Basic and applied research of long-chained unsaturated fatty acid for preventing anti- arteriosclerosis

• Project/Area Number: 19H04055
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: The University of Tokushima
• Principal Investigator: SAKAUE Hiroshi 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (60372645)
• Co-Investigator(Kenkyū-buntansha): 黒田 雅士 徳島大学, 大学院医歯薬学研究部(医学域), 特任助教 (00803579) ; 堤 理恵 徳島大学, 大学院医歯薬学研究部(医学域), 講師 (80510172)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000); Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2019: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
• Keywords: 一価不飽和脂肪酸 / 生活習慣病 / 抗動脈硬化作用 / 腸内細菌 / TMAO / GLP-1 / RCT / 動脈硬化 / 魚油 / 二重盲検試験 / トリメチルアミン-N-オキシド / グルカゴン様ペプチド-1 / SCFA / 血管内皮機能

Outline of Research at the Start

生活習慣病とその重症化予防に対する革新的な技術開発を目的に、極長鎖一価不飽和脂肪酸の作用機序を解明するとともに標的分子を明らかとし、動脈硬化症への有効性の検証と分析法の確立などによって、この魚油由来の極長鎖一価不飽和脂肪酸の可能性を最大限に探索し、その臨床応用への可能性を検討することを目的とする。

Outline of Final Research Achievements

Healthy participants from the LCMUFA group in a double-blind, randomized, placebo-controlled, parallel-group, multi-center study showed improvements in endothelial function and a lower trimethylamine-N-oxide level, which is a predictor of coronary artery disease. LCMUFA significantly improved atherosclerotic lesions in mice with an improvement in the gut microbiota environment, as evident from the decreased ratio of Firmicutes/Bacteroidetes, increase in the abundance of Akkermansia, and upregulation of short-chain fatty acid (SCFA)-induced glucagon-like peptide-1 (GLP-1) expression and serum GLP-1 level. We also found the synergistic effects between LCMA and EPA with different actions. Fish oil-derived long-chain monounsaturated fatty acids might thus help to protect against cardiovascular disease.

Academic Significance and Societal Importance of the Research Achievements

極長鎖一価不飽和脂肪酸は既存のEPAやDHAとは異なるコレステロール低下作用などの代謝改善作用や動脈硬化発症の重症化を強力に予防する。EPAと異なる作用機序から優位性を有しており、本研究成果である抗動脈硬化作用の解明によって、極長鎖一価不飽和脂肪酸の新たな学術的な意義が得られた。海に囲まれ、世界でも有数の海域をもつ本邦の強みを活かした新たな産業基盤の創出として、魚由来の極長鎖一価不飽和脂肪酸に着目し、その生活習慣病に対する機能性の解明とする本研究成果は学術的な独自性のみでなく、新たな創造性をもって科学技術基本計画に沿った形で社会に貢献できる。

Research Products

• [Int'l Joint Research] National Institutes of Health(米国)
• [Journal Article] Necessity of daily 1000-IU vitamin D supplementation for maintaining a sufficient vitamin D status (2022)
  • Author(s): Ikezumi Yuya、Matsuura Yasushi、Morishita Teruhiro、Ide Noriko、Kitada Isao、Katayama Takafumi、Tsutsumi Rie、Sakaue Hiroshi、Taketani Yutaka、Sairyo Koichi、Takeda Eiji
  • Journal Title: The Journal of Medical Investigation Volume: 69 Issue: 1.2 Pages: 135-140
  • DOI: 10.2152/jmi.69.135
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Taste receptor gene expression is associated with decreased eGFR in patients with diabetes (2022)
  • Author(s): Beppu Kana、Kawakami Ayuka、Mishima Yuna、Tsutsumi Rie、Kuroda Masashi、Mori Hiroyasu、Kuroda Akio、Matsuhisa Munehisa、Sakaue Hiroshi
  • Journal Title: The Journal of Medical Investigation Volume: 69 Issue: 1.2 Pages: 120-126
  • DOI: 10.2152/jmi.69.120
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Development of a screening system for agents that modulate taste receptor expression with the CRISPR-Cas9 system in medaka (2022)
  • Author(s): Beppu Kana、Tsutsumi Rie、Ansai Satoshi、Ochiai Nana、Terakawa Mai、Mori Marie、Kuroda Masashi、Horikawa Kazuki、Tomoi Takumi、Sakamoto Joe、Kamei Yasuhiro、Naruse Kiyoshi、Sakaue Hiroshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 601 Pages: 65-72
