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Elucidation of cognitive and learning mechanism of cerebral cortex by multiscale optogenetics

Research Project

Project/Area Number 19H05642
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Review Section Broad Section G
Research InstitutionThe University of Tokyo

Principal Investigator

Ohki Kenichi  東京大学, 大学院医学系研究科(医学部), 教授 (50332622)

Co-Investigator(Kenkyū-buntansha) 松井 鉄平  同志社大学, 脳科学研究科, 教授 (10725948)
Project Period (FY) 2019-06-26 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥203,060,000 (Direct Cost: ¥156,200,000、Indirect Cost: ¥46,860,000)
Fiscal Year 2023: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2022: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2021: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2020: ¥28,990,000 (Direct Cost: ¥22,300,000、Indirect Cost: ¥6,690,000)
Fiscal Year 2019: ¥87,100,000 (Direct Cost: ¥67,000,000、Indirect Cost: ¥20,100,000)
Keywords視覚野 / イメージング / 光遺伝学 / 神経回路 / 情報処理
Outline of Research at the Start

研究の目的であげた二つの目的を実行するため、光遺伝学を駆使してスパインレベルの機能イメージング法を開発し、個々のシナプスに入力する情報を可視化し、その変化を継続的に観察し、脳の情報処理の素過程と、学習・記憶の素過程をシナプスレベルで解明する。さらに、細胞集団のイメージングと組み合わせて、これらの素過程がネットワーク全体としての学習にどのように寄与しているのかを解明する。最後に、細胞集団を光遺伝学を用いて人工的に活性化し、細胞集団の活動が知覚・学習と因果関係を持つかどうかを検討する。

Outline of Final Research Achievements

We developed a functional imaging method for spines using optogenetics to elucidate the mechanisms of orientation and phase selectivity formation in cells of the visual cortex. We developed a method to systematically investigate the complex receptive fields of cells in higher visual cortex using deep learning. We elucidated the mechanisms and their learning rules by which the connections between cortical areas are precisely formed during development. We reconstructed the visual information represented in cell populations in the visual cortex, paving the way for understanding perception in normal and diseased animals. We trained mice in a visual discrimination task for novel shapes and found that with learning, a sparse representation pattern emerges. We developed a method to activate and inactivate cell populations while measuring neural activity in the whole brain, and were able to artificially induce perception and plasticity using light stimulation.

Academic Significance and Societal Importance of the Research Achievements

視覚野の細胞集団に表現されている視覚情報を再構成する方法の開発は、マウスが何を見ているのかを理解する道を開き、今後の正常・疾患マウスを用いた知覚研究に対して強力な方法論となる。深層学習を用いた視覚野の神経細胞の非線形で複雑な受容野を系統的に調べる方法の開発については、実際の脳活動をニューラルネットワーク上に写しこんで解析しており、脳活動を模した脳型人工知能の開発にもつながる。大脳皮質の領野をつなぐ階層的か並列的なネットワークが発達時に精密に形成されるメカニズムを初めて解明したことは、網膜からの活動伝播の重要性を示唆し、早期失明の病態理解にもつながる。

Assessment Rating
Ex-post Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, expected outcomes of research have been produced.

Assessment Rating
Interim Assessment Comments (Rating)

A: In light of the aim of introducing the research area into the research categories, the expected progress has been made in research.

Report

(11 results)
  • 2024 Ex-post Assessment (Comments) ( PDF )
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Abstract (Interim Assessment) ( PDF )   Annual Research Report   Interim Assessment (Comments) ( PDF )
  • 2020 Annual Research Report
  • 2019 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report
  • Research Products

    (103 results)

All 2023 2022 2021 2020 2019 2018 Other

All Journal Article (18 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 17 results,  Open Access: 14 results) Presentation (82 results) (of which Int'l Joint Research: 10 results,  Invited: 32 results) Remarks (3 results)

  • [Journal Article] Evaluation of the Hierarchical Correspondence between the Human Brain and Artificial Neural Networks: A Review2023

