• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Comprehensive understanding of mechanisms underlying the piRNA pathway

Research Project

Project/Area Number 19H05466
Research Category

Grant-in-Aid for Specially Promoted Research

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionThe University of Tokyo

Principal Investigator

Siomi Mikiko  東京大学, 大学院理学系研究科(理学部), 教授 (20322745)

Project Period (FY) 2019-04-23 – 2024-03-31
Project Status Completed (Fiscal Year 2024)
Budget Amount *help
¥542,490,000 (Direct Cost: ¥417,300,000、Indirect Cost: ¥125,190,000)
Fiscal Year 2023: ¥92,690,000 (Direct Cost: ¥71,300,000、Indirect Cost: ¥21,390,000)
Fiscal Year 2022: ¥105,300,000 (Direct Cost: ¥81,000,000、Indirect Cost: ¥24,300,000)
Fiscal Year 2021: ¥104,650,000 (Direct Cost: ¥80,500,000、Indirect Cost: ¥24,150,000)
Fiscal Year 2020: ¥104,650,000 (Direct Cost: ¥80,500,000、Indirect Cost: ¥24,150,000)
Fiscal Year 2019: ¥135,200,000 (Direct Cost: ¥104,000,000、Indirect Cost: ¥31,200,000)
KeywordspiRNA / トランスポゾン / PIWI / サイレンシング / 生殖 / RNAサイレンシング
Outline of Research at the Start

生殖組織特異的小分子RNAであるpiRNAはトランスポゾンの利己的転移を抑制することにより生殖ゲノムをDNA 損傷から守る。piRNAの機能欠失は生殖組織の発生・分化阻害、卵子・精子の形成不全、ひいては不妊を引き起こす。piRNAの発見以降、piRNA機構の動作原理を解明する研究は国内外で精力的に行われているが、全容解明には至っていない。そこで本研究ではこれまでに培った知識や手法、発想などを十分に生かした研究を展開することによってpiRNA研究の集大成に挑む。本研究の成果は、piRNA機構の統合的理解のみならず、生殖システムの包括的理解、自己・非自己の識別分子機構の理解、ひいては生殖医療へと繋がる。

Outline of Final Research Achievements

In this study, we aimed to achieve an integrated understanding of the piRNA pathway by focusing on five key topics, with particular emphasis on the "decision-making mechanisms of piRNA biogenesis in ovarian somatic cells." Building on years of accumulated knowledge and experience, we incorporated advanced interdisciplinary approaches, spanning biochemistry, cell biology, genetics, bioinformatics, and structural biology. The research progressed according to the original plan, and the intended goals were successfully accomplished. Over the course of the project, we published 26 papers, with several more currently in preparation. Among the published works, three are review articles that summarize recent advances in piRNA research and have made substantial contributions to the field.

Academic Significance and Societal Importance of the Research Achievements

細菌からヒトに伝わる細菌のゲノムには、太古の昔にウイルス由来のトランスポゾンが襲い、現在に至るまで宿主と共存している。トランスポゾンはゲノム上を自由に転移することが可能で(よって「動く遺伝子」としても知られる)、その利己的な転移性は生物進化の原動力となってきた。能力が高く、それは最終的に不妊の原因となる。 不妊等による人口減少は、国内が考える喫緊の社会課題の一つであるが、本特別推進研究の成果はこの問題の解決に向けて重要な糸口となる可能性を秘めている。

Assessment Rating
Ex-post Assessment

A+: 期待以上の成果があった

Assessment Rating
Interim Assessment

A: 順調に研究が進展しており、期待どおりの成果が見込まれる

Report

(11 results)
  • 2025 Ex-post Assessment (Comments) ( PDF )
  • 2024 Final Research Report ( PDF )
  • 2023 Annual Research Report
  • 2022 Annual Research Report
  • 2021 Abstract (Interim Assessment) ( PDF )   Annual Research Report   Interim Assessment (Comments) ( PDF )
  • 2020 Annual Research Report
  • 2019 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (142 results)

All 2025 2024 2023 2022 2021 2020 2019 Other

All Journal Article (25 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 23 results,  Open Access: 25 results) Presentation (114 results) (of which Int'l Joint Research: 20 results,  Invited: 14 results) Remarks (3 results)

  • [Journal Article] Dipteran-specific Daedalus controls Zucchini endonucleolysis in piRNA biogenesis independent of exonucleases2024

    • Author(s)
      Koga Yuica、Hirakata Shigeki、Negishi Mayu、Yamazaki Hiroya、Fujisawa Tatsuya、Siomi Mikiko C.
    • Journal Title

      Cell Reports

      Volume: 43 Issue: 11 Pages: 114923-114923

    • DOI

      10.1016/j.celrep.2024.114923

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Priming Epigenetic Landscape at Gene Promoters through Transcriptional Activation in Mammalian Germ Cells2024

    • Author(s)
      Li Peilin、Fujisawa Tatsuya、Narita Haruka、Uneme Yuta、Seki Masahide、Hu Mengwen、Narumi Ryohei、Namekawa Satoshi H.、Khan Shehroz S.、Davie James R.、Suzuki Yutaka、Adachi Jun、Ashraf Ahmed、Inoue Azusa、Siomi Mikiko C.、Yamanaka Soichiro
    • Journal Title

      bioRχiv

      Volume: -

    • DOI

      10.1101/2024.11.24.625111

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] Transient residence of the repulsive client Shutdown in Yb bodies plays a critical role in Piwi-piRISC biogenesis and maintaining fertility2024

    • Author(s)
      Hirakata Shigeki、Fujita Aoi、Siomi Mikiko C.
    • Journal Title

      bioRχiv

      Volume: -

    • DOI

      10.1101/2024.11.13.623522

    • Related Report
      2023 Annual Research Report
    • Open Access
  • [Journal Article] ADMA-histones define genomic loading of Rhino at the initial step of piRNA cluster formation2024

