• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Elucidation of set-point mechanism for phosphate homeostasis and development of a novel therapeutic target for age-related diseases

Research Project

Project/Area Number 19H04053
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59040:Nutrition science and health science-related
Research InstitutionThe University of Tokushima

Principal Investigator

TAKETANI Yutaka  徳島大学, 大学院医歯薬学研究部(医学域), 教授 (30263825)

Co-Investigator(Kenkyū-buntansha) 増田 真志  徳島大学, 大学院医歯薬学研究部(医学域), 助教 (50754488)
山本 浩範  仁愛大学, 人間生活学部, 教授 (60314861)
大西 康太  徳島大学, 大学院医歯薬学研究部(医学域), 助教 (80723816)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords高リン血症 / 異所性石灰化 / 慢性腎臓病 / 老化 / アルカリホスファターゼ / リン / 動脈硬化 / 小児 / リン感知機構 / リン代謝 / ビタミンD / 遺伝子多型 / エンハンサー / ビタミンD
Outline of Research at the Start

ヒトでもマウスでも、乳幼児期は骨の形成を促すためにカルシウムとともに骨の成分となるリンを必要とする目的で血中リン濃度が高くなっている。この時の血中リン濃度は、成人では慢性腎臓病患者などで見られるような血管石灰化を引き起こす濃度に匹敵するにも関わらず、通常は、乳幼児期に血管石灰化などの異常は生じない。乳幼児期と成熟期を比較することで、乳幼児期に血清リンを高値に保つメカニズムと石灰化を防止するメカニズムを解明することができれば、異所性石灰化や高リン血症の予防・治療において新たな治療法開発に応用することが期待できる。

Outline of Final Research Achievements

Blood phosphorus concentration is maintained within a certain range by phosphate regulating hormones. The phosphorus concentration is high in infancy, then decreases as the child grows. The purpose of this study was to identify the factors that determine the phosphorus concentration and to clarify the mechanism of ectopic calcification suppression during the growth period. As a result, we found tissue-non-specific alkaline phosphatase in the liver as a new regulator that determines phosphorus concentration. In addition, an attempt to identify ectopic calcification inhibitor during the growth phase revealed that serum fetuin-A and vascular tissue-nonspecific alkaline phosphatase are important factors for the suppression of ectopic calcification during the growth phase.

Academic Significance and Societal Importance of the Research Achievements

血中リン濃度は、乳幼児期には成人の2倍程度高く、成長するに従って低下する。この乳幼児期のリン濃度は、成人であれば高リン血症とされ、血管などに異所性石灰化を引き起こすには十分な濃度であるにもかかわらず、乳幼児期にはそのような異所性石灰化は生じない。異所性石灰化は老化関連病変の1つであり、慢性腎臓病や糖尿病などの多くの生活習慣病においてみられ、動脈硬化などを引き起こし、生命予後を規定する重要な因子である。本研究成果は、老化様病変である異所性石灰化の新たな予防法・治療法を開発するための基礎的成果である。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (23 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 6 results,  Open Access: 6 results) Presentation (13 results) (of which Int'l Joint Research: 3 results)

  • [Int'l Joint Research] University of Colorado(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] コロラド大学(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1) induces ectopic calcification2022

    • Author(s)
      Yimamu Y, Ohtani A, Takei Y, Furuichi A, Kamei Y, Yamanaka-Okumura H, Ohminami H, Masuda M, Miyazaki M, Yamamoto H, Taketani Y
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 71 Issue: 2 Pages: 103-111

    • DOI

      10.3164/jcbn.22-16

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] All-trans retinoic acid changes muscle fiber type via increasing GADD34 dependent on MAPK signal2022

    • Author(s)
      Adachi Yuichiro、Masuda Masashi、Sakakibara Iori、Uchida Takayuki、Niida Yuki、Mori Yuki、Kamei Yuki、Okumura Yosuke、Ohminami Hirokazu、Ohnishi Kohta、Yamanaka-Okumura Hisami、Nikawa Takeshi、Taketani Yutaka
    • Journal Title

      Life Science Alliance

      Volume: 5 Issue: 7 Pages: e202101345-e202101345

    • DOI

      10.26508/lsa.202101345

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] ビタミンDと加齢2021

    • Author(s)
      竹谷豊
    • Journal Title

      アグリバイオ

      Volume: 5 Pages: 8-12

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Identification of Dietary Phytochemicals Capable of Enhancing the Autophagy Flux in HeLa and Caco-2 Human Cell Lines2020

    • Author(s)
      Ohnishi Kohta、Yano Satoshi、Fujimoto Moe、Sakai Maiko、Harumoto Erika、Furuichi Airi、Masuda Masashi、Ohminami Hirokazu、Yamanaka-Okumura Hisami、Hara Taichi、Taketani Yutaka
    • Journal Title

      Antioxidants

      Volume: 9 Issue: 12 Pages: 1193-1193

    • DOI

      10.3390/antiox9121193

    • NAID

      120007042435

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduction of stearoyl-CoA desaturase (SCD) contributes muscle atrophy through the excess endoplasmic reticulum stress in chronic kidney disease.2020

    • Author(s)
      Niida Y, Masuda M, Adachi Y, Yoshizawa A, Ohminami H, Mori Y, Ohnishi K, Yamanaka-Okumura H, Uchida T, Nikawa T, Yamamoto H, Miyazaki M, Taketani Y.
    • Journal Title

      J Clin Biochem Nutr.