    • Author(s)
      Pham Trung Quang、Matsui Teppei、Chikazoe Junichi
    • Journal Title

      Biology

      Volume: 12 Issue: 10 Pages: 1330-1330

    • DOI

      10.3390/biology12101330

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Adversarial attacks and defenses using feature-space stochasticity2023

    • Author(s)
      Ukita Jumpei、Ohki Kenichi
    • Journal Title

      Neural Networks

      Volume: 167 Pages: 875-889

    • DOI

      10.1016/j.neunet.2023.08.022

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ketamine-induced 1-Hz oscillation of spontaneous neural activity is not directly visible in the hemodynamics2023

    • Author(s)
      Li Ruixiang、Ohki Kenichi、Matsui Teppei
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 678 Pages: 102-108

    • DOI

      10.1016/j.bbrc.2023.08.034

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A method for reconstruction of interpretable brain networks from transient synchronization in resting-state BOLD fluctuations2023

    • Author(s)
      Noro Yusuke、Li Ruixiang、Matsui Teppei、Jimura Koji
    • Journal Title

      Frontiers in Neuroinformatics

      Volume: 16 Pages: 960607-960607

    • DOI

      10.3389/fninf.2022.960607

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Static and Dynamic Functional Connectivity Alterations in Alzheimer's Disease and Neuropsychiatric Diseases2023

    • Author(s)
      Teppei Matsui
    • Journal Title

      Brain Connetivity

      Volume: 5 Issue: 5 Pages: 307-314

    • DOI

      10.1089/brain.2022.0044

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frey T, Murakami T, Maki K, Kawaue T, Tani N, Sugai A, Nakazawa N, Ishiguro K, Adachi T, Kengaku M, Ohki K, Gotoh Y & Kishi Y2023

    • Author(s)
      Age-associated reduction of nuclear shape dynamics in excitatory neurons of the visual cortex
    • Journal Title

      Aging Cell

      Volume: 22 Issue: 9 Pages: 1-14

    • DOI

      10.1111/acel.13925

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thalamocortical circuits for the formation of hierarchical pathways in the mammalian visual cortex2023

    • Author(s)
      Murakami Tomonari、Ohki Kenichi
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 17 Pages: 1155195-1155195

    • DOI

      10.3389/fncir.2023.1155195

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Developmental stage-specific spontaneous activity contributes to callosal axon projections2022

    • Author(s)
      Yuta Tezuka, Kenta M Hagihara, Kenichi Ohki, Tomoo Hirano, Yoshiaki Tagawa
    • Journal Title

      eLife

      Volume: 11 Pages: 1-15

    • DOI

      10.7554/elife.72435

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modular strategy for development of the hierarchical visual network in mice2022

    • Author(s)
      Murakami Tomonari、Matsui Teppei、Uemura Masato、Ohki Kenichi
    • Journal Title

      Nature

      Volume: 608 Issue: 7923 Pages: 578-585

    • DOI

      10.1038/s41586-022-05045-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response Selectivity of the Lateral Posterior Nucleus Axons Projecting to the Mouse Primary Visual Cortex2022

    • Author(s)
      Kondo Satoru、Kiyohara Yuko、Ohki Kenichi
    • Journal Title

      Frontiers in Neural Circuits

      Volume: 16 Pages: 825735-825735

    • DOI

      10.3389/fncir.2022.825735

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Counterfactual Explanation of Brain Activity Classifiers Using Image-To-Image Transfer by Generative Adversarial Network2022

    • Author(s)
      Matsui Teppei、Taki Masato、Pham Trung Quang、Chikazoe Junichi、Jimura Koji
    • Journal Title

      Frontiers in Neuroinformatics

      Volume: 15 Pages: 802938-802938

    • DOI

      10.3389/fninf.2021.802938

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] On co-activation pattern analysis and non-stationarity of resting brain activity.2022

    • Author(s)
      Matsui T, *Pham TQ, Jimura K, Chikazoe J,
    • Journal Title

      Neuroimage

      Volume: 1:249 Pages: 118904-118904

    • NAID

      120007188354

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Executive control by fronto-parietal activity explains counterintuitive decision behavior in complex value-based decision-making2022