    • Author(s)
      Raku Saito, Hirotsugu Ishizu, Ritsuko Harigai, Kensaku Murano, Mikiko C. Siomi
    • Journal Title

      BioRxiv

      Volume: -

    • DOI

      10.1101/2024.03.15.585151

    • Related Report
      2023 Annual Research Report 2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Morc1 reestablishes H3K9me3 heterochromatin on piRNA-targeted transposons in gonocytes2024

    • Author(s)
      Uneme Yuta、Maeda Ryu、Nakayama Gen、Narita Haruka、Takeda Naoki、Hiramatsu Ryuji、Nishihara Hidenori、Nakato Ryuichiro、Kanai Yoshiakira、Araki Kimi、Siomi Mikiko C.、Yamanaka Soichiro
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 121 Issue: 13

    • DOI

      10.1073/pnas.2317095121

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An extended Tudor domain within Vreteno interconnects Gtsf1L and Ago3 for piRNA biogenesis in Bombyx mori2023

    • Author(s)
      Bronkhorst AW, Lee CY, Mockel MM, Ruegenberg S, Domingues AM, Sadouki S, Piccinno R, Sumiyoshi T, Siomi MC, Stelzl L, Luck K, Ketting RF.
    • Journal Title

      EMBO J.

      Volume: 421942 Issue: 24

    • DOI

      10.15252/embj.2023114072

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bombyx Vasa sequesters transposon mRNAs in nuage via phase separation requiring RNA binding and self-association2023

    • Author(s)
      Yamazaki Hiroya、Namba Yurika、Kuriyama Shogo、Nishida Kazumichi M.、Kajiya Asako、Siomi Mikiko C.
    • Journal Title

      Nature Communications

      Volume: 14 Issue: 1 Pages: 1942-1942

    • DOI

      10.1038/s41467-023-37634-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lint‐O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain2022

    • Author(s)
      Yamamoto‐Matsuda Hitomi、Miyoshi Keita、Moritoh Mai、Yoshitane Hikari、Fukada Yoshitaka、Saito Kuniaki、Yamanaka Soichiro、Siomi Mikiko C
    • Journal Title

      EMBO reports

      Volume: 23 Issue: 10

    • DOI

      10.15252/embr.202153813

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Siwi cooperates with Par-1 kinase to resolve the autoinhibitory effect of Papi for Siwi-piRISC biogenesis2022

    • Author(s)
      Yamada Hiromi、Nishida Kazumichi M.、Iwasaki Yuka W.、Isota Yosuke、Negishi Lumi、Siomi Mikiko C.
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 1518-1518

    • DOI

      10.1038/s41467-022-29193-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maelstrom functions in the production of Siwi-piRISC capable of regulating transposons in Bombyx germ cells2022

    • Author(s)
      Namba Yurika、Iwasaki Yuka W.、Nishida Kazumichi M.、Nishihara Hidenori、Sumiyoshi Tetsutaro、Siomi Mikiko C.
    • Journal Title

      iScience

      Volume: 25 Issue: 3 Pages: 103914-103914

    • DOI

      10.1016/j.isci.2022.103914

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] T-hairpin structure found in the RNA element involved in piRNA biogenesis2022

    • Author(s)
      Takase Naomi、Otsu Maina、Hirakata Shigeki、Ishizu Hirotsugu、Siomi Mikiko C.、Kawai Gota
    • Journal Title

      RNA

      Volume: 28 Issue: 4 Pages: 541-550

    • DOI

      10.1261/rna.078967.121

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] piRNA‐ and siRNA‐mediated transcriptional repression in <i>Drosophila</i> , mice, and yeast: new insights and biodiversity2021

    • Author(s)
      Onishi Ryo、Yamanaka Soichiro、Siomi Mikiko C
    • Journal Title

      EMBO reports

      Volume: 22 Issue: 10

    • DOI

      10.15252/embr.202153062

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hamster PIWI proteins bind to piRNAs with stage-specific size variations during oocyte maturation2021

    • Author(s)
      Ishino Kyoko、Hasuwa Hidetoshi、Yoshimura Jun、Iwasaki Yuka W、Nishihara Hidenori、Seki Naomi M、Hirano Takamasa、Tsuchiya Marie、Ishizaki Hinako、Masuda Harumi、Kuramoto Tae、Saito Kuniaki、Sakakibara Yasubumi、Toyoda Atsushi、Itoh Takehiko、Siomi Mikiko C、Morishita Shinichi、Siomi Haruhiko
    • Journal Title

      Nucleic Acids Research

      Volume: 49 Issue: 5 Pages: 2700-2720

    • DOI

      10.1093/nar/gkab059

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DEAD‐box polypeptide 43 facilitates piRNA amplification by actively liberating RNA from Ago3‐piRISC2021

    • Author(s)
      Murakami Ryo、Sumiyoshi Tetsutaro、Negishi Lumi、Siomi Mikiko C
    • Journal Title

      EMBO reports

      Volume: 22 Issue: 4

    • DOI

      10.15252/embr.202051313

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The piRNA pathway in <i>Drosophila</i> ovarian germ and somatic cells2020

    • Author(s)
      SATO Kaoru、SIOMI Mikiko C.
    • Journal Title

      Proceedings of the Japan Academy, Series B

      Volume: 96 Issue: 1 Pages: 32-42

    • DOI

      10.2183/pjab.96.003

    • NAID

      130007783757

    • ISSN
      0386-2208, 1349-2896
    • Year and Date
      2020-01-10
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells2020

    • Author(s)
      Onishi Ryo、Sato Kaoru、Murano Kensaku、Negishi Lumi、Siomi Haruhiko、Siomi Mikiko C.
    • Journal Title

