| Project/Area Number |
19J11009
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 国内 |
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| Review Section |
Basic Section 19010:Fluid engineering-related
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| Research Institution | Okinawa Institute of Science and Technology Graduate University |
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Principal Investigator |
Sathish Shivani 沖縄科学技術大学院大学, 科学技術研究科, 特別研究員(DC2)
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|---|
| Project Period (FY) |
2019-04-25 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥2,100,000 (Direct Cost: ¥2,100,000)
Fiscal Year 2020: ¥1,000,000 (Direct Cost: ¥1,000,000)
Fiscal Year 2019: ¥1,100,000 (Direct Cost: ¥1,100,000)
|
|---|
| Keywords | microfluidic / biomarker detection / kinetic enhancements / protein immobilization / PMMA microfluidics / Point of care testing / Fluid handling |
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| Outline of Research at the Start |
A large population around the world suffer from several treatable disorders if diagnosed early. However, the varied costs and accessibility to healthcare systems hinders patients from getting regular health screens. This can be addressed by providing the population with economical devices for efficient diagnosis to ensure early treatment. To address this demand, my aim is to develop miniaturized and rapid disease diagnostic tools by exploiting the benefits of microfluidics, to enable faster and more sensitive disease detection.
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| Outline of Annual Research Achievements |
When a person is afflicted with a disease, quantities of biomarkers are elevated. This research is focused on developing sensitive and rapid microfluidic systems to detect a wide range of biomarkers. Here, kinetic enhancements in microfluidic bioassay systems were investigated using novel 3D glass devices. Real-time binding events between fluorescently-labelled receptor and ligand antibodies were analyzed. Combining experimental measurements with scaling analysis, two key control dimensionless parameters were proposed to achieve “rapid” and “sensitive” ligand detection: a local Peclet number and a kinetic Damkohler number. Finally, we summarized our observations by providing design rules to support the development of fast and sensitive microfluidic bioassay systems.
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| Research Progress Status |
令和2年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和2年度が最終年度であるため、記入しない。
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