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comprehensive studies on the molecular basis of early development and clonal evolution in cancer using advanced genomics.

Research Project

Project/Area Number 19H05656
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Review Section Broad Section I
Research InstitutionKyoto University

Principal Investigator

小川 誠司  京都大学, 医学研究科, 教授 (60292900)

Co-Investigator(Kenkyū-buntansha) 中川 正宏  京都大学, 医学研究科, 特定准教授 (10431850)
昆 彩奈  京都大学, 医学研究科, 助教 (20772403)
牧島 秀樹  京都大学, 医学研究科, 准教授 (40402127)
南谷 泰仁  京都大学, 医学研究科, 特定准教授 (60451811)
依田 成玄  京都大学, 医学研究科, 特定准教授 (70335454)
Project Period (FY) 2019-06-26 – 2024-03-31
Project Status Granted (Fiscal Year 2021)
Budget Amount *help
¥199,940,000 (Direct Cost: ¥153,800,000、Indirect Cost: ¥46,140,000)
Fiscal Year 2022: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2021: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2020: ¥39,260,000 (Direct Cost: ¥30,200,000、Indirect Cost: ¥9,060,000)
Fiscal Year 2019: ¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Keywordsゲノム生物学 / 腫瘍学
Outline of Research at the Start

主要ながん種の病態に関わるドライバー変異の全体像が明らかにされた一方で、ドライバー変異の獲得に始まる発がん初期のクローン選択の過程や、その後、多数の変異の獲得とクローン選択によってがん細胞集団に高度な多様性が生じ、浸潤・転移・再発が惹起される過程の分子メカニズムについては、なお多くが不明である。これらを理解するには遺伝子変異やその組み合わせと細胞の表現型の関係性や、ゲノムの構造異常について全貌を解明する必要がある。これらの未解決の課題に対して、先端技術によるクローンの単離と全ゲノムシーケンス・単一細胞シーケンス、オルガノイド培養技術とマウスモデルの解析等を駆使して、包括的な探求を行う。

Outline of Annual Research Achievements

わが国における最大の死因であるがんの原因や特性には遺伝子異常が深く関わっている。近年の科学技術の進歩によって、さまざまながんにおいてその発症や悪性度に関わる遺伝子異常の全体像が明らかにされてきた。しかしながら、その一方で、がんにおいて認められる遺伝子異常がすでにがん発症前から獲得されることが明らかにされ、それらが初期のがんの発生過程にどうかかわるかについてはいまだ不明である。さらには、その後に複数の遺伝子異常が積み重なることによってがんが高度に多様な細胞から構成され、他の臓器に浸潤や転移し、また臨床経過中に再発が惹起される過程の分子メカニズムについては、なお多くが不明である。これらを理解するためには、がんの起源である正常組織における微小なクローンに獲得される遺伝子異常を検出すること、遺伝子異常やその組み合わせと細胞のフェノタイプとの関係性を検討することが必要である。その際には通常では発見できないようなゲノムの異常構造などについて全貌を解明することが必須となる。これらの未解決の課題に対して、先端技術による微小なクローンの単離と全ゲノムシーケンス、単一細胞シーケンス、オルガノイド培養技術、遺伝子異常を導入したマウスモデルの解析、大規模コホートでの遺伝子異常と表現型の関係性の解析等を駆使して、包括的な探求を行った。その結果、骨髄異形成症候群(MDS)の多数例での解析により、TP53遺伝子が両アリル異常となっている状態が非常に重要な予後不良因子であることを明らかにした。また、MDSにおいて高頻度に遺伝子異常が共存するRUNX1とSTAG2が、協調的にクロマチンループ形成を阻害することでMDSの発症に関与していることを明らかにした。さらに乳腺や膵臓等での微少組織採取によるシーケンス解析やオルガノイド培養の技術を最適化し、さらなる解析を進めている。

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

大腸癌の初期発生の解明では、前がん状態では選択される変異は大腸癌ではほとんど認めず、がんになりがたい遺伝子異常を同定した。これらは初期発生の解析にも関わらず、がんの治療標的候補にもつながりうる、想定した以上の非常に重要な知見である。
また、クローン造血の解析では、当初想定していなかった大規模な健常者サンプルと臨床情報が得られ、さらに大規模のSNPアレイデータの利用により、最新の超高感度コピー数解析を行うことが可能となった。その結果、クローン造血における遺伝子変異とコピー数解析の両者を同時に施行することが、造血器腫瘍および非腫瘍性疾患のリスク増大に重要なことが判明した。
さらに、当初は細胞レベルでの遺伝子変異と遺伝子発現の解析を単一細胞由来コロニーで解析する予定であったが、この解析では重要なサイトカインを添加した培養系での解析となるため、培養の影響が無視できない可能性が考えられた。我々の開発していた単一細胞での変異と発現同時解析技術の最適化が進み、培養を経ること無く、単一細胞レベルで遺伝子変異と遺伝子発現の同時解析が可能となった。この手法をクローン造血で用いることにより、変異を有する小クローンの遺伝子発現形質を解析可能となり、さらに、変異を有する症例の変異を有しない細胞の解析も可能となり、想定していなかった骨髄環境の変化を観測することができた。
MDSの解析では、我々が長年取り組んできたゲノム解析におけるコピー数異常の高度な解析技術を用いた大規模コホートの解析において、予後不良因子としてよく知られているTP53変異は複数のアリルで異常を来した場合に、強力な予後不良因子となることを明らかにした。治療方針の決定に影響する重要な知見を得ることができた。
これらの当初の期待以上の成果が得られている項目に加えて、他の項目でも順調に研究の進展が得られている。

Strategy for Future Research Activity

当初計画されたとおり、がんにおいて高頻度に認められるドライバー変異が獲得される時期およびそれらの組み合わせや蓄積を、臨床経過と関連させて解析することにより、それらが初期のがんの発生過程にどうかかわるか、また、がんが高度に多様な細胞から構成され、他の臓器に浸潤や転移し、また臨床経過中に再発が惹起される過程の分子メカニズムについて明らかにしていく。この研究では、がんにおいて高頻度に認められるドライバー変異は、すでにがん発症前から獲得されていることのみならず、がんにおけるそれらの検出頻度は正常組織とパターンが異なっており、遺伝子によっては、正常組織に認められるドライバー変異ががん組織で認められるよりも高頻度であることを見出しており、この現象が生じるメカニズムおよび、初期のがんの発生過程との関連を検討し、食道がん、大腸がん、造血器腫瘍において、がんおよび正常組織における遺伝子異常の検出、発症初期のメカニズムの解明、新たな病態の解明など、成果が得られた。その際に、がんの起源である正常組織における遺伝子異常を検出すること、遺伝子異常やその組み合わせと細胞のフェノタイプとの関係性を検討することを可能とした、ごく少量のサンプルからさまざまなシーケンス解析を行う独自の技術をさらに多くのがんに適用し、これまで未知のゲノムの異常を解明することを試みるともに、大規模コホートでの遺伝子異常と表現型の解析や、胚細胞遺伝子変異についても解析を行う。現在、研究が予定されているがんとして、乳がん、胃がん、前立腺がん、大腸がん、脳腫瘍、尿路上皮癌、造血器腫瘍が含まれる。これまで本研究は予定以上の成果をあげており計画の変更あるいは問題点などは認められない。

Assessment Rating
Interim Assessment Comments (Rating)

A+: In light of the aim of introducing the research area into the research categories, more progress has been made in research than expected.

Report

(6 results)
  • 2021 Abstract (Interim Assessment) ( PDF )   Interim Assessment (Comments) ( PDF )
  • 2020 Annual Research Report
  • 2019 Abstract ( PDF )   Comments on the Screening Results ( PDF )   Annual Research Report

Research Products

(208 results)

All 2021 2020 2019 Other

All Int'l Joint Research (12 results) Journal Article (88 results) (of which Int'l Joint Research: 52 results,  Peer Reviewed: 88 results,  Open Access: 78 results) Presentation (102 results) (of which Int'l Joint Research: 38 results,  Invited: 24 results) Remarks (6 results)

  • [Int'l Joint Research] パリ大学(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ブラジル国立がんセンター/リオデジャネイロ大学(ブラジル)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] パビア大学/ビアンキメラクリノモレリ病院(イタリア)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] カロリンスカ大学(スウェーデン)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] ミュンヘン白血病研究所/ハノーバー大学/フライブルグ大学(ドイツ)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] パリ大学(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ブラジル国立がんセンター /リオデジャネイロ大学(ブラジル)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] パビア大学(イタリア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] カロリンスカ大学(スウェーデン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] ミュンヘン白血病研究所/ハノーバー大学/フライブルグ大学(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.2021

    • Author(s)
      Mizumaki H, Hosomichi K, Hosokawa K, Yoroidaka T, Imi T, Zaimoku Y, Katagiri T, Nguyen MAT, Tran DC, Elbadry MIY, Chonabayashi K, Yoshida Y, Takamatsu H, Ozawa T, Azuma F, Kishi H, Fujii Y, Ogawa S, Tajima A, Nakao S.
    • Journal Title

      Haematologica

      Volume: - Pages: 247809-247809

    • DOI

      10.3324/haematol.2020.247809

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Frequent mutations in HLA and related genes in extranodal NK/T cell lymphomas. Leuk Lymphoma2021

    • Author(s)
      Polprasert C, Takeuchi Y, Makishima H, Wudhikarn K, Kakiuchi N, Tangnuntachai N, Assanasen T, Sitthi W, Muhamad H, Lawasut P, Kongkiatkamon S, Bunworasate U, Izutsu K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Yoshida K, Rojnuckarin P
    • Journal Title

      Leukemia & Lymphoma

      Volume: 62(1) Pages: 95-103

    • DOI

      10.1080/10428194.2020.1821011

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Absence of a common founder mutation in patients with cooccurring myelodysplastic syndrome and plasma cell disorder2021

    • Author(s)
      Klimkowska Monika、Nannya Yasuhito、Gran Charlotte、M?nsson Robert、Douagi Iyadh、Ogawa Seishi、Nahi Hareth、Tobiasson Magnus
    • Journal Title

      Blood

      Volume: 137 Pages: 1260-1263

    • DOI

      10.1182/blood.2020007555

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Unbiased Detection of Driver Mutations in Extramammary Paget Disease2021

    • Author(s)
      Ishida Yoshihiro、Ogawa Seishi et al.
    • Journal Title

      Clinical Cancer Research

      Volume: 27 Pages: 1756-1765

    • DOI

      10.1158/1078-0432.ccr-20-3205

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of Philadelphia chromosome-negative acute myeloid leukemia with IDH2 and NPM1 mutations in a patient with chronic myeloid leukemia who showed a major molecular response to tyrosine kinase inhibitor therapy.2021

    • Author(s)
      Nakamura F, Arai H, Nannya Y, Ichikawa M, Furuichi S, Nagasawa F, Takahashi W, Handa T, Nakamura Y, Tanaka H, Nakamura Y, Sasaki K, Miyano S, Ogawa S, Mitani K.
    • Journal Title

      International Journal of Hematology

      Volume: -

    • DOI

      10.1007/s12185-020-03074-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Germline RUNX1 translocation in familial platelet disorder with propensity to myeloid malignancies2021

    • Author(s)
      Sakurai M, Nannya Y, Yamazaki R, Yamaguchi K, Koda Y, Abe R, Yokoyama K, Ogawa S, Mori T.
    • Journal Title

      Annals of Hematology

      Volume: 印刷中

    • DOI

      10.1007/s00277-021-04430-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of high-risk neuroblastoma classification based on expression profiles with differentiation and metabolism2021