      Science Advances

      Volume: 6 Issue: 50

    • DOI

      10.1126/sciadv.aaz7420

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyx mori2020

    • Author(s)
      Nishida KM, Sakakibara K, Sumiyoshi T, Yamazaki H, Mannen T, Kawamura T, Kodama T, Siomi MC.
    • Journal Title

      The EMBO Journal

      Volume: 39 Issue: 20

    • DOI

      10.15252/embj.2020105130

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Mi-2 nucleosome remodeler and the Rpd3 histone deacetylase are involved in piRNA-guided heterochromatin formation2020

    • Author(s)
      Mugat Bruno、Nicot Simon、Varela-Chavez Carolina、Jourdan Christophe、Sato Kaoru、Basyuk Eugenia、Juge Fran?ois、Siomi Mikiko C.、P?lisson Alain、Chambeyron S?verine
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 108-120

    • DOI

      10.1038/s41467-020-16635-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Crystal structure of Drosophila Piwi.2020

    • Author(s)
      Yamaguchi, S., Oe, A., Nishida, KM., Yamashita, K., Kajiya, A., Hirano, S., Matsumoto, N., Dohmae, N., Ishitani, R., Saito, K., Siomi, H., Nishimasu, H., Siomi, MC., and Nureki, O.
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 858-858

    • DOI

      10.1038/s41467-020-14687-1

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Armitage determines PiwiーpiRISC processing from precursor formation and quality control to inter‐organelle translocation2019

    • Author(s)
      Yamashiro Haruna、Negishi Mayu、Kinoshita Tatsuki、Ishizu Hirotsugu、Ohtani Hitoshi、Siomi Mikiko C
    • Journal Title

      EMBO reports

      Volume: 21 Issue: 2

    • DOI

      10.15252/embr.201948769

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Assembly and Function of Gonad-Specific Non-Membranous Organelles in Drosophila piRNA Biogenesis2019

    • Author(s)
      Hirakata Shigeki、Siomi Mikiko C.
    • Journal Title

      Non-Coding RNA

      Volume: 5 Issue: 4 Pages: 52-52

    • DOI

      10.3390/ncrna5040052

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Essential roles of Windei and nuclear monoubiquitination of Eggless/ SETDB 1 in transposon silencing2019

    • Author(s)
      Osumi Ken、Sato Kaoru、Murano Kensaku、Siomi Haruhiko、Siomi Mikiko C
    • Journal Title

      EMBO reports

      Volume: 20 Issue: 12

    • DOI

      10.15252/embr.201948296

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nuclear RNA export factor variant initiates piRNA-guided co-transcriptional silencing2019

    • Author(s)
      Murano, K., Iwasaki Y.W., Ishizu H., Mashiko, A., Shibuya, A., Kondo, S., Adachi, S., Suzuki, S., Saito, K., Natsume, T., Siomi, M.C., Siomi, H.
    • Journal Title

      The EMBO Journal

      Volume: 印刷中 Issue: 17 Pages: 1-20

    • DOI

      10.15252/embj.2019102870

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct and collaborative functions of Yb and Armitage in transposon-targeting piRNA biogenesis2019

    • Author(s)
      Hirotsugu Ishizu, Tatsuki Kinoshita, Shigeki Hirakata, Chihiro Komatsuzaki, and Mikiko C. Siomi
    • Journal Title

      Cell Reports

      Volume: 27 Issue: 6 Pages: 1822-1835

    • DOI

      10.1016/j.celrep.2019.04.029

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Requirements for multivalent Yb body assembly in transposon silencing in Drosophila2019

    • Author(s)
      Shigeki Hirakata, Hirotsugu Ishizu, Aoi Fujita, Yumiko Tomoe, Mikiko C. Siomi
    • Journal Title

      EMBO Reports

      Volume: 印刷中 Issue: 7

    • DOI

      10.15252/embr.201947708

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 宿主-トランスポゾンの軍拡競争と共生2025

    • Author(s)
      塩見美喜子
    • Organizer
      第5回有性生殖研究会/新学術「全能性」最終公開シンポジウム 合同開催「生殖研究の異分野融合」
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 精子幹細胞の確立に寄与するエピジェネティック機構の解析2025

    • Author(s)
      山中総一郎, 藤澤達也, 前田隆, 釆女憂太, 関真秀, 鈴木穣, 塩見美喜子
    • Organizer
      第5回有性生殖研究会/新学術「全能性」最終公開シンポジウム 合同開催「生殖研究の異分野融合」
    • Related Report
      2023 Annual Research Report
  • [Presentation] MOV10L1 S818I Mutation in Mice Leads to the Formation of a Ring-Like SYCP3 Structure and Meiotic Arrest.2025

    • Author(s)
      尉衍凌, 平形樹生, 島田龍輝, 古賀結花, 山中総一郎, 竹田直樹, 荒木喜美, 石黒啓一郎, 塩見美喜子
    • Organizer
      第5回有性生殖研究会/新学術「全能性」最終公開シンポジウム 合同開催「生殖研究の異分野融合」
    • Related Report
      2023 Annual Research Report
  • [Presentation] 恒常的小分子RNAによる遺伝子発現制御機構2025

    • Author(s)
      塩見美喜子
    • Organizer
      令和6年度第4回名古屋産学官・医連携研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] piRNA生合成機構におけるQin依存的なpiRNA前駆体選別のしくみの解明2024

    • Author(s)
      難波祐里香, 西田知訓, 小野幸輝, 岩崎由香, 黒田由惟, 浅井潔, 塩見美喜子
    • Organizer
      先進ゲノム支援2024年度拡大班会議
    • Related Report
      2023 Annual Research Report
  • [Presentation] Diptera-specific Daed controls Zuc endonucleolysis for piRISC production and its function2024

    • Author(s)
      古賀結花, 平形樹生, 根岸茉由, 山崎啓也, 塩見美喜子
    • Organizer
      第47回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] piRNA抑制を逃れたRE springerによるゲノムワイドなN末端欠損型新規タンパク質 アイソフォーム産生機構2024

