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Development of an imaging system of sound speed distribution based on the ultrasound backscattered wave processing

Research Project

Project/Area Number 19H04494
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 90130:Medical systems-related
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

NITTA Naotaka  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (60392643)

Co-Investigator(Kenkyū-buntansha) 鷲尾 利克  国立研究開発法人産業技術総合研究所, 生命工学領域, 主任研究員 (40358370)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Keywords画像診断システム / 医療・福祉 / 生物・生体工学 / 超音波 / 音速 / 後方散乱波
Outline of Research at the Start

生体中を伝搬する超音波(縦波)の音速は組織性状を反映しており、その分布を可視化できれば、疾病の検出や診断に役立つことが期待されている。臨床で広く用いられているハンドヘルド型プローブを用いて音速分布を可視化する試みがあるが、未だ実用化されていない。そこで本研究では、超音波後方散乱制御に基づいて音速分布を再構成する手法を開発する。ファントム(生体模擬材料)や実験動物を用いた実験的検討を通じて、高分解能・高コントラストな音速分布イメージングを可能とするアルゴリズムの確立及びシステムの完成を目指す。

Outline of Final Research Achievements

It is known that the speed of sound of ultrasound propagating through biological tissues is correlated with the tissue degenerations due to diseases, and the measurement of the speed of sound distribution is expected to be useful in the diagnosis for identifying diseased sites. Therefore, in this study, we investigated a method of measuring the speed of sound distribution with high accuracy based on the ultrasound backscattered wave processing. We constructed an experimental system that can control and acquire backscattered waves and clarified the applicability of the sound speed measurement algorithm to actual data using phantoms and extracted animal tissues. As a result, the feasibility of this method was suggested.

Academic Significance and Societal Importance of the Research Achievements

生体組織を伝搬する超音波の音速は、疾病等による組織変性と相関があり、多くの腫瘍では、その周囲の正常な軟組織とは異なる音速を有することが知られている。このような音速の僅かな変化が捉えられれば、多くの疾病に対する早期発見が可能になるものと期待される。今回の成果により音速測定が高精度化され、僅かな音速変化の検出が可能になった。このことから、超音波診断による疾病の早期発見に資する成果が得られたと言える。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (17 results)

All 2022 2021 2020 2019 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 3 results) Remarks (1 results)

  • [Journal Article] Basic investigation on identification of tissue composition based on propagation speeds of longitudinal and shear waves2022

    • Author(s)
      Nitta Naotaka、Washio Toshikatsu、Numano Tomokazu
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 61 Issue: SG Pages: SG1023-SG1023

    • DOI

      10.35848/1347-4065/ac45d5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Longitudinal and Shear Wave Speeds Ultrasonically Measured in Agar-Glycerol Phantoms2021

    • Author(s)
      Nitta Naotaka、Washio Toshikatsu、Numano Tomokazu
    • Journal Title

      2021 IEEE International Ultrasonics Symposium Proceedings

      Volume: 1 Pages: 1-4

    • DOI

      10.1109/ius52206.2021.9593533

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A review of physical and engineering factors potentially affecting shear wave elastography2021

    • Author(s)
      Nitta Naotaka、Yamakawa Makoto、Hachiya Hiroyuki、Shiina Tsuyoshi
    • Journal Title

      Journal of Medical Ultrasonics

      Volume: 48 Issue: 4 Pages: 403-414

    • DOI

      10.1007/s10396-021-01127-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relation between statistical properties of sound speed distribution and average sound speed estimation2021

    • Author(s)
      Nitta Naotaka、Washio Toshikatsu
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 60 Issue: SD Pages: SDDE18-SDDE18

    • DOI

      10.35848/1347-4065/abf4a6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Average Sound Speed Estimation Using Backscattered Signals from Inhomogeneous Media and its Error Analysis2020

    • Author(s)
      Nitta Naotaka、Washio Toshikatsu
    • Journal Title

      2020 IEEE International Ultrasonics Symposium Proceedings

      Volume: 1 Pages: 1-4

    • DOI

      10.1109/ius46767.2020.9251376

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a simulator of backscattered signals from inhomogeneous medium for speed of sound measurement and imaging2019

    • Author(s)
      Naotaka Nitta
    • Journal Title

      2019 IEEE International Ultrasonics Symposium Proceedings

      Volume: 1 Pages: 1466-1469

    • DOI

      10.1109/ultsym.2019.8925896

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Comparison of longitudinal and shear wave speeds ultrasonically measured in agar-glycerol phantoms2021

    • Author(s)
      Naotaka Nitta, Toshikatsu Washio, Tomokazu Numano
    • Organizer
      2021 IEEE International Ultrasonics Symposium
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マルチモダリティ音速測定法の開発と軟骨評価への応用2021

    • Author(s)
      新田尚隆, 三澤雅樹, 沼野智一
    • Organizer
      日本超音波医学会第94回学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 音速分布の統計的性質が平均音速推定に与える影響2021

    • Author(s)
      新田尚隆, 鷲尾利克
    • Organizer
      日本超音波医学会第94回学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 超音波後方散乱波を用いた平均音速推定の信頼性評価2021

    • Author(s)
      新田尚隆, 鷲尾利克
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Basic investigation on identification of tissue composition based on propagation speeds of longitudinal and shear waves2021

    • Author(s)
      新田尚隆, 鷲尾利克, 沼野智一
    • Organizer
      第42回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] Average sound speed estimation using backscattered signals from inhomogeneous media and its error analysis2020

    • Author(s)
      Nitta Naotaka、Washio Toshikatsu
    • Organizer
      2020 IEEE International Ultrasonics Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Relation between statistical properties of sound speed distribution and average sound speed estimation2020

    • Author(s)
      新田尚隆、鷲尾利克
    • Organizer
      第41回超音波エレクトロニクスの基礎と応用に関するシンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 音速分布を反映する後方散乱波の解析2020

    • Author(s)
      新田尚隆、賀谷彰夫、鷲尾利克
    • Organizer
      日本超音波医学会第93回学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 音速分布を考慮した後方散乱波のシミュレーションに関する検討2019

    • Author(s)
      新田尚隆, 鷲尾利克
    • Organizer
      日本超音波医学会第3回基礎技術研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of a simulator of backscattered signals from inhomogeneous medium for speed of sound measurement and imaging2019

    • Author(s)
      Naotaka Nitta
    • Organizer
      2019 IEEE International Ultrasonics Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 産総研生命工学領域

    • URL

      https://www.aist.go.jp/aist_j/dept/dlsbt.html

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report 2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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