  • DOI: 10.1016/j.bbrc.2022.02.082
  • Peer Reviewed
• [Journal Article] TGF‐β‐activated kinase‐1 inhibitor LL‐Z1640‐2 reduces joint inflammation and bone destruction in mouse models of rheumatoid arthritis by inhibiting NLRP3 inflammasome, TACE, TNF‐α and RANKL expression (2022)
  • Author(s): Tenshin H, Teramachi J, Ashtar M, Hiasa M, Inoue Y, Oda A, Tanimoto K, Shimizu S, Higa Yi, Harada T, Oura M, Sogabe K, Hara T, Sumitani R, Maruhashi T, Sebe M, Tsutsumi R, Sakaue H, Endo I, Matsumoto T, Tanaka E, Abe M
  • Journal Title: Clinical & Translational Immunology Volume: 11 Issue: 1
  • DOI: 10.1002/cti2.1371
  • Peer Reviewed / Open Access
• [Journal Article] Saturated fatty acids intake is associated with muscle atrophy in rheumatoid arthritis (2021)
  • Author(s): Sebe Mayu、Tsutsumi Rie、Senoura Satoka、Kishi Jun、Iuchi Marina、Mishima Yuna、Tsutsumi Yasuo M.、Kuroda Masashi、Harada Nagakatsu、Nakaya Yutaka、Kinoshita Seizo、Nishioka Yasuhiko、Sakaue Hiroshi
  • Journal Title: JCSM Rapid Communications Volume: 5 Issue: 1 Pages: 86-101
  • DOI: 10.1002/rco2.53
  • Peer Reviewed
• [Journal Article] Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora (2021)
  • Author(s): Tsutsumi Rie、Yamasaki Yuki、Takeo Jiro、Miyahara Hiroko、Sebe Mayu、Bando Masahiro、Tanba Yousuke、Mishima Yuna、Takeji Kana、Ueshima Nanako、Kuroda Masashi、Masumoto Saeko、Harada Nagakatsu、Fukuda Daiju、Yoshimoto Ryoko、Tsutsumi Yasuo M、Aihara Ken-ichi、Sata Masataka、Sakaue Hiroshi
  • Journal Title: Translational Research Volume: 237 Pages: 16-30
  • DOI: 10.1016/j.trsl.2021.03.016
  • NAID: 120007185164
  • Peer Reviewed
• [Journal Article] Integrated stress response regulates GDF15 secretion from adipocytes, preferentially suppresses appetite for a high-fat diet and improves obesity (2021)
  • Author(s): Miyake Masato、Zhang Jun、Yasue Akihiro、Hisanaga Satoshi、Tsugawa Kazue、Sakaue Hiroshi、Oyadomari Miho、Kiyonari Hiroshi、Oyadomari Seiichi
  • Journal Title: iScience Volume: 24 Issue: 12 Pages: 103448-103448
  • DOI: 10.1016/j.isci.2021.103448
  • Peer Reviewed / Open Access
• [Journal Article] Leucine imparts cardioprotective effects by enhancing mTOR activity and mitochondrial fusion in a myocardial ischemia/reperfusion injury murine model. (2021)
  • Author(s): Morio A, Tsutsumi R, Satomi S, Kondo T, Miyoshi H, Kato T, Kuroda M, Kitamura T, Hara K, Saeki N, Sakaue H, and Tsutsumi YM
  • Journal Title: Diabetol Metab Syndr Volume: 13 Issue: 1 Pages: 39-39
  • DOI: 10.1186/s13098-021-00755-z
  • Peer Reviewed
• [Journal Article] Dietary supplementation with monosodium glutamate with dietary balance such as protein, salt and sugar intake with increasing T1R3 taste receptor gene expression in healthy females (2021)
  • Author(s): Beppu Kana、Shono Hitoshi、Kawakami Ayuka、Takashi Tomoe、Watanabe Suzuno、Yoshida Akari、Kuroda Masashi、Fujimoto Chisa、Kanamura Ryo、Ohnishi Hiroki、Kondo Eiji、Azuma Takahito、Sato Go、Kitamura Yoshiaki、Tsutsumi Rie、Sakaue Hiroshi、Takeda Noriaki
  • Journal Title: The Journal of Medical Investigation Volume: 68 Issue: 3.4 Pages: 315-320
  • DOI: 10.2152/jmi.68.315
  • NAID: 130008115674
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed
• [Journal Article] Effects of daily 1,000-IU vitamin D-fortified milk intake on skeletal muscle mass, power, physical function and nutrition status in Japanese (2021)
  • Author(s): Matsuura Yasushi、Morishita Teruhiro、Sato Michiko、Sumida Nami、Katayama Takafumi、Tsutsumi Rie、Sakaue Hiroshi、Taketani Yutaka、Sairyo Koichi、Kawaura Akihiko、Takeda Eiji