    • Author(s)
      盛藤舞, 森田亨, 竹内力, 岩崎由香, 塩見美喜子
    • Organizer
      第47回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] MOV10L1 S818I Mutant Mouse, a Model of Male Infertility, shows Unique Phenotypes Distinct from MOV10L1-deficient Mouse2024

    • Author(s)
      尉衍凌, 平形樹生, 島田龍輝, 古賀結花, 山中総一郎, 竹田直樹, 荒木喜美, 石黒啓一郎, 塩見美喜子
    • Organizer
      第47回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] DEAD-box型RNAヘリカーゼVasaの核-細胞質間シャトルによってトランスポゾン転写産物はVasa bodyに蓄積する2024

    • Author(s)
      福田瑞希, 山崎啓也, 塩見美喜子
    • Organizer
      第47回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Shaping Epigenome Landscape at Gene Promoters through Resetting Histone Modification in the Mouse Germ Cells2024

    • Author(s)
      李沛霖, 成田晴香, 采女優太, 関真秀, Hu Mengwen
    • Organizer
      第47回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 精子幹細胞の確立に寄与するエピジェネティックな機構の解明2024

    • Author(s)
      藤澤達也, 前田隆、釆女優太, 関真秀, 鈴木穣, 塩見美喜子, 山中総一郎
    • Organizer
      第47回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] The processing of clustered H/ACA box snoRNAs mediated by a Zc3h12 family protein in Drosophila2024

    • Author(s)
      濱島充長, 山野智寛,平形樹生, 塩見美喜子
    • Organizer
      第47回日本分子生物学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Host-transposon arms race via piRNA and symbiosis2024

    • Author(s)
      塩見美喜子
    • Organizer
      WANG YINGLAT LECTURER
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanism of piRNA-mediated transposon silencing2024

    • Author(s)
      塩見美喜子
    • Organizer
      CSHA Meeting: RNA Biology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Repulsive property of Shutdown allows its release from cytosolic droplets, Yb bodies, to promote piRISC generation2024

    • Author(s)
      平形樹生, 塩見美喜子
    • Organizer
      CSHA Meeting: RNA Biology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Extensive Deregulation of Genes in Mouse Embryonic Germ Cells2024

    • Author(s)
      李沛霖, 成田晴香, 采女優太, 塩見美喜子, 山中総一郎
    • Organizer
      CSHA Meeting: RNA Biology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] piRNA Biogenesis in Drosophila2024

    • Author(s)
      塩見美喜子
    • Organizer
      2024Fudan International Symposium of RNA Biology: Frontier and Therapeutics
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Mechanisms and roles of nuclear granule formation by the transposon repressor Morc12024

    • Author(s)
      礒田洋祐, 山崎啓也, 中里大悟, 小迫英尊, 中山弦, 山中総一郎, 塩見美喜子
    • Organizer
      Summer school Epigenetics Montpellier
    • Related Report
      2023 Annual Research Report
  • [Presentation] Diptera-specific Daedalus controls Zucchini endonucleolysis in piRNA biogenesis independent of exonucleases2024

    • Author(s)
      古賀結花, 平形樹生, 根岸茉由, 山崎啓也, 塩見美喜子
    • Organizer
      WINGS-LST全体会議
    • Related Report
      2023 Annual Research Report
  • [Presentation] Drosophila cultured cell-specific isoform production triggered by transposon insertion2024

    • Author(s)
      盛藤舞, 森田亨, 竹内力, 岩崎由香, 塩見美喜子
    • Organizer
      WINGS-LST全体会議
    • Related Report
      2023 Annual Research Report
  • [Presentation] Extensive Deregulation of Genes in Mouse Embryonic Germ Cells2024

    • Author(s)
      李沛霖, 成田晴香, 采女優太, 塩見美喜子, 山中総一郎
    • Organizer
      第25回日本RNA学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Mitochondrial protein Daed regulates Zuc cleavage position in piRISC maturation to optimize transposon repression2024

    • Author(s)
      古賀結花, 平形樹生, 根岸茉由, 山崎啓也, 塩見美喜子
    • Organizer
      第25回日本RNA学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Drosophila ovarian somatic cell-specific isoform production triggered by transposon insertion2024

    • Author(s)
      盛藤舞, 森田亨, 竹内力, 岩崎由香, 塩見美喜子
    • Organizer
      第25回日本RNA学会年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ミトコンドリアタンパク質DaedによるZuc依存的なpiRNA前駆体切断の制御2024

    • Author(s)
      古賀結花, 平形樹生, 根岸茉由, 山崎啓也, 塩見美喜子
    • Organizer
      第23回東京大学生命科学シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] トランスポゾン転移によるショウジョウバエ生殖系体細胞OSC特異的アイソフォームの産生機構2024

    • Author(s)
      盛藤舞, 森田亨, 竹内力, 岩崎由香, 塩見美喜子
    • Organizer
      第23回東京大学生命科学シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] The piRNA pathway and transposons in cultured fly ovarian soma<c cells.2024

    • Author(s)
      塩見美喜子
    • Organizer
      piRNAs and PIWI proteins
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mitochondrial protein Daed optimize Zuc endonucleosis in piRISC maturation2024

    • Author(s)
      古賀結花, 平形樹生, 根岸茉由, 山崎啓也, 塩見美喜子
    • Organizer
      piRNAs and PIWI proteins
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of molecular contribution of mitochondrial scaffold protein Daed to piRISC maturation2024

    • Author(s)
      Yuica Koga, Shigeki Hirakata, Mayu Negishi, Mikiko C. SIomi
    • Organizer
      JST-EMBO Matchmaking Workshop
    • Related Report
      2022 Annual Research Report
  • [Presentation] LTR-type transposon Springer invasion in the L(3)mbt gene leads to the production of an isoform unique to cultured Drosophila ovarian somatic cells2024

