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High-precision measurement of the production yield of 211-astatine by high-temperature superconducting SQUID beam ammeter

Research Project

Project/Area Number 19H04403
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 80040:Quantum beam science-related
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

Watanabe Tamaki  国立研究開発法人理化学研究所, 仁科加速器科学研究センター, 特別嘱託技師 (30342877)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
Fiscal Year 2021: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2020: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords高温超伝導 / SQUID / ビーム電流計 / 非破壊計測 / アスタチン211 / 非破壊 / 高精度 / 高温超伝導SQUID / ビスマス系高温超伝導体 / 電流計 / 加速器 / ビーム診断 / アスタチン
Outline of Research at the Start

最先端のがん治療薬として、α線を放射する短寿命放射性同位元素であるアスタチン211(211At)が、今注目を集めている。この製造量と質を正しく見積もるためには、加速されたビームの電流の高精度な測定は極めて重要である。申請者は世界に先駆けて高温超伝導SQUID(超伝導量子干渉素子)ビーム電流計の研究を続け、実用化と特許登録に至っている。211At生成収量は照射積算電流量に依存性を持つが、その測定結果は研究機関毎にばらつきがあるのが現状である。高温超伝導SQUIDビーム電流計により、生成収量の精度を大幅に向上し、211Atの製造法の最適化を実現する。

Outline of Final Research Achievements

The purpose of this study is to develop a high-temperature superconducting SQUID beam current meter for the nondestructive and accurate measurement of the production yield of Astatine 211, which is attracting attention as a cutting-edge cancer drug. A SQUID is an ultra-sensitive magnetic sensor used to measure magnetoencephalography and magnetocardiography. In this study, we have developed and successfully fabricated (1) a high-temperature superconducting pickup loop that efficiently transfers the shielding current induced by the Meissner effect to the SQUID when the beam passes through it, and (2) a superconducting magnetic shield that utilizes the perfect diamagnetism of superconductors. These successful results are attributed to continued research on two different methods of high-Tc superconductors, the Bi2212 and Bi2223 phases.

Academic Significance and Societal Importance of the Research Achievements

RI(放射性同位元素)は、基礎科学研究分野に留まらず、医療や産業など様々な分野において、すでに私達の身近で利用されている。特に近年、最先端のがん治療薬として、α線を放射する短寿命放射性同位元素であるアスタチン211(211At)が注目を集め、実用化が進められている。この製造量と質を正しく見積もるためには、加速されたビームの電流とエネルギーの高精度な測定は極めて重要である。高温超伝導SQUIDビーム電流計は、非破壊・リアルタイムでの測定が可能であり、211AtをはじめとしてRI製造に於ける生成収量の精度向上に寄与する。

Report

(4 results)
  • 2023 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (6 results)

All 2024 2022 2019 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Int'l Joint Research] Forschungszentrum Julich GmbH(ドイツ)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Improvement of the high temperature superconducting properties for the HTc SQUID current meter2022

    • Author(s)
      T.Watanabe, I Watanabe, and U.Widyaiswari
    • Journal Title

      RIKEN Accelerator Progress Report

      Volume: 56 Pages: 70-70

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Development of a beam current monitor using a High-Tc SQUID for heavy ion accelerators2024

    • Author(s)
      T. Watanabe
    • Organizer
      Forschungszentrum Julich GmbH ER-C Colloquium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Remarks] 仁科加速器科学研究センター 運転技術チーム

    • URL

      https://www.riken.jp/research/labs/rnc/accel/beam_dyn_diagn/index.html

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Patent(Industrial Property Rights)] FR, DE Patent2019

    • Inventor(s)
      T. Watanabe, N, Fukunishi
    • Industrial Property Rights Holder
      T. Watanabe, N, Fukunishi
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2021
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] JY Patent2019

    • Inventor(s)
      T. Watanabe, N, Fukunishi
    • Industrial Property Rights Holder
      T. Watanabe, N, Fukunishi
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2021
    • Related Report
      2020 Annual Research Report

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Published: 2019-04-18   Modified: 2025-01-30  

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