    • Author(s)
      Matsui Teppei、Hattori Yoshiki、Tsumura Kaho、Aoki Ryuta、Takeda Masaki、Nakahara Kiyoshi、Jimura Koji
    • Journal Title

      NeuroImage

      Volume: 249 Pages: 118892-118892

    • DOI

      10.1016/j.neuroimage.2022.118892

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chromatic micromaps in primary visual cortex2021

    • Author(s)
      Chatterjee Soumya、Ohki Kenichi、Reid R. Clay
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 2315-2315

    • DOI

      10.1038/s41467-021-22488-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-Range Interhemispheric Projection Neurons Show Biased Response Properties and Fine-Scale Local Subnetworks in Mouse Visual Cortex2021

    • Author(s)
      Kenta M Hagihara, Ayako Wendy Ishikawa, Yumiko Yoshimura, Yoshiaki Tagawa, Kenichi Ohki
    • Journal Title

      Cerebral Cortex

      Volume: 31 Issue: 2 Pages: 1307-1315

    • DOI

      10.1093/cercor/bhaa297

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Natural images are reliably represented by sparse and variable populations of neurons in visual cortex2020

    • Author(s)
      Yoshida Takashi、Ohki Kenichi
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 1-19

    • DOI

      10.1038/s41467-020-14645-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 神経‐グリア‐fMRI信号を繋ぐ脳活動イメージング2019

    • Author(s)
      松井鉄平, 大木研一
    • Journal Title

      実験医学増刊号「グリア」

      Volume: 10

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Neuronal Origin of the Temporal Dynamics of Spontaneous BOLD Activity Correlation.2018

    • Author(s)
      T. Matsui, T. Murakami, K. Ohki
    • Journal Title

      Cerebral Cortex

      Volume: in press Issue: 4 Pages: 4500-5000

    • DOI

      10.1093/cercor/bhy045

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] Modular strategy for development of the hierarchical visual system2023

    • Author(s)
      Ohki K
    • Organizer
      iPlasticity 8211; IRCN International
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Noise in the Brain and AI2023

    • Author(s)
      Ohki K
    • Organizer
      The 3rd International Symposium of the Institute for AI and Beyond
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Cerebral Cortex and AI2023

    • Author(s)
      Ohki K
    • Organizer
      The 100th Anniversary Annual Meeting of The Physiological Society of Japan, AI technology pioneers a new era of medicine, physiology, and life sciences
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Development of 2-photon functional imaging and study of functional architecture of visual cortex2023

    • Author(s)
      Kenichi Ohki
    • Organizer
      Nakaakira Tsukahara Memorial Award Lecture The 46th Annual Meeting of Japan Neuroscience Society
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Neuronal activity that allows us to perceive familiar images even at low contrast2023

    • Author(s)
      Kimura R, Ohki K, Yoshimura Y
    • Organizer
      3rd International Symposium on Brain Information Dynamics 2023
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] A neural mechanism underlying the perception of low-contrast familiar objects2023

    • Author(s)
      Kimura R, Ohki K, Yoshimura Y
    • Organizer
      5th Stockholm-Tokyo Workshop 2023: Research Theme 1 The Brain and Society
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Synaptic organization of simple and complex cells in the mouse primary visual cortex2023

    • Author(s)
      Fukuda Y, Kondo S, Ohki K
    • Organizer
      The 100th Anniversary Annual Meeting of The Physiological Society of Japan
    • Related Report
      2023 Annual Research Report
  • [Presentation] Neural activity that enables stable behavioral output even when visual input changes slightly2023

    • Author(s)
      Kimura R, Yoshimura Y, Ohki K
    • Organizer
      The 100th Anniversary Annual Meeting of The Physiological Society of Japan
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Auditory responses in a visual area representing object size in the mouse temporal cortex2023