    • Author(s)
      Mai Moritoh, Toru Morita, Chikara Takeuchi, Yuka W. Iwasaki, Mikiko C. Siomi
    • Organizer
      JST-EMBO Matchmaking Workshop
    • Related Report
      2022 Annual Research Report
  • [Presentation] Mechanisms and roles of nuclear granule formation by the transposon repressor Morc12024

    • Author(s)
      Yosuke Isota, Hiroya Yamazaki, Gen Nakayama, Soichiro Yamanaka, Mikiko C. Siomi
    • Organizer
      JST-EMBO Matchmaking Workshop
    • Related Report
      2022 Annual Research Report
  • [Presentation] トランスポゾン転移による生殖系体細胞OSC特異的アイソフォームの産生機構2024

    • Author(s)
      盛藤舞, 森田亨, 竹内力, 岩崎由香, 塩見美喜子
    • Organizer
      第4回有性生殖研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] H3K4メチル化修飾から紐解く,胎仔期の雄性生殖細胞における発生プログラム2024

    • Author(s)
      藤澤達也, 前田隆, 采女優太, 塩見美喜子, 山中総一郎
    • Organizer
      第4回有性生殖研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ゴノサイトにおけるポリコームとDNAメチル化の遺伝子共同制御機構2024

    • Author(s)
      Peilin Li, Tatsuya Fujisawa, Haruka Narita, Yuta Uneme, Mikiko C Siomi, Soichiro Yamanaka
    • Organizer
      第4回有性生殖研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] piRNA生合成機構におけるQin依存的なpiRNA前駆体選別のしくみの解明2023

    • Author(s)
      難波祐里香, 西田知訓, 小野幸輝, 岩崎由香, 黒田由惟, 浅井潔, 塩見美喜子
    • Organizer
      先進ゲノム支援2023年度拡大班会議
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] The process of defining piRNA clusters involves histone arginine methylation2023

    • Author(s)
      齋藤絡, 針谷律子, 石津大嗣, 塩見美喜子
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analysis of molecular contribution of mitochondrial scaffold protein Daed to piRISC maturation2023

    • Author(s)
      古賀結花, 平形樹生, 根岸茉由, 塩見美喜子
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] LTR型トランスポゾンSpringerが引き起こすショウジョウバエ培養細胞株OSC特異的なL(3)mbtアイソフォーム産生機構2023

    • Author(s)
      盛藤舞, 森田亨, 竹内力, 岩崎由香, 塩見美喜子
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ショウジョウバエCG42360は卵巣体細胞においてトランスポゾンの発現を抑制する2023

    • Author(s)
      山野智寛
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] アルギニンメチル化によるRNAサイレンシングの多角的制御2023

    • Author(s)
      坂根由都, 齋藤絡, 針谷律子, 小迫英尊, 塩見美喜子
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 新規LTR型レトロトランスポゾンCountdownの解析2023

    • Author(s)
      黒田由惟, 難波祐里香, 西田知訓, 信藤知子, 芝田晋介, 塩見美喜子
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] トランスポゾン転写産物がVasa bodyへと濃縮するメカニズムの解明2023

    • Author(s)
      福田瑞希, 山﨑啓也. 塩見美喜子
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] トランスポゾン抑制関連タンパク質Morc1の核内顆粒形成とヒストン修飾を介したトランスポゾン抑制機構の解明2023

    • Author(s)
      中里大瑚, 礒田洋祐, 山﨑啓也, 塩見美喜子
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 雄性生殖細胞特異的クロマチンタンパク質であるMorc1はトランスポゾン上でのヘテロクロマチン形成を介して宿主遺伝子の適切な発現状態を可能にする2023

    • Author(s)
      前田隆, 采女優太, 中山弦, 成田晴香, 竹田直樹, 平松竜司, 西原秀典, 中戸隆一郎, 金井克晃, 荒木善美, 塩見美喜子, 山中総一郎
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] マウスゴノサイトにおけるポリコームの不活化は遺伝子の異所的な発現を誘導する2023

    • Author(s)
      成田晴香, 李沛霖, 采女優太, 藤澤達也, 青木愛珠, メングエンフウ, 行川賢, 井上梓, 塩見美喜子, 山中総一郎
    • Organizer
      第46回日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] LTR-type Springer Invaded in the L(3)mbt Gene Leads to the Production of an Isoform Unique to Cultured Drosophila Ovarian Somatic Cells2023

    • Author(s)
      Mai Moritoh, Chikara Takeuchi, Yuka W. Iwasaki, Mikiko C. Siomi
    • Organizer
      KEYSTONE SYMPOSIA: Transposable Elements at the Crossroads of Evolution, Health and Disease (F2)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] piRNAs protect the germline genome from transposon invasion2023

    • Author(s)
      Mikiko C. Siomi
    • Organizer
      2023Taiwan-Japan Bilateral Meetiong on RNA and Biofunction
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of molecular contribution of mitochondrial scaffold protein Daed to piRISC maturation2023

    • Author(s)
      Yuica Koga, Shigeki Hirakata, Mayu Negishi, Mikiko C. SIomi
    • Organizer
      The 34th Tokyo RNA Club
    • Related Report
      2022 Annual Research Report
  • [Presentation] LTR型レトロトランスポゾンspringerのゲノム転移によるL(3)mbt遺伝子の機能発現への影響2023

    • Author(s)
      盛藤舞
    • Organizer
      The 34th Tokyo RNA Club
    • Related Report
      2022 Annual Research Report
  • [Presentation] Elucidation of the molecular function of Qin in the germline piRNA pathway2023

    • Author(s)
      Yurika Namba, Kazumichi M. Nishida, Yukiteru Ono, Yui Kuroda, Kiyoshi Asai, Mikiko C. Siomi
    • Organizer
      第24回日本RNA学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ミトコンドリア外膜上足場タンパク質DaedのpiRNA成熟化への寄与の解析2023