  • Journal Title: The Journal of Medical Investigation Volume: 68 Issue: 3.4 Pages: 249-255
  • DOI: 10.2152/jmi.68.249
  • NAID: 130008115641
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed
• [Journal Article] Dietary Supplementation with Monosodium Glutamate Suppresses Chemotherapy-Induced Downregulation of the T1R3 Taste Receptor Subunit in Head and Neck Cancer Patients (2021)
  • Author(s): Shono Hitoshi、Tsutsumi Rie、Beppu Kana、Matsushima Rina、Watanabe Suzuno、Fujimoto Chisa、Kanamura Ryo、Ohnishi Hiroki、Kondo Eiji、Azuma Takahiro、Sato Go、Kawai Misako、Matsumoto Hideki、Kitamura Yoshiaki、Sakaue Hiroshi、Takeda Noriaki
  • Journal Title: Nutrients Volume: 13 Issue: 9 Pages: 2921-2921
  • DOI: 10.3390/nu13092921
  • Peer Reviewed
• [Journal Article] Sudachi peel extract powder including the polymethoxylated flavone sudachitin improves visceral fat content in individuals at risk for developing diabetes (2021)
  • Author(s): Shikishima Yasuhiro、Tsutsumi Rie、Kawakami Ayuka、Miura Hiroyuki、Nii Yoshitaka、Sakaue Hiroshi
  • Journal Title: Food Science & Nutrition Volume: 9 Issue: 8 Pages: 4076-4084
  • DOI: 10.1002/fsn3.2339
  • Peer Reviewed
• [Journal Article] Leucine induces cardioprotection in vitro by promoting mitochondrial function via mTOR and Opa-1 signaling. (2021)
  • Author(s): Morio A, Tsutsumi R, Kondo T, Miyoshi H, Kato T, Narasaki S, Satomi S, Nakaya E, Kuroda M, Sakaue H, Kitamura T, Tsutsumi YM
  • Journal Title: Nutr Metab Cardiovasc Dis Volume: 31 Issue: 10 Pages: 2979-2986
  • DOI: 10.1016/j.numecd.2021.06.025
  • Peer Reviewed
• [Journal Article] Assessment of catabolic state in infants with the use of urinary titin N-fragment (2021)
  • Author(s): Fukushima Sachiyo、Nakanishi Nobuto、Fujioka Kazumichi、Suga Kenichi、Shirakawa Taku、Osawa Kayo、Hara Kanako、Tsutsumi Rie、Urushihara Maki、Nakagawa Ryuji、Awano Hiroyuki、Oto Jun、Sakaue Hiroshi、Iijima Kazumoto、Matsuo Masafumi
  • Journal Title: Pediatric Research Volume: 17 Issue: 7 Pages: 1-6
  • DOI: 10.1038/s41390-021-01658-5
  • NAID: 120007163987
  • Peer Reviewed
• [Journal Article] Rectus Femoris Mimicking Ultrasound Phantom for Muscle Mass Assessment: Design, Research, and Training Application (2021)
  • Author(s): Nakanishi Nobuto、Inoue Shigeaki、Tsutsumi Rie、Akimoto Yusuke、Ono Yuko、Kotani Joji、Sakaue Hiroshi、Oto Jun
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 12 Pages: 2721-2721
  • DOI: 10.3390/jcm10122721
  • Peer Reviewed / Open Access
• [Journal Article] Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome (2021)
  • Author(s): Nakanishi Nobuto、Tsutsumi Rie、Hara Kanako、Matsuo Masafumi、Sakaue Hiroshi、Oto Jun
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 4 Pages: 614-614
  • DOI: 10.3390/jcm10040614
  • Peer Reviewed
• [Journal Article] Elevated Urinary Titin and its Associated Clinical Outcomes after Acute Stroke (2021)
  • Author(s): Ishihara Manabu、Nakanishi Nobuto、Tsutsumi Rie、Hara Kanako、Machida Kyoka、Yamamoto Nobuaki、Kanematsu Yasuhisa、Sakaue Hiroshi、Oto Jun、Takagi Yasushi
  • Journal Title: Journal of Stroke and Cerebrovascular Diseases Volume: 30 Issue: 3 Pages: 105561-105561
  • DOI: 10.1016/j.jstrokecerebrovasdis.2020.105561
  • Peer Reviewed / Open Access
• [Journal Article] UCP1-dependent and UCP1-independent metabolic changes induced by acute cold exposure in brown adipose tissue of mice. (2020)
  • Author(s): Okamatsu-Ogura Y, Kuroda M, Tsutsumi R, Tsubota A, Saito M, Kimura K, Sakaue H.
