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内在性レトロウイルスを摂動とする遺伝子発現および腫瘍病態の変容メカニズムの解明

Research Project

Project/Area Number 19J01713
Research Category

Grant-in-Aid for JSPS Fellows

Allocation TypeSingle-year Grants
Section国内
Review Section Basic Section 43050:Genome biology-related
Research InstitutionThe University of Tokyo

Principal Investigator

伊東 潤平  東京大学, 医科学研究所, 特任助教

Project Period (FY) 2019-04-25 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywordsがん / 遺伝子発現制御ネットワーク / トランスポゾン / ジャンクDNA / 内在性レトロウイルス / Pan-cancer analysis
Outline of Research at the Start

ヒト内在性レトロウイルス(HERV)の発現は、正常な組織においてはエピジェネティックな機構により抑制されているが、腫瘍においては異常に活性化されていることが知られている。申請者はこれまでに、腫瘍検体マルチオミクスデータの大規模な再解析(5,550検体分)を行い、「腫瘍におけるHERVの異常な活性化が、転写抑制因子群の発現誘導を介し、腫瘍の形質および病態予後に影響を及ぼす」という仮説を見出した。
本研究では、生物情報学的および細胞生物学的手法を融合したアプローチにより上述の仮説の実証することで、がん患者臨床転帰の不均一性の背景にHERV活性化の摂動が存在することの実証を目指す。

Outline of Annual Research Achievements

ヒト内在性レトロウイルス (HERV) はゲノムに存在するジャンクDNAの一種である。HERVの一部はエンハンサーとして働き、近傍に存在する遺伝子の発現に様々な影響を与える。HERVのエンハンサー活性は、一部のがん細胞において特に活性化していることが知られている。腫瘍において多数のHERVが一度に活性化すると、HERV近傍に存在する多数の遺伝子の発現が変化し、腫瘍の形質が大きく変化する可能性があるが、この可能性は検証されていなかった。
本研究では、TCGAの提供する12種類のがんの腫瘍マルチオミクスデータ (5,470人分) を解析することで、腫瘍におけるHERVの活性化が遺伝子発現および形質に与える影響を解析した。その結果、一部の患者の腫瘍において多数のHERVが協調的に活性化していること、さらに、活性化したHERVはエンハンサーとして働くことでKRAB zinc-finger protein (KZFP) ファミリー遺伝子の発現を誘導することが明らかとなった。KZFPは強力な抑制性転写因子であるため、腫瘍におけるKZFPの発現上昇は様々な遺伝子の発現を変化させ、腫瘍の形質を変化させる可能性がある。そこで、がん細胞におけるKZFPの機能を、培養細胞を用いた実験により検証したところ、KZFPの発現上昇はがんの進行に関わる様々な遺伝子の発現を低下させ、がん細胞の増殖および浸潤を抑制することが明らかとなった。さらに、腫瘍におけるHERVおよびKZFPの活性化状態とがん患者の病態の関連を解析したところ、HERVおよびKZFPの活性が高い患者ほど良好な病態を示すことが分かった。本研究の結果から、腫瘍におけるHERVの活性化は、KZFPの発現を誘導することで、腫瘍の進行に対し抑制的に働くことが示唆された。本研究成果は、米国科学雑誌「Science Advances」から出版された。

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

Report

(3 results)
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (47 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (5 results) Journal Article (27 results) (of which Int'l Joint Research: 18 results,  Peer Reviewed: 24 results,  Open Access: 26 results) Presentation (11 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Remarks (4 results)

  • [Int'l Joint Research] University of Pennsylvania(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] スイス連邦工科大学ローザンヌ校(スイス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] スイス連邦工科大学ローザンヌ校 (EPFL)(スイス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] The University of Glasgow(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of Pennsylvania(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Attenuated fusogenicity and pathogenicity of SARS-CoV-2 Omicron variant2022

    • Author(s)
      Suzuki Rigel、Yamasoba Daichi、Kimura Izumi、Wang Lei他
    • Journal Title