    • Author(s)
      Kimura Shunsuke、Sekiguchi Masahiro、Watanabe Kentaro、Hiwatarai Mitsuteru、Seki Masafumi、Yoshida Kenichi、Isobe Tomoya、Shiozawa Yusuke、Suzuki Hiromichi、Hoshino Noriko、Hayashi Yasuhide、Oka Akira、Miyano Satoru、Ogawa Seishi、Takita Junko
    • Journal Title

      PLOS ONE

      Volume: 16 Pages: 0245526-0245526

    • DOI

      10.1371/journal.pone.0245526

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discovery of Functional Alternatively Spliced PKM Transcripts in Human Cancers2021

    • Author(s)
      Li X, Kim W, Arif M, Gao C, Hober A, Kotol D, Strandberg L, Forsström B, Sivertsson Å, Oksvold P, Turkez H, Grøtli M, Sato Y, Kume H, Ogawa S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A
    • Journal Title

      Cancers

      Volume: 13(2) Pages: 348-348

    • DOI

      10.3390/cancers13020348

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clonal hematopoiesis in adult pure red cell aplasia.2021

    • Author(s)
      Fujishima N, Kohmaru J, Koyota S, Kuba K, Saga T, Omokawa A, Moritoki Y, Ueki S, Ishida F, Nakao S, Matsuda A, Ohta A, Tohyama K, Yamasaki H, Usuki K, Nakashima Y, Sato S, Miyazaki Y, Nannya Y, Ogawa S, Sawada K, Mitani K, Hirokawa M.
    • Journal Title

      Scientific Reports

      Volume: 1 Pages: 2253-2253

    • DOI

      10.1038/s41598-021-81890-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequent genetic alterations in immune checkpoint-related genes in intravascular large B-cell lymphoma2021

    • Author(s)
      Shimada Kazuyuki、Yoshida Kenichi、Suzuki Yasuhiro、Iriyama Chisako、Inoue Yoshikage、Sanada Masashi、Kataoka Keisuke、Yuge Masaaki、Takagi Yusuke、Kusumoto Shigeru、Masaki Yasufumi、Ito Takahiko、Inagaki Yuichiro、Okamoto Akinao、Kuwatsuka Yachiyo、Nakatochi Masahiro、Shimada Satoko、Miyoshi Hiroaki et al.
    • Journal Title

      Blood

      Volume: 137 Pages: 1491-1502

    • DOI

      10.1182/blood.2020007245

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of disease model iPSCs derived from patients with a novel Fanconi anemia-like IBMFS ADH5/ALDH2 deficiency.2021

    • Author(s)
      Anfeng Mu, Asuka Hira, Akira Niwa, Mitsujiro Osawa, Kenichi Yoshida, Minako Mori, Yusuke Okamoto, Kazuko Inoue, Keita Kondo, Masato T. Kanemaki, Tomonari Matsuda, Etsuro Ito, Seiji Kojima, Tatsutoshi Nakahata, Seishi Ogawa, Keigo Tanaka, Keitaro Matsuo, Megumu K. Saito, Minoru Takata.
    • Journal Title

      Blood Online ahead of print.

      Volume: 137 Pages: 2021-2032

    • DOI

      10.1182/blood.2020009111

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] XPO1 inhibitors represent a novel therapeutic option in Adult T-cell Leukemia, triggering p53-mediated caspase-dependent apoptosis2021

    • Author(s)
      Boons Eline、Nogueira Tatiane C.、Dierckx Tim、Menezes Soraya Maria、Jacquemyn Maarten、Tamir Sharon、Landesman Yosef、Farr? Lourdes、Bittencourt Achil?a、Kataoka Keisuke、Ogawa Seishi、Snoeck Robert、Andrei Graciela、Van Weyenbergh Johan、Daelemans Dirk
    • Journal Title

      Blood Cancer Journal

      Volume: 11

    • DOI

      10.1038/s41408-021-00409-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical significance of RAS pathway alterations in pediatric acute myeloid leukemia.2021

    • Author(s)
      Kaburagi T, Yamato G, Shiba N, Yoshida K, Hara Y, Tabuchi K, Shiraishi Y,Ohki K, Sotomatsu M, Arakawa H, Matsuo H, Shimada A, Taki T, Kiyokawa N, Tomizawa D, Horibe K, Miyano S, Taga T, Adachi S, Ogawa S, Hayashi Y.
    • Journal Title

      Haematologica.

      Volume: -

    • DOI

      10.3324/haematol.2020.269431

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Somatic mutations in lymphocytes in patients with immune-mediated aplastic anemia2021

    • Author(s)
      Lundgren S, Kankainen M, Huuhtanen J, Walldin G, Kerr CM, Clemente M, Ebeling F, Rajala H, Brück O, Lähdesmäki H, Hannula S, Hannunen T, Ellonen P, Young NS, Ogawa S, Maciejewski JP, Hellström-Lindberg E, Mustjoki S
    • Journal Title

      Leukemia

      Volume: 35(5) Pages: 1365-1379

    • DOI

      10.1038/s41375-021-01231-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Targeted deep next generation sequencing identifies potential somatic and germline variants for predisposition to familial Burkitt lymphoma2021

    • Author(s)
      Okabe Motohito、Morishita Takanobu、Yasuda Takahiko、Sakaguchi Hirotoshi、Sanada Masashi、Kataoka Keisuke、Ogawa Seishi、Shiraishi Yuichi、Ichiki Tomoe、Kawaguchi Yuka、Ohbiki Marie、Matsumoto Rena、Osaki Masahide、Goto Tatsunori、Ozawa Yukiyasu、Miyamura Koichi
    • Journal Title

      European Journal of Haematology

      Volume: -

    • DOI

      10.1111/ejh.13629

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.2021

    • Author(s)
      Hosokawa K, Mizumaki H, Yoroidaka T, Maruyama H, Imi T, Tsuji N, Urushihara R, Tanabe M, Zaimoku Y, Nguyen MAT, Tran DC, Ishiyama K, Yamazaki H, Katagiri T, Takamatsu H, Hosomichi K, Tajima A, Azuma F, Ogawa S, Nakao S.
    • Journal Title

      Blood

      Volume: -

    • DOI

      10.1182/blood.2020010586

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A possible association between a novel NLRP1 mutation and an autoinflammatory disease involving liver cirrhosis2021

    • Author(s)
      Yasudo Hiroki、Ando Taiki、Maehara Akie、Ando Tomoaki、Izawa Kumi、Tanabe Atsushi、Kaitani Ayako、Nomura Shigeru、Seki Masafumi、Yoshida Kenichi、Oda Hirotsugu、Okamoto Yoko、Wang Hexing、Kamei Anna、Kojima Mayuki、Kimura Meiko、Uchida Koichiro、Nakano Nobuhiro、Kaneko Junichi、et al.
    • Journal Title

      Hepatology

      Volume: -

    • DOI

      10.1002/hep.31818

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Poor Myocardial Compaction in a Patient with Recessive <i>MYL2</i> Myopathy2021

    • Author(s)
      Tamamitsu Ayaka Monoi、Nakagama Yu、Domoto Yukako、Yoshida Kenichi、Ogawa Seishi、Hirono Keiichi、Shindo Takahiro、Ogawa Yosuke、Nakano Katsutoshi、Asakai Hiroko、Hirata Yoichiro、Matsui Hikoro、Inuzuka Ryo
    • Journal Title

      Int. Heart J.

      Volume: 62 Issue: 2 Pages: 445-447

    • DOI

      10.1536/ihj.20-639

    • NAID

      130008007427

    • ISSN
      1349-2365, 1349-3299
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clonal expansion in non-cancer tissues2021

    • Author(s)
      Kakiuchi Nobuyuki、Ogawa Seishi
    • Journal Title

      Nature Reviews Cancer

      Volume: 21 Pages: 239-256

    • DOI

      10.1038/s41568-021-00335-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dasatinib is an effective treatment for angioimmunoblastic T-cell lymphoma.2020

    • Author(s)
      Nguyen TB, Sakata-Yanagimoto M, Fujisawa M, Tanzima Nuhat S, Miyoshi H, Nannya Y, Hashimoto K, Fukumoto K, Bernard OA, Kiyoki Y, Ishitsuka K, Momose H, Sukegawa S, Shinagawa A, Suyama T, Sato Y, Nishikii H, Obara N, Kusakabe M, Yanagimoto S, Ogawa S, Ohshima K, Chiba S.
    • Journal Title

      Cancer Research

      Volume: - Pages: 1875-1884

    • DOI

      10.1158/0008-5472.can-19-2787

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] TET2 haploinsufficiency alters reprogramming into induced pluripotent stem cells2020

    • Author(s)
      Secardin Lise、Limia Cintia Elisabeth Gomez、di Stefano Antonio、Bonamino Martin Hernan、Saliba Joseph、Kataoka Keisuke、Rehen Stevens K.、Raslova Hana、Marty Caroline、Ogawa Seishi、Vainchenker William、Monte-Mor Barbara da Costa Reis、Plo Isabelle
    • Journal Title

      Stem Cell Research

      Volume: 44 Pages: 101755-101755

    • DOI

      10.1016/j.scr.2020.101755

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Combined Cohesin-RUNX1 Deficiency Synergistically Perturbs Chromatin Looping and Causes Myelodysplastic Syndromes.2020

    • Author(s)
      Ochi Y, Kon A, Sakata T, Nakagawa MM, Nakazawa N, Kakuta M, Kataoka K, Koseki H, Nakayama M, Morishita D, Tsuruyama T, Saiki R, Yoda A, Okuda R, Yoshizato T, Yoshida K, Shiozawa Y, Nannya Y, Kotani S, Kogure Y, Kakiuchi N, Nishimura T, Makishima H, Malcovati L, Yokoyama A, Takeuchi K, Sugihara E, Sato TA, Sanada M, Takaori-Kondo A, Cazzola M, Kengaku M, Miyano S, Shirahige K, Suzuki HI, Ogawa S.
    • Journal Title

      Cancer Discovery

      Volume: - Issue: 6 Pages: 836-853

    • DOI

      10.1158/2159-8290.cd-19-0982

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] LUBAC accelerates B-cell lymphomagenesis by conferring resistance to genotoxic stress on B cells2020

    • Author(s)
      Jo Tomoyasu、Nishikori Momoko、Kogure Yasunori、Arima Hiroshi、Sasaki Katsuhiro、Sasaki Yoshiteru、Nakagawa Tomoko、Iwai Fumie、Momose Shuji、Shiraishi Aki、Kiyonari Hiroshi、Kagaya Noritaka、Onuki Tetsuo、Shin-ya Kazuo、Yoshida Minoru、Kataoka Keisuke、Ogawa Seishi、Iwai Kazuhiro、Takaori-Kondo Akifumi
    • Journal Title

      Blood

      Volume: 136 Pages: 684-697

    • DOI

      10.1182/blood.2019002654

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SF3B1-mutant MDS as a distinct disease subtype: a proposal from the International Working Group for the Prognosis of MDS2020

    • Author(s)
      Malcovati Luca、Ogawa Seishi et al.
    • Journal Title

      Blood

      Volume: 136 Pages: 157-170

    • DOI

      10.1182/blood.2020004850

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genomic analysis of multiple myeloma using targeted capture sequencing in the Japanese cohort.2020

