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Potentiality of dietary fiber for healthy longevity

Research Project

Project/Area Number 19K02314
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionTokyo Gakugei University

Principal Investigator

Minami Michiko  東京学芸大学, 教育学部, 名誉教授 (70272432)

Co-Investigator(Kenkyū-buntansha) 櫛山 暁史  明治薬科大学, 薬学部, 教授 (30435820)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords食物繊維 / 生化学的分析 / 食の欧米化 / 動物実験 / 遺伝子発現 / 臓器重量 / 体重変化 / 健康寿命 / 食餌中の脂質含量 / アンケート調査 / 血液生化学分析
Outline of Research at the Start

研究代表者らは、食物繊維摂取減少に着目して研究を遂行する。食物繊維の摂取は野菜におっている事が多いが、その1日摂取量は目標量の350gを超えない状態が続いている。特に若年層での摂取不足が顕著である。本研究では各世代の実態調査をして摂取量減少の理由等を明らかにし、食物繊維摂取量の実態を調査する。さらに本研究では、加齢や生活習慣病と、食物繊維による腸内細菌叢の変動の血中サイトカイン量、及び臓器障害に対する交絡や健康寿命の観点から検討を行う。以上のように、生化学・生物学的な手法に加えて統計学的手法を用い、食物繊維量摂取の視点から健康寿命延伸をするための新たな可能性の提案を行うものとする。

Outline of Final Research Achievements

In modern Japan, there is an abundance of various foods, and disordered eating habits are becoming a problem. In paticular, the diet of modern Japan is insuffficient calcium and increasing the intake of saturated fatty acids, especially among the younger generation.
The study of nutrient intake in university students using a reproduced diet revealed that some students were in a significantly worse state of nutrition than the results of the National Nutrition Survey. While most nutritional studies focus on a single nutrient, this study conducted animal experiments using food containing multiple nutrients defects that reflect the diet of modern people, and there are very few previous studies on this topic. When young mice were fed the test diet and then biochemically analyzed in their organs when they reached the growth stage, it was found that the diet may lead to the development of lifestyle-related diseases.

Academic Significance and Societal Importance of the Research Achievements

国民栄養調査では、年代別に栄養摂取の結果を公表しているが、同じ年代でも各々の生活習慣でかなり栄養摂取が違うと考えられ、また健康に影響を及ぼす栄養摂取を行う人については、国民栄養調査に協力的な人の結果とは違うと考えられる。そこで、まず大学生を運動習慣や食生活を管理してくれる食事を整えてくれる家族と同居の有無で食事調査を行うことにした。また、その結果をもとに動物実験を行って、生化学的な分析を行うことを計画した。現代日本の若年層の食生活を再現して、複数の栄養素の不足を食物繊維が増加することで、どの程度通常の食物繊維量であるコントロールに近い値に改善するのか、または変化がみられないのかも検討する。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (54 results)

All 2023 2022 2021 2020 2019

All Journal Article (37 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 28 results,  Open Access: 35 results) Presentation (14 results) (of which Int'l Joint Research: 1 results) Book (3 results)

  • [Journal Article] Analysis of Adverse Events of Cholinesterase Inhibitors and NMDA Receptor Antagonists on Arrhythmias Using the Japanese Adverse Drug Event Report Database2023

    • Author(s)
      Kobayashi S, Sugama N, Nagano H, Miyamori A, Takahashi M, Kushiyama A.
    • Journal Title

      Drugs Real World Outcomes

      Volume: 10 Issue: 2 Pages: 321-329

    • DOI

      10.1007/s40801-023-00362-6

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of Prescribing Patterns in Hemodialysis Outpatients Taking Multiple Medications.2023

    • Author(s)
      Nagano H, Tomori K, Koiwa M, Kobayashi S, Takahashi M, Makabe H, Okada H, Kushiyama A
    • Journal Title

      Pharmacy (Basel)

      Volume: 11 Issue: 2 Pages: 43-43

    • DOI

      10.3390/pharmacy11020043

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Renally inappropriate medications in elderly outpatients and inpatients with an impaired renal function.2023

    • Author(s)
      Kobayashi S, Sugama N, Nagano H, Takahashi M, Kushiyama A
    • Journal Title

      Hosp Pract

      Volume: 51 Issue: 2 Pages: 76-81

    • DOI

      10.1080/21548331.2023.2173412

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pilot study of diabetic retinopathy in a porcine model of maturity onset diabetes of the young type 3 (MODY3)2023

    • Author(s)
      Takase K, Yokota H, Ohno A, Watanabe M, Kushiyama A, Kushiyama S, Yamagami S, Nagaoka T
    • Journal Title

      Exp Eye Res.

