などの生活活動が抑うつ予防に重要である可能性やアクアエクササイズによるサルコペニア肥満者の減量効果が確認できた。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (36 results)

All 2023 2022 2021 2020 2019 Other

All Journal Article (17 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 17 results,  Open Access: 11 results) Presentation (15 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results) Book (3 results) Remarks (1 results)

  • [Journal Article] Interaction Between Sarcopenic Obesity and Nonlocomotive Physical Activity on the Risk of Depressive Symptoms in Community-Dwelling Older Adult Japanese Women2023

    • Author(s)
      Osugi Yu、Imai Aiko、Kurihara Toshiyuki、Kishigami Keiko、Higashida Kazuhiko、Sanada Kiyoshi
    • Journal Title

      Journal of Aging and Physical Activity

      Volume: - Issue: 4 Pages: 1-7

    • DOI

      10.1123/japa.2022-0142

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of water exercise on body composition and components of metabolic syndrome in older females with sarcopenic obesity2023

    • Author(s)
      Qi Shumeng、Horii Naoki、Kishigami Keiko、Miyachi Motohiko、Iemitsu Motoyuki、Sanada Kiyoshi
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 35 Issue: 1 Pages: 24-30

    • DOI

      10.1589/jpts.35.24

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overlap of Physical, Cognitive, and Social Frailty Affects Ikigai in Community-Dwelling Japanese Older Adults2022

    • Author(s)
      Tsujishita Soma、Nagamatsu Masaki、Sanada Kiyoshi
    • Journal Title

      Healthcare

      Volume: 10 Issue: 11 Pages: 2216-2216

    • DOI

      10.3390/healthcare10112216

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between skeletal muscle mass or percent body fat and metabolic syndrome development in Japanese women: A 7-year prospective study2022

    • Author(s)
      Yamada Yosuke、Murakami Haruka、Kawakami Ryoko、Gando Yuko、Nanri Hinako、Nakagata Takashi、Watanabe Daiki、Yoshida Tsukasa、Hatamoto Yoichi、Yoshimura Eiichi、Sanada Kiyoshi、Miyatake Nobuyuki、Miyachi Motohiko
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 10 Pages: e0263213-e0263213

    • DOI

      10.1371/journal.pone.0263213

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-dependent relationships between exercise training-induced changes in nitric oxide production and hormone regulation2022

    • Author(s)
      Fujie Shumpei、Sanada Kiyoshi、Hamaoka Takafumi、Iemitsu Motoyuki
    • Journal Title

      Experimental Gerontology

      Volume: 166 Pages: 111888-111888

    • DOI

      10.1016/j.exger.2022.111888

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between thigh muscle cross-sectional areas and single leg stand-up test in Japanese older women2022

    • Author(s)
      Kishigami Keiko、Kanehisa Hiroaki、Qi Shumeng、Arimitsu Takuma、Miyachi Motohiko、Iemitsu Motoyuki、Sanada Kiyoshi
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 6 Pages: e0269103-e0269103

    • DOI

      10.1371/journal.pone.0269103

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 中高齢女性を対象とした動脈硬化関連指標に対する プレサルコペニアと鉄摂取量との交互作用2021

    • Author(s)
      黄 克欽, 栗原俊之, 長谷川夏輝, 濱口佳奈子, 家光素行, 真田樹義
    • Journal Title

      京都滋賀体育学研究

      Volume: 37 Pages: 1-11

    • NAID

      130008159366

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations between locomotive and non-locomotive physical activity and physical performance in older community-dwelling females with and without locomotive syndrome: a cross-sectional study2021

    • Author(s)
      Nishimura T, Hagio A, Hamaguchi K, Kurihara T, Iemitsu M, Sanada K.
    • Journal Title

      Journal of Physiological Anthropology

      Volume: 40 Issue: 1 Pages: 18-18

    • DOI

      10.1186/s40101-021-00268-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of a 1-year intervention comprising brief counselling sessions and low-dose physical activity recommendations in Japanese adults, and retention of the effect at 2 years: a randomized trial2021

    • Author(s)
      Tripette J, Gando Y, Murakami H, Kawakami R, Tanisawa K, Ohno H, Konishi K, Tanimoto M, Tanaka N, Kawano H, Yamamoto K, Morishita A, Iemitsu M, Sanada K, Miyatake N, Miyachi M
    • Journal Title

      BMC Sports Sci Med Rehabil

      Volume: 13 Issue: 1 Pages: 133-133

    • DOI

      10.1186/s13102-021-00360-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ロコモティブシンドロームを有する高齢者における歩行介入が身体機能および生活活動に及ぼす効果2021