    • Author(s)
      Kanamori T, Sanada M, Ri M, Ueno H, Nishijima D, Yasuda T, Tachita T, Narita T, Kusumoto S, Inagaki A, Ishihara R, Murakami Y, Kobayashi N, Shiozawa Y, Yoshida K, Nakagawa MM, Nannya Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Horibe K, Handa H, Ogawa S, Iida S.
    • Journal Title

      British Journal of Hematology

      Volume: - Pages: 755-763

    • DOI

      10.1111/bjh.16720

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Case of Tyrosine Kinase Inhibitor-Resistant Chronic Myeloid Leukemia, Chronic Phase with ASXL1 Mutation2020

    • Author(s)
      Imataki Osamu、Ishida Tomoya、Kubo Hiroyuki、Uemura Makiko、Nanya Yasuhito、Kawakami Kimihiro、Ogawa Seishi、Kadowaki Norimitsu
    • Journal Title

      Case Reports in Oncology

      Volume: 13 Pages: 449-455

    • DOI

      10.1159/000506452

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Whole-Exome Sequencing-Based Approach for Germline Mutations in Patients with Inborn Errors of Immunity2020

    • Author(s)
      Okano Tsubasa、Imai Kohsuke、Naruto Takuya、Okada Satoshi、Yamashita Motoi、Yeh Tzu-wen、Ono Shintaro、Tanaka Keisuke、Okamoto Keisuke、Tanita Kay、Matsumoto Kazuaki、Toyofuku Etsushi、Kumaki-Matsumoto Eri、Okamura Miko、Ueno Hiroo、Ogawa Seishi、Ohara Osamu、Takagi Masatoshi、Kanegane Hirokazu、Morio Tomohiro
    • Journal Title

      J Clin Immunol

      Volume: 40 Pages: 729-740

    • DOI

      10.1007/s10875-020-00798-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical utility of target capture‐based panel sequencing in hematological malignancies: A multicenter feasibility study2020

    • Author(s)
      Yasuda T, Sanada M, Nishijima D, Kanamori T, Iijima Y, Hattori H, Saito A, Miyoshi H, Ishikawa Y, Asou N, Usuki K, Hirabayashi S, Kato M, Abe M.
    • Journal Title

      Cancer Sci

      Volume: 111 Pages: 3367-3378

    • DOI

      10.1111/cas.14552

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated multiomics analysis of hepatoblastoma unravels its heterogeneity and provides novel druggable targets.2020

    • Author(s)
      Sekiguchi M, Seki M, Kawai T, Yoshida K, Yoshida M, Isobe T, Hoshino N, Shirai R, Tanaka M, Souzaki R, Watanabe K, Arakawa Y, Nannya Y, Suzuki H, Fujii Y, Kataoka K, Shiraishi Y, Chiba K, Tanaka H, Shimamura T, Sato Y, Sato-Otsubo A, Kimura S, Kubota Y, Hiwatari M, et al
    • Journal Title

      npj Precision Oncology

      Volume: Jul 7;4:20. Pages: 20-20

    • DOI

      10.1038/s41698-020-0125-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Resistance of KIR Ligand-Missing Leukocytes to NK Cells In Vivo in Patients with Acquired Aplastic Anemia.2020

    • Author(s)
      Nguyen MAT, Hosokawa K, Yoroidaka T, Maruyama H, Espinoza JL, Elbadry MI, Mohiuddin M, Tanabe M, Katagiri T, Nakagawa N, Chonabayashi K, Yoshida Y, Arima N, Kashiwase K, Saji H, Ogawa S, Nakao S.
    • Journal Title

      ImmunoHorizons

      Volume: 4 Pages: 430-441

    • DOI

      10.4049/immunohorizons.2000046

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes2020

    • Author(s)
      Bernard E, Nannya Y, Hasserjian RP, Ogawa S, Papaemmanuil E
    • Journal Title

      Nature Medicine

      Volume: 26(10) Pages: 1549-1556

    • DOI

      10.1038/s41591-020-1008-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The transcription factor E2A activates multiple enhancers that drive Rag expression in developing T and B cells2020

    • Author(s)
      Miyazaki Kazuko、Watanabe Hitomi、Yoshikawa Genki、Chen Kenian、Hidaka Reiko、Aitani Yuki、Osawa Kai、Takeda Rie、Ochi Yotaro、Tani-ichi Shizue、Uehata Takuya、Takeuchi Osamu、Ikuta Koichi、Ogawa Seishi、Kondoh Gen、Lin Yin C.、Ogata Hiroyuki、Miyazaki Masaki
    • Journal Title

      Science Immunology,

      Volume: 5 Pages: 1455-1455

    • DOI

      10.1126/sciimmunol.abb1455

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond?Blackfan anemia2020

    • Author(s)
      Koyamaishi Shun、Ogawa Seishi et al.
    • Journal Title

      Bone Marrow Transplantation

      Volume: 56 Pages: 1013-1020

    • DOI

      10.1038/s41409-020-01056-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fusion partner?specific mutation profiles and KRAS mutations as adverse prognostic factors in MLL-rearranged AML2020

    • Author(s)
      Matsuo Hidemasa、Yoshida Kenichi、Nakatani Kana、... 、Haferlach Claudia、Ogawa Seishi、Adachi Souichi
    • Journal Title

      Blood Advances

      Volume: 4 Pages: 4623-4631

    • DOI

      10.1182/bloodadvances.2020002457

    • NAID

      120006890711

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] VAV1 mutations contribute to development of T-cell neoplasms in mice2020

    • Author(s)
      Fukumoto Kota、Sakata-Yanagimoto Mamiko、Fujisawa Manabu、Sakamoto Tatsuhiro、Miyoshi Hiroaki、Suehara Yasuhito、Nguyen Tran B.、Suma Sakurako、Yanagimoto Shintaro、Shiraishi Yuichi、Chiba Kenichi、Bouska Alyssa、Kataoka Keisuke、Ogawa Seishi、Iqbal Javeed、Ohshima Koichi、Chiba Shigeru
    • Journal Title

      Blood

      Volume: 136 Pages: 3018-3032

    • DOI

      10.1182/blood.2020006513

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comprehensive genetic analysis of pediatric germ cell tumors identifies potential drug targets.2020

    • Author(s)
      Kubota Y, Seki M, Kawai T, Isobe T, Yoshida M, Sekiguchi M, Kimura S, Watanabe K, Sato-Otsubo A, Yoshida K, Suzuki H, Kataoka K, Fujii Y, Shiraishi Y, Chiba K, Tanaka H, Hiwatari M, Oka A, Hayashi Y, Miyano S, Ogawa S, Hata K, Tanaka Y, Takita J.
    • Journal Title

      Communications Biology

      Volume: Sep 30;3(1) Pages: 544-544

    • DOI

      10.1038/s42003-020-01267-8

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correction: Reduced-intensity conditioning is effective for hematopoietic stem cell transplantation in young pediatric patients with Diamond-Blackfan anemia2020

    • Author(s)
      Koyamaishi Shun、Ogawa Seishi et al.
    • Journal Title

      Bone Marrow Transplantation

      Volume: 56 Pages: 1218-1219

    • DOI

      10.1038/s41409-020-01076-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetic and clinical landscape of breast cancers with germline BRCA1/2 variants2020

    • Author(s)
      Inagaki-Kawata Yukiko、Ogawa Seishi et al.
    • Journal Title

      Communications Biology

      Volume: 3

    • DOI

      10.1038/s42003-020-01301-9

    • NAID

      120006895406

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Landscape of driver mutations and their clinical impacts in pediatric B-cell precursor acute lymphoblastic leukemia2020

    • Author(s)
      Ueno H、Yoshida K、et al, 、Sanada M
    • Journal Title

      Blood Advances

      Volume: 4 Pages: 5165-5173

    • DOI

      10.1182/bloodadvances.2019001307

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two aldehyde clearance systems are essential to prevent lethal formaldehyde accumulation in mice and humans.2020

    • Author(s)
      Dingler FA†, Wang M†, Mu A† (Co-first), ....Takata M, Patel KJ.
    • Journal Title

      Molecular Cell

      Volume: 80 Pages: 996-1012

    • DOI

      10.1016/j.molcel.2020.10.012

    • NAID

      120006951779

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acquisition of monosomy 7 and a RUNX1 mutation in Pearson syndrome2020

    • Author(s)
      Nishimura Akira、Hirabayashi Shinsuke、Hasegawa Daisuke、Yoshida Kenichi、Shiraishi Yuichi、Ashiarai Miho、Hosoya Yosuke、Fujiwara Tohru、Harigae Hideo、Miyano Satoru、Ogawa Seishi、Manabe Atsushi
    • Journal Title

      Pediatric Blood & Cancer

      Volume: 68

    • DOI

      10.1002/pbc.28799

    • NAID

      120007189936

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel COL4A1 mutations identified in infants with congenital hemolytic anemia in association with brain malformations2020

    • Author(s)
      Ogura Hiromi、Ohga Shouichi、Aoki Takako、Utsugisawa Taiju、Takahashi Hidehiro、Iwai Asayuki、Watanabe Kenichiro、Okuno Yusuke、Yoshida Kenichi、Ogawa Seishi、Miyano Satoru、Kojima Seiji、Yamamoto Toshiyuki、Yamamoto-Shimojima Keiko、Kanno Hitoshi
    • Journal Title

      Human Genome Variation

      Volume: 7 Pages: 42-42

    • DOI

      10.1038/s41439-020-00130-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2P95-mutated neoplasms2020

    • Author(s)
      Todisco G, Creignou M, Guglielmelli P, Rumi E, Roncador M, Rizzo E, Nannya Y, Pietra D, Elena C, Bono E, Molteni E, Rosti V, Catrical&#225; S, Sarchi M, Dimitriou M, Ungerstedt J, Vannucchi AM, Hellstr&#246;m-Lindberg E, Ogawa S, Cazzola M, Malcovati L
    • Journal Title

      Leukemia

      Volume: ??

    • DOI

      10.1038/s41375-020-01106-z

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genome analysis of myelodysplastic syndromes among atomic bomb survivors in Nagasaki2020

    • Author(s)
      Taguchi M, Mishima H, Shiozawa Y, Hayashida C, Kinoshita A, Nannya Y, Makishima H, Horai M, Matsuo M, Sato S, Itonaga H, Kato T, Taniguchi H, Imanishi D, Imaizumi Y, Hata T, Takenaka M, Moriuchi Y, Shiraishi Y, Miyano S, Ogawa S, Yoshiura K-i, Miyazaki Y
    • Journal Title

      Haematologica

      Volume: 105 Pages: 358-365

    • DOI

      10.3324/haematol.2019.219386

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Frequent mutations that converge on the NFKBIZ pathway in ulcerative colitis2020

    • Author(s)
      Kakiuchi Nobuyuki et al.
    • Journal Title

      Nature.

      Volume: 577 Pages: 260-265

    • DOI

      10.1038/s41586-019-1856-1

    • NAID

      120006777064

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Persistent clonal cytogenetic abnormality with del(20q) from an initial diagnosis of acute promyelocytic leukemia.2020

    • Author(s)
      Fujioka M, Itonaga H, Kato T, Nannya Y, Hashimoto M, Kasai S, Toriyama E, Kamijo R, Taguchi M, Taniguchi H, Sato S, Atogami S, Imaizumi Y, Hata T, Moriuchi Y, Ogawa S, Miyazaki Y.
    • Journal Title

      Int J Hematol

      Volume: 111 Pages: 311-316

    • DOI

      10.1007/s12185-019-02731-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] DNA methylation-based classification reveals difference between pediatric T-cell acute lymphoblastic leukemia and normal thymocytes2020

    • Author(s)
      Kimura Shunsuke、Ogawa Seishi., et al.
    • Journal Title

      Leukemia.