      Nature

      Volume: 603 Issue: 7902 Pages: 700-705

    • DOI

      10.1038/s41586-022-04462-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enhanced fusogenicity and pathogenicity of SARS-CoV-2 Delta P681R mutation2021

    • Author(s)
      Saito Akatsuki、Irie Takashi、Suzuki Rigel、Maemura Tadashi、Nasser Hesham、Uriu Keiya、Kosugi Yusuke、Other 43 authors、Tanaka Shinya、Nakagawa So、Ikeda Terumasa、Fukuhara Takasuke、Kawaoka Yoshihiro、Sato Kei、The Genotype to Phenotype Japan (G2P-Japan) Consortium
    • Journal Title

      Nature

      Volume: 602 Issue: 7896 Pages: 300-306

    • DOI

      10.1038/s41586-021-04266-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Clonality of HIV-1 and HTLV-1 infected cells in naturally coinfected individuals2021

    • Author(s)
      Katsuya H, Cook L, Rowan AG, Melamed A, Turpin J, Ito J, Islam S, Miyazato P, Tan B, Matsuo M, Miyakawa T, Nakata H, Matsushita S, Taylor GP, Bangham CRM, Kimura S, Satou Y.
    • Journal Title

      The Journal of Infectious Diseases

      Volume: 0 Issue: 2 Pages: 0-0

    • DOI

      10.1093/infdis/jiab202

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Elucidation of the Complicated Scenario of Primate APOBEC3 Gene Evolution2021

    • Author(s)
      Uriu Keiya、Kosugi Yusuke、Suzuki Narumi、Ito Jumpei、Sato Kei
    • Journal Title

      Journal of Virology

      Volume: 95 Issue: 12 Pages: 00-00

    • DOI

      10.1128/jvi.00144-21

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive discovery of CRISPR-targeted terminally redundant sequences in the human gut metagenome: Viruses, plasmids, and more2021

    • Author(s)
      Sugimoto Ryota、Nishimura Luca、Nguyen Phuong Thanh、Ito Jumpei、Parrish Nicholas F.、Mori Hiroshi、Kurokawa Ken、Nakaoka Hirofumi、Inoue Ituro
    • Journal Title

      PLOS Computational Biology

      Volume: 17 Issue: 10 Pages: e1009428-e1009428

    • DOI

      10.1371/journal.pcbi.1009428

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] SARS-CoV-2 spike L452R variant evades cellular immunity and increases infectivity2021

    • Author(s)
      Motozono Chihiro、Toyoda Mako、Zahradnik Jiri、Saito Akatsuki、Other 19 authors、Ikeda Terumasa、Nakagawa So、Ueno Takamasa、Sato Kei
    • Journal Title

      Cell Host & Microbe

      Volume: 29 Issue: 7 Pages: 1124-1136

    • DOI

      10.1016/j.chom.2021.06.006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A comprehensive investigation on the interplay between feline APOBEC3Z3 proteins and feline immunodeficiency virus Vif proteins. Journal of Virology.2021

    • Author(s)
      Yusuke Kosugi‡, Keiya Uriu‡, Narumi Suzuki‡, Keisuke Yamamoto‡, Shumpei Nagaoka‡, Izumi Kimura‡, Yoriyuki Konno‡, Hirofumi Aso‡, Brian J Willett, Tomoko Kobayashi, Yoshio Koyanagi, Mahoko Takahashi Ueda, Jumpei Ito and Kei Sato. ‡Equal contribution.
    • Journal Title

      Journal of Virology

      Volume: 00178-21 Issue: 13 Pages: 00-00

    • DOI

      10.1128/jvi.00178-21

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Virus-like insertions with sequence signatures similar to those of endogenous non-retroviral RNA viruses in the human genome.2021

    • Author(s)
      Kojima S, Yoshikawa K, Ito J, Nakagawa S, Parrish NF, Horie M, Kawano S, Tomonaga K.
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 118 Issue: 5

    • DOI

      10.1073/pnas.2010758118

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An additional NF-κB site allows HIV-1 subtype C to evade restriction by nuclear PYHIN proteins2021

