Effect of exercise and nutritional intervention on genetic risk score in sarcopenic obesity patients
| Project/Area Number |
19H04039
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 59040:Nutrition science and health science-related
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| Research Institution | Ritsumeikan University |
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Principal Investigator |
Sanada Kiyoshi 立命館大学, スポーツ健康科学部, 教授 (50421227)
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| Co-Investigator(Kenkyū-buntansha) |
家光 素行 立命館大学, スポーツ健康科学部, 教授 (90375460)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2020: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Keywords | サルコペニア / 肥満 / 遺伝子多型 / 運動処方 / 栄養処方 |
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| Outline of Research at the Start |
これまでのBMI，ウエスト/ヒップ比，およびその他の肥満フェノタイプに関する網羅的なゲノムワイド関連研究では，300を超える一塩基多型が同定され，複数の遺伝要因を統合した肥満リスクスコアと身体活動や食習慣との関連が報告されている．しかし現在のところサルコペニア肥満関連遺伝子多型について網羅的に解析し，同定された関連遺伝子多型によるリスクをスコア化した報告は国内外で認められない．
本研究は，サルコペニア肥満関連遺伝子多型を網羅的に複数同定するとともに，遺伝的な保有リスクをスコア化し，サルコペニア肥満の遺伝リスクスコアごとに，運動および食事療法による改善効果がどの程度得られるのかについて検証する．
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| Outline of Final Research Achievements |
In this study, we conducted a literature review on the prevention of sarcopenia and its genetic effects due to exercise, a cross-sectional study on the relationship between depression and physical activity in obese subjects with sarcopenia, and a study on sarcopenia and atherosclerosis-related indices in middle-aged and elderly women. Interaction with iron intake, exercise intervention for sarcopenic obesity was conducted. To summarize the relationships between sarcopenia-related genes and muscle mass and muscle function, they can be classified into (1) genes related to physical strength, (2) genes related to skeletal muscle metabolism, and (3) genes related to inflammation. Sarcopenic obesity showed depressive symptoms when the amount of daily activity was low. In addition, continuous aqua exercise can be expected to reduce body fat.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の結果は、サルコペニア肥満者の運動療法に活用することができる。特にACEやACTN3遺伝子多型の保有者は体力の向上を、VDRやIGF-1遺伝子多型の保有者は、筋量の維持・増加と運動機能の向上を、CRP遺伝子多型の保有者は、炎症反応抑制のための腹部肥満の予防などが求められると考えられる。また、高齢女性においては、家事などの生活活動が抑うつ予防に重要である可能性やアクアエクササイズによるサルコペニア肥満者の減量効果が確認できた。
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Report
(4 results)
Research Products
(36 results)
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[Journal Article] Effect of a 1-year intervention comprising brief counselling sessions and low-dose physical activity recommendations in Japanese adults, and retention of the effect at 2 years: a randomized trial2021
Author(s)
Tripette J, Gando Y, Murakami H, Kawakami R, Tanisawa K, Ohno H, Konishi K, Tanimoto M, Tanaka N, Kawano H, Yamamoto K, Morishita A, Iemitsu M, Sanada K, Miyatake N, Miyachi M
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Journal Title
BMC Sports Sci Med Rehabil
Volume: 13
Issue: 1
Pages: 133-133
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Chronic dietary animal protein intake cancels resistance training-induced increase in arterial stiffness in older women2021
Author(s)
Hiroki Kajimoto, Kenichiro Inoue, Naoki Horii, Shumpei Fujie, Natsuki Hasegawa, Masataka Uchida, Shosaku Kato, Yasushi Shinohara, Motohiko Miyachi, Kiyoshi Sanada, Motoyuki Iemitsu
Organizer
68th Annual Meeting of the American College of Sports Medicine
Related Report
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[Presentation] Changes in Salivary Cortisol and Iga Levels are Associated with Fatigue after Acute Endurance Exercise2019
Author(s)
Natsuka Hashizume, Natsuki Hasegawa, Naoki Horii, Maki Yoshikawa, Katsunori Tsuji, Masataka Uchida, Keiko Iemitsu, Takeshi Hashimoto, Kiyoshi Sanada, Masao Kanamori, Kohei Watanabe, Motoyuki Iemitsu
Organizer
66th Annual Meeting of the American College of Sports Medicine
Related Report
Int'l Joint Research
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