    • Author(s)
      Yuto Oyamada, Nana Nishio, Kenichi Ohki
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] An association between a visual area representing object size in the mouse temporal cortex and approach / vigilance behaviors2023

    • Author(s)
      Nana Nishio, Katsuei Shibuki, Kenichi Ohki
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Neural activity underlying the local cue detection during visual discrimination in mouse visual cortex2023

    • Author(s)
      Kumiko Saitou, Takashi Yoshida, Kenichi Ohki
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Visual-somatosensory integration in the dorsal visual areas of adult mice.2023

    • Author(s)
      Mengyuan Chen, Tomonari MurakamiKenichi Ohki K,
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] A visual area representing object size in the mouse temporal cortex is involved in approach / vigilance behavior2023

    • Author(s)
      Nana Nishio, Katsuei Shibuki, Kenichi Ohki
    • Organizer
      視覚科学フォーラム 2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] Visual information representation in V1 adapts to changes in the external environment after learning2023

    • Author(s)
      Rie Kimura, Yumiko Yoshimura, Kenichi Ohki
    • Organizer
      Visual information representation in V1 adapts to changes in the external environment after learning
    • Related Report
      2023 Annual Research Report
  • [Presentation] Modular strategy for the development of hierarchical networks in the mouse visual system2022

    • Author(s)
      Ohki K
    • Organizer
      SPONT2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 種を越える脳科学2022

    • Author(s)
      大木研一
    • Organizer
      次世代脳 神経科学と情報工学の共創の場から考える脳科学研究の未来予想図
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Modular strategy for development of the hierarchical visual system2022

    • Author(s)
      Ohki K
    • Organizer
      iPlasticity IRCN International Symposium
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Cerebral Cortex and AI2022

    • Author(s)
      Ohki K
    • Organizer
      The 100th Anniversary Annual Meeting of The Physiological Society of Japan, AI technology pioneers a new era of medicine, physiology, and life sciences
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Modular strategy for development of the hierarchical visual system2022

    • Author(s)
      Ohki K
    • Organizer
      Neuro2022,
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Development of next generation AI by modeling brain information2022

    • Author(s)
      Ohki K
    • Organizer
      Beyond AI 研究成果発表会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 脳機能データベースに学ぶ 霊長類の情報処理2022

    • Author(s)
      大木研一
    • Organizer
      革新脳・国際脳合同シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Beyond AI: neuro-inspired network function and formation2022

    • Author(s)
      Ohki K
    • Organizer
      IRCN & U Tokyo NY Office Event: How does human intelligence arise?
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Noise in the Brain and AI2022

    • Author(s)
      Ohki K
    • Organizer
      The 3rd International Symposium of the Institute for AI and Beyond
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] A visual area in mouse temporal cortex represents the size of visual objects and has projections to areas associated with positive or negative behaviors2022

    • Author(s)
      Nishio N., Shibuki K., Ohki K.
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Wide-field calcium imaging reveals area map and functional segregation of rat visual cortex2022

    • Author(s)
      Nishiyama K., Sasaki K., Hashimoto T., Kimura R., Nishio N., Ohki K.
    • Organizer
      Neuro2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] A visual area representing object size in mouse temporal cortex can be associated with approach / vigilance behavior2022

    • Author(s)
      Nishio N., Shibuki K., Ohki K.
    • Organizer
      「次世代シナプス生理学による脳神経機能の理解」生理学研究所 研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] A visual area in mouse temporal cortex represents the size of visual objects and is associated with positive or negative behaviors2022

    • Author(s)
      Nishio N., Shibuki K., Ohki K.
    • Organizer
      生理研研究会「機能と構造の視覚科学研究会」視覚科学フォーラム 2022 第25回研究会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Neuronal activity supporting orientation discrimination at low contrast2022

    • Author(s)
      Kimura R., Ohki K., Yoshimura Y.
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Neuronal activity that allows us to perceive familiar images even at low contrast2022

    • Author(s)
      Kimura R., Ohki K., Yoshimura Y.
    • Organizer
      3rd International Symposium on Brain Information Dynamics 2023
    • Related Report
      2022 Annual Research Report
  • [Presentation] A neural mechanism underlying the perception of low-contrast familiar objects2022