  • Journal Title: Metab Clin Exp Volume: 113 Pages: 154396-154396
  • DOI: 10.1016/j.metabol.2020.154396
  • NAID: 120007186809
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Electrical Muscle Stimulation on Upper and Lower Limb Muscles in Critically Ill Patients: A Two-Center Randomized Controlled Trial (2020)
  • Author(s): Nakanishi Nobuto、Oto Jun、Tsutsumi Rie、Yamamoto Tomoko、Ueno Yoshitoyo、Nakataki Emiko、Itagaki Taiga、Sakaue Hiroshi、Nishimura Masaji
  • Journal Title: Critical Care Medicine Volume: 48 Issue: 11 Pages: e997-e1003
  • DOI: 10.1097/ccm.0000000000004522
  • NAID: 120007126567
  • Peer Reviewed / Open Access
• [Journal Article] Phosphatemic Index Is a Novel Evaluation Tool for Dietary Phosphorus Load: A Whole-Foods Approach. (2020)
  • Author(s): Narasaki Y, Yamasaki M, Matsuura S, Morinishi M, Nakagawa T, Matsuno M, Katsumoto M, Nii S, Fushitani Y, Sugihara K, Noda T, Yoneda T, Masuda M, Yamanaka-Okumura H, Takeda E, Sakaue H, Yamamoto H, Taketani Y.
  • Journal Title: J Ren Nutr. Volume: 30(6) Issue: 6 Pages: 493-502
  • DOI: 10.1053/j.jrn.2020.02.005
  • Peer Reviewed / Open Access
• [Journal Article] Urinary Titin Is a Novel Biomarker for Muscle Atrophy in Nonsurgical Critically Ill Patients: A Two-Center, Prospective Observational Study (2020)
  • Author(s): Nakanishi Nobuto、Tsutsumi Rie、Hara Kanako、Takashima Takuya、Nakataki Emiko、Itagaki Taiga、Matsuo Masafumi、Oto Jun、Sakaue Hiroshi
  • Journal Title: Critical Care Medicine Volume: 48 Issue: 9 Pages: 1327-1333
  • DOI: 10.1097/ccm.0000000000004486
  • NAID: 120007120176
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of insulin resistance in the skeletal muscle of mice using positron emission tomography/computed tomography imaging (2020)
  • Author(s): Miyatake Yumiko、Mishima Yuna、Tsutsumi Rie、Otani Tamaki、Suemasa Naoya、Masumoto Saeko、Kuroda Masashi、Sakaue Hiroshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 528 Issue: 3 Pages: 499-505
  • DOI: 10.1016/j.bbrc.2020.05.165
  • Peer Reviewed
• [Journal Article] Differential regulation of Actn2 and Actn3 expression during unfolded protein response in C2C12 myotubes (2020)
  • Author(s): Harada Nagakatsu、Gotoda Yuka、Hatakeyama Adzumi、Nakagawa Tadahiko、Miyatake Yumiko、Kuroda Masashi、Masumoto Saeko、Tsutsumi Rie、Nakaya Yutaka、Sakaue Hiroshi
  • Journal Title: Journal of Muscle Research and Cell Motility Volume: 41 Issue: 2-3 Pages: 199-209
  • DOI: 10.1007/s10974-020-09582-7
  • Peer Reviewed
• [Journal Article] Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription (2020)
  • Author(s): Kuroda Masashi、Nishiguchi Misa、Ugawa Naho、Ishikawa Etsuko、Kawabata Yasuyo、Okamoto Saya、Sasaki Waka、Miyatake Yumiko、Sebe Mayu、Masumoto Saeko、Tsutsumi Rie、Harada Nagakatsu、Sakaue Hiroshi
  • Journal Title: PLOS ONE Volume: 15 Issue: 5 Pages: e0233390-e0233390
  • DOI: 10.1371/journal.pone.0233390