      Volume: 227 Pages: 109379-109379

    • DOI

      10.1016/j.exer.2022.109379

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of Weight Reduction, Change in Parameters and Safety of a Very Low Carbohydrate Diet in Comparison to a Low Carbohydrate Diet in Obese Japanese Subjects with Metabolic Disorders.2023

    • Author(s)
      Kikuchi T, Kushiyama A, Yanai M, Kashiwado C, Seto T, Kasuga M.
    • Journal Title

      Nutrients.

      Volume: 15 Issue: 6 Pages: 1342-1342

    • DOI

      10.3390/nu15061342

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PRIZE Study Investigators. Factors associated with carotid intima-media thickness progression in patients with asymptomatic hyperuricemia: insights from the PRIZE study2023

    • Author(s)
      Saito Y, Tanaka A, Ishizu T, Yoshida H, Kubota Y, Nanasato M, Matsuhisa M, Ohya Y, Kobayashi Y, Node K
    • Journal Title

      Sci Rep.

      Volume: 13 Issue: 1 Pages: 10927-10927

    • DOI

      10.1038/s41598-023-37183-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dilation of porcine retinal arterioles to nobiletin, a polymethoxyflavonoid: Roles of nitric oxide and voltage-dependent potassium channel2023

    • Author(s)
      Watanabe M, Miyata Y, Ohno A, Yokota H, Takase K, Hanaguri J, Kushiyama A, Yamagami S, Harino S, Nagaoka T
    • Journal Title

      Exp Eye Res

      Volume: 233 Pages: 109548-109548

    • DOI

      10.1016/j.exer.2023.109548

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Auraptene Enhances AMP-Activated Protein Kinase Phosphorylation and Thereby Inhibits the Proliferation, Migration and Expression of Androgen Receptors and Prostate-Specific Antigens in Prostate Cancer Cells2023

    • Author(s)
      Akasaka Y, Hasei S, Ohata Y, Kanna M, Nakatsu Y, Sakoda H, Fujishiro M, Kushiyama A, Ono H, Matsubara A, Hinata N, Asano T, Yamamotoya T.
    • Journal Title

      Int J Mol Sci.

      Volume: 24(21) Issue: 21 Pages: 16011-16011

    • DOI

      10.3390/ijms242116011

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 緑黄色野菜に関する行政上の分類および教科書記述の分析と 大学生の緑黄色野菜に関する知識2023

    • Author(s)
      櫛 山 櫻・早 川 尚 子・横山 英吏子・南 道 子
    • Journal Title

      東京学芸大学紀要

      Volume: 74 Pages: 406-417

    • Related Report
      2022 Research-status Report
    • Open Access
  • [Journal Article] シームレスな「人体の構造と機能」の学習を実現するための 医療系大学入学前後の学習項目の調査2023

    • Author(s)
      本間 典子・櫛山 櫻・南 道子
    • Journal Title

      東京学芸大学紀要

      Volume: 74 Pages: 418-428

    • Related Report
      2022 Research-status Report
    • Open Access
  • [Journal Article] 現行教科書に記載されている食領域の教育内容分析 (献立作成フローおよび調理品の記載例に着目して)2023

    • Author(s)
      横山 英吏子・齋藤 美奈子・櫛 山 櫻・南 道 子
    • Journal Title

      東京学芸大学紀要

      Volume: 74 Pages: 394-405

    • Related Report
      2022 Research-status Report
    • Open Access
  • [Journal Article] Metabolism-dependent Vascular Pathophysiology in Adult Diseases2022