    • Author(s)
      Kimura R., Ohki K., Yoshimura Y.
    • Organizer
      5th Stockholm-Tokyo Workshop 2023: Research Theme 1 The Brain and Society
    • Related Report
      2022 Annual Research Report
  • [Presentation] Neural activity that enables stable behavioral output even when visual input changes slightly2022

    • Author(s)
      Kimura R., Yoshimura Y., Ohki K.
    • Organizer
      The 100th Anniversary Annual Meeting of The Physiological Society of Japan
    • Related Report
      2022 Annual Research Report
  • [Presentation] Neural basis of motion aftereffect mediated by predictive coding in the marmoset motion-selective visual areas2022

    • Author(s)
      Hashimoto T., Matsui T., Uemura M., Murakami T., Kikuta K., Kato T., Ukita J., Isomura T., Ohki K.
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Functional reorganization of visual representation after eye opening in the mouse primary visual cortex (V1).2022

    • Author(s)
      Kishino F., Yoshida T., Uemura M., Ohki K.
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Asymmetric information flow in mouse higher visual areas2022

    • Author(s)
      Ishida H., Murakami T., Ohki K.
    • Organizer
      FENS Forum
    • Related Report
      2022 Annual Research Report
  • [Presentation] The role of bottom-up inputs from the primary visual cortex and higher visual thalamus in functional development of higher visual areas2022

    • Author(s)
      Kato T., Uemura M., Murakami T. and Ohki K.
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Synaptic organization of simple and complex cells in the mouse primary visual cortex2022

    • Author(s)
      Fukuda Y., Kondo S., Ohki K.
    • Organizer
      The 100th Anniversary Annual Meeting of The Physiological Society of Japan
    • Related Report
      2022 Annual Research Report
  • [Presentation] Functional identification of the mouse higher visual areas in the dorsal pathway2022

    • Author(s)
      Matsumoto H., Murakami T.,Ohki K.
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Hierarchical neocortical areal network in marmoset visual cortex orthogonalize spontaneous and stimulus-driven activity2022

    • Author(s)
      Kenichi Ohki
    • Organizer
      The 11th Annual Meeting of Japan Society for Marmoset Research
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Combined dendritic and somatic non-linear integration of synaptic inputs determine the output tuning in the mouse primary visual cortex neurons.2021

    • Author(s)
      Kondo S, Kikuta K and Ohki K
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] Inter-stimulus activity in mouse primary visual cortex encodes the timing of future visual events2021

    • Author(s)
      Nakano M, Yoshida T, Ohki K
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] マウスの視覚 サルの視覚2021

    • Author(s)
      大木研一
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Functional imaging of axonal projections from V1 and LPN to higher visual areas in developing mice2021

    • Author(s)
      Kato T, Uemura M, Murakami T, Ohki K
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] Neural activity pattern in the mouse visual cortex related to a behavioral strategy during a visual discrimination task2021

    • Author(s)
      Yoshida T, Saitou K, Ohki K
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] マウス一次視覚野における自然画像の表現2021

    • Author(s)
      吉田盛史、大木研一
    • Organizer
      視覚科学フォーラム2021(生理学研究所研究会)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] マウスの視覚 サルの視覚2021

    • Author(s)
      大木研一
    • Organizer
      Brain Club(慶応大学)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Visualization of extra-classical receptive fields that affect visual representation in mouse V12021

    • Author(s)
      Ishida H, Ohki K
    • Organizer
      Society for Neuroscience
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 視覚弁別課題におけるマウスの行動戦略及び、関連した視覚野の活動2021

    • Author(s)
      吉田盛史、斎藤久美子、大木研一
    • Organizer
      令和3年度大脳皮質を中心とした神経回路:構造と機能、その作動原理
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Multimodal topography-like structures represented in spontaneous activity in a mouse higher visual area during development2021

