| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
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| Outline of Final Research Achievements |
In this study, we clarified the skeletal muscle changes that occur in the process of remodeling the whole body into a body suitable for hibernation in a mammalian hibernator Syrian hamster. Specifically, we identified that Syrian hamsters reduce skeletal muscle mass during the pre-hibernation period, but maintain skeletal muscle mass during hibernation period. We then described the distribution of muscle fiber types in the back muscle that acts on shivering thermogenesis, and its changes during the body remodeling. We also set-up functional analysis of candidate genes that were identified as those assumed to be involved in the remodeling of skeletal muscles. These findings provide the basis for approaching mechanisms of the muscular atrophy tolerance in mammalian hibernators.
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