    • Author(s)
      Kushiyama Akifumi、Takahashi Masahiro、Kushiyama Sakura、Kikuchi Takako、Asano Tomoichiro
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 142 Issue: 5 Pages: 465-471

    • DOI

      10.1248/yakushi.21-00176-3

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2022-05-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent Advances in the Studies of Metabolic Syndromes and Applications to the Development of New Drugs2022

    • Author(s)
      Kushiyama Akifumi、Nakatsu Yusuke
    • Journal Title

      YAKUGAKU ZASSHI

      Volume: 142 Issue: 5 Pages: 447-448

    • DOI

      10.1248/yakushi.21-00176-F

    • ISSN
      0031-6903, 1347-5231
    • Year and Date
      2022-05-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic deterioration of prognosis associated with decreased grip strength and hyporesponse to erythropoiesis-stimulating agents in patients undergoing hemodialysis2022

    • Author(s)
      Kobayashi S, Tanaka K, Hoshino J, Hara S, Kushiyama A, Tanaka Y, Motonishi S, Sakai K, Ozawa T.
    • Journal Title

      Ren Fail

      Volume: 44 Issue: 1 Pages: 1801-1810

    • DOI

      10.1080/0886022x.2022.2106873

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Different Kinetics of Activated Clotting Time Among Uninterrupted Oral Anticoagulants During Catheter Ablation Procedure.2022

    • Author(s)
      Kawaji T, Morimoto T, Aizawa T, Hojo S, Kushiyama A, Yaku H, Nakatsuma K, Kaneda K, Kato M, Yokomatsu T, Miki S, Kimura T.
    • Journal Title

      J Clin Pharmacol.

      Volume: 62 Issue: 6 Pages: 792-800

    • DOI

      10.1002/jcph.2018

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of prorenin peptide vaccine on the early phase of diabetic retinopathy in a murine model of type 2 diabetes2022

    • Author(s)
      Yokota Harumasa、Hayashi Hiroki、Hanaguri Junya、Yamagami Satoru、Kushiyama Akifumi、Nakagami Hironori、Nagaoka Taiji
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 1 Pages: e0262568-e0262568

    • DOI

      10.1371/journal.pone.0262568

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of neuronal and muscular Trk-fused gene (TFG) defects in the development of neurodegenerative diseases2022

    • Author(s)
      Yamamotoya Takeshi、Hasei Shun、Akasaka Yasuyuki、Ohata Yukino、Nakatsu Yusuke、Kanna Machi、Fujishiro Midori、Sakoda Hideyuki、Ono Hiraku、Kushiyama Akifumi、Misawa Hidemi、Asano Tomoichiro
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 1966-1966

    • DOI

      10.1038/s41598-022-05884-7

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fenofibrate Nano-Eyedrops Ameliorate Retinal Blood Flow Dysregulation and Neurovascular Coupling in Type 2 Diabetic Mice2022

    • Author(s)
      Hanaguri Junya、Nagai Noriaki、Yokota Harumasa、Kushiyama Akifumi、Watanabe Masahisa、Yamagami Satoru、Nagaoka Taiji
    • Journal Title

      Pharmaceutics

      Volume: 14 Issue: 2 Pages: 384-384

    • DOI

      10.3390/pharmaceutics14020384

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Concomitant Spatiotemporal Electrogram Dispersion and Low Voltage During Atrial Fibrillation Is Associated With Refractory Atrial Fibrillation After Catheter Ablation2022

    • Author(s)
      Kawaji T, Aizawa T, Hojo S, Kushiyama A, Yaku H, Nakatsuma K, Kaneda K, Kato M, Yokomatsu T, Miki S
    • Journal Title

      Circ Arrhythm Electrophysiol

      Volume: 15 Issue: 5 Pages: 340-340

    • DOI

      10.1161/circep.121.010707

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Effect of Sodium-Dependent Glucose Cotransporter 2 Inhibitor Tofogliflozin on Neurovascular Coupling in the Retina in Type 2 Diabetic Mice2022