    • Author(s)
      Matsumoto H, Murakami T, Nishio N, Yoshida T, Ohki K
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] Somatotopy-like patterns of neural activity in somatosensory and motor cortices of developing mice2021

    • Author(s)
      Go C, Murakami T, Nishio N, Yoshida T, Ohki K
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] Orthogonality between maps of direction-selectivity and spatial frequency in the cat primary visual cortex2021

    • Author(s)
      Matsui T, Nishiyama M, Murakami T, Hagihara K, Ohki K
    • Organizer
      The 44th Annual Meeting of the Japan Neuroscience Society
    • Related Report
      2021 Annual Research Report
  • [Presentation] Functional Organization of Marmoset Visual Cortex2020

    • Author(s)
      Kenichi Ohki
    • Organizer
      Harvard Neurobiology Seminar
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Multiscale calcium imaging of spontaneous activity in the primate visual cortical network2020

    • Author(s)
      T. Matsui, T. Hashimoto, T. Murakami, M. Uemura, K.Kikuta, T. Kato, K. Ohki
    • Organizer
      生理学研究所研究会「意思決定研究の新展開」生理学研究所
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] モザイク遺伝子ノックアウトを用いた、マウス一次視覚野の神経応答特性の形成におけるNMDA受容体の役割の解明2020

    • Author(s)
      菊田浩平、大木研一
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マウス一次視覚野における反応適応と逸脱検知2020

    • Author(s)
      中野誠大、吉田盛史、大木研一
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マウス側頭皮質の新規高次視覚野は、前後の小領域ごとに異なる神経投射を示す2020

    • Author(s)
      西尾奈々、澁木克栄、大木研一
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] in vivo大脳皮質広域カルシウムイメージングによるCdkl5機能欠損マウスにおける機能的結合性変化の同定2020

    • Author(s)
      野村俊貴、村上知成、斎藤久美子、大木研一、田中輝幸
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 聴覚性驚愕反応の馴化におけるマウス大脳皮質の神経応答2020

    • Author(s)
      古澤孝太郎、根東覚、大木研一、榎本和生
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Multiscale calcium imaging of spontaneous activity in the primate visual cortical network2020

    • Author(s)
      T. Matsui, T. Hashimoto, T. Murakami, M. Uemura, K.Kikuta, T. Kato, K. Ohki
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Coupling and decoupling between neural activity and hemodynamics revealed by multispectral imaging2020

    • Author(s)
      R. Li, T. Matsui, K. Ohki
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Functional organization of response-selective inputs on dendrites of mouse primary visual cortex neurons.2020

    • Author(s)
      根東 覚、菊田浩平、大木研一
    • Organizer
      第8回神経局所回路国際会議
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional Oraganization of Marmoset Visual Cortex.2020

    • Author(s)
      Ohki K
    • Organizer
      UK-Japan Neuroscience Symposium 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional calcium imaging in marmoset cortical area MT/MST.2020

    • Author(s)
      橋本昂之、松井鉄平、上村允人、村上知成、菊田浩平、加藤利樹、大木研一
    • Organizer
      第9回 日本マーモセット研究会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Development and Application of Multi-Scale Ca2+ Imaging in the Primate Visual Cortical Network.2020

    • Author(s)
      Matsui T, Hashimoto T, Uemura M, Murakami T, Kikuta K, Kato T, Ohki K
    • Organizer
      The 8th RIEC International Symposium on Brain Functions and Brain Computer
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Functional organization of response-selective inputs on dendrites of mouse primary visual cortex neurons.2020

    • Author(s)
      根東 覚、菊田浩平、大木研一
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Spatiotemporal structure of spontaneous activity in the marmoset visual cortex.2020

    • Author(s)
      Matsui T, Hashimoto T, Uemura M, Murakami T, Kikuta K, Kato T, Ohki K
    • Organizer
      第97回日本生理学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス一次視覚野に分布するLPN投射軸索の反応特性2020

    • Author(s)
      根東 覚、清原 悠嵩、大木研一
    • Organizer
      第125回日本解剖学会総会・全国学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 細胞集団による情報表現(ランチョンセミナー)2019