    • Author(s)
      西村朋浩, 萩尾敦史, 浜口佳奈子, 栗原俊之, 家光素行, 真田樹義
    • Journal Title

      日本サルコペニア・フレイル学会誌

      Volume: 5(1) Pages: 131-137

    • NAID

      40022636306

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aerobic Exercise Restores Aging‐Associated Reductions in Arterial Adropin Levels and Improves Adropin‐Induced Nitric Oxide‐Dependent Vasorelaxation2021

    • Author(s)
      Fujie Shumpei、Hasegawa Natsuki、Horii Naoki、Uchida Masataka、Sanada Kiyoshi、Hamaoka Takafumi、Padilla Jaume、Martinez‐Lemus Luis A.、Maeda Seiji、Iemitsu Motoyuki
    • Journal Title

      Journal of the American Heart Association

      Volume: - Issue: 10

    • DOI

      10.1161/jaha.120.020641

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Relationship between plasma asymmetric dimethylarginine and nitric oxide levels affects aerobic exercise training-induced reduction of arterial stiffness in middle-aged and older adults2021

    • Author(s)
      Shimomura Mio、Fujie Shumpei、Sanada Kiyoshi、Kajimoto Hiroki、Hamaoka Takafumi、Iemitsu Motoyuki
    • Journal Title

      Physical Activity and Nutrition

      Volume: 25 Issue: 1 Pages: 16-22

    • DOI

      10.20463/pan.2021.0003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 特集【運動・身体活動による健康増進・疾患予防と遺伝】運動によるサルコペニア予防と遺伝的影響2021

    • Author(s)
      真田樹義
    • Journal Title

      日本トレーニング科学会

      Volume: 33(1) Pages: 9-13

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Associations among Bone Mineral Density, Physical Activity and Nutritional Intake in Middle-Aged Women with High Levels of Arterial Stiffness: A Pilot Study2020

    • Author(s)
      Hamaguchi Kanako、Kurihara Toshiyuki、Fujimoto Masahiro、Sato Koji、Iemitsu Motoyuki、Hamaoka Takafumi、Sanada Kiyoshi
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 5 Pages: 1620-1620

    • DOI

      10.3390/ijerph17051620

    • NAID

      120006873068

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adverse effects of the coexistence of locomotive syndrome and sarcopenia on the walking ability and performance of activities of daily living in Japanese elderly females: a cross-sectional study2020

    • Author(s)
      Nishimura Tomohiro、Imai Aiko、Fujimoto Masahiro、Kurihara Toshiyuki、Kagawa Kentaro、Nagata Taketoyo、Sanada Kiyoshi
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 32 Issue: 3 Pages: 227-232

    • DOI

      10.1589/jpts.32.227

    • NAID

      130007807457

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between non-locomotive light-intensity physical activity and depressive symptoms in Japanese older women: A cross-sectional study2020

    • Author(s)
      Imai Aiko、Kurihara Toshiyuki、Kimura Daisuke、Tanaka Noriko、Sanada Kiyoshi
    • Journal Title

      Mental Health and Physical Activity

      Volume: 18 Pages: 100303-100303

    • DOI

      10.1016/j.mhpa.2019.100303

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aerobic exercise training-induced irisin secretion is associated with the reduction of arterial stiffness via nitric oxide production in adults with obesity.2019

    • Author(s)
      Inoue K, Fujie S, Hasegawa N, Horii N, Uchida M, Iemitsu K, Sanada K, Hamaoka T, Iemitsu M.
    • Journal Title

      Appl Physiol Nutr Metab

      Volume: - Issue: 7 Pages: 715-722

    • DOI

      10.1139/apnm-2019-0602

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 高齢女性における習慣的な高強度レジスタンス運動と高たんぱく質摂取の併用が筋力・筋量および動脈硬化度に及ぼす影響2022

    • Author(s)
      山崎エンヒ、藤江隼平、堀居直希、井上健一郎、家光恵子、内田昌孝、篠原靖司、真田樹義、宮地元彦、家光素行
    • Organizer
      第9回日本サルコペニア・フレイル学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Sarcopenic Obesity Consensus Statement におけるパラメータを利用した肥満指標とサルコペニア指標の検討2022

    • Author(s)
      西田千裕、家光素行、栗原俊之、真田樹義
    • Organizer
      第9回日本サルコペニア・フレイル学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 抑うつに対するサルコペニア肥満と非歩行性身体活動量との相互関係2022

    • Author(s)
      大杉 優、今井あい子、栗原俊之、岸上慶子、東田一彦、真田樹義
    • Organizer
      第9回日本サルコペニア・フレイル学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 習慣的な有酸素性運動による動脈硬化の低下効果に関与するマイオカイン・apelinの経時的変化2022

    • Author(s)
      藤江隼平、真田樹義、家光素行
    • Organizer
      第9回日本サルコペニア・フレイル学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 日本人高齢女性における肥満指標およびサルコペニア指標の相関関係2021