      Volume: 34 Pages: 1163-1165

    • DOI

      10.1038/s41375-019-0626-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular pathogenesis of progression to myeloid leukemia from TET-insufficient status.2020

    • Author(s)
      Shrestha R, Sakata-Yanagimoto M, Maie K, Oshima M, Ishihara M, Suehara Y, Fukumoto K,1 Nakajima-Takagi Y, Matsui H, Kato T, Muto H, Sakamoto T, Kusakabe M, Nannya Y, Makishima H, Ueno H, Saiki R, Ogawa S, Chiba K, Shiraishi Y, Miyano S, Mouly E, Bernard OA, Inaba T, Koseki H, Iwama A, Chiba S
    • Journal Title

      Blood Advances

      Volume: 4(5) Pages: 845-854

    • DOI

      10.1182/bloodadvances.2019001324

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Classification of clear cell renal cell carcinoma based on PKM alternative splicing.2020

    • Author(s)
      Li X, Turanli B, Juszczak K, Kim W, Arif M, Sato Y, Ogawa S, Turkez H, Nielsen J, Boren J, Uhlen M, Zhang C, Mardinoglu A.
    • Journal Title

      Heliyon.

      Volume: 6(2)

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Single-cell analysis based dissection of clonality in myelofibrosis.2020

    • Author(s)
      Mylonas E, Yoshida K, Frick M, Hoyer K, Christen F, Kaeda J, Obenaus M, Noerenberg D, Hennch C, Chan W, Ochi Y, Shiraishi Y, Shiozawa Y, Zenz T, Oakes CC, Sawitzki B, Schwarz M, Bullinger L, le Coutre P, Rose-Zerilli MJJ, Ogawa S, Damm F.
    • Journal Title

      Nature Communications

      Volume: 11(1) Pages: 73-73

    • DOI

      10.1038/s41467-019-13892-x

    • NAID

      120006782217

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel DDX41 variants in Thai patients with myeloid neoplasms2020

    • Author(s)
      Polprasert Chantana、Ogawa Seishi., et al.
    • Journal Title

      International of Journal of Hematology

      Volume: 111 Pages: 241-246

    • DOI

      10.1007/s12185-019-02770-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic basis of myelodysplastic syndromes2020

    • Author(s)
      OGAWA Seishi
    • Journal Title

      Proc. Jpn. Acad., Ser. B

      Volume: 96 Issue: 3 Pages: 107-121

    • DOI

      10.2183/pjab.96.009

    • NAID

      130007807427

    • ISSN
      0386-2208, 1349-2896
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct and convergent consequences of splice factor mutations in myelodysplastic syndromes2020

    • Author(s)
      Madan V, Li J, Zhou S, Teoh WW, Han L, Meggendorfer M, Malcovati L, Cazzola M, Ogawa S, Haferlach T, Yang H, Koeffler HP.
    • Journal Title

      Am J Hematol.

      Volume: 95(2) Pages: 133-143

    • DOI

      10.1002/ajh.25673

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Prominence of nestin-expressing Schwann cells in bone marrow of patients with myelodysplastic syndromes with severe fibrosis2019

    • Author(s)
      Cao-Sy Luan、Obara Naoshi、Sakamoto Tatsuhiro、Kato Takayasu、Hattori Keiichiro、Sakashita Shingo、Nannya Yasuhito、Ogawa Seishi、Harada Hironori、Sakata-Yanagimoto Mamiko、Nishikii Hidekazu、Chiba Shigeru
    • Journal Title

      Int J Hematol

      Volume: 109 Pages: 309-318

    • DOI

      10.1007/s12185-018-02576-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] RNAmut: robust identification of somatic mutations in acute myeloid leukemia using RNA-seq.2019

    • Author(s)
      Gu M, Zwiebel M, Ong SH, Boughton N, Nomdedeu J, Basheer F, Nannya Y, Quiros PM, Ogawa S, Cazzola M, Rad R, Butler AP, Vijayabaskar MS, Vassiliou G.
    • Journal Title

      Haematologica.

      Volume: -

    • DOI

      10.3324/haematol.2019.230821

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular heterogeneity in peripheral T-cell lymphoma, not otherwise specified revealed by comprehensive genetic profiling2019

    • Author(s)
      Watatani Yosaku,Ogawa Seishi., et al.
    • Journal Title

      Blood Advances

      Volume: 33 Pages: 2867-2883

    • DOI

      10.1038/s41375-019-0473-1

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Acute myeloid leukemia with a cryptic NUP98/PRRX2 rearrangement developing after low-dose methotrexate therapy for rheumatoid arthritis2019

    • Author(s)
      Chonabayashi Kazuhisa、Yoshida Yoshinori、Kitawaki Toshio、Nannya Yasuhito、Nakamura Momoko、Oshima Shinichiro、Hishizawa Masakatsu、Yamashita Kouhei、Ogawa Seishi、Takaori-Kondo Akifumi
    • Journal Title

      Annals of Hematology

      Volume: 98 Pages: 2841-2843

    • DOI

      10.1007/s00277-019-03838-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ring sideroblasts in AML are associated with adverse risk characteristics and have a distinct gene expression pattern2019

    • Author(s)
      Berger Gerbrig、Gerritsen Mylene、Yi Guoqiang、Koorenhof-Scheele Theresia N.、Kroeze Leonie I.、Stevens-Kroef Marian、Yoshida Kenichi、Shiraishi Yuichi、van den Berg Eva、Schepers Hein、Huls Geert、Mulder Andr? B.、Ogawa Seishi、Martens Joost H. A.、Jansen Joop H.、Vellenga Edo
    • Journal Title

      Blood Adv.

      Volume: 3 Pages: 3111-3122

    • DOI

      10.1182/bloodadvances.2019000518

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transcriptome analysis offers a comprehensive illustration of the genetic background of pediatric acute myeloid leukemia2019

    • Author(s)
      Shiba N, Yoshida K, Hara Y, Yamato G, Shiraishi Y, Matsuo H, Okuno Y, Chiba K, Tanaka H, Kaburagi T, Takeuchi M, Ohki K, Sanada M, Okubo J, Tomizawa D, Taki T, Shimada A, Sotomatsu M, Horibe K, Taga T, Adachi S, Tawa A, Miyano S, Ogawa S, Hayashi Y
    • Journal Title

      Blood Advances

      Volume: 3 Pages: 3157-3169

    • DOI

      10.1182/bloodadvances.2019000404

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A founder variant in the South Asian population leads to a high prevalence of FANCL Fanconi anemia cases in India2019

    • Author(s)
      Donovan Frank X.、Ogawa Seishi., et al.
    • Journal Title

      Human Mutation

      Volume: 41 Pages: 122-128

    • DOI

      10.1002/humu.23914

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differential expression of individual transcript variants of PD-1 and PD-L2 genes on Th-1/Th-2 status is guaranteed for prognosis prediction in PCNSL2019

    • Author(s)
      Takashima Y, Kawaguchi A, Sato R, Yoshida K, Hayano A, Homma J, Fukai J, Iwadate Y, Kajiwara K, Ishizawa S, Hondoh H, Nakano M, Ogawa S, Tashiro K, Yamanaka R
    • Journal Title

      Scientific Reports

      Volume: 9(1) Pages: 10004-10004

    • DOI

      10.1038/s41598-019-46473-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequent germline mutations of HAVCR2 in sporadic subcutaneous panniculitis-like T-cell lymphoma2019

    • Author(s)
      Polprasert C, Takeuchi Y, Kakiuchi N, Yoshida K, Assanasen T, Sitthi W, Bunworasate U, Pirunsarn A, Wudhikarn K, Lawasut P, Uaprasert N, Kongkiatkamon S, Moonla C, Sanada M, Akita N, Takeda J, Fujii Y, Suzuki H, Nannya Y, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Rojnuckarin P, Ogawa S, Makishima H
    • Journal Title

      Blood Adv

      Volume: 3 Pages: 588-595

    • DOI

      10.1182/bloodadvances.2018028340

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Novel neuroblastoma amplified sequence (NBAS) mutations in a Japanese boy with fever-triggered recurrent acute liver failure.2019

    • Author(s)
      Ono S, Matsuda J, Watanabe E, Akaike H, Teranishi H, Miyata I, Otomo T, Sadahira Y, Mizuochi T, Kusano H, Kage M, Ueno H, Yoshida K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Hayashi Y, Kanegane H, Ouchi K.
    • Journal Title

      Human Genome Variation

      Volume: 7;6:2 Pages: 1-9

    • DOI

      10.1038/s41439-018-0035-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Defective Epstein-Barr virus in chronic active infection and haematological malignancy.2019

    • Author(s)
      Okuno Y, Murata T, Sato Y,Yoshida K, Sawada A, Inoue M, Kawa K, Seto M, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Nishida T, Kiyoi H, Kato S, Nakamura S, Morishima S, Yoshikawa T, Fujiwara S, Shimizu N, Isobe Y, Noguchi M, Kikuta A, Iwatsuki K, Takahashi Y, Kojima S, Ogawa S, Kimura H.
    • Journal Title

      Nature Microbiology

      Volume: 4 Pages: 404-413

    • DOI

      10.1038/s41564-018-0334-0

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Hematopoietic Stem Cell Transplantation for Progressive Combined Immunodeficiency and Lymphoproliferation in Activated PI3K <delta> Syndrome Type 12019

    • Author(s)
      Okano T, Imai K, ..., Nonoyama S, Morio T. et al.
    • Journal Title

      J Allergy Clin Immunol.

      Volume: 印刷中 Pages: 266-275

    • DOI

      10.1016/j.jaci.2018.04.032

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Invariant patterns of clonal succession determine specific clinical features of myelodysplastic syndromes2019

    • Author(s)
      Nagata Yasunobu、Ogawa Seishi., et al.
    • Journal Title

      Nat Commun

      Volume: 10 Pages: 5386-5386

    • DOI

      10.1038/s41467-019-13001-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic and transcriptional landscape of plasma cells in POEMS syndrome2019

    • Author(s)
      Nagao Y, Mimura N, Takeda J, Yoshida K, Shiozawa Y, Oshima M, Aoyama K, Nishijima D, Isshiki Y, Kayamori K, Kawajiri-Manako C, Oshima-Hasegawa N, Tsukamoto S, Mitsukawa S, Takeda Y, Ohwada C, Takeuchi M, Iseki T, Misawa S, Miyano S, Ohara O, Yokote K, Sakaida E, Kuwabara S, Sanada M, Iwama A, Ogawa S, Nakaseko C.
    • Journal Title

      Leukemia.

      Volume: - Pages: 1723-1735

    • DOI

      10.1038/s41375-018-0348-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathogenic mutations identified by a multimodality approach in 117 Japanese Fanconi anemia patients.2019

    • Author(s)
      Mori M, Hira A, Yoshida K, Muramatsu H, Okuno Y, Shiraishi Y, Anmae M, Yasuda J, Tadaka S, Kinoshita K, Osumi T, Noguchi Y, Adachi S, Kobayashi R, Kawabata H, Imai K, Morio T, Tamura K, Takaori-Kondo A, Yamamoto M, Miyano S, Kojima S, Ito E, Ogawa S, Matsuo K, Yabe H, Yabe M, Takata M.
    • Journal Title

      Haematologica

      Volume: - Pages: 1962-1973

    • DOI

      10.3324/haematol.2018.207241

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Myelodysplastic Syndrome-Associated SRSF2 Mutations Cause Splicing Changes by Altering Binding Motif Sequences2019

    • Author(s)
      Masaki So、Ikeda Shun、Hata Asuka、Shiozawa Yusuke、Kon Ayana、Ogawa Seishi、Suzuki Kenji、Hakuno Fumihiko、Takahashi Shin-Ichiro、Kataoka Naoyuki
    • Journal Title

      Frontiers in Genetics

      Volume: 10 Pages: 338-338

    • DOI

      10.3389/fgene.2019.00338

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome2019

    • Author(s)
      Labuhn Maurice、Ogawa Seishi., et al.
    • Journal Title

      Cancer Cell.