    • Author(s)
      Bosso Matteo、Sturzel Christina M.、Kmiec Dorota、Badarinarayan Smitha Srinivasachar、Braun Elisabeth、Ito Jumpei、Sato Kei、Hahn Beatrice H.、Sparrer Konstantin M.J.、Sauter Daniel、Kirchhoff Frank
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 12 Pages: 109735-109735

    • DOI

      10.1016/j.celrep.2021.109735

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection2021

    • Author(s)
      Inagaki T, Sato Y, Ito J, Takaki M, Okuno Y, Yaguchi M, Masud MHAA, Watanabe T, Sato K, Iwami S, MurataT, Kimura H
    • Journal Title

      Frontiers in Microbiology

      Volume: 11 Pages: 575255-575255

    • DOI

      10.3389/fmicb.2020.575255

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Battle between Retroviruses and APOBEC3 Genes: Its Past and Present2021

    • Author(s)
      Uriu Keiya、Kosugi Yusuke、Ito Jumpei、Sato Kei
    • Journal Title

      Viruses

      Volume: 13 Issue: 1 Pages: 124-124

    • DOI

      10.3390/v13010124

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A tissue level atlas of the healthy human virome2020

    • Author(s)
      Kumata Ryuichi、Ito Jumpei、Takahashi Kenta、Suzuki Tadaki、Sato Kei
    • Journal Title

      BMC Biology

      Volume: 18 Issue: 1 Pages: 1-15

    • DOI

      10.1186/s12915-020-00785-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inherited chromosomally integrated HHV-6 possibly modulates human gene expression2020

    • Author(s)
      Kumata Ryuichi、Ito Jumpei、Sato Kei
    • Journal Title

      Virus Genes

      Volume: 56 Issue: 3 Pages: 386-389

    • DOI

      10.1007/s11262-020-01745-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multiomics Investigation Revealing the Characteristics of HIV-1-Infected Cells In?Vivo2020

    • Author(s)
      Aso Hirofumi、Nagaoka Shumpei、Kawakami Eiryo、Ito Jumpei、Islam Saiful、Tan Benjy Jek Yang、Nakaoka Shinji、Ashizaki Koichi、Shiroguchi Katsuyuki、Suzuki Yutaka、Satou Yorifumi、Koyanagi Yoshio、Sato Kei
    • Journal Title

      Cell Reports

      Volume: 32 Issue: 2 Pages: 107887-107887

    • DOI

      10.1016/j.celrep.2020.107887

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phosphoregulation of a Conserved Herpesvirus Tegument Protein by a Virally Encoded Protein Kinase in Viral Pathogenicity and Potential Linkage between Its Evolution and Viral Phylogeny2020

    • Author(s)
      Shibazaki Misato、Kato Akihisa、Takeshima Kosuke、Ito Jumpei、Suganami Mai、Koyanagi Naoto、Maruzuru Yuhei、Sato Kei、Kawaguchi Yasushi
    • Journal Title

      Journal of Virology

      Volume: 94 Issue: 18 Pages: 1-4

    • DOI

      10.1128/jvi.01055-20

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endogenization and excision of human herpesvirus 6 in human genomes.2020

    • Author(s)
      Xiaoxi Liu, Shunichi Kosugi, Rie Koide, Yoshiki Kawamura, Jumpei Ito, Hiroki Miura, Nana Matoba, Motomichi Matsuzaki , and other 14 authors
    • Journal Title

      PLOS Genetics

      Volume: 16 Issue: 8 Pages: 1008915-1008915

    • DOI

      10.1371/journal.pgen.1008915

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A role for gorilla APOBEC3G in shaping lentivirus evolution including transmission to humans2020

    • Author(s)
      Nakano Yusuke、Yamamoto Keisuke、Ueda Mahoko Takahashi、Soper Andrew、Konno Yoriyuki、Kimura Izumi、Uriu Keiya、Kumata Ryuichi、Aso Hirofumi、Misawa Naoko、Nagaoka Shumpei、Shimizu Soma、Mitsumune Keito、Kosugi Yusuke、Juarez-Fernandez Guillermo、Ito Jumpei、...、Koyanagi Yoshio、Harris Reuben S.、Sato Kei
    • Journal Title

      PLOS Pathogens

      Volume: 16 Issue: 9 Pages: 1008812-1008812

    • DOI

      10.1371/journal.ppat.1008812

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endogenous retroviruses drive KRAB zinc-finger protein family expression for tumor suppression2020

    • Author(s)
      Ito Jumpei、Kimura Izumi、Soper Andrew、Coudray Alexandre、Koyanagi Yoshio、Nakaoka Hirofumi、Inoue Ituro、Turelli Priscilla、Trono Didier、Sato Kei
    • Journal Title

      Science Advances

      Volume: 6 Issue: 43 Pages: 3020-3020

    • DOI

      10.1126/sciadv.abc3020

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The significance of disseminated intravascular coagulation on multiple organ dysfunction during the early stage of acute respiratory distress syndrome2020

    • Author(s)
      Gando S、Fujishima S、Saitoh D、Shiraishi A、Yamakawa K、Kushimoto S、Ogura H、Abe T、et al
    • Journal Title

      Thrombosis Research

      Volume: 191 Issue: 1 Pages: 15-21

    • DOI

      10.1093/qjmed/hcaa296

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconstitution of prospermatogonial specification in vitro from human induced pluripotent stem cells2020

    • Author(s)
      Hwang Young Sun、Suzuki Shinnosuke、Seita Yasunari、Ito Jumpei、Sakata Yuka、Aso Hirofumi、Sato Kei、Hermann Brian P.、Sasaki Kotaro
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 5656-5656

    • DOI

      10.1038/s41467-020-19350-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Direct evidence of abortive lytic infection-mediated establishment of Epstein-Barr virus latency during B-cell infection2020

    • Author(s)
      Inagaki Tomoki、Sato Yoshitaka、Ito Jumpei、Takaki Mitsuaki、Okuno Yusuke、Yaguchi Masahiro、Al Masud H. M. Abdullah、Watanabe Takahiro、Sato Kei、Iwami Shingo、Murata Takayuki、Kimura Hiroshi
    • Journal Title

      BioRxiv

      Volume: -

    • DOI

      10.1101/2020.03.23.004440

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Endogenous retroviruses drive KRAB zinc-finger family protein expression for tumor suppression2020

    • Author(s)
      Ito Jumpei、Kimura Izumi、Soper Andrew、Coudray Alexandre、Koyanagi Yoshio、Nakaoka Hirofumi、Inoue Ituro、Turelli Priscilla、Trono Didier、Sato Kei
    • Journal Title

      BioRxiv

      Volume: -

    • DOI

      10.1101/2020.02.02.931501

    • Related Report
      2019 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Retroviruses drive the rapid evolution of mammalian APOBEC3 genes2020

    • Author(s)
      Jumpei Ito, Robert J. Gifford, Kei Sato
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 117 Issue: 1 Pages: 610-618

    • DOI

      10.1073/pnas.1914183116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endogenization and excision of human herpesvirus 6 in human genomes2019

    • Author(s)
      Liu Xiaoxi、Kosugi Shunichi、Koide Rie、Kawamura Yoshiki、Ito Jumpei、...、Parrish Nicholas F.、Kamatani Yoichiro
    • Journal Title

      BioRxiv

      Volume: -

    • DOI

      10.1101/2019.12.19.882522

    • Related Report
      2019 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] HTLV-1 contains a high CG dinucleotide content and is susceptible to the host antiviral protein ZAP2019

    • Author(s)
      Miyazato Paola、Matsuo Misaki、Tan Benjy J. Y.、Tokunaga Michiyo、Katsuya Hiroo、Islam Saiful、Ito Jumpei、Murakawa Yasuhiro、Satou Yorifumi
    • Journal Title

      Retrovirology

      Volume: 16 Issue: 1 Pages: 38-38

    • DOI

      10.1186/s12977-019-0500-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Nature of the HTLV-1 Provirus in Naturally Infected Individuals Analyzed by the Viral DNA-Capture-Seq Approach2019