  • NAID: 120006952362
  • Peer Reviewed / Open Access
• [Journal Article] The PDK1-FoxO1 Signaling in Adipocytes Controls Systemic Insulin Sensitivity Through the 5-lipoxygenase-leukotriene B 4 Axis (2020)
  • Author(s): Hosooka T, Hosokawa Y, Matsugi K, Shinohara M, Senga Y, Tamori Y, Aoki C, Matsui S, Sasaki T, Kitamura T, Kuroda M, Sakaue H, Nomura K, Yoshino K, Nabatame Y, Itoh Y, Yamaguchi K, Hayashi Y, Nakae J, Accili D, Yokomizo T, Seino S, Kasuga M, Ogawa W.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: Online ahead of print Issue: 21 Pages: 11674-11684
  • DOI: 10.1073/pnas.1921015117
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gene-expression profile reveals the genetic and acquired phenotypes of hyperactive mutant SPORTS rat (2020)
  • Author(s): Horiguchi Taigo、Miyatake Yumiko、Miyoshi Keiko、Tanimura Ayako、Hagita Hiroko、Sakaue Hiroshi、Noma Takafumi
  • Journal Title: The Journal of Medical Investigation Volume: 67 Issue: 1.2 Pages: 51-61
  • DOI: 10.2152/jmi.67.51
  • NAID: 130007839959
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Assessment of postoperative nutritional status and physical function between open surgical aortic valve replacement and transcatheter aortic valve implantation in elderly patients (2020)
  • Author(s): Mayu Sebe, Rie Tsutsumi, Takuro Oyama, Yousuke T. Horikawa, Yuta Uemura, Nami Kakuta, Yoko Sakai, Atsushi Morio, Hirotsugu Miyoshi, Takashi Kondo, Tomoaki Urabe, Yuko Noda, Satoshi Kamiya, Noboru Saeki, Masashi Kuroda, Katsuya Tanaka, Yasuo M. Tsutsumi, and Hiroshi Sakaue.
  • Journal Title: The Journal of Medical Investigation Volume: 67 Issue: 1.2 Pages: 139-144
  • DOI: 10.2152/jmi.67.139
  • NAID: 130007839863
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Branched-chain amino acids-induced cardiac protection against ischemia/reperfusion injury. (2020)
  • Author(s): Satomi S, Morio A, Miyoshi H, Nakamura R, Tsutsumi R, Sakaue H, Yasuda T, Saeki N, Tsutsumi YM
  • Journal Title: Life Science Volume: 245 Pages: 117368-117368
  • DOI: 10.1016/j.lfs.2020.117368
  • NAID: 120006993613
  • Peer Reviewed / Open Access
• [Journal Article] All-trans retinoic acid reduces the transcriptional regulation of intestinal sodium-dependent phosphate co-transporter gene (Npt2b). (2020)
  • Author(s): Masuda M, Yamamoto H, Takei Y, Nakahashi O, Adachi Y, Ohnishi K, Ohminami H, Yamanaka-Okumura H, Sakaue H, Miyazaki M, Takeda E, Taketani Y.
  • Journal Title: The Biochemical journal. Volume: 477(4) Issue: 4 Pages: 817-831
  • DOI: 10.1042/bcj20190716
  • NAID: 120006980557
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] DNA Methylation Status Influences Insulin-Induced Glucose Transport in 3T3-L1 Adipocytes by Mediating p53 Expression (2020)
  • Author(s): Kuroda M, Onoyama R, Sasaki W, Sebe M, Kitamura T, Masumoto S, Tsutsumi R, Harada N, Sakaue H.
