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Development of environmental impact reduction technology related to MRI gadolinium contrast agent

Research Project

Project/Area Number 19H04304
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 64020:Environmental load reduction and remediation-related
Research InstitutionTokyo Metropolitan University

Principal Investigator

Inoue Kazumasa  東京都立大学, 人間健康科学研究科, 教授 (20508105)

Co-Investigator(Kenkyū-buntansha) 福士 政広  東京都立大学, 人間健康科学研究科, 客員教授 (70199199)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Fiscal Year 2023: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2022: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2021: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2019: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywordsガドリニウム造影剤 / MRI / 希土類元素 / MRI造影剤 / 環境負荷低減技術 / 環境負荷 / ガドリニウム
Outline of Research at the Start

近年、先進国を中心として河川や内湾の水に含まれる希土類元素ガドリニウムの濃度が、他の希土類元素と比較して顕著に高いことが報告されている。その原因として、使用量が急増しているMRI検査用のガドリニウム造影剤が原因であることが海外関連学会から報告されている。本申請研究では、都内の河川・沿岸における中期的実態調査と水生生物への影響調査および環境負荷低減技術の構築を行い水質改善を行う。

Outline of Final Research Achievements

The environmental dynamics of gadolinium contrast agents were investigated in treated water from water reclamation centers, river water, and tap water in Tokyo. Gadolinium contrast agents were not removed by current sewage treatment and were discharged into rivers. It was suggested that some of the released gadolinium contrast agent may have passed through the water treatment plant and ended up in the tap water.

Academic Significance and Societal Importance of the Research Achievements

大都市部におけるガドリニウム造影剤の環境動態を明確化することは、今後の環境負荷低減技術の検討において有用となる。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (9 results)

All 2022 2020 2019

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (5 results)

  • [Journal Article] Measurements and future projections of Gd-based contrast agents for MRI exams in wastewater treatment plants in the Tokyo metropolitan area2022

    • Author(s)
      Inoue Kazumasa、Fukushi Masahiro、Sahoo Sarata Kumar、Veerasamy Nimelan、Furukawa Akira、Soyama Sho、Sakata Ami、Isoda Ryo、Taguchi Yoshiaki、Hosokawa Shota、Sagara Hiroaki、Natarajan Thennaarassan
    • Journal Title

      Marine Pollution Bulletin

      Volume: 174 Pages: 113259-113259

    • DOI

      10.1016/j.marpolbul.2021.113259

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact on gadolinium anomaly in river waters in Tokyo related to the increased number of MRI devices in use2020

    • Author(s)
      Inoue Kazumasa、Fukushi Masahiro、Furukawa Akira、Sahoo Sarata Kumar、Veerasamy Nimelan、Ichimura Ken、Kasahara Shogo、Ichihara Mai、Tsukada Mizuho、Torii Minori、Mizoguchi Manami、Taguchi Yoshiaki、Nakazawa Shuto
    • Journal Title

      Marine Pollution Bulletin

      Volume: 154 Pages: 111148-111148

    • DOI

      10.1016/j.marpolbul.2020.111148

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact on gadolinium anomaly in river waters in Tokyo related to the increased number of MRI devices in use2020

    • Author(s)
      Inoue K, Fukushi M, Furukawa A, Sahoo SK, Verrasamy N, Ichimura K, Kasahara S, Ichihara M, Tsukada M, Torii M, Mizoguchi M, Taguchi Y, Nakazawa S
    • Journal Title

      Marine Pollution Bulletin

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of anthropogenic gadolinium in river waters in Hokkaido, Japan2020

    • Author(s)
      Inoue K, Fukushi M, Furukawa A, Sahoo SK, Verrasamy N, Kurokawa M, Kondo H, Shimizu H, Tsuruoka H, Mitsumoto T, Koyama K, Hosokawa S
    • Journal Title

      Japanese Journal of Education for Radiological Technology

      Volume: -

    • NAID

      40022719374

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大阪市内の下水道処理施設における人為起源 Gd 濃度の実態調査2022

    • Author(s)
      磯田凌、井上一雅、高畠賢、福士政広
    • Organizer
      日本放射線技術学会第76回東京支部春期学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 福岡市の主要河川における希土類元素ガドリニウムの濃度調査2019

    • Author(s)
      花岡慶秋,井上一雅,福士政広
    • Organizer
      第73回日本放射線技術学会東京支部春季学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] MRI造影剤に起因した都市河川水中に含まれるガドリニウム濃度の調査2019

    • Author(s)
      市村賢,井上一雅,福士政広
    • Organizer
      関東甲信越診療放射線技師学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 北海道内の河川水中のガドリニウム濃度分布調査2019

    • Author(s)
      飯盛貴斗,井上一雅,福士政広
    • Organizer
      関東甲信越診療放射線技師学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 東京都内の都市河川水中に含まれるガドリニウム濃度の調査2019

    • Author(s)
      市村賢,井上一雅,Veerasamy Nimelan,笠原彰倖,福士政広
    • Organizer
      第13回日本診療放射線学教育学会学術集会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2025-01-30  

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