    • Author(s)
      西田千裕、家光素行、栗原俊之、真田樹義
    • Organizer
      第8回日本サルコペニア・フレイル学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ロコモティブシンドロームを有する高齢女性における歩行速度と中高強度生活活動の関係性の検討:横断研究2021

    • Author(s)
      西村朋浩、萩尾敦史、浜口佳奈子、栗原俊之、家光素行、真田樹義
    • Organizer
      第8回日本サルコペニア・フレイル学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 教育講演 Meet the Expert8「健康長寿と身体活動・運動~フレイル・ロコモティブ・サルコペニアの予防~」2021

    • Author(s)
      真田樹義
    • Organizer
      第8回日本サルコペニア・フレイル学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Higher ratio of plasma nitric oxide to asymmetric dimethylarginine levels affects aerobic exercise training-induced reduction of arterial stiffness in middle-aged and older adults2021

    • Author(s)
      Mio Shimomura, Shumpei Fujie, Kiyoshi Sanada, Hiroki Kajimoto, Takafumi Hamaoka, Motoyuki Iemitsu
    • Organizer
      26th Annual Congress European College of Sport Science
    • Related Report
      2020 Annual Research Report
  • [Presentation] Chronic dietary animal protein intake cancels resistance training-induced increase in arterial stiffness in older women2021

    • Author(s)
      Hiroki Kajimoto, Kenichiro Inoue, Naoki Horii, Shumpei Fujie, Natsuki Hasegawa, Masataka Uchida, Shosaku Kato, Yasushi Shinohara, Motohiko Miyachi, Kiyoshi Sanada, Motoyuki Iemitsu
    • Organizer
      68th Annual Meeting of the American College of Sports Medicine
    • Related Report
      2020 Annual Research Report
  • [Presentation] ( セッション2)サルコペニアの診断と運動生理学的観点から予防2020

    • Author(s)
      真田樹義
    • Organizer
      第2回日本抗加齢医学会 九州地方会 学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] (Meet the Expert3)サルコペニアに対する運動療法-入院高齢者に対する集団起立運動のススメ2019

    • Author(s)
      真田樹義
    • Organizer
      第6回日本サルコペニア・フレイル学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of underwater exercise on the indexes of sarcopenia in elderly women with sarcopenia2019

    • Author(s)
      Qi Shumeng, Shosaku Kato, Naoki Horii, Keiko Kishigami, Motohiko Miyachi, Motoyuki Iemitsu, Kiyoshi Sanada
    • Organizer
      5th Asian Conference for Frailty and Sarcopenia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relationship between sarcopenia and thigh muscle cross-sectional area in Japanese older women2019

    • Author(s)
      Keiko Kishigami, Qi Shumeng, Takuma Arimitsu, Motohiko Miyachi, Motoyuki Iemitsu, Kiyoshi Sanada
    • Organizer
      5th Asian Conference for Frailty and Sarcopenia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects Of Nutritional Status On Arterial Stiffness In The Subjects With Pre-sarcopenia2019

    • Author(s)
      Keqin Huang, Shizue Itano, Kanako Hamaguchi, Toshiyuki Kurihara, Natsuki Hasegawa, Motoyuki Iemitsu, Kiyoshi Sanada
    • Organizer
      66th Annual Meeting of the American College of Sports Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Changes in Salivary Cortisol and Iga Levels are Associated with Fatigue after Acute Endurance Exercise2019

    • Author(s)
      Natsuka Hashizume, Natsuki Hasegawa, Naoki Horii, Maki Yoshikawa, Katsunori Tsuji, Masataka Uchida, Keiko Iemitsu, Takeshi Hashimoto, Kiyoshi Sanada, Masao Kanamori, Kohei Watanabe, Motoyuki Iemitsu
    • Organizer
      66th Annual Meeting of the American College of Sports Medicine
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] 漢方によるフレイル対策ガイドブック2022

    • Author(s)
      真田樹義、編集:乾 明夫
    • Total Pages
      281
    • Publisher
      株式会社 先端医学社
    • Related Report
      2021 Annual Research Report
  • [Book] 認知症plus予防教育:運動・食事・社会参加など最新の知見からの提案2020

    • Author(s)
      真田樹義、編集:金森雅夫
    • Total Pages
      216
    • Publisher
      株式会社日本看護協会出版会
    • ISBN
      9784818022485
    • Related Report
      2019 Annual Research Report
  • [Book] スポーツでのばす健康寿命:科学で解き明かす運動と栄養の効果2019

    • Author(s)
      真田樹義、編集:深代千之、安部孝
    • Total Pages
      304
    • Publisher
      一般財団法人 東京大学出版会
    • ISBN
      9784130537025
    • Related Report
      2019 Annual Research Report
  • [Remarks] 真田研究室ホームページ

    • URL

      https://sanada-lab.wixsite.com/sanadazemi

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

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