    • Author(s)
      Hanaguri Junya、Yokota Harumasa、Kushiyama Akifumi、Kushiyama Sakura、Watanabe Masahisa、Yamagami Satoru、Nagaoka Taiji
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 3 Pages: 1362-1362

    • DOI

      10.3390/ijms23031362

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Beneficial Effect of Long-Term Administration of Supplement With Trapa Bispinosa Roxb. and Lutein on Retinal Neurovascular Coupling in Type 2 Diabetic Mice2022

    • Author(s)
      Hanaguri Junya、Yokota Harumasa、Kushiyama Akifumi、Kushiyama Sakura、Watanabe Masahisa、Yamagami Satoru、Nagaoka Taiji
    • Journal Title

      Frontiers in Physiology

      Volume: 13 Pages: 788034-788034

    • DOI

      10.3389/fphys.2022.788034

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 高等学校家庭科における食生活への気づきをもたらす献立作成学習2021

    • Author(s)
      斎藤美奈子、櫛山櫻、南道子
    • Journal Title

      東京学芸大学紀要

      Volume: 73 Pages: 346-37

    • Related Report
      2021 Research-status Report
    • Open Access
  • [Journal Article] 拡張現実(AR)技術を用いた人体構造の理解を深めるための三次元教材の開発とその有効性2021

    • Author(s)
      本間典子、櫛山櫻、南 道子
    • Journal Title

      東京学芸大学紀要

      Volume: 73 Pages: 239-254

    • NAID

      120007184524

    • Related Report
      2021 Research-status Report
    • Open Access
  • [Journal Article] 学校現場における栄養に関する教育内容の変遷と課題―学習指導要領および教科書における食物繊維の記載に着目してー2021

    • Author(s)
      櫛山櫻、斎 麻倫、南 道
    • Journal Title

      東京学芸大学紀要

      Volume: 73 Pages: 363-374

    • Related Report
      2021 Research-status Report
    • Open Access
  • [Journal Article] Characteristics Associated with Early Worsening of Retinopathy in Patients with Type 2 Diabetes Diagnosed with Retinopathy at Their First Visit: A Retrospective Observational Study2021

    • Author(s)
      Sugawa Sayaka Wakabayashi、Yoshida Yoko、Hikima Yusuke、Sato Haruhiko、Shimada Akira、Noda Mitsuhiko、Kushiyama Akifumi
    • Journal Title

      Journal of Diabetes Research

      Volume: 2021 Pages: 1-9

    • DOI

      10.1155/2021/7572326

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pathological Role of Pin1 in the Development of DSS-Induced Colitis2021

    • Author(s)
      Matsunaga Yasuka、Hasei Shun、Yamamotoya Takeshi、Honda Hiroaki、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Ito Hisanaka、Okabe Takayoshi、Asano Tomoichiro、Nakatsu Yusuke
    • Journal Title

      Cells

      Volume: 10 Issue: 5 Pages: 1230-1230

    • DOI

      10.3390/cells10051230

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Retinal blood flow dysregulation precedes neural retinal dysfunction in type 2 diabetic mice2021

    • Author(s)
      Hanaguri Junya、Yokota Harumasa、Watanabe Masahisa、Yamagami Satoru、Kushiyama Akifumi、Kuo Lih、Nagaoka Taiji
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 18401-18401

    • DOI

      10.1038/s41598-021-97651-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Plasma Xanthine Oxidoreductase Activity on the Mechanisms of Distal Symmetric Polyneuropathy Development in Patients with Type 2 Diabetes2021

    • Author(s)
      Fujishiro Midori、Ishihara Hisamitsu、Ogawa Katsuhiko、Murase Takayo、Nakamura Takashi、Watanabe Kentaro、Sakoda Hideyuki、Ono Hiraku、Yamamotoya Takeshi、Nakatsu Yusuke、Asano Tomoichiro、Kushiyama Akifumi
    • Journal Title

      Biomedicines

      Volume: 9 Issue: 8 Pages: 1052-1052

    • DOI

      10.3390/biomedicines9081052

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quantitative sonographic assessment of quadriceps muscle thickness for fall injury prediction in patients undergoing maintenance hemodialysis: an observational cohort study2021

