| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2022: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
Skeletal muscle has an intrinsically remarkable regenerative capacity, but its regenerative capacity declines with age. One of the factors contributing to the age-related decline in muscle regenerative capacity is ectopic fat formation in skeletal muscle. We have previously identified and reported on mesenchymal progenitors that are responsible for ectopic fat formation. In the course of analysing the regulatory mechanisms of mesenchymal progenitors, we found that retinoic acid (RA) signalling is activated in mesenchymal progenitors during successful muscle regeneration and that RA signalling markedly inhibits adipogenesis of mesenchymal progenitors. The aim of the present study was to clarify the functional significance of RA signalling in mesenchymal progenitors and to understand the mechanisms by which aging impairs muscle regenerative capacity.
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