      Volume: 36 Pages: 123-138

    • DOI

      10.1016/j.ccell.2019.06.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Integrated genetic and epigenetic analysis revealed heterogeneity of acute lymphoblastic leukemia in Down syndrome2019

    • Author(s)
      Kubota Yasuo、Ogawa Seishi., et al.
    • Journal Title

      Cancer Sci.

      Volume: 110 Pages: 3358-3367

    • DOI

      10.1111/cas.14160

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KLF1 Mutation E325K Induces Cell-cycle Arrest in Erythroid Cells Differentiated from Congenital Dyserythropoietic Anemia (CDA) Patient-specific Induced Pluripotent Stem Cells.2019

    • Author(s)
      Kohara H, Utsugisawa T, Sakamoto C, Hirose L, Ogawa Y, Ogura H, Sugawara A, Aoki T, Iwasaki T, Asai T, Doisaki S, Okuno Y, Muramatsu H, Abe T, Kurita R, Miyamoto S, Sakuma T, Shiba M, Yamamoto T, Ohga S, Yoshida K, Ogawa S, Ito E, Kojima S, Kanno H, Tani K.
    • Journal Title

      Experimental Hematology

      Volume: 73 Pages: 25-37

    • DOI

      10.1016/j.exphem.2019.03.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] NOTCH1 pathway activating mutations and clonal evolution in pediatric T-cell acute lymphoblastic leukemia.2019

    • Author(s)
      Kimura S, Seki M, Yoshida K, Shiraishi Y, Akiyama M, Koh K, Imamura T, Manabe A, Hayashi Y, Kobayashi M, Oka A, Miyano S, Ogawa S, Takita J.
    • Journal Title

      Cancer Science

      Volume: 110(2) Pages: 784-794

    • DOI

      10.1111/cas.13859

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Duplication of ALK F1245 missense mutation due to acquired uniparental disomy associated with aggressive progression in a patient with relapsed neuroblastoma2019

    • Author(s)
      Kimura Shunsuke、Hasegawa Daisuke、Yoshimoto Yuri、Seki Masafumi、Daida Atsuro、Sekiguchi Masahiro、Hirabayashi Shinsuke、Hosoya Yosuke、Kobayashi Masao、Miyano Satoru、Ogawa Seishi、Takita Junko、Manabe Atsushi
    • Journal Title

      Oncol Lett.

      Volume: 50 Pages: 3323-3329

    • DOI

      10.3892/ol.2019.9985

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of genetic aberrations linked to tumorigenesis in regenerative nodules of liver cirrhosis2019

    • Author(s)
      Kim Soo Ki、Takeda Haruhiko、Takai Atsushi、Matsumoto Tomonori、Kakiuchi Nobuyuki、Yokoyama Akira、Yoshida Kenichi、Kaido Toshimi、Uemoto Shinji、Minamiguchi Sachiko、Haga Hironori、Shiraishi Yuichi、Miyano Satoru、Seno Hiroshi、Ogawa Seishi、Marusawa Hiroyuki
    • Journal Title

      J Gastroenterol

      Volume: 印刷中 Pages: 628-640

    • DOI

      10.1007/s00535-019-01555-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Frequent structural variations involving programmed death ligands in Epstein-Barr virus-associated lymphomas2019

    • Author(s)
      Kataoka Keisuke, Miyoshi Hiroaki, Sakata Seiji, Dobashi Akito, Couronne Lucile, Kogure Yasunori, Sato Yasuharu, Nishida Kenji, Gion Yuka, Shiraishi Yuichi, Tanaka Hiroko, et al
    • Journal Title

      Leukemia.

      Volume: Epub ahead of print Pages: 1687-1699

    • DOI

      10.1038/s41375-019-0380-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Modification of cellular and humoral immunity by somatically reverted T cells in X-linked lymphoproliferative syndrome type 12019

    • Author(s)
      Hoshino A, Yang X, Tanita K, Yoshida K, Ono T, Nishida N, Okuno Y, Kanzaki T, Goi K, Fujino H, Ohshima K, Shiraishi Y, Chiba K, Tanaka H, Miyano S, Ogawa S, Kojima S, Morio T, Kanegane H.
    • Journal Title

      Journal of Allergy and Clinical Immunology

      Volume: 143 Pages: 421-424

    • DOI

      10.1016/j.jaci.2018.07.044

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] International Working Group for MDSMPC. TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.2019

    • Author(s)
      Haase D, Ogawa S.et al.,
    • Journal Title

      Leukemia

      Volume: - Pages: 1747-1758

    • DOI

      10.1038/s41375-018-0351-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Role of Donor Clonal Hematopoiesis in Allogeneic Hematopoietic Stem-Cell Transplantation.2019

    • Author(s)
      Frick M, Ogawa S.et al.,
    • Journal Title

      Journal of Clinical Oncology

      Volume: 37 Pages: 375-385

    • DOI

      10.1200/jco.2018.79.2184

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.2019

    • Author(s)
      Elbadry MI, Ogawa S.et al.,
    • Journal Title

      Haematologica

      Volume: - Pages: 210856-210856

    • DOI

      10.3324/haematol.2018.210856

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PAK Kinase Inhibition Has Therapeutic Activity in Novel Preclinical Models of Adult T-Cell Leukemia/Lymphoma2019

    • Author(s)
      Chung Elaine Y.、Mai Yun、Shah Urvi A.、Wei Yongqiang、Ishida Elise、Kataoka Keisuke、Ren Xiaoxin、Pradhan Kith、Bartholdy Boris、Wei Xiaolei、Zou Yiyu、Zhang Jinghang、Ogawa Seishi、Steidl Ulrich、Zang Xingxing、Verma Amit、Janakiram Murali、Ye B. Hilda
    • Journal Title

      Clinical Cancer Research

      Volume: 25 Pages: 3589-3601

    • DOI

      10.1158/1078-0432.ccr-18-3033

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21):2019

    • Author(s)
      Christen F, Hoyer K, Yoshida K, Hou HA, Waldhueter N, Heuser M, Hills RK, Chan W, Hablesreiter R, Blau O, Ochi Y, Klement P, Chou WC, Blau IW, Tang JL, Zemojtel T, Shiraishi Y, Shiozawa Y, Thol F, Ganser A, Lowenberg B, Linch DC, Bullinger L, Valk PJM, Tien HF, Gale RE, Ogawa S, Damm F.
    • Journal Title

      Blood

      Volume: 133 Pages: 1140-1151

    • DOI

      10.1182/blood-2018-05-852822

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Identification of enhancer of mRNA decapping 4 as a novel fusion partner of MLL in acute myeloid leukemia.2019

    • Author(s)
      Becker H, Greve G, Kataoka K, Mallm JP, Duque-Afonso J, Ma T, Niemoller C, Pantic M, Duyster J, Cleary ML, Schuler J, Rippe K, Ogawa S, Lubbert M.
    • Journal Title

      Blood Advances

      Volume: 3 Pages: 761-765

    • DOI

      10.1182/bloodadvances.2018023879

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Remission clone in acute myeloid leukemia shows growth advantage after chemotherapy but is distinct from leukemic clone.2019

    • Author(s)
      Ahn JS, Kim T, Kim YK, Cho YC, Cho S, Jung SH, Ahn SY, Jung SY, Yang DH, Lee JJ, Choi S, Lee JY, Shin MG, Yoshida K, Ogawa S, Kim IC, Zhang Z, Kim HJ, Kim DDH
    • Journal Title

      Experimental Hematology

      Volume: 75 Pages: 26-30

    • DOI

      10.1016/j.exphem.2019.06.001

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Essential thrombocythemia correctly diagnosed through the guidance of comprehensive genomic profiling2019

    • Author(s)
      Shibata S, Kitano T, Okamoto Y, Takiuchi Y, Yamamoto K, Tabata S, Aiba A, Yoshida Y, Nannya Y, Ogawa S, Arima N
    • Journal Title

      Jpn. J. Clin. Hematol.

      Volume: 60(12) Issue: 12 Pages: 1630-1634

    • DOI

      10.11406/rinketsu.60.1630

    • NAID

      130007776363

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predisposed genomic instability in pre-treatment bone marrow evolves to therapy-related myeloid neoplasms in malignant lymphoma.2019

    • Author(s)
      Katagiri S, Makishima H, Azuma K, Nannya Y, Saitoh Y, Yoshizawa S, Akahane D, Fujimoto H, Ito Y, Velaga R, Umezu T, Ohyashiki JH, Ogawa S, Ohyashiki K.
    • Journal Title

      Haematologica

      Volume: Nov 7 Pages: 229856-229856

    • DOI

      10.3324/haematol.2019.229856

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful treatment of pure red cell aplasia with cyclosporin in a patient with T-cell large granular lymphocytic leukemia harboring the <i>STAT3</i> D661V mutation2019

    • Author(s)
      Adachi M, Yoshida K, Shiraishi Y, Chiba K, Miyano S, Ogawa S.
    • Journal Title

      Jpn. J. Clin. Hematol.

      Volume: 60(1) Issue: 1 Pages: 39-45

    • DOI

      10.11406/rinketsu.60.39

    • NAID

      130007590318

    • ISSN
      0485-1439, 1882-0824
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genetics of MDS2019

    • Author(s)
      Ogawa Seishi
    • Journal Title

      Blood

      Volume: 133 Pages: 1049-1059

    • DOI

      10.1182/blood-2018-10-844621

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 潰瘍性大腸炎における上皮細胞のクローン進化2021

    • Author(s)
      垣内 伸之
    • Organizer
      第29回日本癌病態治療研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 炎症性腸疾患の発癌メカニズム2021

    • Author(s)
      垣内 伸之
    • Organizer
      日本消化器病学会近畿支部 第65回教育講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 造血器腫瘍を対象とする遺伝子パネル検査2021

    • Author(s)
      Seishi Ogawa
    • Organizer
      第41回メディコピア教育講演シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Cancer mutations in normal tissues2021

    • Author(s)
      Seishi Ogawa
    • Organizer
      CVMW2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] CTX-712, a novel CLK inhibitor targeting myeloid neoplasms with SRSF2 mutation2020

    • Author(s)
      Akinori Yoda, Daisuke Morishita, Akio Mizutani, Yotaro Ochi, Hirokazu Tozaki, Yoshihiko Satoh, June Takeda, Yasuhito Nannya, Hideki Makishima, Hiroshi Miyake, Seishi Ogawa
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
  • [Presentation] CTX-712, a novel CLK inhibitor targeting myeloid neoplasms with SRSF2 mutation2020

    • Author(s)
      Akinori Yoda, Daisuke Morishita, Akio Mizutani, Yotaro Ochi, Hirokazu Tozaki, Yoshihiko Satoh, June Takeda, Yasuhito Nannya, Hideki Makishima, Hiroshi Miyake, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] Clonal evolution of proliferative lesions into breast cancers.2020