    • Author(s)
      大木研一
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Deep-learning-based identification of spatiotemporal visual feature representation in the mouse ectorhinal cortex.2019

    • Author(s)
      Fukagawa S, Ukita J, Nishio N, Ohki K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Visually-evoked spine imaging under the optogenetic inhibition of somatic depolarization.2019

    • Author(s)
      Kondo S, Ohki K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Response selectivity of LPN projections to the mouse primary and higher visual cortex.2019

    • Author(s)
      Kiyohara Y, Kondo S, Ohki K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Structured spontaneous activity in the marmoset visual cortex studied with in vivo calcium imaging.2019

    • Author(s)
      Matsui T, Hashimoto T, Uemura M, Murakami T, Kikuta K, Kato T, Ohki K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Differential projections from subregions in a novel higher visual area in the mouse temporal cortex.2019

    • Author(s)
      Nishio N, Shibuki K, Ohki K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Independent development of lower- and higher-order visual networks.2019

    • Author(s)
      Murakami T, Matsui T, Ohki K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Top-down modulation from the frontal cortex enhances the visual response of higher visual areas.2019

    • Author(s)
      Kasahara C, Murakami T, Ohki K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Higher visual areas receive functionally specific inputs from the primary visual area soon after eye opening.2019

    • Author(s)
      Kato T, Uemura M, Murakami T, Ohki K
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Multiscale Calcium imaging of Visual Cortex in Marmoset Monkeys The 15th Asia-Pacific Conference on Vision.2019

    • Author(s)
      Ohki K
    • Organizer
      The 15th Asia-Pacific Conference on Vision.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] In vivo wide-field Ca2+ imaging of the cortical spontaneous activity in the Cdkl5 knockout mice.2019

    • Author(s)
      Nomura T, Murakami T, Saitou K, Ohki K, Tanaka T
    • Organizer
      CDKL5 Workshop in Asia
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Spatiotemporal structure of spontaneous activity in the primate visual cortex.2019

    • Author(s)
      Matsui T, Hashimoto T, Uemura M, Murakami T, Kikuta K, Kato T, Ohki K
    • Organizer
      神経ダイナミクスミニワークショップ
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Dynamic functional changes of neurons in visual cortex after eye opening.2019

    • Author(s)
      Kishino F, Uemura M, Trägenap S, Kaschube M, Ohki K
    • Organizer
      49th Annual Meeting of Society for Neuroscience
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] In vivo wide-field Ca2+ imaging of the cortical spontaneous activity in the Cdkl5 knock-out mice.2019

    • Author(s)
      Nomura T, Murakami T, Saitou K, Ohki K, Tanaka T
    • Organizer
      2019 CDKL5 Forum in Boston
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Robust representation of natural images by sparse and variable population of active neurons in visual cortex.2019

    • Author(s)
      Ohki K
    • Organizer
      2019 International Conference on Neural Cells, Circuits and Behavior
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Differential projections from subregions in a novel higher visual area in the mouse temporal cortex.2019

    • Author(s)
      西尾 奈々、澁木 克栄、大木 研一
    • Organizer
      生理学研究所シナプス研究会
    • Related Report
      2019 Annual Research Report
  • [Remarks] マウスが見ている世界を再現:不安定な脳活動に隠された安定な知覚

    • URL

      https://www.m.u-tokyo.ac.jp/news/press.html#20200214

    • Related Report
      2019 Annual Research Report
  • [Remarks] How Does a Mouse’s Visual Cortex “See” the World?

    • URL

      https://ircn.jp/en/pressrelease/20200213-kenichiohki

    • Related Report
      2019 Annual Research Report
  • [Remarks] 【記者発表】大木研一主任研究者『マウスが見ている世界を再現:不安定な脳活動に隠された安定な知覚』

    • URL

      https://ircn.jp/pressrelease/20200213-kenichiohki

    • Related Report
      2019 Annual Research Report

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Published: 2019-06-27   Modified: 2025-02-04  

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