    • Author(s)
      古賀結花, 根岸茉由, 藤澤達也, 平形樹生, 塩見美喜子
    • Organizer
      第22回東京大学生命科学シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] LTR型トランスポゾンspringerと宿主ゲノムの共生と攻防戦2023

    • Author(s)
      盛藤舞, 山田紘実, 塩見美喜子
    • Organizer
      第22回東京大学生命科学シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] The piRNA pathway in Drosophila-How does the molecular machinary protect the genome from transposon invasion in the germline?2023

    • Author(s)
      Mikiko C. Siomi
    • Organizer
      The Now and Future of RNA Therapeutics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ミトコンドリア外膜上足場タンパク質DaedのpiRNA成熟化への寄与の解析2023

    • Author(s)
      古賀結花, 根岸茉由, 平形樹生, 塩見美喜子
    • Organizer
      WINGS-LST発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Coexistence and arms race between LTR-type retrotransposon springer and the host genome2023

    • Author(s)
      Mai Moritoh, Hiromi Yamada, Mikiko C. Siomi
    • Organizer
      WINGS-LST発表会
    • Related Report
      2022 Annual Research Report
  • [Presentation] piRNAs protect the germline genome from transposon invasion2023

    • Author(s)
      Mikiko C. Siomi
    • Organizer
      第75回日本細胞生物学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエ卵巣体細胞におけるpiRNA生合成の場Yb bodyへのPiwi局在化機構とその制御2023

    • Author(s)
      平形樹生, 藤田あおい, 塩見美喜子
    • Organizer
      第75回日本細胞生物学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Mechanism and regulation of Piwi localization to Yb body, the site of piRNA biogenesis in Drosophila ovarian somatic cells2023

    • Author(s)
      Shigeki Hirakata, Aoi Fujita, Mikiko C. Siomi
    • Organizer
      The 28th Annual Meeting of the RNA Society
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Germline-specific DEAD-box RNA helicase Vasa sequesters transposon mRNAs in nuage via phase separation requiring RNA binding and self-association2023

    • Author(s)
      Hiroya Yamazaki, Yurika Namba, Shogo Kuriyama, Kazumichi M. Nishida, Asako Kajiya, Mikiko C. Siomi
    • Organizer
      The 28th Annual Meeting of the RNA Society
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of the mechanism of nuclear granule formation mediated by phase separation of the transposon repressor Morc12023

    • Author(s)
      Yosuke Isota, Hiroya Yamazaki, Gen Nakayama, Soichiro Yamanaka, Mikiko C. Siomi
    • Organizer
      The 28th Annual Meeting of the RNA Society
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ショウジョウバエ卵巣体細胞におけるpiRNA生合成の場Yb bodyへのPiwi局在化のメカニズムとその制御2022

    • Author(s)
      平形樹生、藤田あおい、巴裕美子、塩見美喜子
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] piRNA生合成機構におけるQinの分子機能解析2022

    • Author(s)
      難波祐里香、西田知訓、小野幸輝、岩崎由香、鍛治屋麻子、浅井潔、塩見美喜子
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 脳腫瘍抑制因子L(3)mbtによるpiRNA増幅システムの制御機構の解明2022

    • Author(s)
      山田紘実、黒田李花子、塩見美喜子
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ミトコンドリア上足場タンパク質Gasz/Daedヘテロ複合体のpiRISC成熟化への寄与の解析2022

    • Author(s)
      古賀結花、根岸茉由、藤澤達也、平形樹生、塩見美喜子
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] トランスポゾン抑制因子Morc1の相分離を介した顆粒形成メカニズムの解析2022

    • Author(s)
      礒田洋祐、山﨑啓也、中山弦、山中総一郎、塩見美喜子
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] DNA結合タンパク質Morc1はマウスゴノサイトにおいてレトロトランスポゾンにH3K9me3を導入する2022

    • Author(s)
      采女優太、中山弦、前田隆、塩見美喜子、山中総一郎
    • Organizer
      第45回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Mechanism and regulation of Piwi localization to Yb bodies the piRNA biogenesis center in Drosophila ovarian somatic cells2022

    • Author(s)
      Shigeki Hirakata, Aoi Fujita, Yumiok Tomoe, Mikiko C. Siomi
    • Organizer
      第23回日本RNA学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Characterization of the germline-specific DEAD-box RNA helicase Vasa in LLPS-mediated formation of germ granules2022

    • Author(s)
      Hiroya Yamazaki, Yurika NAMBA, Kazumichi M. Nishida, Ryo Murakami, Shogo Kuriyama, Asako Kajiya, Mikiko C. Siomi
    • Organizer
      第23回日本RNA学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Maelstrom functions in the production of Siwi-piRISC capable of regulating transposons in Bombyx germ cells2022

    • Author(s)
      Yurika NAMBA, Yuka W. Iwasaki, Kazumichi M. Nishida, Hidenori Nishihara, Tetsutaro Sumiyoshi, Mikiko C. Siomi
    • Organizer
      第23回日本RNA学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Analysis of the mechanism underlying Piwi-piRISC production via phasing in Drosophila ovarian somatic cells2022

    • Author(s)
      Yuica Koga, Mayu Negishi, Shigeki Hirakata, Mikiko C. Siomi
    • Organizer
      第23回日本RNA学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Siwi cooperates with Par-1 kinase to resolve the autoinhibitory effect of Papi for Siwi-piRISC biogenesis2022

    • Author(s)
      Hiromi Yamada, Kazumichi M. Nishida, Yuka W. Iwasaki, Yosuke Isota, Lumi Negishi, Mikiko C. Siomi
    • Organizer
      第23回日本RNA学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Lint-O cooperates with L(3)mbt in gene regulation to maintain homeostasis in Drosophila ovary and brain2022