    • Author(s)
      Katsuya H, Islam S, Tan, Ito J, Miyazato P, Matsuo, Inada Y, Iwase, Uchiyama Yoshikazu、Hata Hiroyuki、Sato T, Yagishita N, Araya N, Ueno T, Nosaka K, Tokunaga M, Yamagishi M, Watanabe T, Uchimaru K, Fujisawa J-i, Utsunomiya A, Yamano Y, Satou Y
    • Journal Title

      Cell Reports

      Volume: 29 Issue: 3 Pages: 724-735

    • DOI

      10.1016/j.celrep.2019.09.016

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] HIV-1 DNA-capture-seq is a useful tool for the comprehensive characterization of HIV-1 provirus2019

    • Author(s)
      Iwase Saori C.、Miyazato Paola、Katsuya Hiroo、Islam Saiful、Yang Benjy Tan Jek、Ito Jumpei、Matsuo Misaki、Takeuchi Hiroaki、Ishida Takaomi、Matsuda Kouki、Maeda Kenji、Satou Yorifumi
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 12326-12326

    • DOI

      10.1038/s41598-019-48681-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] トランスポゾンと多重遺伝子ファミリーの進化生態学2021

    • Author(s)
      伊東潤平、佐藤佳
    • Organizer
      日本遺伝学会第93回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Coevolutionary dynamics of multigene families and transposable elements in vertebrates2021

    • Author(s)
      Jumpei Ito, Kei Sato
    • Organizer
      5th Uppsala Transposon Symposium
    • Related Report
      2021 Annual Research Report
  • [Presentation] 多重遺伝子ファミリーとトランスポゾンの進化生態学2021

    • Author(s)
      伊東潤平, 佐藤佳
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 公的シーケンスデータ解析のウイルス研究への応用可能性2020

    • Author(s)
      伊東潤平
    • Organizer
      第43回日本分子生物学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] データ駆動科学で乗り出すウイルス研究の新天地2020

    • Author(s)
      伊東潤平
    • Organizer
      2020年日本バイオインフォマティクス学会年会・第9回生命医薬情報学連合大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 内在性レトロウイルスの駆動する生命現象と生物進化2020

    • Author(s)
      伊東潤平
    • Organizer
      山口大学 微生物研究推進体 研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 内在性レトロウイルスと抗レトロウイルス遺伝子ファミリー間に起こった進化的軍拡競争の描出2020

    • Author(s)
      伊東潤平
    • Organizer
      第92回日本遺伝学会, 紙面開催
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 4.腫瘍の遺伝子発現制御ネットワークを司る「ウイルス由来ジャンクDNA」の同定2020

    • Author(s)
      伊東潤平
    • Organizer
      ウイルス学若手研究集会2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 哺乳類における内在性レトロウイルスとAPOBEC3遺伝子の進化的軍拡競争2019

    • Author(s)
      伊東 潤平、Robert Gifford、佐藤 佳
    • Organizer
      第67回日本ウイルス学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Ancient retroviruses drove the rapid evolution of mammalian APOBEC3 family genes.2019

    • Author(s)
      Ito J, Gifford RJ, and Sato K
    • Organizer
      American Society of Human Genetics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evolutionary conflict of endogenous retroviruses and APOBEC3 family genes in mammals2019

    • Author(s)
      Ito J, Gifford RJ, and Sato K
    • Organizer
      Cold Spring Harbor Laboratory Meeting on Retroviruses
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 腫瘍の遺伝子発現制御ネットワークを司る「ウイルス由来ジャンクDNA」の発見

    • URL

      https://www.ims.u-tokyo.ac.jp/imsut/jp/about/press/page_00043.html

    • Related Report
      2020 Annual Research Report
  • [Remarks] ほ乳類とレトロウイルスの進化的軍拡競争の網羅的描出

    • URL

      https://www.u-tokyo.ac.jp/focus/ja/press/z0201_00103.html

    • Related Report
      2019 Annual Research Report
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      https://jugem.hatenadiary.jp/entry/SystemsVirology_191224

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Published: 2019-05-29   Modified: 2024-03-26  

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