    • Author(s)
      Tomomi Nishimura,Ogawa Seishi et al.
    • Organizer
      American Association for Cancer Research Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonal evolution of proliferative lesions into breast cancers2020

    • Author(s)
      Tomomi Nishimura, Nobuyuki Kakiuchi, Kenichi Yoshida, Yasuhide Takeuchi, Hirona Maeda, Yusuke Shiozawa, Masahiro Hirata, Tatsuki R. Kataoka, Takaki Sakurai, Satoko Baba, Kengo Takeuchi, Hironori Haga, Satoru Miyano, Masakazu Toi, Seishi Ogawa.
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] 乳管上皮増殖性病変から乳癌へ至るクローン進化2020

    • Author(s)
      西村 友美, 垣内 伸之, 吉田 健一, 竹内 康英, 前田 紘奈, 塩澤 裕介, 中川 正宏, 越智 陽太郎, 川田 有希子, 平田 勝啓, 片岡 竜貴, 桜井 孝規, 馬場 郷子, 白石 友一, 千葉 健一, 竹内 賢吾, 羽賀 博典, 宮野 悟, 戸井 雅和, 小川 誠司.
    • Organizer
      The 28th Annual Meeting of the Japanese Breast Cancer Society
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of mechanisms underlying clonal evolution of MDS and AML by single-cell DNA/RNA2020

    • Author(s)
      Ryosaku Inagaki, Masahiro M Nakagawa, Yasuhito Nannya, Xingxing Qi, June Takeda, Akinori Yoda, Ayana Kon, Hideki Makishima, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of mechanisms underlying clonal evolution of MDS and AML by single-cell DNA/RNA sequencing2020

    • Author(s)
      Ryosaku Inagaki, Masahiro M Nakagawa, Yasuhito Nannya, Xingxing Qi, Zhao Lanying, June Takeda, Akinori Yoda, Ayana Kon, Hisashi Tsurumi, Hideki Makishima, Seishi Ogawa
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
  • [Presentation] Analysis of Clonal Evolution of AML Using Simultaneous Single-cell DNA/RNA Analysis2020

    • Author(s)
      Ryosaku Inagaki, Masahiro M Nakagawa, Yasuhito Nannya, Xingxing Qi, Lanying Zhao, June Takeda, Akinori Yoda, Ayana Kon, Hisashi Tsurumi, Hideki Makishima, Seishi Ogawa
    • Organizer
      the 62nd ASH Annual Meeting and Exposition
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic profiling and prognosis of blast crisis in chronic myeloid leukemia2020

    • Author(s)
      Yotaro Ochi, Kenichi Yoshida, Ko Sasaki, Noriko Hosoya, Yusuke Shiozawa, Yasuhito Nannya, Takayuki Ishikawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Masashi Sanada, Hideki Makishima, Akifumi Takaori-Kondo, Satoru Miyano, Kinuko Mitani, and Seishi Ogawa
    • Organizer
      the 62nd ASH Annual Meeting and Exposition
    • Related Report
      2020 Annual Research Report
  • [Presentation] Prognostic Relevance of Genetic Abnormalities in Blastic Transformation of Chronic Myeloid Leukemia2020

    • Author(s)
      Yotaro Ochi, Ogawa Seishi et al.
    • Organizer
      the 62nd ASH Annual Meeting and Exposition
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COMBINED COHESIN-RUNX1 DEFICIENCY SYNERGISTICALLY PERTURBS CHROMATIN LOOPING2020

    • Author(s)
      Yotaro Ochi, Ogawa Seishi et al.
    • Organizer
      25th Congress of EHA
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.2020

    • Author(s)
      Rurika Okuda, Ogawa Seishi et al.
    • Organizer
      25th Congress of EHA
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.2020

    • Author(s)
      Rurika Okuda, Yasuhito Nannya, Yotaro Ochi, Kazuhisa Chonabayashi, Maria Creignou, Hideki Makishima, June Takeda, Ayana Kon, Satoru Miyano, Hiroshi Handa, Shigeru Chiba, Kazuma Ohyashiki, Torsten Haferlach, Eva Hellstrom-Lindberg, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.2020

    • Author(s)
      Rurika Okuda, Ogawa Seishi et al.
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multiple paragangliomas showed parallel evolution with unique HIF2α mutations in cyanotic congenital heart disease2020

    • Author(s)
      Tatsuki Ogasawara, Yoichi Fujii, Yusuke Shiozawa, Hideki Makishima, Eijiro Nakamura, Tomoaki Tanaka, Yuichi Shiraishi, Satoru Miyano, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] The role of germline and somatic DDX41 mutations on myeloid malignancies.2020

    • Author(s)
      Yasuhito Nannya, Ogawa Seishi et al.
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
  • [Presentation] Precision medicine for AML in Japan and identification of novel therapeutic target.2020

    • Author(s)
      Yasuhito Nannya
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] The role of germline and somatic DDX41 mutations on myeloid malignancies.2020

    • Author(s)
      Yasuhito Nannya, Hideki Makishima, June Takeda, Yukihide Momozawa, Ryunosuke Saiki, Yasushi Miyazaki, Takayuki Ishikawa, Kazuma Ohyashiki, Eva Hellstr_m Lindberg, Mario Cazzola, Torsten Haferlach, YoichiroKamatani, Michiaki Kubo, Satoru Miyano, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] Frequent mutational alterations to evade the immune system in colorectal cancer with POLE gene mutation2020

    • Author(s)
      Yoshikage Inoue, Nobuyuki Kakiuchi, Kenichi Yoshida, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Tetsuichi Yoshizato, Yasuhide Takeuchi, Hiroko Tanaka, Ai Okada, Satoshi Nagayama, Satoru Miyano, Yoshiharu Sakai, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] Frequent genomic alterations to evade the immune system in colorectal cancer with POLE gene mutation2020

    • Author(s)
      Yoshikage Inoue, Nobuyuki Kakiuchi, Kenichi Yoshida, Yasuhide Takeuchi, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Tetsuichi Yoshizato, Hiroko Tanaka, Ai Okada, Satoshi Nagayama, Satoru Miyano, Yoshiharu Sakai and Seishi Ogawa
    • Organizer
      American Association for Cancer Research Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations affecting IL-17 signaling pathway and novel cancer vulnerability2020

    • Author(s)
      Nobuyuki Kakiuchi, Kenichi Yoshida, Motoi Uchino, Takako Kihara, Akaki Kotaro, Yoshikage Inoue, Kenji Kawada, Satoshi Nagayama, Akira Yokoyama, Tomonori Hirano, Yasuhide Takeuchi, Hiroyuki Miyoshi, Yoshiharu Sakai, Hironori Haga, Seiichi Hirota, Hiroki Ikeuchi, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa
    • Organizer
      American Association for Cancer Research Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals novel cancer vulnerability/潰瘍性大腸炎における大腸上皮クローン進化から明らかとなった大腸がんの脆弱性2020

    • Author(s)
      Nobuyuki Kakiuchi, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Akira Yokoyama, Tomonori Hirano, Seiichi Hirota, Hiroki Ikeuchi, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] Tissue remodeling by positively selected clones in esophagus and colon/遺伝子変異クローンによる食道および大腸組織の再構築の解明2020

    • Author(s)
      Nobuyuki Kakiuchi, Akira Yokoyama, Motoi Uchino, Takako Kihara, Kotaro Akaki, Yoshikage Inoue, Tomonori Hirano, Seiichi Hirota, Hiroki Ikeuchi, Osamu Takeuchi, Satoru Miyano, Hiroshi Seno, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 潰瘍性大腸炎における大腸上皮細胞のクローン進化について2020

    • Author(s)
      垣内 伸之
    • Organizer
      第57回日本消化器免疫学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 潰瘍性大腸炎における大腸上皮細胞のクローン進化と発がん2020

    • Author(s)
      垣内 伸之、妹尾 浩、小川 誠司
    • Organizer
      Japan Digestive Disease Week 2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Analysis of clonal expansion in epithelium affected by ulcerative colitis reveals frequent mutations converging on NFKBIZ and novel cancer vulnerability/潰瘍性大腸炎における上皮細胞のクローン進化と大腸発がん2020

    • Author(s)
      Nobuyuki Kakiuchi and Seishi Ogawa
    • Organizer
      The 43rd Annual Meeting of the Molecular Biology Society of Japan
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Genetic analysis of metachronous pancreatic cancers2020

    • Author(s)
      Tomonori Hirano, Ogawa Seishi et al.
    • Organizer
      American Association for Cancer Research Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic analysis of metachronous pancreatic cancers2020

    • Author(s)
      Tomonori Hirano, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Toshihiko Masui, Yuichi Shiraishi, Satoru Miyano, Norimitsu Uza, Yuzo Kodama, Hiroshi Seno, and Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] The functional role of compound DDX41 germline and somatic R525H mutations in the development of myeloid neoplasms2020

    • Author(s)
      Kon A, Nakagawa MM, Inagaki R, Kataoka K, Ochi Y, Makishima H, Nakayama M, Koseki H, Nannya Y, Ogawa S
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] The functional characterization of compound DDX41 germline and somatic R525H mutations in the development of myeloid malignancies2020

    • Author(s)
      Kon A, Nakagawa MM, Inagaki R, Kataoka K, Ochi Y, Makishima H, Nakayama M, Koseki H, Nannya Y, Ogawa S
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
  • [Presentation] Functional characterization of compound DDX41 germline and somatic R525H mutations in the development of myeloid malignancies2020

    • Author(s)
      Kon A, Nakagawa MM, Inagaki R, Kataoka K, Ochi Y, Makishima H, Nakayama M, Koseki H, Nannya Y, Ogawa S
    • Organizer
      62nd ASH Annual Meeting and Exposition
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Distinct molecular subtypes and a high diagnostic urinary biomarker of Upper Urinary Tract Urothelial Carcinoma2020

    • Author(s)
      Yoichi Fujii, Yusuke Sato, Hiromichi Suzuki, Yusuke Shiozawa, Tetsuichi Yoshizato, Kenichi Yoshida, Yuichi Shiraishi, Tohru Nakagawa, Hiroaki Nishimatsu, Toshikazu Okaneya, Masashi Sanada, Hideki Makishima, Satoru Miyano, Yukio Homma, Haruki Kume, Seishi Ogawa
    • Organizer
      American Association for Cancer Research Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] Molecular subtypes and novel diagnostics of upper urinary tract urothelial carcinoma,2020

    • Author(s)
      Yoichi Fujii, Yusuke Sato, Hiromichi Suzuki, Yusuke Shiozawa, Tetsuichi Yoshizato, Kenichi Yoshida, Yuichi Shiraishi, Tohru Nakagawa, Hiroaki Nishimatsu, Toshikazu Okaneya, Masashi Sanada, Hideki Makishima, Satoru Miyano, Seishi Ogawa, Haruki Kume
    • Organizer
      European Urology Association Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] Distinct molecular subtypes and a high diagnostic urinary biomarker of upper urinary tract urothelial carcinoma2020

    • Author(s)
      Yoichi Fujii, Yusuke Sato, Hiromichi Suzuki, Yusuke Shiozawa, Tetsuichi Yoshizato, Kenichi Yoshida, Yuichi Shiraishi, Tohru Nakagawa, Hiroaki Nishimatsu, Toshikazu Okaneya, Masashi Sanada, Hideki Makishima, Satoru Miyano, Seishi Ogawa, Haruki Kume
    • Organizer
      American Urology Association Annual Meeting 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 上部尿路上皮癌の変異に基づく分子病型分類とその臨床応用の可能性2020

    • Author(s)
      Yoichi Fujii, Yusuke Sato, Hiromichi Suzuki, Yusuke Shiozawa, Tetsuichi Yoshizato, Kenichi Yoshida, Yuichi Shiraishi, Tohru Nakagawa, Hiroaki Nishimatsu, Toshikazu Okaneya, Masashi Sanada, Hideki Makishima, Satoru Miyano, Seishi Ogawa, Haruki Kume
    • Organizer
      第108回日本泌尿器科学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Combined Landscape of Gene Mutations and Copy Number Alterations in Clonal Hematopoiesis: Analysis in 10,612 Japanese Individuals2020

    • Author(s)
      Ryunosuke Saiki, Tetsuichi Yoshizato, Yasuhito Nanya, Yukihide Momozawa, Chikashi Terao, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Atsushi Niida, Seiya Imoto, Koichi Matsuda, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Michiaki Kubo, Satoru Miyano, Hideki Makishima, Seishi Ogawa
    • Organizer
      62nd ASH Annual Meeting and Exposition
    • Related Report
      2020 Annual Research Report
  • [Presentation] INTEGRATED LANDSCAPE OF GENE MUTATIONS AND COPY NUMBER ALTERATIONS IN CLONAL HEMATOPOIESIS: ANALYSIS IN 10,852 JAPANESE INDIVIDUALS2020

    • Author(s)
      Ryunosuke Saiki, Tetsuichi Yoshizato, Yukihide Momozawa, Chikashi Terao, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Koichi Matsuda, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Michiaki Kubo, Satoru Miyano, Hideki Makishima, Seishi Ogawa
    • Organizer
      25th Congress of EHA
    • Related Report
      2020 Annual Research Report
  • [Presentation] Integrated Analysis of Gene Mutations and Copy Number Alterations in Clonal hematopoiesis2020

    • Author(s)
      Ryunosuke Saiki, Tetsuichi Yoshizato, Yukihide Momozawa, Chikashi Terao, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Koichi Matsuda, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Michiaki Kubo, Satoru Miyano, Hideki Makishima, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] Landscape of Gene Mutations and Copy Number Alterations in Clonal Hematopoiesis2020

    • Author(s)
      Ryunosuke Saiki, Tetsuichi Yoshizato, Yukihide Momozawa, Chikashi Terao, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Koichi Matsuda, Takayuki Morisaki, Yoshinori Murakami, Yoichiro Kamatani, Michiaki Kubo, Satoru Miyano, Hideki Makishima, Seishi Ogawa
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
  • [Presentation] Distinct pathogenesis of clonal hematopoiesis revealed by single cell RNA sequencing integrated with highly sensitive genotyping method2020

    • Author(s)
      Masahiro M Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Zhao Lanying, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda and Seishi Ogawa
    • Organizer
      62nd ASH Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Early Clonal evolution of myeloid malignancies.2020

    • Author(s)
      Masahiro M Nakagawa, Ryosaku Inagaki, Yasuhito Nannya, Zhao Lanying, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda and Seishi Ogawa
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Distinct pathogenesis of clonal hematopoiesis revealed by single-cell RNA/DNA sequencing2020

    • Author(s)
      Masahiro M Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Zhao Lanying, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda and Seishi Ogawa
    • Organizer
      第82回日本血液学会学術総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Distinct pathogenesis of clonal hematopoiesis revealed by high throughput single cell RNA sequencing integrated with highly sensitive genotyping method2020

    • Author(s)
      Masahiro M Nakagawa, Ryosaku Inagaki, Yutaka Kuroda, Yasuhito Nannya, Zhao Lanying, Yotaro Ochi, June Takeda, Xingxing Qi, Akinori Yoda, Ayana Kon, Nobuyuki Kakiuchi, Hideki Makishima, Shuichi Matsuda and Seishi Ogawa
    • Organizer
      25th Congress of the European Hematology Association
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] JAK STAT Pathway is a Promising Therapeutic target in Acute Erythroid Leukemia2020

    • Author(s)
      June Takeda, Ogawa Seishi et al.
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] 急性赤白血病に対するJAK STAT パスウェイ阻害薬の有用性の検討2020

    • Author(s)
      June Takeda, Ogawa Seishi et al.
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
  • [Presentation] _NOVEL MOLECULAR PATHOGENESIS AND THERAPEUTIC TARGETS IN ACUTE ERYTHROID LEUKEMIA2020

    • Author(s)
      June Takeda, Ogawa Seishi et al.
    • Organizer
      25th Congress of the European Hematology Association
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genotype-Phenotype Relationships and Therapeutic Targets in Acute Erythroid Leukemia2020

    • Author(s)
      June Takeda, Ogawa Seishi et al.
    • Organizer
      63nd ASH Annual Meeting and Exposition
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonal expansion in bile duct associated with chronic inflammation2020

    • Author(s)
      Hirona Maeda, Nobuyuki Kakiuchi, Ito Takashi,Eri ogawa, Masahiro Shiokawa, Norimitsu Uza, Yoko Tanaka, Yasuhito Nannya, Hideki Makishima, Shinji Uemoto, Satoru Miyano, Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] 加齢に伴うゲノム異常と発がん2020

    • Author(s)
      Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Mutaions in normal tissues2020

    • Author(s)
      Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] がんの起源について2020

    • Author(s)
      Seishi Ogawa
    • Organizer
      関西医科大学大学院セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] がんの起源について2020

    • Author(s)
      Seishi Ogawa
    • Organizer
      第31回日本消化器癌発生学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] がんの起源について2020

    • Author(s)
      Seishi Ogawa
    • Organizer
      第84回日本皮膚科学会東京支部学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Clonal heterogeneity and evolution of MPN revealed by single-cell RNA/DNA sequencing2020

    • Author(s)
      Xingxing Qi, Masahiro M Nakagawa, Ryosaku Inagaki, Sosuke Sumiyoshi, Tomoe Nakagawa, Yasuhito Nannya, Zhao Lanying, Hisashi Tsurumi,Hideki Makishima, and Seishi Ogawa
    • Organizer
      25th Congress of EHA
    • Related Report
      2020 Annual Research Report
  • [Presentation] Clonal heterogeneity and evolution of MPN revealed by single-cell RNA/DNA sequencing2020

    • Author(s)
      Xingxing Qi, Masahiro M Nakagawa, Ryosaku Inagaki, Sosuke Sumiyoshi, Tomoe Nakagawa, Yasuhito Nannya, Zhao Lanying, Hisashi Tsurumi,Hideki Makishima, and Seishi Ogawa
    • Organizer
      The 79th Annual Meeting of the Japanese Cancer Association
    • Related Report
      2020 Annual Research Report
  • [Presentation] Clonal heterogeneity and evolution of MPN revealed by single-cell RNA/DNA sequencing2020

    • Author(s)
      Xingxing Qi, Masahiro M Nakagawa, Ryosaku Inagaki, Sosuke Sumiyoshi, Tomoe Nakagawa, Yasuhito Nannya, Zhao Lanying, Hisashi Tsurumi,Hideki Makishima, and Seishi Ogawa
    • Organizer
      The 82nd Annual Meeting of the Japanese Society of Hematology
    • Related Report
      2020 Annual Research Report
  • [Presentation] Mutational landscape of colorectal cancer with POLE gene mutation・ポスター2019

    • Author(s)
      Yoshikage Inoue, Nobuyuki Kakiuchi, Kenichi Yoshida, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Tetsuichi Yoshizato, Hiroko Tanaka, Ai Okada, Satoshi Nagayama, Satoru Miyano, Yoshiharu Sakai and Seishi Ogawa
    • Organizer
      American Association_for Cancer Research_Annual Meeting 2019.Atlanta, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Myxofibrosarcoma is characterized by frequent abnormalities in TP53 and increased genetic instability2019

    • Author(s)
      Yasuhide Takeuchi, Annegret Kunitz, Hiromichi Suzuki, Kenichi Yoshida, Yuichi Shiraishi, Teppei Shimamura, Kenichi Chiba, Hiroko Tanaka, Nobuyuki Kakiuchi, Yusuke Shiozawa, Akira Yokoyama, Tetsuichi Yoshizato, Kosuke Aoki, Yoichi Fujii, Hideki Makishima, Hironori Haga, Satoru Miyano, Frederik Damm, Seishi Ogawa
    • Organizer
      American Association for Cancer Research Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonal evolution of non-malignant proliferative lesions into breast cancers(ポスター)2019

    • Author(s)
      Tomomi Nishimura, Kenichi Yoshida, Yukiko Kawata, Yasuhide Takeuchi, Nobuyuki Kakiuchi, Yusuke Shiozawa, Kosuke Aoki, Masahiro Hirata, Tatsuki R. Kataoka, Takaki Sakurai, Satoko Baba, Yuichi Shiraishi, Kenichi Chiba, Kengo Takeuchi, Hironori Haga, Satoru Miyano, Masakazu Toi, Seishi Ogawa
    • Organizer
      AACR Annual meeting 2019 (Atlanta, USA)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic analysis of pheochromocytoma2019

    • Author(s)
      Tatsuki Ogasawara, Yoichi Fujii, Masanori Fujimoto, Yusuke Shiozawa, Hiromichi Suzuki, Tetsuichi Yoshizato, Kenichi Yoshida, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Hideki Makishima, Satoru Miyano, Tomoaki Tanaka, Seishi Ogawa
    • Organizer
      American Association for Cancer Research Annual Meeting 2019, Atlanta, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Genetic analysis of pancreatic neoplasms grade 32019

    • Author(s)
      Nobuyuki Kakiuchi, Ogawa Seishi., et al.
    • Organizer
      AACR Annual Metting 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 特別講演「がんの起源について2019

    • Author(s)
      小川誠司
    • Organizer
      第56回日本臨床分子医学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] がんの起源について2019

    • Author(s)
      小川誠司
    • Organizer
      第30回日本医学会総会 2019 中部
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.(Poster)2019

    • Author(s)
      Rurika Okuda, Ogawa Seishi., et al.
    • Organizer
      15th MDS Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular characteristics that predict response to azacitidine therapy(Poster)2019

    • Author(s)
      Yasuhito Nannya, Ogawa Seishi., et al.
    • Organizer
      Th 15th International Symposium on Myelodysplastic Syndromes, Copenhagen, Denmark
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 孤発例の皮下脂肪織炎様T細胞リンパ腫でも高頻度でTIM3の胚細胞変異を認める2019

    • Author(s)
      竹内 康英, Chantana Polprasert, 垣内 伸之, 吉田 健一, 真田 昌, 秋田 直洋, 竹田 淳恵, 藤井 陽一, 鈴木 啓道, 南谷 泰仁, 白石 友一, 千葉 健一, 田中 洋子, 宮野 悟, Ponlapat Rojnuckarin, 小川 誠司, 牧島 秀樹
    • Organizer
      第108回病理学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Germline DDX41 mutations in the Japanese populations(口頭)2019

    • Author(s)
      Seishi Ogawa
    • Organizer
      The 10th JSH International
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clonal hematopoiesis in Aplastic anemia2019

    • Author(s)
      Seishi Ogawa
    • Organizer
      24th Congress of European Hematology Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Biological characterization of the U2af1 S34F mutation in the pathogenesis of myelodysplasia2019

    • Author(s)
      Ayana Kon Yasuhito Nannya, Keisuke Kataoka, Manabu Nakayama, Haruhiko Koseki, Masashi Sanada, Hideki Makishima, Marshall Masahiro Nakagawa, Seishi Ogawa
    • Organizer
      24th Congress of European Hematology Association
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] NOVEL MOLECULAR PATHOGENESIS AND THERAPEUTIC TARGET IN ACUTE ERYTHROID LEUKEMIA(Poster)2019

    • Author(s)
      June Takeda , Ogawa Seishi., et al.
    • Organizer
      24th EHA Congress, Amsterdam,
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonal evolution of non-malignant proliferative lesions into breast cancers(口頭)2019

    • Author(s)
      Tomomi Nishimura, Kenichi Yoshida, Yukiko Kawata, Yasuhide Takeuchi, Nobuyuki Kakiuchi, Yusuke Shiozawa, Kosuke Aoki, Masahiro Hirata, Tatsuki R. Kataoka, Takaki Sakurai, Satoko Baba, Yuichi Shiraishi, Kenichi Chiba, Kengo Takeuchi, Hironori Haga, Satoru Miyano, Masakazu Toi, Seishi Ogawa
    • Organizer
      第27回日本乳癌学会学術総会(東京)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonal expansion in non-cancer tissues(口頭)2019

    • Author(s)
      Seishi Ogawa
    • Organizer
      The XVIIIth KICancer-StratCan Retreat
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Molecular profiles in Myelodysplastic Syndromes(口頭)2019

    • Author(s)
      Seishi Ogawa
    • Organizer
      QOL-ONE IV Annual Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical and Genetic Characteristics of Colorectal Cancer with POLE Gene Mutation・口頭2019

    • Author(s)
      Yoshikage Inoue, Nobuyuki Kakiuchi, Kenichi Yoshida, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Tetsuichi Yoshizato, Hiroko Tanaka, Ai Okada, Satoshi Nagayama, Satoru Miyano, Yoshiharu Sakai and Seishi Ogawa
    • Organizer
      The 78thAnnual_Meeting of the Japan_Cancer Association,_Kyoto
    • Related Report
      2019 Annual Research Report
  • [Presentation] 粘液線維肉腫にみられるTP53の異常と著明な遺伝的不安定性2019

    • Author(s)
      竹内 康英, 鈴木 啓道, 吉田 健一, 白石 友一, 垣内 伸之, 塩澤 裕介, 井上 善景, 千葉 健一, 牧島 秀樹, 宮野 悟, 羽賀 博典, Damm Frederik, 小川 誠司
    • Organizer
      第78回日本癌学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 急性赤白血病のゲノム解析と治療標的 (oral)2019

    • Author(s)
      June Takeda , Ogawa Seishi., et al.
    • Organizer
      第78月回日本癌学会学術総会, 京都, 日本
    • Related Report
      2019 Annual Research Report
  • [Presentation] Clonal evolution of proliferative lesions into breast cancers(口頭)2019

    • Author(s)
      Tomomi Nishimura, Kenichi Yoshida, Yasuhide Takeuchi, Nobuyuki Kakiuchi, Yusuke Shiozawa, Tatsuki R. Kataoka, Takaki Sakurai, Kengo Takeuchi, Hironori Haga, Satoru Miyano, Masakazu Toi, Seishi Ogawa
    • Organizer
      第78回日本癌学会学術総会(京都)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of mechanisms underlying clonal evolution in MDS to sAML transformation by single-cell sequencing2019

    • Author(s)
      Ryosaku Inagaki, Masahiro M Nakagawa, Yasuhito Nannya, Xingxing Qi, June Takeda, Akinori Yoda, Ayana Kon, Hideki Makishima, Seishi Ogawa
    • Organizer
      The 78th JCA conference
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨髄系腫瘍におけるコピー数異常と遺伝子変異の統合解析2019

    • Author(s)
      佐伯 龍之介、塩澤 裕介、吉里 哲一、南谷 泰仁、竹田 淳恵、吉田 健一、白石 友一、千葉 滋、石川 隆之、宮野 悟、牧島 秀樹、小川 誠司
    • Organizer
      第78回日本癌学会学術総会, 京都, 日本
    • Related Report
      2019 Annual Research Report
  • [Presentation] Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.(Poster)2019

    • Author(s)
      Rurika Okuda, Ogawa Seishi., et al.
    • Organizer
      78th Japanese Cancer Association
    • Related Report
      2019 Annual Research Report
  • [Presentation] Distinct ethnic, clinical, and genetic characteristics of der(1;7) in myelodysplastic syndromes.(PlenarySessioin)2019

    • Author(s)
      Rurika Okuda, Ogawa Seishi., et al.
    • Organizer
      81st Japanese Society of Haematology
    • Related Report
      2019 Annual Research Report
  • [Presentation] Novel combinations of genetic events and subtypes in myeloid tumors revealed by Integrated analysis2019

    • Author(s)
      Yasuhito Nannya, June Takeda, Hiroko Tanaka, Kenichi Chiba, Yuichi Shiraishi, Masahiro Nakagawa, Hideki Makishima, Kenichi Yoshida, Shigeru Chiba, Yasushi Miyazaki, Kazuma Ohyashiki, Satoru Miyano, and Seishi Ogawa
    • Organizer
      The 81st Annual Meeting of the Japanese Society of Hematology, Kyoto
    • Related Report
      2019 Annual Research Report
  • [Presentation] 骨髄系腫瘍におけるコピー数異常と遺伝子変異の統合解析2019

    • Author(s)
      Ryunosuke Saiki, Ogawa Seishi., et al.
    • Organizer
      第81回日本血液学会学術集会、東京、日本
    • Related Report
      2019 Annual Research Report
  • [Presentation] 孤発例の皮下脂肪織炎様T細胞リンパ腫でも高頻度でTIM3の胚細胞変異を認める2019

    • Author(s)
      竹内 康英, Chantana Polprasert, 垣内 伸之, 吉田 健一, 真田 昌, 秋田 直洋, 竹田 淳恵, 藤井 陽一, 鈴木 啓道, 南谷 泰仁, 白石 友一, 千葉 健一, 田中 洋子, 宮野 悟, Ponlapat Rojnuckarin, 小川 誠司, 牧島 秀樹
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] NOVEL MOLECULAR PATHOGENESIS AND THERAPEUTIC TARGET IN ACUTE ERYTHROID LEUKEMIA (Oral)2019

    • Author(s)
      June Takeda , Ogawa Seishi., et al.
    • Organizer
      The 81th Annual Meeting of the Japanese_Cancer_Association, Tokyo, Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] Clinical significance of TP53 mutations in pediatric B cell acute lymphoblastic leukemia2019

    • Author(s)
      Hiroo Ueno, Ogawa Seishi., et al.
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Analysis of mechanisms underlying clonal evolution of AML by a new single-cell sequencing platform2019

    • Author(s)
      Ryosaku Inagaki, Masahiro M Nakagawa, Yasuhito Nannya, Xingxing Qi, Zhao Lanying, June Takeda, Akinori Yoda, Ayana Kon, Hisashi Tsurumi, Hideki Makishima, Seishi Ogawa
    • Organizer
      The 81st JCA conference 2019, Tokyo, Japan
    • Related Report
      2019 Annual Research Report
  • [Presentation] On the Origin of Cancer2019

    • Author(s)
      Seishi Ogawa
    • Organizer
      The 7th Mcgill-Kyoto Training course & Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Clonal Origin of Cancer2019

    • Author(s)
      Seishi Ogawa
    • Organizer
      XXIX IACRLRD SYMPOSIUM IACRLRD2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 潰瘍性大腸炎における上皮細胞の陽性選択2019

    • Author(s)
      垣内 伸之, 内野 基, 木原 多佳子, 赤木 宏太朗, 井上 善景, 長山 聡, 横山 顕礼, 平野 智紀, 竹内 康英, 越智 陽太郎, 塩澤 裕介, 片岡 圭亮, 中川 正宏, 依田 成玄, 南谷 泰仁, 牧島 秀樹, 白石 友一, 千葉 健一, 真田 昌, 三好 弘之, 坂井 義治, 桜井 孝規, 羽賀 博典, 廣田 誠一, 池内 浩基, 竹内 理, 宮野 悟, 妹尾 浩, 小川 誠司
    • Organizer
      第42回日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] A Unique Mechanism of Cancer Immune Evasion via the Disruption of PD-L1 3’-UTR(口頭)2019

    • Author(s)
      小川 誠司
    • Organizer
      第50回記念高松宮妃癌研究基金国際シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] CTX-712, a novel CLK inhibitor targeting myeloid neoplasms with splicing factor mutations (Oral)2019

    • Author(s)
      Akinori Yoda, Daisuke Morishita, Akio Mizutani, Hirokazu Tozaki, Yotaro Ochi, Yoshihiko Satoh, Yasuhito Nannya, Hideki Makishima, Hiroshi Miyake and Seishi Ogawa
    • Organizer
      The 61st Annual Meeting and Exposition of American Society of Hematology, Orlando, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Molecular characteristics that predict response to azacitidine therapy (Poster)2019

    • Author(s)
      Yasuhito Nannya, Ogawa Seishi., et al.
    • Organizer
      61st ASH Annual Meeting & Exposition, Orland, FL
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel molecular pathogenesis and2019

    • Author(s)
      June Takeda , Ogawa Seishi., et al.
    • Organizer
      61st ASH Annual Meeting & Exposition, Orland, FL
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] therapeutic targets in acute erythroid leukemia (Oral)2019

    • Author(s)
      June Takeda ,Ogawa Seishi., et al.
    • Organizer
      61st ASH Annual Meeting & Exposition, Orland, FL
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integrated Analysis of Copy-Number Alterations and Gene Mutations in 2,000 Patients with Myeloid Neoplasms2019

    • Author(s)
      Ryunosuke Saiki, Ogawa Seishi., et al.
    • Organizer
      The 61st Annual Meeting and Exposition of American Society of Hematology, Orlando, USA
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of mechanisms underlying clonal evolution of AML by a new single-cell sequencing platform2019

    • Author(s)
      Ryosaku Inagaki, Masahiro M Nakagawa, Yasuhito Nannya, Xingxing Qi, Lanying Zhao, June Takeda, Akinori Yoda, Ayana Kon, Hisashi Tsurumi, Hideki Makishima, Seishi Ogawa
    • Organizer
      62nd American Society of Hematology Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clonal evolution of proliferative lesions into breast cancers2019

    • Author(s)
      Tomomi Nishimura, Kenichi Yoshida, Nobuyuki Kakiuchi, Yasuhide Takeuchi, Yukiko Kawata, Hirona Maeda, Yusuke Shiozawa, Kosuke Aoki, Masahiro Hirata, Tatsuki R. Kataoka, Takaki Sakurai, Satoko Baba, Yuichi Shiraishi, Kenichi Chiba, Kengo Takeuchi, Hironori Haga, Satoru Miyano, Masakazu Toi, and Seishi Ogawa
    • Organizer
      San Antonio Breast Cancer Symposium 2019(San Antonio, USA)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Remarks]

    • URL

      https://www.med.kyoto-u.ac.jp/organization-staff/research/doctoral_course/r-006/

    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/kyoto_tumorpatho/

    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      https://researchmap.jp/7000009356/

    • Related Report
      2020 Annual Research Report
  • [Remarks]

    • URL

      https://www.med.kyoto-u.ac.jp/organization-staff/research/doctoral_course/r-006/

    • Related Report
      2019 Annual Research Report
  • [Remarks]

    • URL

      http://plaza.umin.ac.jp/kyoto_tumorpatho/

    • Related Report
      2019 Annual Research Report
  • [Remarks]

    • URL

      https://researchmap.jp/7000009356/

    • Related Report
      2019 Annual Research Report

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Published: 2019-06-27   Modified: 2022-05-19  

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