    • Author(s)
      Keita Miyoshi, Hitomi Yamamoto-Matsuda, Mai Moritoh, Hikari Yoshitane, Yoshitaka Fukuda, Kuniaki Saito, Soichiro Yamanaka, Mikiko C. Siomi
    • Organizer
      第23回日本RNA学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヘテロ複合体足場タンパク質によるpiRNA前駆体ミトコンドリア繋留機構の解析2022

    • Author(s)
      古賀 結花
    • Organizer
      第21回東京大学生命科学シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] piRNA biogenesis and its regulation in Drosophila2021

    • Author(s)
      Mikiko C. Siomi
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ショウジョウバエ卵巣体細胞におけるPiwiタンパク質のYb body局在機構の解析2021

    • Author(s)
      平形樹生、巴裕美子、塩見美喜子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] SiwiはPar-1キナーゼと協調して、PapiによるSiwi-piRISC生合成の自己抑制効果を解消する2021

    • Author(s)
      山田紘実、西田知訓、岩崎由香、礒田洋祐、根岸瑠美、塩見美喜子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生殖細胞においてMaelstromは転移因子を効率的に抑制するSiwi-piRISCの生合成に寄与する2021

    • Author(s)
      難波祐里香、岩崎由香、西田知訓、住吉哲太朗、塩見美喜子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Characterization of the DEAD-box RNA helicase Vasa in LLPS-mediated formation of germ granule, which is the piRNA biogenesis center in ovarian germ cells2021

    • Author(s)
      Hiroya Yamazaki, Kazumichi M. Nishida, Ryo Murakami, Shogo Kuriyama, Asako Kajiya, Mikiko C. Siomi
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ゴノサイト一過的なクロマチン弛緩を駆動する分子機構の解明2021

    • Author(s)
      名取達哉、関真秀、鈴木穣、塩見美喜子、山中総一郎
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ヘテロ二量体足場タンパク質によるpiRISC前駆体ミトコンドリア繋留機構の解析2021

    • Author(s)
      古賀結花、根岸茉由、平形樹生、塩見美喜子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ゴノサイトにおいてDNAメチル化関連因子Morc1タンパク質が担う核内動態2021

    • Author(s)
      中山弦、塩見美喜子、山中総一郎
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] piRNAクラスターの選択性に関わる因子群の核局在と顆粒形成2021

    • Author(s)
      久保田博和、平形樹生、齋藤絡、塩見美喜子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] piRNA生合成機構におけるQinの分子機能解析2021

    • Author(s)
      西田知訓、難波祐里香、岩崎由香、鍛治屋麻子、塩見春彦、塩見美喜子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 脳腫瘍抑制因子L(3)mbtによるpiRNA因子群の転写制御機構の解明2021

    • Author(s)
      山本瞳、山中総一郎、盛藤舞、吉種光、深田吉孝、塩見美喜子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ショウジョウバエLint-Oは体細胞において生殖細胞特異的遺伝子群の発現を抑制する2021

    • Author(s)
      三好啓太、山中総一郎、塩見美喜子、齋藤都暁
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Siwi cooperates with Par-1 kinase to resolve the autoinhibitory effect of Papi for Siwi-piRISC biogenesis2021

    • Author(s)
      Hiromi Yamada
    • Organizer
      EMBL Symposium: The Non-Coding Genome
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of the DEAD-box RNA helicase Vasa in LLPS-mediated formation of germ granules2021

    • Author(s)
      Hiroya Yamazaki
    • Organizer
      EMBL Symposium: The Non-Coding Genome
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Maelstrom ensures production of Siwi-piRISC capable of regulating transposon expression in germ cells2021

    • Author(s)
      Yurika Namba
    • Organizer
      EMBL Symposium: The Non-Coding Genome
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of the DEAD-box RNA helicase Vasa in LLPS-mediated formation of nuage, which is the piRNA biogenesis center in ovarian germ cells2021

    • Author(s)
      Hiroya Yamazaki
    • Organizer
      第22回日本RNA学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 1.Characterization of DEAD-box RNA helicase Vasa in LLPS-mediated nuage formation in ovarian germ cells.2020

    • Author(s)
      Yamazaki H, Murakami R, Kuriyama S, Kajiya A, and Siomi MC.
    • Organizer
      第43回日本分子生物学会年会(MBSJ)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 2.Siwi levels reversibly regulate secondary piRISC biogenesis by affecting Ago3 body morphology in Bombyx mori.2020

    • Author(s)
      Nishida KM, Sakakibara K, Sumiyoshi T, Yamazaki H, Mannen T, Kawamura T, Kodama T, and Siomi MC.
    • Organizer
      第43回日本分子生物学会年会(MBSJ)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3.Elucidation of transcriptional regulatory mechanism of piRNA factors by tumor suppressor gene lethal(3) malignant brain tumor.2020

    • Author(s)
      山本瞳、山中総一郎、佐藤薫、吉種光、深田吉孝、塩見美喜子
    • Organizer
      第43回日本分子生物学会年会(MBSJ)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 4.Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in ovarian somatic cells2020

    • Author(s)
      大西遼、佐藤薫、村野健作、根岸瑠美、塩見春彦、塩見美喜子
    • Organizer
      第43回日本分子生物学会年会(MBSJ)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of processing mechanism of piRNA precursors in piRNA biogenesis in Drosophila2020

    • Author(s)
      Haruna Yamashiro, Mayu Negishi, Tatsuki Kinoshita, Hirotsugu Ishizu, Mikiko C. Siomi
    • Organizer
      Noncoding RNA:Mechanism,Function and Therapies
    • Related Report
      2019 Annual Research Report
  • [Presentation] Piwi suppresses transcription of Brahma-dependent transposons via Maelstrom in the piRNA pathway2020

    • Author(s)
      Ryo Onishi, Kaoru Sato, Kensaku Murano, Lumi Negishi,Haruhiko Siomi, Mikiko C. Siomi
    • Organizer
      Noncoding RNA:Mechanism,Function and Therapies
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of processing mechanism of piRNA precursors in piRNA biogenesis in Drosophila2020

    • Author(s)
      Tatsuki Kinoshita, Hirotsugu Ishizu, Shigeki Hirakata, Limi Negishi, Mikiko C. Siomi
    • Organizer
      Noncoding RNA:Mechanism,Function and Therapies
    • Related Report
      2019 Annual Research Report
  • [Presentation] 第一次piRNA生成経路におけるQinの分子機能解析2020

    • Author(s)
      西田知訓、鍛治屋麻子、宮田祐実、岩崎由香、塩見春彦、塩見美喜子
    • Organizer
      先端モデル動物支援プラットフォーム
    • Related Report
      2019 Annual Research Report
  • [Presentation] piRNA Biogenesis and functions in Drosophila2019

    • Author(s)
      Mikiko C. Siomi
    • Organizer
      【ISEV2019】International Society for Extracellular Vesicles
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] piRNA Biogenesis and functions in Drosophila2019

    • Author(s)
      Mikiko C. Siomi
    • Organizer
      Cell Symposia Regulatory RNAs
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] piRNA Biogenesis and functions in Drosophila2019

    • Author(s)
      Mikiko C. Siomi
    • Organizer
      The RNA Localization and Local Translation Conferrence
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of ping-pong dependent piRNA biogenesis2019

    • Author(s)
      住吉哲太朗、榊原和洋、西田知訓、塩見美喜子
    • Organizer
      第11回日本RNAi研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of processing mechanism of piRNA precursors in piRNA biogenesis in Drosophila2019

    • Author(s)
      木下達貴、山城はるな、根岸茉由、石津大嗣、塩見美喜子
    • Organizer
      第11回日本RNAi研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ショウジョウバエ卵巣においてYb bodyはゲノムをトランスポゾンから保護する2019

    • Author(s)
      平形樹生、石津大嗣、藤田あおい、巴裕美子、塩見美喜子
    • Organizer
      AdAMS若手支援技術講習会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Functional analysis of Gtsf1 in the Piwi-piRISC-mediated transcriptional silencing2019

    • Author(s)
      Horikoshi Mina, Onishi Ryo, Mikiko C. Siomi
    • Organizer
      RNAフロンティアミーティング2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] piRNA前駆体のオルガネラ間輸送機構の解明2019

    • Author(s)
      根岸茉由、山城はるな、塩見美喜子
    • Organizer
      RNAフロンティアミーティング2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] カイコpiRNA生合成経路におけるQin及びSpn-Eの機能解析2019

    • Author(s)
      鍛治屋麻子、西田知訓、宮田祐実、吉種光、深田吉孝、塩見美喜子
    • Organizer
      RNAフロンティアミーティング2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Molecular function of Qin in piRNA biogenesis in silkworm ovarian germ cells2019

    • Author(s)
      Kazumichi Nishida, Yumi Miyata, Asako Kajiya, Yuka W. Iwasaki, Haruhiko Siomi, Mikiko C. Siomi
    • Organizer
      Japanese-Russian Symposium on piRNA Silencing
    • Related Report
      2019 Annual Research Report
  • [Presentation] PiwiはMaelstromを介してBrm依存的なトランスポゾンの転写を抑制する2019

    • Author(s)
      大西遼、佐藤薫、村野健作、堀越美菜、根岸瑠美、塩見春彦、塩見美喜子
    • Organizer
      第6回北陸エピジェネティクス研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] piRNA biogenesis and function2019

    • Author(s)
      Mikiko C. Siomi
    • Organizer
      EMBO Member's Meeting2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular mechanism underlying inter-organelle translocation of piRNA precursor2019

    • Author(s)
      Haruna Yamashiro, Mayu Negishi, Tatsuki Kinoshita, Hirotsugu Ishizu, Mikiko C. Siomi
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] RNAヘリカーゼBmVasaによるnuage形成機構の解明2019

    • Author(s)
      栗山渉吾、村上僚、塩見美喜子
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] カイコpiRNA生合成経路におけるQinの機能解析2019

    • Author(s)
      西田知訓、宮田祐実、鍛治屋麻子、岩崎由香、塩見春彦、塩見美喜子
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ショウジョウバエpiRNA経路におけるYb bodyの機能と形成機構2019

    • Author(s)
      平形樹生、石津大嗣、藤田あおい、巴裕美子、塩見美喜子
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] カイコpiRNA因子GTSFに対する抗体作製とそれを用いた生化学的解析2019

    • Author(s)
      住吉哲太朗、Walter Bronkhorst、Rene Ketting、西田知訓、塩見美喜子
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] カイコ卵巣由来生殖細胞のpiRNA生合成機構におけるPapiリン酸化修飾の生物学的意義2019

    • Author(s)
      山田紘実、西田知訓、根岸瑠美、塩見美喜子
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Remarks] 東京大学大学院理学系研究科 生物科学専攻 塩見研究室 SIOMI Laboratory

    • URL

      http://www-siomilab.biochem.s.u-tokyo.ac.jp/index.html

    • Related Report
      2023 Annual Research Report
  • [Remarks] SIOMI Laboratory

    • URL

      http://www-siomilab.biochem.s.u-tokyo.ac.jp/index.html

    • Related Report
      2022 Annual Research Report 2020 Annual Research Report
  • [Remarks] 東京大学大学院理学系研究科 生物科学専攻 塩見研究室

    • URL

      http://www-siomilab.biochem.s.u-tokyo.ac.jp/index.html

    • Related Report
      2021 Annual Research Report 2019 Annual Research Report

URL: 

Published: 2019-05-29   Modified: 2026-03-16  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi