車椅子アスリートの体幹制御機構の解明-ハイパフォーマンスを実現する神経機序とは-

• Project/Area Number: 19J22927
• Research Category: Grant-in-Aid for JSPS Fellows
• Allocation Type: Single-year Grants
• Section: 国内
• Review Section: Basic Section 59020:Sports sciences-related
• Research Institution: The University of Tokyo
• Principal Investigator: 佐々木 睦 東京大学, 総合文化研究科, 特別研究員(DC1)
• Project Period (FY): 2019-04-25 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥3,400,000 (Direct Cost: ¥3,400,000); Fiscal Year 2021: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2020: ¥1,100,000 (Direct Cost: ¥1,100,000); Fiscal Year 2019: ¥1,200,000 (Direct Cost: ¥1,200,000)
• Keywords: 運動制御 / TMS / 体幹筋

Outline of Research at the Start

ヒトの体幹筋はあらゆる身体運動において身体を支える役割を担う。腕を挙げるという動作でさえ、上肢運動と同時に体幹筋が姿勢保持をすることで初めて遂行可能となる。この場合動作の意識は腕を挙げることにあり、体幹筋の活動は意識されることはない。それにも関わらず、体幹筋は上肢の運動に協調し、適切なタイミング・強さで活動する。こうした体幹筋の活動を我々の脳や脊髄といった中枢神経系はどう制御しているのだろうか。本研究では車椅子アスリートを優れた体幹制御能力を有するモデルとし、種々の神経学的手法を用いその制御特性を明らかにすることで、優れた体幹制御を可能にする神経メカニズムを解明する。

Outline of Annual Research Achievements

前年度までは四肢の運動に協調して働く体幹筋の神経制御メカニズムに関して、上肢-体幹間の神経的結合性に注目し、その存在の有無や特性について健常者および、車椅子アスリートを対象に研究をしてきた。
最終年度ではこの神経的結合性がヒトにおいてどのような機能的意義を持つかという点に注目して検討した。特に、行われる運動の種類や強度に依存して、結合性を強める(あるいは弱める)変調が見られた場合、神経的結合性は筋間の協調的な運動に寄与している可能性が考えられた。前年度までに確立した経頭蓋磁気刺激（TMS）による神経的結合性の評価法を用いてこれを検証した。その結果、運動の種類や強度に依存して、上肢-体幹間の神経的結合の程度が変調し、さらに体幹筋の中でも屈筋(腹直筋)や伸筋(脊柱起立筋)など、機能の異なる筋では、上肢運動に対する神経活動の変調の程度が異なることも明らかとなった。この結果は上肢-体幹間における神経的結合は運動の種類や強度によってその結合強度が変わり、上肢-体幹間の協調運動に寄与している可能性を示唆した。この研究に関する成果は国際学術誌eNeuro誌に掲載された。
さらに上記の研究から発展して、TMSの２連発刺激などの手法を用いて、異なる筋間の協調運動に関与する皮質内の抑制・促通機構の働きをを明らかにした。この結果は論文にまとめ、国際学術誌への投稿準備をしている。
以上のように四肢と協調して働く体幹筋の制御に関して、その神経メカニズムをさまざまな観点から検討し、国際学術誌に発表するなど、当該研究を大きく進めることができた。

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

Research Products

• [Int'l Joint Research] University of Toronto(カナダ)
• [Int'l Joint Research] Houston Methodist Research Institute(米国)
• [Journal Article] Evidence for basic units of upper limb muscle synergies underlying a variety of complex human manipulations (2022)
  • Author(s): Saito Hiroki、Yokoyama Hikaru、Sasaki Atsushi、Kato Tatsuya、Nakazawa Kimitaka
  • Journal Title: Journal of Neurophysiology Volume: 127 Issue: 4 Pages: 958-968
  • DOI: 10.1152/jn.00499.2021
  • Peer Reviewed
• [Journal Article] Corticospinal excitability and somatosensory information processing of the lower limb muscle during upper limb voluntary or electrically induced muscle contractions (2022)
  • Author(s): Kato Tatsuya、Kaneko Naotsugu、Sasaki Atsushi、Endo Nozomi、Yuasa Akiko、Milosevic Matija、Watanabe Katsumi、Nakazawa Kimitaka
  • Journal Title: European Journal of Neuroscience Volume: 55 Issue: 7 Pages: 1810-1824
  • DOI: 10.1111/ejn.15643
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Short-term facilitation effects elicited by cortical priming through theta burst stimulation and functional electrical stimulation of upper-limb muscles (2022)
  • Author(s): Cao Na、Sasaki Atsushi、Yuasa Akiko、Popovic Milos R.、Milosevic Matija、Nakazawa Kimitaka
  • Journal Title: Experimental Brain Research Volume: In press Issue: 5 Pages: 1565-1578
  • DOI: 10.1007/s00221-022-06353-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Muscle-specific movement-phase-dependent modulation of corticospinal excitability during upper-limb motor execution and motor imagery combined with virtual action observation (2021)
  • Author(s): Yoshiyuki Suzuki, Naotsugu Kaneko, Atsushi Sasaki, FumiyaTanaka, Kimitaka Nakazawa, Taishin Nomura and Matija Milosevic
  • Journal Title: Neuroscience Letters Volume: 755 Pages: 135907-135907
  • DOI: 10.1016/j.neulet.2021.135907
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Selectivity and excitability of upper-limb muscle activation during cervical transcutaneous spinal cord stimulation in humans (2021)
  • Author(s): de Freitas Roberto M.、Sasaki Atsushi、Sayenko Dimitry G.、Masugi Yohei、Nomura Taishin、Nakazawa Kimitaka、Milosevic Matija
  • Journal Title: Journal of Applied Physiology Volume: 131 Issue: 2 Pages: 746-759
  • DOI: 10.1152/japplphysiol.00132.2021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cortical Re-organization After Traumatic Brain Injury Elicited Using Functional Electrical Stimulation Therapy: A Case Report (2021)
  • Author(s): Milosevic Matija、Nakanishi Tomoya、Sasaki Atsushi、Yamaguchi Akiko、Nomura Taishin、Popovic Milos R.、Nakazawa Kimitaka
  • Journal Title: Frontiers in Neuroscience Volume: 15 Pages: 1-15
  • DOI: 10.3389/fnins.2021.693861
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Robust Identification of Motor Unit Discharges From High-Density Surface EMG in Dynamic Muscle Contractions of the Tibialis Anterior (2021)
  • Author(s): Yokoyama Hikaru、Sasaki Atsushi、Kaneko Naotsugu、Saito Akira、Nakazawa Kimitaka
  • Journal Title: IEEE Access Volume: 9 Pages: 123901-123911
  • DOI: 10.1109/access.2021.3107283
  • Peer Reviewed / Open Access
• [Journal Article] Low-Intensity and Short-Duration Continuous Cervical Transcutaneous Spinal Cord Stimulation Intervention Does Not Prime the Corticospinal and Spinal Reflex Pathways in Able-Bodied Subjects (2021)
  • Author(s): Sasaki Atsushi、de Freitas Roberto M.、Sayenko Dimitry G.、Masugi Yohei、Nomura Taishin、Nakazawa Kimitaka、Milosevic Matija
  • Journal Title: Journal of Clinical Medicine Volume: 10 Issue: 16 Pages: 3633-3633
  • DOI: 10.3390/jcm10163633
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] The Effects of Paired Associative Stimulation with Transcutaneous Spinal Cord Stimulation on Corticospinal Excitability in Multiple Lower-limb Muscles (2021)
  • Author(s): Kaneko Naotsugu、Sasaki Atsushi、Masugi Yohei、Nakazawa Kimitaka
  • Journal Title: Neuroscience Volume: 476 Pages: 45-59
  • DOI: 10.1016/j.neuroscience.2021.08.028
  • Peer Reviewed
• [Journal Article] Task- and Intensity-Dependent Modulation of Arm-Trunk Neural Interactions in the Corticospinal Pathway in Humans (2021)
  • Author(s): Sasaki Atsushi、Kaneko Naotsugu、Masugi Yohei、Kato Tatsuya、Milosevic Matija、Nakazawa Kimitaka
  • Journal Title: eNeuro Volume: 8 Issue: 5 Pages: 0111-21
  • DOI: 10.1523/eneuro.0111-21.2021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Flexible Recruitments of Fundamental Muscle Synergies in the Trunk and Lower Limbs for Highly Variable Movements and Postures (2021)
  • Author(s): Saito Hiroki、Yokoyama Hikaru、Sasaki Atsushi、Kato Tatsuya、Nakazawa Kimitaka
  • Journal Title: Sensors Volume: 21 Issue: 18 Pages: 6186-6186
  • DOI: 10.3390/s21186186
  • Peer Reviewed / Open Access
• [Journal Article] 経皮的脊髄電気刺激を用いた脊髄ニューロモジュレーションと運動制御研究 (2021)
  • Author(s): 佐々木睦、中澤公孝
  • Journal Title: 運動器リハビリテーション Volume: 32 Pages: 242-254
  • Peer Reviewed
• [Journal Article] Cortical and subcortical neural interactions between trunk and upper-limb muscles in humans (2020)
  • Author(s): Atsushi Sasaki, Matija Milosevic and Kimitaka Nakazawa
  • Journal Title: Neuroscience Volume: 451 Pages: 126-136
  • DOI: 10.1016/j.neuroscience.2020.10.011
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Interlimb neural interactions in corticospinal and spinal reflex circuits during preparation and execution of isometric elbow flexion (2020)
  • Author(s): Atsushi Sasaki, Naotsugu Kaneko, Yohei Masugi, Matija Milosevic and Kimitaka Nakazawa
  • Journal Title: Journal of Neurophysiology Volume: 124(3) Issue: 3 Pages: 652-667
  • DOI: 10.1152/jn.00705.2019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Motor Point Stimulation in Spinal Paired Associative Stimulation can Facilitate Spinal Cord Excitability (2020)
  • Author(s): Fok Kai Lon、Kaneko Naotsugu、Sasaki Atsushi、Nakagawa Kento、Nakazawa Kimitaka、Masani Kei
  • Journal Title: Frontiers in Human Neuroscience Volume: 14 Pages: 593806-593806
  • DOI: 10.3389/fnhum.2020.593806
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cortical reorganization of lower-limb motor representations in an elite archery athlete with congenital amputation of both arms (2020)
  • Author(s): Nakagawa K, Takemi M, Nakanishi T, Sasaki A, Nakazawa K.
  • Journal Title: NeuroImage: Clinical Volume: 25 Pages: 102144-102144
  • DOI: 10.1016/j.nicl.2019.102144
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] On the reflex mechanisms of cervical transcutaneous spinal cord stimulation in human subjects (2019)
  • Author(s): Milosevic Matija、Masugi Yohei、Sasaki Atsushi、Sayenko Dimitry G.、Nakazawa Kimitaka
  • Journal Title: Journal of Neurophysiology Volume: 121 Issue: 5 Pages: 1672-1679
  • DOI: 10.1152/jn.00802.2018
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Remote muscle contraction enhances spinal reflexes in multiple lower-limb muscles elicited by transcutaneous spinal cord stimulation (2019)
  • Author(s): Masugi Yohei、Sasaki Atsushi、Kaneko Naotsugu、Nakazawa Kimitaka
  • Journal Title: Experimental Brain Research Volume: 印刷中 Issue: 7 Pages: 1793-1803
  • DOI: 10.1007/s00221-019-05536-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of neuromuscular electrical stimulation and voluntary commands on the spinal reflex excitability of remote limb muscles (2019)
  • Author(s): Kato Tatsuya、Sasaki Atsushi、Yokoyama Hikaru、Milosevic Matija、Nakazawa Kimitaka
  • Journal Title: Experimental Brain Research Volume: 237 Issue: 12 Pages: 3195-3205
  • DOI: 10.1007/s00221-019-05660-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Force Control of Ankle Dorsiflexors in Young Adults: Effects of Bilateral Control and Leg Dominance (2019)
  • Author(s): Yamaguchi Akiko、Milosevic Matija、Sasaki Atsushi、Nakazawa Kimitaka
  • Journal Title: Journal of Motor Behavior Volume: 52 Issue: 2 Pages: 226-235
  • DOI: 10.1080/00222895.2019.1609408
  • Peer Reviewed
• [Presentation] Neural interactions between the trunk and the upper-limb muscles in humans: Effect of cortical and subcortical contributions (2020)
  • Author(s): Sasaki Atsushi、Milosevic Matija、Nakazawa Kimitaka
  • Organizer: 12th Federation of European Neuroscience Societies (FENS) Forum of Neuroscience
  • Int'l Joint Research
• [Presentation] Effect of neuromuscular electrical stimulation on excitability of subcortical circuits in trunk muscles (2019)
  • Author(s): Sasaki Atsushi、Cao Na、Adonay Gebrehiwot、Yamaguchi Akiko、Milosevic Matija、Nakazawa Kimitaka
  • Organizer: RehabWeek 2019, International functional electrical stimulation society (IFESS) 2019
  • Int'l Joint Research
• [Presentation] Facilitatory effects of ipsilateral, contralateral and bilateral upper-limb muscle contractions on corticospinal and spinal reflex excitabilities in lower-limb muscles (2019)
  • Author(s): Sasaki Atsushi、Kaneko Naotsugu、Masugi Yohei、Milosevic Matija、Nakazawa Kimitaka
  • Organizer: Neural Control of Movement (NCM) 2019
  • Int'l Joint Research