  • Journal Title: Biochem Biophys Res Commun Volume: 525 Issue: 1 Pages: 39-45
  • DOI: 10.1016/j.bbrc.2020.02.038
  • Peer Reviewed / Open Access
• [Journal Article] Role of orexin in exercise-induced leptin sensitivity in the mediobasal hypothalamus of mice (2019)
  • Author(s): Shiuchi Tetsuya、Miyatake Yumiko、Otsuka Airi、Chikahisa Sachiko、Sakaue Hiroshi、Sei Hiroyoshi
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 514 Issue: 1 Pages: 166-172
  • DOI: 10.1016/j.bbrc.2019.04.145
  • NAID: 120006881396
  • Peer Reviewed / Open Access
• [Journal Article] Effect of olive oil consumption on aging in a senescence-accelerated mice-prone 8 (SAMP8) model (2019)
  • Author(s): Bando Masahiro、Masumoto Saeko、Kuroda Masashi、Tsutsumi Rie、Sakaue Hiroshi
  • Journal Title: The Journal of Medical Investigation Volume: 66 Issue: 3.4 Pages: 241-247
  • DOI: 10.2152/jmi.66.241
  • NAID: 130007732954
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Monitoring of muscle mass in critically ill patients: comparison of ultrasound and two bioelectrical impedance analysis devices. (2019)
  • Author(s): Nobuto Nakanishi, Rie Tsutsumi, Yoshihiro Okayama, Takuya Takashima, Yoshitoyo Ueno, Taiga Itagaki, Yasuo Tsutsumi, Hiroshi Sakaue, and Jun Oto.
  • Journal Title: Journal of Intensive Care Volume: 7 Issue: 1 Pages: 61-61
  • DOI: 10.1186/s40560-019-0416-y
  • NAID: 120006939635
  • Peer Reviewed / Open Access
• [Presentation] 飽和脂肪酸の過剰摂取は疾患性サルコペニア発症のリスクとなる (2022)
  • Author(s): 堤 理恵, 阪上 浩
  • Organizer: 第４２回日本肥満学会
• [Presentation] Long-chain monounsaturated fatty acids improve endothelial function with altering microbial flora (2021)
  • Author(s): Rie Tsutsumi, Hiroshi Sakaue
  • Organizer: The 19th International Symposium on Atherosclerosis
  • Int'l Joint Research
• [Presentation] 極長鎖一価不飽和脂肪酸は腸内細菌叢の変化を介して血管内皮機能を改善 (2021)
  • Author(s): 米田 祥広, 阪上 浩
  • Organizer: 第 54 回 日本栄養食糧学会 中国四国支部大会
• [Presentation] 極長鎖一価不飽和脂肪酸は腸内細菌叢の変化を介して血管内皮機能を改善する (2021)
  • Author(s): 米田 祥広, 阪上 浩
  • Organizer: 第263回徳島医学会
• [Presentation] 関節リウマチ患者におけるサルコペニア有病率と体組成評価の有用性 (2021)
  • Author(s): 瀬部 真由, 阪上 浩
  • Organizer: 第１３回日本臨床栄養代謝学会中国四国支部学術集会
• [Presentation] 血管内皮機能改善作用を有する新たな機能性脂質の同定 (2019)
  • Author(s): 阪上 浩, 丹波 洋介, 宮原 裕子, 竹尾 仁良, 板東 正浩, 瀬部 真由, 山崎 幸, 竹治 香菜, 黒田 雅士, 升本 早枝子, 堤 理恵
  • Organizer: 日本栄養・食糧学会大会
• [Presentation] 血管内皮機能改善作用を有する新たな機能性脂質の同定 (2019)
  • Author(s): 阪上 浩, 丹波 洋介, 宮原 裕子, 竹尾 仁良, 板東 正浩, 瀬部 真由, 山崎 幸, 竹治 香菜, 黒田 雅士, 升本 早枝子, 堤 理恵
  • Organizer: 日本糖尿病学会
• [Book] 外科と代謝・栄養 (2019)
  • Author(s): 侵襲時のオートファジー制御とn-3系脂肪酸投与
  • Total Pages: 71
  • Publisher: 日本外科代謝栄養学会
• [Remarks] 徳島大学大学院 医歯薬学研究部 代謝栄養学分野ホームページ/Graphical abstract
  • URL: https://taishaeiyo.jimdofree.com/graphical-abstracts/