      Volume: 67(2) Issue: 2 Pages: 179-187

    • DOI

      10.3164/jcbn.20-24

    • NAID

      130007894915

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isorhamnetin, a 3’-methoxylated flavonol, enhances the lysosomal proteolysis in J774.1 murine macrophages in a TFEB-independent manner.2020

    • Author(s)
      Sakai Maiko、Ohnishi Kohta、Masuda Masashi、Ohminami Hirokazu、Yamanaka-Okumura Hisami、Hara Taichi、Taketani Yutaka
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 84 Issue: 6 Pages: 1221-1231

    • DOI

      10.1080/09168451.2020.1727309

    • NAID

      130008108983

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【CKD-MBD up to date】管理・治療 透析、食事による管理2020

    • Author(s)
      竹谷豊、楢﨑遥子、織田奈央子、伊美友紀子
    • Journal Title

      腎と透析

      Volume: 88 Pages: 113-117

    • Related Report
      2020 Annual Research Report
  • [Journal Article] All-trans retinoic acid reduces the transcriptional regulation of intestinal sodium-dependent phosphate co-transporter gene (Npt2b).2020

    • Author(s)
      Masuda M, Yamamoto H, Takei Y, Nakahashi O, Adachi Y, Ohnishi K, Ohminami H, Yamanaka-Okumura H, Sakaue H, Miyazaki M, Takeda E, Taketani Y.
    • Journal Title

      The Biochemical journal.

      Volume: 477(4) Issue: 4 Pages: 817-831

    • DOI

      10.1042/bcj20190716

    • NAID

      120006980557

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 成長期における血管石灰化抑制機構の解明2021

    • Author(s)
      亀井優輝、大南博和、大西康太、増田真志、奥村仙示、竹谷豊
    • Organizer
      第75回日本栄養・食糧学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 慢性腎臓病におけるall-trans retinoic acid水酸化酵素Cyp26b1制御機構の解明2021

    • Author(s)
      佐々木皓平、増田真志、足立雄一郎、森優樹、野邊悠太郎、大南博和、大西康太、奥村仙示 山本浩範、竹谷豊
    • Organizer
      日本ビタミン学会 第73回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Hypervitaminosis A Contributes to Kidney Injury Through Excessive Endoplasmic Reticulum Stress in CKD2021

    • Author(s)
      Y.Adachi, M.Masuda; K.Sasaki, H.Ohminami, H.Yamanaka-Okumura, H.Yamamo, Y. Taketani
    • Organizer
      ASN Kidney Week 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝細胞における組織非特異的アルカリフォスファターゼ遺伝子発現とリン酸代謝に対するSNPrs1697421の影響2020

    • Author(s)
      石谷さとの、新居紗知、楢﨑遥子、奥村仙示、山本浩範、増田真志、大西康太、大南博和、竹谷豊
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] All-trans retinoic acidは腸管II型ナトリウム依存性リン酸輸送担体(Npt2b)遺伝子発現を低下させる2020

    • Author(s)
      増田真志、山本浩範、竹谷豊
    • Organizer
      第38回日本骨代謝学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 妊娠前の食餌性リン負荷が、仔マウスのリン応答性に及ぼす影響2020

    • Author(s)
      小松原彩乃、岸本麻希、林眞由、江原みゆ、大南博和、大西康太、増田真志、奥村仙示、竹谷豊
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 栄養素応答シグナルmTORC2を介したリソソーム活性制御機構の解明2020

    • Author(s)
      坂井麻衣子、大西康太、増田真志、大南博和、奥村仙示、原太一、竹谷豊
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 妊娠前の高リン食摂取は、仔マウスの食後血中リン濃度上昇を亢進させる2020

    • Author(s)
      小松原彩乃、岸本麻希、多々納詩織、林眞由、江原みゆ、大南博和、大西康太、増田真志、奥村仙示、竹谷豊
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 糖尿病時におけるビタミンD・カルシウム代謝異常の分子機構の解明2020

    • Author(s)
      山本浩範、田尻真梨、中橋乙起、増田真志、大南博和、大西康太、武田英二、竹谷豊
    • Organizer
      第74回日本栄養・食糧学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 小児期において血中 Fetuin-A 濃度とリン濃度は相関する2019

    • Author(s)
      亀井 優輝, 大南 博和, 大西 康太, 増田 真志, 奥村 仙示, 竹谷 豊
    • Organizer
      第52回日本栄養・食糧学会 中国・四国支部会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dietary Phosphate Disturbs of Gut Microbiome in Mice2019

    • Author(s)
      Naoko Oda, Kohei Sugihara, Miho Ikeda, Yuho Higashimura, Takashi Uebanso, Hirokazu Ohminami, Kohta Ohnishi, Masashi Masuda, Hisami Yamanaka-Okumura, Yutaka Taketani
    • Organizer
      Kidney Week 2019, Annual Meeting of American Society of Nephrology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Crossover Study of Continuous Intake of the Different Phosphorus Bioavailability Meal in Healthy Japanese2019

    • Author(s)
      Yoko Narasaki, Michiyo Yamasaki, Misaki Katsumoto, Yutaka Taketani
    • Organizer
      Kidney Week 2019, Annual Meeting of American Society of Nephrology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 高リン食が腸内環境を介して慢性腎臓病に与える影響2019

    • Author(s)
      池田 美萌, 織田 奈央子, 上番増 喬, 大南 博和, 大西 康太, 増田 真志, 奥村 仙示, 竹谷 豊
    • Organizer
      第23回日本病態栄養学会年次集会
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi