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Comprehensive search of cancer specific enzymatic activities and creation of innovative neutron capture therapy probe

Research Project

Project/Area Number 19H05632
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Review Section Broad Section E
Research InstitutionThe University of Tokyo

Principal Investigator

URANO Yasuteru  東京大学, 大学院薬学系研究科(薬学部), 教授 (20292956)

Co-Investigator(Kenkyū-buntansha) 石沢 武彰  大阪公立大学, 大学院医学研究科, 教授 (10422312)
田村 磨聖  大阪大学, 核物理研究センター, 特任講師(常勤) (20747109)
Project Period (FY) 2019-06-26 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥200,330,000 (Direct Cost: ¥154,100,000、Indirect Cost: ¥46,230,000)
Fiscal Year 2023: ¥36,790,000 (Direct Cost: ¥28,300,000、Indirect Cost: ¥8,490,000)
Fiscal Year 2022: ¥37,050,000 (Direct Cost: ¥28,500,000、Indirect Cost: ¥8,550,000)
Fiscal Year 2021: ¥38,480,000 (Direct Cost: ¥29,600,000、Indirect Cost: ¥8,880,000)
Fiscal Year 2020: ¥40,950,000 (Direct Cost: ¥31,500,000、Indirect Cost: ¥9,450,000)
Fiscal Year 2019: ¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Keywords蛍光プローブ / がん / 量子化学計算 / バイオマーカー / 中性子捕捉療法
Outline of Research at the Start

本申請課題では、量子化学計算に基づく蛍光プローブの論理的設計法を確立し、これに基づいて新規プローブライブラリーを創製して、従来法では可視化できなかったがん種の特異的バイオマーカー酵素を発見することで、迅速蛍光イメージング技法の確立を目指す。さらにこのがん特異的酵素活性を活用して、深部微小がんの治療・発見を実現する革新的中性子捕捉療法プローブの創製も達成する。

Outline of Final Research Achievements

We have conducted four major research projects simultaneously to discover cancer-specific biomarker enzymes that cannot be visualized by conventional methods, to achieve intraoperative rapid and precise fluorescence imaging, and to create innovative neutron capture therapy probes for the treatment and detection of deeply located micro cancers. First, for the logical design of fluorescence probes based on quantum chemical calculations and the creation of probe libraries, we established a molecular design method based on precise prediction of spirocyclization equilibrium constants by quantum chemical calculations and succeeded in developing a set of multicolor fluorescence probes. By creating a library of these fluorescence probes and applying them to clinical samples, we succeeded in discovering various cancer biomarker enzyme activities. (Other results will be reported later due to patent issues.)

Academic Significance and Societal Importance of the Research Achievements

量子化学計算に基づく蛍光プローブの精密分子設計は、励起状態の予測が非常に難しいため従来は不可能であったが、本研究では基底状態分子間の平衡制御に基づく全く新たな分子設計法を想起し、これが機能することを明らかにした。これは各種光機能性プローブの設計全般に大きな進展をもたらすものであり、学術的な意義が大きいことはもちろんのこと、本原理に基づくプローブライブラリーの構築によって、がんなどの様々な疾患で特徴的に変化している酵素活性を見いだすことも可能であることが本研究によって明らかとなるなど、新たな医療技術の創製にも直結する成果であるため、その社会的意義も非常に大きい。

Assessment Rating
Ex-post Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.

Assessment Rating
Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Report

(11 results)
  • 2024 Ex-post Assessment (Comments) ( PDF )
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Abstract (Interim Assessment) ( PDF )   Annual Research Report   Interim Assessment (Comments) ( PDF )
  • 2020 Annual Research Report
  • 2019 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (189 results)

All 2024 2023 2022 2021 2020 2019 Other

All Journal Article (55 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 55 results,  Open Access: 28 results) Presentation (110 results) (of which Int'l Joint Research: 29 results,  Invited: 59 results) Book (5 results) Remarks (5 results) Patent(Industrial Property Rights) (14 results) (of which Overseas: 7 results)

  • [Journal Article] Activity-Based Fluorescence Diagnostics for Cancer2024

    • Author(s)
      Fujita Kyohhei、Urano Yasuteru
    • Journal Title

      Chemical Reviews

      Volume: 124 Issue: 7 Pages: 4021-4078

    • DOI

      10.1021/acs.chemrev.3c00612

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advancement of fluorescent aminopeptidase probes for rapid cancer detection?current uses and neurosurgical applications2024

    • Author(s)
      Shimizu Takenori、Tanaka Shota、Kitagawa Yosuke、Sakaguchi Yusuke、Kamiya Mako、Takayanagi Shunsaku、Takami Hirokazu、Urano Yasuteru、Saito Nobuhito
    • Journal Title

      Frontiers in Surgery

      Volume: 11 Pages: 1298709-1298709

    • DOI

      10.3389/fsurg.2024.1298709

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A general fluorescence off/on strategy for fluorogenic probes: Steric repulsion-induced twisted intramolecular charge transfer (sr-TICT)2024

    • Author(s)
      Hanaoka Kenjiro、Ikeno Takayuki、Iwaki Shimpei、Deguchi Sayaka、Takayama Kazuo、Mizuguchi Hiroyuki、Tao Fumiya、Kojima Nobuhiko、Ohno Hisashi、Sasaki Eita、Komatsu Toru、Ueno Tasuku、Maeda Kazuya、Kusuhara Hiroyuki、Urano Yasuteru
    • Journal Title

      Science Advances

      Volume: 10 Issue: 7

    • DOI

      10.1126/sciadv.adi8847

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of pancreatic chymotrypsin activity for on-site prediction of clinically relevant postoperative pancreatic fistula2024

    • Author(s)
      Watanabe Genki、Ishizawa Takeaki、Kuriki Yugo、Kamiya Mako、Ichida Akihiko、Kawaguchi Yoshikuni、Akamatsu Nobuhisa、Kaneko Junichi、Arita Junichi、Kokudo Norihiro、Urano Yasuteru、Hasegawa Kiyoshi
    • Journal Title

      Pancreatology

      Volume: 24 Issue: 1 Pages: 169-177

    • DOI

      10.1016/j.pan.2023.11.017

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modular Design Platform for Activatable Fluorescence Probes Targeting Carboxypeptidases Based on ProTide Chemistry2023

    • Author(s)
      Kuriki Yugo、Sogawa Mari、Komatsu Toru、Kawatani Minoru、Fujioka Hiroyoshi、Fujita Kyohhei、Ueno Tasuku、Hanaoka Kenjiro、Kojima Ryosuke、Hino Rumi、Ueo Hiroki、Ueo Hiroaki、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: 146 Issue: 1 Pages: 521-531

    • DOI

      10.1021/jacs.3c10086

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thioester‐Based Coupled Fluorogenic Assays in Microdevice for the Detection of Single‐Molecule Enzyme Activities of Esterases with Specified Substrate Recognition2023

    • Author(s)
      Ukegawa Tatsuya、Komatsu Toru、Minoda Mayano、Matsumoto Takuya、Iwasaka Takumi、Mizuno Tadahaya、Tachibana Ryo、Sakamoto Shingo、Hanaoka Kenjiro、Kusuhara Hiroyuki、Honda Kazufumi、Watanabe Rikiya、Urano Yasuteru
    • Journal Title

      Advanced Science

      Volume: 11 Issue: 10 Pages: 2306559-2306559

    • DOI

      10.1002/advs.202306559

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Real-Time Fluorescence Imaging to Identify Cholangiocarcinoma in the Extrahepatic Biliary Tree Using an Enzyme-Activatable Probe.2023

    • Author(s)
      Takahashi R, Ishizawa T, Inagaki Y, Tanaka M, Ogasawara A, Kuriki Y, Fujita K, Kamiya M, Ushiku T, Urano Y, Hasegawa K.
    • Journal Title

      Liver Cancer.

      Volume: 12 Issue: 6 Pages: 590-602

    • DOI

      10.1159/000530645

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of a cystathionine γ-lyase (CSE) selective inhibitor targeting active-site pyridoxal 5′-phosphate (PLP) via Schiff base formation2023

    • Author(s)
      Echizen Honami、Hanaoka Kenjiro、Shimamoto Kazuhito、Hibi Ryota、Toma-Fukai Sachiko、Ohno Hisashi、Sasaki Eita、Komatsu Toru、Ueno Tasuku、Tsuchiya Yukihiro、Watanabe Yasuo、Otsuka Takao、Saito Hiroaki、Nagatoishi Satoru、Tsumoto Kouhei、Kojima Hirotatsu、Okabe Takayoshi、Shimizu Toshiyuki、Urano Yasuteru
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 16456-16456

    • DOI

      10.1038/s41598-023-43536-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis2023

    • Author(s)
      Norimichi Nagano、Yuki Ichihashi、Toru Komatsu、Hiroyuki Matsuzaki、Keisuke Hata、Toshiaki Watanabe、Yoshihiro Misawa、Misa Suzuki、Shingo Sakamoto、Yu Kagami、Ayumi Kashiro、Keiko Takeuchi、Yukihide Kanemitsu、Hiroki Ochiai、Rikiya Watanabe、Kazufumi Honda、Yasuteru Urano
    • Journal Title

      Chemical Science

      Volume: 14 Issue: 17 Pages: 4495

    • DOI

      10.1039/d2sc07029d

    • URL

      https://pure.teikyo.jp/en/publications/094adf20-babb-4867-a603-738cc7c12746

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid imaging of thymoma and thymic carcinoma with a fluorogenic probe targeting γ-glutamyltranspeptidase2023

    • Author(s)
      Yoshida Daisuke、Kamiya Mako、Kawashima Shun、Yoshioka Takafusa、Hino Haruaki、Abe Atsuki、Fujita Kyohhei、Kojima Ryosuke、Shinozaki-Ushiku Aya、Urano Yasuteru、Nakajima Jun
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 3757-3757

    • DOI

      10.1038/s41598-023-30753-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a fluorescent probe library enabling efficient screening of tumour-imaging probes based on discovery of biomarker enzymatic activities2022

    • Author(s)
      Kuriki Yugo、Yoshioka Takafusa、Kamiya Mako、Komatsu Toru、Takamaru Hiroyuki、Fujita Kyohhei、Iwaki Hirohisa、Nanjo Aika、Akagi Yuki、Takeshita Kohei、Hino Haruaki、Hino Rumi、Kojima Ryosuke、Ueno Tasuku、Hanaoka Kenjiro、Abe Seiichiro、Saito Yutaka、Nakajima Jun、Urano Yasuteru
    • Journal Title

      Chemical Science

      Volume: 13 Issue: 16 Pages: 4474-4481

    • DOI

      10.1039/d1sc06889j

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Measuring the pH of Acidic Vesicles in Live Cells with an Optimized Fluorescence Lifetime Imaging Probe2022

    • Author(s)
      Koda Kinuko、Keller Sascha、Kojima Ryosuke、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Analytical Chemistry

      Volume: 94 Issue: 32 Pages: 11264-11271

    • DOI

      10.1021/acs.analchem.2c01840

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] General Design Strategy to Precisely Control the Emission of Fluorophores via a Twisted Intramolecular Charge Transfer (TICT) Process2022

    • Author(s)
      Hanaoka Kenjiro、Iwaki Shimpei、Yagi Kiyoshi、Myochin Takuya、Ikeno Takayuki、Ohno Hisashi、Sasaki Eita、Komatsu Toru、Ueno Tasuku、Uchigashima Motokazu、Mikuni Takayasu、Tainaka Kazuki、Tahara Shinya、Takeuchi Satoshi、Tahara Tahei、Uchiyama Masanobu、Nagano Tetsuo、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: 144 Issue: 43 Pages: 19778-19790

    • DOI

      10.1021/jacs.2c06397

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Rapid visualization of mammary gland tumor lesions of dogs using the enzyme-activated fluorogenic probe; γ-glutamyl hydroxymethyl rhodamine green2022

    • Author(s)
      HIROSE Yui、UCHIDA Mona、TSUBOI Masaya、NAKAGAWA Takayuki、YAGA Leo、MAEDA Shingo、MOMOI Yasuyuki、KURIKI Yugo、KAMIYA Mako、URANO Yasuteru、YONEZAWA Tomohiro
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 84 Issue: 4 Pages: 593-599

    • DOI

      10.1292/jvms.22-0003

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid imaging of lung cancer using a red fluorescent probe to detect dipeptidyl peptidase 4 and puromycin-sensitive aminopeptidase activities2022

    • Author(s)
      Kawashima Shun、Yoshida Daisuke、Yoshioka Takafusa、Ogasawara Akira、Fujita Kyohhei、Yanagiya Masahiro、Nagano Masaaki、Konoeda Chihiro、Hino Haruaki、Kitano Kentaro、Sato Masaaki、Hino Rumi、Kojima Ryosuke、Komatsu Toru、Kamiya Mako、Urano Yasuteru、Nakajima Jun
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 12665-9

    • DOI

      10.1038/s41598-022-12665-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular design of near-infrared (NIR) fluorescent probes targeting exopeptidase and application for detection of dipeptidyl peptidase 4 (DPP-4) activity2022

    • Author(s)
      Hoshino Yuki、Hanaoka Kenjiro、Sakamoto Kei、Yasunaga Masahiro、Kojima Takashi、Kotani Daisuke、Nomoto Ayumu、Sasaki Eita、Komatsu Toru、Ueno Tasuku、Takamaru Hiroyuki、Saito Yutaka、Seto Yasuyuki、Urano Yasuteru
    • Journal Title

      RSC Chemical Biology

      Volume: - Issue: 7 Pages: 859-867

    • DOI

      10.1039/d1cb00253h

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid visualization of deeply located tumors in vivo by intravenous administration of a γ-glutamyltranspeptidase-activated fluorescent probe2022

    • Author(s)
      Akihiro Nakada, Takuma Maruyama, Mako Kamiya, Kenjiro Hanaoka, Yasuteru Urano
    • Journal Title

      Bioconjugate Chemistry

      Volume: 33 Issue: 3 Pages: 523-529

    • DOI

      10.1021/acs.bioconjchem.2c00039

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular probes for fluorescence image-guided cancer surgery2022

    • Author(s)
      Ito Ren、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Current Opinion in Chemical Biology

      Volume: 67 Pages: 102112-102112

    • DOI

      10.1016/j.cbpa.2021.102112

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Discovery of an F-actin-binding small molecule serving as a fluorescent probe and a scaffold for functional probes2021

    • Author(s)
      Takagi T, Ueno T, Ikawa K, Asanuma D, Nomura Y, Uno S, Komatsu T, Kamiya M, Hanaoka K, Okimura C, Iwadate Y, Hirose K, Nagano T, Sugimura K and Urano Y.
    • Journal Title

      Science Advances

      Volume: 7(47) Issue: 47

    • DOI

      10.1126/sciadv.abg8585

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Establishment of live-cell-based coupled assay system for identification of compounds to modulate metabolic activities of cells2021

    • Author(s)
      Yanagi Kouichi、Komatsu Toru、Ogihara Shusuke、Okabe Takayoshi、Kojima Hirotatsu、Nagano Tetsuo、Ueno Tasuku、Hanaoka Kenjiro、Urano Yasuteru
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 1 Pages: 109311-109311

    • DOI

      10.1016/j.celrep.2021.109311

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Amino BODIPY-Based Blue Fluorescent Probes for Aldehyde Dehydrogenase 1-Expressing Cells2021

    • Author(s)
      Yagishita Atsushi、Ueno Tasuku、Tsuchihara Katsuya、Urano Yasuteru
    • Journal Title

      Bioconjugate Chemistry

      Volume: 32 Issue: 2 Pages: 234-238

    • DOI

      10.1021/acs.bioconjchem.0c00565

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fluorescence Imaging Using Enzyme-Activatable Probes for Real-Time Identification of Pancreatic Cancer2021

    • Author(s)
      Takahashi Ryugen、Ishizawa Takeaki、Sato Masumitsu、Inagaki Yoshinori、Takanka Mariko、Kuriki Yugo、Kamiya Mako、Ushiku Tetsuo、Urano Yasuteru、Hasegawa Kiyoshi
    • Journal Title

      Frontiers in Oncology

      Volume: 11 Pages: 714527-714527

    • DOI

      10.3389/fonc.2021.714527

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photoactivatable fluorophores for durable labelling of individual cells2021

    • Author(s)
      Kashima Hiroki、Kamiya Mako、Obata Fumiaki、Kojima Ryosuke、Nakano Shotaro、Miura Masayuki、Urano Yasuteru
    • Journal Title

      Chemical Communications

      Volume: 57 Issue: 47 Pages: 5802-5805

    • DOI

      10.1039/d1cc01488a

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] β-Galactosidase is a target enzyme for detecting peritoneal metastasis of gastric cancer2021

    • Author(s)
      Kubo Hidemasa、Murayama Yasutoshi、Ogawa Soichiro、Matsumoto Tatsuya、Yubakami Masayuki、Ohashi Takuma、Kubota Takeshi、Okamoto Kazuma、Kamiya Mako、Urano Yasuteru、Otsuji Eigo
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 10664-10664

    • DOI

      10.1038/s41598-021-88982-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Topical Fluorescent Probe for Detection of Glioblastoma2021

    • Author(s)
      Kitagawa Yosuke、Tanaka Shota、Kamiya Mako、Kuriki Yugo、Yamamoto Kyoko、Shimizu Takenori、Nejo Takahide、Hana Taijun、Matsuura Reiko、Koike Tsukasa、Yamazawa Erika、Kushihara Yoshihiro、Takahashi Satoshi、Nomura Masashi、Takami Hirokazu、Takayanagi Shunsaku、Mukasa Akitake、Urano Yasuteru、Saito Nobuhito
    • Journal Title

      Clinical Cancer Research

      Volume: 27 Issue: 14 Pages: 3936-3947

    • DOI

      10.1158/1078-0432.ccr-20-4518

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid fluorescence imaging of human hepatocellular carcinoma using the β-galactosidase-activatable fluorescence probe SPiDER-βGal2021

    • Author(s)
      Ogawa Soichiro、Kubo Hidemasa、Murayama Yasutoshi、Kubota Takeshi、Yubakami Masayuki、Matsumoto Tatsuya、Yamamoto Yusuke、Morimura Ryo、Ikoma Hisashi、Okamoto Kazuma、Kamiya Mako、Urano Yasuteru、Otsuji Eigo
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 17946-17946

    • DOI

      10.1038/s41598-021-97073-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid and Sensitive Detection of Cancer Cells with Activatable Fluorescent Probes for Enzyme Activity2021

    • Author(s)
      Fujita Kyohhei、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Methods Mol Biol.

      Volume: 2274 Pages: 193-206

    • DOI

      10.1007/978-1-0716-1258-3_17

    • ISBN
      9781071612576, 9781071612583
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence Probes for Imaging Basic Carboxypeptidase Activity in Living Cells with High Intracellular Retention2021

    • Author(s)
      Iwaki Hirohisa、Kamiya Mako、Kawatani Minoru、Kojima Ryosuke、Yamasoba Tatsuya、Urano Yasuteru
    • Journal Title

      Analytical Chemistry

      Volume: 93 Issue: 7 Pages: 3470-3476

    • DOI

      10.1021/acs.analchem.0c04793

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural and behavioral control in Caenorhabditis elegans by a yellow-light?activatable caged compound2021

    • Author(s)
      Takahashi Hironori、Kamiya Mako、Kawatani Minoru、Umezawa Keitaro、Ukita Yoshiaki、Niwa Shinsuke、Oda Toshiyuki、Urano Yasuteru
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 118 Issue: 6

    • DOI

      10.1073/pnas.2009634118

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiplexed single-molecule enzyme activity analysis for counting disease-related proteins in biological samples2020

    • Author(s)
      Shingo Sakamoto, Toru Komatsu, Rikiya Watanabe, Yi Zhang, Taiki Inoue, Mitsuyasu Kawaguchi, Hidehiko Nakagawa, Takaaki Ueno, Takuji Okusaka, Kazufumi Honda, Hiroyuki Noji, Yasuteru Urano
    • Journal Title

      Science Advances

      Volume: 6 Issue: 11

    • DOI

      10.1126/sciadv.aay0888

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Antibody Clicking as a Strategy to Modify Antibody Functionalities on the Surface of Targeted Cells2020

    • Author(s)
      Komatsu Toru、Kyo Etsu、Ishii Haruki、Tsuchikama Kyoji、Yamaguchi Aiko、Ueno Tasuku、Hanaoka Kenjiro、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 37 Pages: 15644-15648

    • DOI

      10.1021/jacs.0c05331

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging2020

    • Author(s)
      Morozumi Akihiko、Kamiya Mako、Uno Shin-nosuke、Umezawa Keitaro、Kojima Ryosuke、Yoshihara Toshitada、Tobita Seiji、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: - Pages: 9625-9633

    • DOI

      10.1021/jacs.0c00451

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular design strategy of fluorogenic probes based on quantum chemical prediction of intramolecular spirocyclization2020

    • Author(s)
      Tachibana Ryo、Kamiya Mako、Suzuki Satoshi、Morokuma Keiji、Nanjo Aika、Urano Yasuteru
    • Journal Title

      Communications Chemistry

      Volume: 3 Issue: 1 Pages: 82-82

    • DOI

      10.1038/s42004-020-0326-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] On-Site Monitoring of Postoperative Bile Leakage Using Bilirubin-Inducible Fluorescent Protein2020

    • Author(s)
      Kono Yoshiharu、Ishizawa Takeaki、Kokudo Norihiro、Kuriki Yugo、Iwatate Ryu J.、Kamiya Mako、Urano Yasuteru、Kumagai Akiko、Kurokawa Hiroshi、Miyawaki Atsushi、Hasegawa Kiyoshi
    • Journal Title

      World Journal of Surgery

      Volume: 44 Issue: 12 Pages: 4245-4253

    • DOI

      10.1007/s00268-020-05774-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Companion Diagnosis for Retinal Neuroprotective Treatment by Real-Time Imaging of Calpain Activation Using a Novel Fluorescent Probe2020

    • Author(s)
      Asano Toshifumi、Nagayo Yuri、Tsuda Satoru、Ito Azusa、Kobayashi Wataru、Fujita Kosuke、Sato Kota、Nishiguchi Koji M.、Kunikata Hiroshi、Fujioka Hiroyoshi、Kamiya Mako、Urano Yasuteru、Nakazawa Toru
    • Journal Title

      Bioconjugate Chemistry

      Volume: 31 Issue: 9 Pages: 2241-2251

    • DOI

      10.1021/acs.bioconjchem.0c00435

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design of spontaneously blinking fluorophores for live-cell super-resolution imaging based on quantum-chemical calculations2020

    • Author(s)
      Tachibana Ryo、Kamiya Mako、Morozumi Akihiko、Miyazaki Yoshiyuki、Fujioka Hiroyoshi、Nanjo Aika、Kojima Ryosuke、Komatsu Toru、Ueno Tasuku、Hanaoka Kenjiro、Yoshihara Toshitada、Tobita Seiji、Urano Yasuteru
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 86 Pages: 13173-13176

    • DOI

      10.1039/d0cc05126h

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ?-glutamyl hydroxymethyl rhodamine green fluorescence as a prognostic indicator for lung cancer2020

    • Author(s)
      Kawashima Shun、Yoshioka Takafusa、Hino Haruaki、Kitano Kentaro、Nagayama Kazuhiro、Sato Masaaki、Kojima Ryosuke、Kamiya Mako、Urano Yasuteru、Nakajima Jun
    • Journal Title

      General Thoracic and Cardiovascular Surgery

      Volume: 68 Issue: 12 Pages: 1418-1424

    • DOI

      10.1007/s11748-020-01395-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid and Accurate Visualization of Breast Tumors with a Fluorescent Probe Targeting α-Mannosidase 2C12020

    • Author(s)
      Fujita Kyohhei、Kamiya Mako、Yoshioka Takafusa、Ogasawara Akira、Hino Rumi、Kojima Ryosuke、Ueo Hiroaki、Urano Yasuteru
    • Journal Title

      ACS Central Science

      Volume: 6 Issue: 12 Pages: 2217-2227

    • DOI

      10.1021/acscentsci.0c01189

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] γ‐Glutamyltranspeptidase (GGT)‐Activatable Fluorescence Probe for Durable Tumor Imaging2020

    • Author(s)
      Obara Rui、Kamiya Mako、Tanaka Yoko、Abe Atsuki、Kojima Ryosuke、Kawaguchi Tokuichi、Sugawara Minoru、Takahashi Akiko、Noda Tetsuo、Urano Yasuteru
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 60 Issue: 4 Pages: 2125-2129

    • DOI

      10.1002/anie.202013265

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel sialidase-activatable fluorescence probe with improved stability for the sensitive detection of sialidase2020

    • Author(s)
      Rivas Charlotte、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 30 Issue: 2 Pages: 126860-126860

    • DOI

      10.1016/j.bmcl.2019.126860

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activatable fluorescent probes for hydrolase enzymes based on coumarin-hemicyanine hybrid fluorophores with large Stokes shifts2020

    • Author(s)
      Fujioka Hiroyoshi、Uno Shin-nosuke、Kamiya Mako、Kojima Ryosuke、Johnsson Kai、Urano Yasuteru
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 42 Pages: 5617-5620

    • DOI

      10.1039/d0cc00559b

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of early adenocarcinoma of the esophagogastric junction by spraying an enzyme-activatable fluorescent probe targeting Dipeptidyl peptidase-IV2020

    • Author(s)
      Yamamoto Keiko、Ohnishi Shunsuke、Mizushima Takeshi、Kodaira Junichi、Ono Masayoshi、Hatanaka Yutaka、Hatanaka Kanako C.、Kuriki Yugo、Kamiya Mako、Ehira Nobuyuki、Shinada Keisuke、Takahashi Hiroaki、Shimizu Yuichi、Urano Yasuteru、Sakamoto Naoya
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 64-64

    • DOI

      10.1186/s12885-020-6537-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rational Design of A Near-infrared Fluorescence Probe for Ca2+ Based on Phosphorus-substituted Rhodamines Utilizing Photoinduced Electron Transfer2020

    • Author(s)
      Shodai Takahashi, Kenjiro Hanaoka, Yohei Okubo, Honami Echizen, Takayuki Ikeno, Toru Komatsu, Tasuku Ueno, Kenzo Hirose, Masamitsu Iino, Tetsuo Nagano, Yasuteru Urano
    • Journal Title

      Chem. Asian J.

      Volume: 15 Issue: 4 Pages: 524-530

    • DOI

      10.1002/asia.201901689

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Fluorescent Probe for Rapid, High-Contrast Visualization of Folate-Receptor-Expressing Tumors in Vivo2020

    • Author(s)
      Koji Numasawa, Kenjiro Hanaoka, Naoko Saito, Yoshifumi Yamaguchi, Takayuki Ikeno, Honami Echizen, Masahiro Yasunaga, Toru Komatsu, Tasuku Ueno, Masayuki Miura, Tetsuo Nagano, Yasuteru Urano
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: 59 Issue: 15 Pages: 6015-6020

    • DOI

      10.1002/anie.201914826

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Red Fluorescence Probe Targeted to Dipeptidylpeptidase-IV for Highly Sensitive Detection of Esophageal Cancer2019

    • Author(s)
      Ogasawara Akira、Kamiya Mako、Sakamoto Kei、Kuriki Yugo、Fujita Kyohhei、Komatsu Toru、Ueno Tasuku、Hanaoka Kenjiro、Onoyama Haruna、Abe Hiroyuki、Tsuji Yosuke、Fujishiro Mitsuhiro、Koike Kazuhiko、Fukayama Masashi、Seto Yasuyuki、Urano Yasuteru
    • Journal Title

      Bioconjugate Chemistry

      Volume: 30 Issue: 4 Pages: 1055-1060

    • DOI

      10.1021/acs.bioconjchem.9b00198

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence Detection of Prostate Cancer by an Activatable Fluorescence Probe for PSMA Carboxypeptidase Activity2019

    • Author(s)
      Kawatani Minoru、Yamamoto Kyoko、Yamada Daisuke、Kamiya Mako、Miyakawa Jimpei、Miyama Yu、Kojima Ryosuke、Morikawa Teppei、Kume Haruki、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: 141 Issue: 26 Pages: 10409-10416

    • DOI

      10.1021/jacs.9b04412

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Activatable Photosensitizer for Targeted Ablation of lacZ-Positive Cells with Single-Cell Resolution2019

    • Author(s)
      Chiba Mayumi、Kamiya Mako、Tsuda-Sakurai Kayoko、Fujisawa Yuya、Kosakamoto Hina、Kojima Ryosuke、Miura Masayuki、Urano Yasuteru
    • Journal Title

      ACS Central Science

      Volume: 5 Issue: 10 Pages: 1676-1681

    • DOI

      10.1021/acscentsci.9b00678

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly sensitive fluorescence imaging of cancer with avidin-protease probe conjugate2019

    • Author(s)
      Yamamoto Kyoko、Kamiya Mako、Urano Yasuteru
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Issue: 20 Pages: 126663-126663

    • DOI

      10.1016/j.bmcl.2019.126663

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel method for rapid detection of a Helicobacter pylori infection using a γ-glutamyltranspeptidase-activatable fluorescent probe2019

    • Author(s)
      Akashi Taro、Isomoto Hajime、Matsushima Kayoko、Kamiya Mako、Kanda Tsutomu、Nakano Masayuki、Onoyama Takumi、Fujii Masashi、Akada Junko、Akazawa Yuko、Ohnita Ken、Takeshima Fuminao、Nakao Kazuhiko、Urano Yasuteru
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 9467-9467

    • DOI

      10.1038/s41598-019-45768-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Spray Fluorescent Probes for Fluorescence-Guided Neurosurgery2019

    • Author(s)
      Kitagawa Yosuke、Tanaka Shota、Kuriki Yugo、Yamamoto Kyoko、Ogasawara Akira、Nejo Takahide、Matsuura Reiko、Koike Tsukasa、Hana Taijun、Takahashi Satoshi、Nomura Masashi、Takayanagi Shunsaku、Mukasa Akitake、Kamiya Mako、Urano Yasuteru、Saito Nobuhito
    • Journal Title

      Frontiers in Oncology

      Volume: 9 Pages: 727-727

    • DOI

      10.3389/fonc.2019.00727

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design and Synthesis of an Activatable Photoacoustic Probe for Hypochlorous Acid2019

    • Author(s)
      Ikeno Takayuki、Hanaoka Kenjiro、Iwaki Shimpei、Myochin Takuya、Murayama Yoshiaki、Ohde Hisashi、Komatsu Toru、Ueno Tasuku、Nagano Tetsuo、Urano Yasuteru
    • Journal Title

      Analytical Chemistry

      Volume: 91 Issue: 14 Pages: 9086-9092

    • DOI

      10.1021/acs.analchem.9b01529

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Design strategy for germanium-rhodamine based pH-activatable near-infrared fluorescence probes suitable for biological applications2019

    • Author(s)
      Yuichiro Koide, Ryosuke Kojima, Kenjiro Hanaoka, Koji Numasawa, Toru Komatsu, Tetsuo Nagano, Hisataka Kobayashi, Yasuteru Urano
    • Journal Title

      Commun. Chem.

      Volume: 2 Issue: 1 Pages: 94-94

    • DOI

      10.1038/s42004-019-0194-4

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Separation-Based Enzymomics Assay for the Discovery of Altered Peptide-Metabolizing Enzymatic Activities in Biosamples2019

    • Author(s)
      Ichihashi Yuki、Komatsu Toru、Kyo Etsu、Matsuzaki Hiroyuki、Hata Keisuke、Watanabe Toshiaki、Ueno Tasuku、Hanaoka Kenjiro、Urano Yasuteru
    • Journal Title

      Analytical Chemistry

      Volume: 91 Issue: 18 Pages: 11497-11501

    • DOI

      10.1021/acs.analchem.9b03016

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of ratiometric carbohydrate sensor based on boron dipyrromethene (BODIPY) scaffold2019

    • Author(s)
      Cheruthu Nusaiba Madappuram、Komatsu Toru、Ueno Tasuku、Hanaoka Kenjiro、Urano Yasuteru
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters

      Volume: 29 Issue: 22 Pages: 126684-126684

    • DOI

      10.1016/j.bmcl.2019.126684

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Metabolic-Pathway-Oriented Screening Targeting S-Adenosyl-l-methionine Reveals the Epigenetic Remodeling Activities of Naturally Occurring Catechols2019

    • Author(s)
      Ogihara Shusuke、Komatsu Toru、Itoh Yukihiro、Miyake Yuka、Suzuki Takayoshi、Yanagi Kouichi、Kimura Yusuke、Ueno Tasuku、Hanaoka Kenjiro、Kojima Hirotatsu、Okabe Takayoshi、Nagano Tetsuo、Urano Yasuteru
    • Journal Title

      Journal of the American Chemical Society

      Volume: 142 Issue: 1 Pages: 21-26

    • DOI

      10.1021/jacs.9b08698

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Chemical Medicine: Development of novel chemistry-based theranostics technologies for cancer2024

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 11th Takeda Science Foundation Symposium on PharmSciences
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗原に結合して活性が上昇する生体直交性レポーター加水分解酵素の開発2024

    • Author(s)
      木地陸揮、小嶋良輔、王子儀、清家直樹、浦野泰照
    • Organizer
      日本薬学会第144年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] A novel cancer imaging strategy achieving high signal-to-noise ratio with a bio-orthogonal, engineered probe-reporter enzyme pair2024

    • Author(s)
      Ziyi Wang, Ryosuke Kojima, Kyohhei Fujita, Yasuteru Urano
    • Organizer
      The 11th Takeda Science Foundation Symposium on PharmaSciences
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Identification and utilization of biomarker enzyme activities for the development of cancer imaging probes and anticancer prodrugs2024

    • Author(s)
      Kyohhei Fujita, Yasuteru Urano
    • Organizer
      The 11th Takeda Science Foundation Symposium on PharmaSciences
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗原認識タンパク質上に導入した蛍光団のスピロ環化制御による新規抗原検出法の開発2024

    • Author(s)
      清家直樹、中館眞美子、小嶋良輔、浦野泰照
    • Organizer
      日本薬学会第144年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Development of novel fluorogenic probes for antigens by utilizing DARPin-Silicon pyronine conjugates2024

    • Author(s)
      Mamiko Nakadate, Ryosuke Kojima, Yasuteru Urano
    • Organizer
      The 11th Takeda Science Foundation Symposium on PharmaSciences
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a fluorogenic probe for an antigen based on a conjugate of an environment-sensitive fluorophore and an antibody mimetic2024

    • Author(s)
      Naoki Seike, Ryosuke Kojima, Yasuteru Urano
    • Organizer
      The 11th Takeda Science Foundation Symposium on PharmaSciences
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化学と酵素を活用した新たながんセラノスティクス医療2023

    • Author(s)
      浦野 泰照
    • Organizer
      In vivoイメージングフォーラム2023
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ケミカルメディシン ~ 化学に基づく新たながん医療技術創製 ~2023

    • Author(s)
      浦野 泰照
    • Organizer
      第1回EPOC/CPOTレクチャー形式セミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 酵素活性の可視化・活用を軸とする、新たな低分子がんセラノスティクス技術の創製2023

    • Author(s)
      浦野 泰照
    • Organizer
      第61回日本癌治療学会学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Development of enzyme-activatable fluorescence probes for intraoperative rapid cancer imaging2023

    • Author(s)
      Yasuteru Urano
    • Organizer
      SICS-OMICS Cancer Organoids: Domain Expansion
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intraoperative fluorescence imaging probes for gastric cancer2023

    • Author(s)
      Yasuteru Urano
    • Organizer
      KINGCA WEEK 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical Medicine: Development of novel chemistry-based theranostics technologies for cancer2023

    • Author(s)
      Yasuteru Urano
    • Organizer
      FASEB Science Research Conferences; The Optical Probes Conference
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 光機能性プローブの論理的開発に基づく新たながん医療技術の創製2023

    • Author(s)
      浦野 泰照
    • Organizer
      2023光化学討論会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 低分子ケミカルプローブ・治療薬で実現する新たながんセラノスティクス医療2023

    • Author(s)
      浦野 泰照
    • Organizer
      第3回鹿児島がんと代謝セミナー
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] バイオマーカー酵素活性の発見・同定・活用による、新たながん蛍光ガイド手術・治療技術の創製2023

    • Author(s)
      浦野 泰照
    • Organizer
      日本蛍光ガイド手術研究会 第6回学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 低分子ケミカルプローブによるがんの迅速可視化と新たなセラノスティクス医療への展開2023

    • Author(s)
      浦野 泰照
    • Organizer
      第63回ニューロ・オンコロジィの会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 術中迅速がん可視化プローブの開発と医療蛍光イメージングの未来2023

    • Author(s)
      浦野 泰照
    • Organizer
      第45回日本光医学・光生物学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 新たな疾患検出・患者層別化に向けた、蛍光プローブ群の各種新鮮臨床検体への適用によるライブ酵素活性データ群の取得2023

    • Author(s)
      浦野 泰照
    • Organizer
      第5回日本メディカルAI学会学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ケミカルメディシン ~化学に基づく新たな医療技術創製~2023

    • Author(s)
      浦野 泰照
    • Organizer
      第22回山梨医学フォーラム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ケミカルメディシン:化学に基づく新たながんセラノスティクス医療の実現2023

    • Author(s)
      浦野 泰照
    • Organizer
      第74回日本電気泳動学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] オリジナル蛍光プローブの開発による術中微小がんイメージングと治療応用2023

    • Author(s)
      浦野 泰照
    • Organizer
      第31回日本医学会総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Bio-orthogonalな蛍光プローブ・改変酵素ペアを用いた新規がんイメージング手法の開発2023

    • Author(s)
      王子儀、小嶋良輔、藤田恭平、浦野泰照
    • Organizer
      第17回日本分子イメージング学会総会・学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] A novel cancer imaging strategy by utilizing a bio-orthogonal, engineered fluorescence probe・reporter enzyme pair2023

    • Author(s)
      王子儀、小嶋良輔、藤田恭平、浦野泰照
    • Organizer
      第82回日本癌学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Rapid intraoperative imaging of cancer with small-molecule fluorescence probes2023

    • Author(s)
      Kyohhei Fujita, Yasuteru Urano
    • Organizer
      第82回日本癌学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] バイオマーカー酵素活性の同定と活用による新規がん医療の創製2023

    • Author(s)
      藤田恭平、浦野泰照
    • Organizer
      第17回バイオ関連化学シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] Development of enzyme-activatable fluorophores for cancer specific imaging2023

    • Author(s)
      Yasuteru Urano
    • Organizer
      KSSO-ISFGS AP Chapter Joint Symposium, SISSO2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Chemical Medicine: Development of novel chemistry-based medical technologies for cancer2023

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 2nd Annual MGH (Wellman)/UTokyo (WINGS-LST/C2CPT) Graduate Students Symposium 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ケミカルメディシン:化学に基づく新たながんセラノスティクス医療の実現2023

    • Author(s)
      浦野泰照
    • Organizer
      第44回北海道大学獣医学部学術交流基金群 講演会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 1細胞レベル分解能で酵素高活性細胞のみをアルキン標識可能な機能性プローブの開発2023

    • Author(s)
      常冨純矢、浦野泰照
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 細胞内Click反応を利用したLAT1発現細胞の迅速蛍光イメージング技術の開発2023

    • Author(s)
      伊藤廉、神谷真子、浦野泰照
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 重度な低酸素環境を特異的に検出可能な近赤外蛍光プローブの開発2023

    • Author(s)
      笠井貴文、藤田恭平、平沢壮、石原美弥、浦野泰照
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高感度・低バックグランドながんイメージングを可能とするbio-orthogonalな蛍光プローブ・改変レポーター酵素ペア2023

    • Author(s)
      王子儀、小嶋良輔、藤田恭平、浦野泰照
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 抗原認識タンパク質上に導入した蛍光団のスピロ環化制御による新規抗原検出法の開発2023

    • Author(s)
      清家直樹、小嶋良輔、浦野恭照
    • Organizer
      日本薬学会 第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] α-マンノシダーゼ2C1を標的とした蛍光プローブによる 乳癌迅速術中蛍光イメージングの実現2023

    • Author(s)
      藤田恭平、神谷真子、上尾裕昭、浦野泰照
    • Organizer
      第44回 日本光医学・光生物学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Fluorescence imaging of LAT1-expressing cancer cells using Click chemistry2023

    • Author(s)
      Ren Ito, Mako Kamiya, Yasuteru Urano
    • Organizer
      FUTURE DRUG DISCOVERY Empowered by Chemical Biology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 近赤外光刺激応答性リポソームの開発と蛍光イメージングへの応用2023

    • Author(s)
      岩下貴美子、浦野泰照
    • Organizer
      日本薬学会 第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 重度な低酸素環境を特異的に検出可能な近赤外蛍光プローブの開発2023

    • Author(s)
      笠井貴文、藤田恭平、平沢壮、石原美弥、浦野泰照
    • Organizer
      日本薬学会 第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Highly sensitive far-red to near-infrared fluorescence probe for hypoxia to detect at oxygen concentrations around 1% and below.2023

    • Author(s)
      Takafumi K, Kyohhei Fujita, Toru Komatsu, Tasuku Ueno, Ryosuke Kojima, Kenjiro Hanaoka, Yasuteru Urano.
    • Organizer
      Future Durg Discovery Empowered by Chemical Biology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 化学蛍光プローブを基盤とする新がん医療技術創製2022

    • Author(s)
      浦野泰照
    • Organizer
      第240回生命科学フォーラム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Efficient screening of rapid tumor imaging probes and discovery of biomarker enzyme activities based on a proprietary fluorescent probe library2022

    • Author(s)
      Yasuteru Urano
    • Organizer
      Computer Assisted Radiology and Surgery (CARS) 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ライブ蛍光イメージングによるがんバイオマーカー酵素活性の発見とその治療への応用2022

    • Author(s)
      浦野泰照
    • Organizer
      日本光学会 生体光イメージング産学連携専門委員会キックオフシンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ライブイメージングと最新化学に基づく新がん医療技術の創製2022

    • Author(s)
      浦野泰照
    • Organizer
      第8回がんと代謝研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 化学プローブとライブイメージングに基づく新がん精密医療技術の創製2022

    • Author(s)
      浦野泰照
    • Organizer
      第26回薬物動態談話会セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Chemical medicine: New cancer medical technology based on live fluorescence imaging of each patient2022

    • Author(s)
      Yasuteru Urano
    • Organizer
      EMBO Workshop: Chemical biology 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 蛍光プローブライブラリーの活用による術中迅速がん可視化技術の開発2022

    • Author(s)
      浦野泰照
    • Organizer
      日本蛍光ガイド手術研究会 第5回学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] ライブイメージングと最新化学に基づく新がん医療技術の創製2022

    • Author(s)
      浦野泰照
    • Organizer
      第81回日本癌学会学術総会 第7回JCA-SSPプログラム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Chemical medicine: New cancer medical technology based on live fluorescence imaging2022

    • Author(s)
      Yasuteru Urano
    • Organizer
      Redox Week 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 化学プロープとライブイメージングに基づく新がん精密医療技術の創製2022

    • Author(s)
      浦野泰照
    • Organizer
      第59回全国衛生化学技術協議会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Chemical Medicine: New personalized medical technology for cancer using chemistry-based in vivo fluorescence imaging2022

    • Author(s)
      Yasuteru Urano
    • Organizer
      The 22nd Tateshina Conference on Organic Chemistry
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 化学プロープの精密開発とその生物学研究・医療技術創製への応用2022

    • Author(s)
      浦野泰照
    • Organizer
      第18回がんとハイポキシア研究会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 蛍光プローブライブラリーの活用による術中迅速がん可視化技術の開発2022

    • Author(s)
      浦野泰照
    • Organizer
      日本再生医療学会第2回科学シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 細胞内Click 反応によるLAT1 発現がんの蛍光イメージング2022

    • Author(s)
      伊藤廉、神谷真子、浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会 第16回年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Fluorescence imaging of LAT1-expressing cancer cells based on intracellular click reaction2022

    • Author(s)
      Ren Ito, Mako Kamiya, Yasuteru Urano
    • Organizer
      EMBO Workshop Chemical biology 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 低酸素感受性Activatable型光音響プローブの開発2022

    • Author(s)
      笠井貴文、平沢壮、石原美弥、浦野泰照
    • Organizer
      第16回日本分子イメージング学会総会・学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 低酸素環境下で活性化する Activatable 型光音響プローブの開発と応用2022

    • Author(s)
      笠井貴文、平沢壮、石原美弥、浦野泰照
    • Organizer
      第54回若手ペプチド夏の勉強会
    • Related Report
      2022 Annual Research Report
  • [Presentation] がん疾患における低酸素環境を標的とする光イメージングプローブの開発2022

    • Author(s)
      笠井貴文、藤田恭平、平沢壮、石原美弥、浦野泰照
    • Organizer
      第18回がんとハイポキシア研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 個別化医療を指向したがん特異的酵素活性標的小分子BNCT薬剤の開発2022

    • Author(s)
      常冨純矢、浦野泰照
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生体直交性を有する蛍光プローブ・改変酵素ペアを用いた新規がんイメージング手法の開発2022

    • Author(s)
      王子儀、小嶋良輔、浦野泰照
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 深部腫瘍可視化技術としての応用を志向した、近赤外光で励起可能なactivatable型光音響イメージングプローブの開発2022

    • Author(s)
      高木太尊、阿部篤生、平沢壮、石原美弥、浦野泰照
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Activatable型PAIプローブの開発と応用2022

    • Author(s)
      笠井貴文、平沢壮、石原美弥、浦野泰照
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ProTide chemistryに基づく新規カルボキシペプチダーゼ活性検出プローブの開発2022

    • Author(s)
      曽川マリー、栗木優五、神谷真子、浦野泰照
    • Organizer
      日本薬学会第142回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of activatable fluorescence probe for carboxypeptidase activity to visualize cancer2022

    • Author(s)
      Minoru Kawatani, Mako Kamiya, Hirohisa Iwaki, Kyoko Yamamoto, Yasuteru Urano
    • Organizer
      日本化学会 第102春季年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Intraoperative Rapid Imaging of Tiny Tumors by Novel Fluorogenic Probes for Exopeptidases and Glycosidases2021

    • Author(s)
      Yasuteru Urano
    • Organizer
      Bioorthogonal and Bioresponsive Symposium 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ケミカルバイオロジーからケミカルメディシンへ ~臨床検体のバイオイメージングに基づく新がん医療技術の創製~2021

    • Author(s)
      浦野泰照
    • Organizer
      第43回日本光医学・光生物学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] ライブイメージングと最新化学に基づく新たながん医療技術の創製2021

    • Author(s)
      浦野泰照
    • Organizer
      第7回次世代を担う若手のためのレギュラトリーサイエンスフォーラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Rapid cancer imaging by rationally designed fluorescence probes2021

    • Author(s)
      Yasuteru Urano, Mako Kamiya
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 蛍光ライブイメージングに基づく新たながん診断・治療技術の創製2021

    • Author(s)
      浦野泰照
    • Organizer
      第61回日本核医学会学術総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Selective imaging and ablation of target cells with single-cell resolution by novel activatable fluorescence and photosensitizing probes2021

    • Author(s)
      Yasuteru Urano
    • Organizer
      Pacifichem2021, Opto-bioanalysis: Imaging and controlling biomolecules in live cells (#40)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intraoperative rapid imaging of tiny tumors by novel fluorogenic probes for exopeptidases and glycosidases2021

    • Author(s)
      Yasuteru Urano
    • Organizer
      Pacifichem2021, Recent Contribution of Chemistry to Clinics for Realizing Novel Theranostics (#187)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ライブイメージング化学に基づく新たながん個別化医療の実現2021

    • Author(s)
      浦野泰照
    • Organizer
      新学術領域研究「分子夾雑の生命化学」関西シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] キノンメチドケミストリーを利用した細胞内滞留型小分子BNCT薬剤の開発2021

    • Author(s)
      常冨純矢、神谷真子、浦野泰照
    • Organizer
      第17回日本中性子捕捉療法学会日本中性子捕捉療法学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] キノンメチドケミストリーを利用した細胞内滞留型小分子BNCT薬剤の開発2021

    • Author(s)
      常冨純矢、神谷真子、浦野泰照
    • Organizer
      第53回若手ペプチド夏の勉強会日本ペプチド学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Identifications and Utilization of Biomarker Glycosidases for Rapid and Clinical Fluorescence Imaging of Breast and Lung Cancer2021

    • Author(s)
      藤田恭平、神谷真子、中島淳、上尾裕昭、浦野泰照
    • Organizer
      第15回 日本分子イメージング学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] がんのカルボキシペプチダーゼ活性を検出するactivatable型蛍光プローブ2021

    • Author(s)
      河谷稔、神谷真子、岩城弘尚、山本恭子、浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会第15回年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Intraoperative Rapid Imaging of Tiny Tumors by Novel Fluorogenic Probes for Exopeptidases and Glycosidases2021

    • Author(s)
      Yasuteru Urano
    • Organizer
      OIST and UT joint talk series for future science
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ライブイメージングと最新化学に基づく新たながん医療技術の創製2021

    • Author(s)
      浦野 泰照
    • Organizer
      消化器領域seminar from Asahikawa
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] がんバイオマーカー酵素活性を利用した細胞内滞留型小分子BNCT薬剤の開発2021

    • Author(s)
      常冨 純矢、神谷 真子、浦野 泰照
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] がん蛍光イメージングに資するLAT1蛍光基質の開発2021

    • Author(s)
      伊藤廉、神谷真子、浦野泰照
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 複数酵素活性の同時検出が可能なactivatable型ラマンプローブ2021

    • Author(s)
      藤岡礼任、神谷真子、寿景文、小関泰之、浦野泰照
    • Organizer
      日本化学会第101回春季年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 化学プローブを精密にデザインして新しい医療を創製する2020

    • Author(s)
      浦野 泰照
    • Organizer
      日本化学会「君たちの将来と化学の未来 -東大で過ごす化学な週末」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] オリジナル蛍光プローブの開発によるがん蛍光イメージングの実現2020

    • Author(s)
      浦野 泰照
    • Organizer
      第3回蛍光ガイド手術研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] エキソ型ペプチダーゼ活性検出蛍光プローブの開発による術中迅速微小がんイメージングの実現2020

    • Author(s)
      浦野 泰照
    • Organizer
      日本放射線影響学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Novel in vivo imaging system with newly developed activatable luminescent probes2020

    • Author(s)
      浦野 泰照
    • Organizer
      第93回日本生化学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] ライブイメージングに基づく新たながん医療技術の創製2020

    • Author(s)
      浦野 泰照
    • Organizer
      第109回日本病理学会総会 共催セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Rational design of fluorescence probes based on quantum chemical prediction of intramolecular spirocyclization2020

    • Author(s)
      Sascha G. Keller, Ryo Tachibana, Mako Kamiya, Yasuteru Urano
    • Organizer
      Resonance Bio International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] がん蛍光イメージングに資するLAT1蛍光基質の開発2020

    • Author(s)
      伊藤廉、神谷真子、浦野泰照
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞内滞留型アミノペプチダーゼ活性検出蛍光イメージングプローブの開発2020

    • Author(s)
      小原塁、神谷真子、浦野泰照
    • Organizer
      日本化学会 第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of a Novel Cancer Imaging Strategy by Utilizing a Bio-orthogonal Fluorescence Probe & Reporter Enzyme Pair2020

    • Author(s)
      王子儀、小嶋良輔、藤田恭平、浦野泰照
    • Organizer
      日本薬学会第140年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Development of activatable fluorescence probes for detecting basic carboxypeptidase activity2020

    • Author(s)
      岩城弘尚、神谷真子、浦野泰照
    • Organizer
      日本化学会 第100春季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Intraoperative Rapid Imaging of Tiny Tumors with Novel Fluorogenic Probes for Exopeptidases2020

    • Author(s)
      Yasuteru Urano
    • Organizer
      7th US-Japan Workshop on Biomarkers for Cancer Early Detection
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intraoperative Rapid Imaging of Tiny Tumors with Novel Fluorogenic Probes for Exopeptidases2020

    • Author(s)
      Yasuteru Urano
    • Organizer
      7th Annual International Congress for Fluorescence Guided Surgery
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rational design of fluorescence probes based on quantum chemical prediction of intramolecular spirocyclization2019

    • Author(s)
      Sascha G. Keller, Ryo Tachibana, Mako Kamiya, Yasuteru Urano
    • Organizer
      Resonance Bio International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 計算化学を駆使した蛍光プローブ及び酵素活性の理論的設計法の開発2019

    • Author(s)
      橘椋, 神谷真子, 吉原利忠, 飛田成史, 浦野泰照
    • Organizer
      第51回若手ペプチド夏の勉強会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 膠芽腫を標識する噴霧式新規蛍光プローブの開発2019

    • Author(s)
      北川陽介・田中將太・小笠原輝・栗木優五・山本恭子・神谷真子・武笠晃丈・浦野泰照・斉藤延人
    • Organizer
      日本分子脳神経外科学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 膠芽腫を標識する噴霧式新規蛍光プローブの開発2019

    • Author(s)
      北川陽介・田中將太・栗木優五・山本恭子・花大洵・小池司・串原義啓・山澤恵理香・高柳俊作・神谷真子・浦野泰照・齊藤延人
    • Organizer
      第78回 脳神経外科学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 個体・組織への細胞標識を目指した新規ケージド蛍光団の開発2019

    • Author(s)
      鹿島大幹、神谷真子、浦野泰照
    • Organizer
      第14回 日本分子イメージング学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Cancer Specific Fluorescence Imaging by Development of Fluorescent Probes for Intact Glycosidase Activities2019

    • Author(s)
      藤田恭平、神谷真子、吉岡孝房、中島淳、上尾裕明、浦野泰照○藤田恭平、神谷真子、吉岡孝房、中島淳、上尾裕明、浦野泰照
    • Organizer
      第14回 日本分子イメージング学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Glycosidaseを標的とした蛍光プローブ群の開発と腫瘍特異的蛍光イメージングの実現2019

    • Author(s)
      藤田恭平、神谷真子、吉岡孝房、中島淳、上尾裕明、浦野泰照
    • Organizer
      日本ケミカルバイオロジー学会第14回年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 糖分解酵素活性検出蛍光プローブ群の開発と悪性及び良性腫瘍特異的蛍光イメージングへの応用2019

    • Author(s)
      藤田恭平、神谷真子、吉岡孝房、小笠原輝、上尾裕明、浦野泰照
    • Organizer
      第13回バイオ関連化学シンポジウム2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Novel Chemistry- and Imaging-driven Approaches For the Next Generation of Precision Medicine2019

    • Author(s)
      Yasuteru Urano
    • Organizer
      54th Burgenstock Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 新規蛍光プローブを用いた 乳がん、食道がん術中診断(治験準備中)2019

    • Author(s)
      浦野泰照
    • Organizer
      蛍光ガイド手術研究会第2回学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] オリジナル蛍光プローブの開発による 新しい疾患イメージング2019

    • Author(s)
      浦野泰照
    • Organizer
      日本学術振興会第185委員会 2019年度第1回研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] A Library-based Approach to Realize Intraoperative Rapid Imaging of Tiny Tumors by Novel Fluorogenic Probes for Aminopeptidases and Carboxypeptidases2019

    • Author(s)
      Yasuteru Urano
    • Organizer
      50th General Assembly & 47th IUPAC World Chemistry Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ケミカルバイオロジーから ケミカルメディスンへ2019

    • Author(s)
      浦野泰照
    • Organizer
      JASIS2019 ライフサイエンスイノベーション 日本生化学会「見る生化学」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Intraoperative Rapid Imaging of Tiny Tumors by Novel Fluorogenic Probes for Exopeptidases2019

    • Author(s)
      Yasuteru Urano
    • Organizer
      7th Symposium RIKEN & Max Planck Joint Research Center
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 化学蛍光プローブによる 術中がん部位迅速可視化2019

    • Author(s)
      浦野泰照
    • Organizer
      第92回日本生化学会大会 シンポジウム「がんのバイオマーカー探索と診断法の社会実装」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Intraoperative rapid imaging of tiny tumors by novel fluorogenic probes for exopeptidases2019

    • Author(s)
      Yasuteru Urano
    • Organizer
      2019 Cold Spring Harbor Asia Conference “Chemical Biology & Drug Discovery”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Intraoperative Rapid Imaging of Tiny Tumors with Novel Fluorogenic Probes for Exopeptidases2019

    • Author(s)
      Yasuteru Urano
    • Organizer
      Joint meeting of JSPS Core to core program-UT MD Anderson Cancer Center “Cancer theranostics and molecular imaging“
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ライブイメージングに基づく 新たながん医療技術の創製2019

    • Author(s)
      浦野泰照
    • Organizer
      第3回高分子のための分析セミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Book] Precision Medicine2023

    • Author(s)
      浦野 泰照
    • Total Pages
      6
    • Publisher
      北隆館
    • Related Report
      2022 Annual Research Report
  • [Book] 癌と化学療法2021

    • Author(s)
      浦野泰照
    • Total Pages
      5
    • Publisher
      癌と化学療法社
    • Related Report
      2020 Annual Research Report
  • [Book] 核酸化学ハンドブック2021

    • Author(s)
      浦野泰照、神谷真子
    • Total Pages
      6
    • Publisher
      講談社
    • Related Report
      2020 Annual Research Report
  • [Book] 月刊細胞2020

    • Author(s)
      曽川マリー、神谷真子、浦野泰照
    • Total Pages
      4
    • Publisher
      ニューサイエンス社
    • Related Report
      2020 Annual Research Report
  • [Book] 生体分子反応を制御する2020

    • Author(s)
      日本化学会
    • Total Pages
      212
    • Publisher
      化学同人
    • ISBN
      9784759813968
    • Related Report
      2019 Annual Research Report
  • [Remarks] 化学の力で細胞を狙い撃ち

    • URL

      https://www.u-tokyo.ac.jp/focus/ja/articles/z0508_00027.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 1細胞レベルで標的細胞の細胞死誘導が可能な試薬を開発

    • URL

      http://www.f.u-tokyo.ac.jp/topics.html?page=2&key=1570499711

    • Related Report
      2019 Annual Research Report
  • [Remarks] 微小な前立腺がんを術中にその場で光らせて検出する 前立腺がんの迅速蛍光可視化プローブの開発

    • URL

      https://www.u-tokyo.ac.jp/focus/ja/articles/z0508_00019.html

    • Related Report
      2019 Annual Research Report
  • [Remarks] 前立腺がんをその場で光らせて検出する新しい種類の蛍光試薬を開発

    • URL

      http://www.f.u-tokyo.ac.jp/topics.html?page=2&key=1566960648

    • Related Report
      2019 Annual Research Report
  • [Remarks] 動物体内で葉酸受容体を高発現しているがん部位を、短時間ではっきりと蛍光検出する新たな蛍光試薬を開発

    • URL

      http://www.f.u-tokyo.ac.jp/topics.html?page=1&key=1580371357

    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] がん特異的酵素活性を標的とした新規プロドラッグ型抗がん剤2024

    • Inventor(s)
      浦野泰照、藤田恭平、内海武憲
    • Industrial Property Rights Holder
      浦野泰照、藤田恭平、内海武憲
    • Industrial Property Rights Type
      特許
    • Filing Date
      2024
    • Related Report
      2023 Annual Research Report
  • [Patent(Industrial Property Rights)] ホウ素中性子捕捉療法(BNCT)プローブ2022

    • Inventor(s)
      浦野泰照、神谷真子、常冨純矢
    • Industrial Property Rights Holder
      浦野泰照、神谷真子、常冨純矢
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] MUTANTS OF B-GLUCOSIDASE TD2F2 THAT SHOW SPECIAL ACTIVITIES2022

    • Inventor(s)
      小嶋良輔、王子儀。浦野泰照
    • Industrial Property Rights Holder
      小嶋良輔、王子儀。浦野泰照
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 新規がん高集積型SPECTプローブ2022

    • Inventor(s)
      浦野泰照、神谷真子、阿部篤生、藤井博史、大貫和信
    • Industrial Property Rights Holder
      浦野泰照、神谷真子、阿部篤生、藤井博史、大貫和信
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] FLUOROGENIC SUBSTRATES TO DETECT THIOL AND RELATED COMPOUNDS IN MICRODEVICE2022

    • Inventor(s)
      浦野泰照、小松徹、坂本眞伍、請川達也
    • Industrial Property Rights Holder
      浦野泰照、小松徹、坂本眞伍、請川達也
    • Industrial Property Rights Type
      特許
    • Filing Date
      2022
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] すい臓がん検出用蛍光プローブ2021

    • Inventor(s)
      浦野泰照、神谷真子、長谷川潔、石沢武彰、高橋龍玄
    • Industrial Property Rights Holder
      浦野泰照、神谷真子、長谷川潔、石沢武彰、高橋龍玄
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 蛍光プローブ2021

    • Inventor(s)
      浦野泰照、上野匡、中田絵麻、柳下淳
    • Industrial Property Rights Holder
      浦野泰照、上野匡、中田絵麻、柳下淳
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 蛍光プローブ2021

    • Inventor(s)
      浦野泰照、神谷真子、橘椋、南條愛華
    • Industrial Property Rights Holder
      浦野泰照、神谷真子、橘椋、南條愛華
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ホウ素中性子捕捉療法(BNCT)プローブ2021

    • Inventor(s)
      浦野泰照、神谷真子、常冨純矢
    • Industrial Property Rights Holder
      浦野泰照、神谷真子、常冨純矢
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] LAT1基質となる蛍光プローブ2021

    • Inventor(s)
      浦野泰照、神谷真子、伊藤廉
    • Industrial Property Rights Holder
      浦野泰照、神谷真子、伊藤廉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2020 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 癌検出蛍光プローブ2020

    • Inventor(s)
      浦野泰照,神谷真子,藤田恭平
    • Industrial Property Rights Holder
      浦野泰照,神谷真子,藤田恭平
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] FLUORESCENT PROBE FOR LAT12020

    • Inventor(s)
      浦野泰照,神谷真子,伊藤廉
    • Industrial Property Rights Holder
      浦野泰照,神谷真子,伊藤廉
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Related Report
      2019 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] がん特異的酵素活性を利用したプロドラッグ型抗がん剤2019

    • Inventor(s)
      浦野泰照、神谷真子、林健人
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2024
    • Related Report
      2023 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ピューロマイシン感受性アミノペプチターゼ又はプレオマイシン加水分解酵素検出用蛍光プローブ2019

    • Inventor(s)
      浦野泰照,神谷真子,保科克行,赤木大輔,栗木優五,瀬尾明彦
    • Industrial Property Rights Holder
      浦野泰照,神谷真子,保科克行,赤木大輔,栗木優五,瀬尾明彦
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-186211
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2019-06-27   Modified: 2025-03-27  

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