    • Author(s)
      Sai A, Tanaka K, Ohashi Y, Kushiyama A, Tanaka Y, Motonishi S, Sakai K, Hara S, Ozawa T.
    • Journal Title

      BMC Nephrol

      Volume: 22 Issue: 1 Pages: 191-191

    • DOI

      10.1186/s12882-021-02347-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of febuxostat on left ventricular diastolic function in patients with asymptomatic hyperuricemia: a sub analysis of the PRIZE Study2021

    • Author(s)
      Kusunose K, Yoshida H, Tanaka A, Teragawa H, Akasaki Y, Fukumoto Y, Eguchi K, Kamiya H, Kario K, Yamada H, Sata M, Node K; PRIZE Study Investigators.
    • Journal Title

      Hypertension Research

      Volume: 45 Issue: 1 Pages: 106-115

    • DOI

      10.1038/s41440-021-00752-9

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Decline in renal function associated with cardiovascular autonomic neuropathy positively coordinated with proteinuria in patients with type?2 diabetes2021

    • Author(s)
      Muramatsu Taichi、Takahashi Masahiro、Kakinuma Rena、Sato Tomoyo、Yamamoto Mitsuyo、Akazawa Manabu、Tanaka Kentaro、Kikuchi Takako、Kushiyama Akifumi
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 13 Issue: 1 Pages: 102-111

    • DOI

      10.1111/jdi.13625

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synergistic association of the copper/zinc ratio under inflammatory conditions with diabetic kidney disease in patients with type 2 diabetes: The Asahi Diabetes Complications Study2021

    • Author(s)
      Takao Toshiko、Yanagisawa Hiroyuki、Suka Machi、Yoshida Yoko、Onishi Yukiko、Tahara Tazu、Kikuchi Takako、Kushiyama Akifumi、Anai Motonobu、Takahashi Kazuyuki、Wakabayashi Sugawa Sayaka、Yamazaki Hiroki、Kawazu Shoji、Iwamoto Yasuhiko、Noda Mitsuhiko、Kasuga Masato
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 13 Issue: 2 Pages: 299

    • DOI

      10.1111/jdi.13659

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 若年層の食の課題と家庭科の食の授業2021

    • Author(s)
      斎藤美奈子、櫛山櫻、南道子
    • Journal Title

      東京学芸大学紀要

      Volume: 72 Pages: 323-338

    • Related Report
      2020 Research-status Report
    • Open Access
  • [Journal Article] 運動習慣の有無による食品と栄養素の摂取状況2021

    • Author(s)
      渕上美咲、南道子、櫛山櫻
    • Journal Title

      東京学芸大学紀要

      Volume: 72 Pages: 339-350

    • NAID

      120007046367

    • Related Report
      2020 Research-status Report
    • Open Access
  • [Journal Article] Luminal ion deficiency upregulates Dmt1 mRNA expression in IEC-6, but not CACO2, monolayer.2020

    • Author(s)
      SHINODA Shoko, KATO Takako, OOTSHUKA Sae and MINAMI Michiko
    • Journal Title

      Bulletin of Tokyo Gakugei University Division of Comprehensive Education science

      Volume: 71 Pages: 395-403

    • Related Report
      2019 Research-status Report
    • Open Access
  • [Journal Article] Possible involvement of normalized Pin1 expression level and AMPK activation in the molecular mechanisms underlying renal protective effects of SGLT2 inhibitors in mice2019

    • Author(s)
      Inoue Masa-Ki、Matsunaga Yasuka、Nakatsu Yusuke、Yamamotoya Takeshi、Ueda Koji、Kushiyama Akifumi、Sakoda Hideyuki、Fujishiro Midori、Ono Hiraku、Iwashita Misaki、Sano Tomomi、Nishimura Fusanori、Morii Kenichi、Sasaki Kensuke、Masaki Takao、Asano Tomoichiro
    • Journal Title

      Diabetology & Metabolic Syndrome

      Volume: 11 Issue: 1 Pages: 57-57

    • DOI

      10.1186/s13098-019-0454-6

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Xanthine Oxidase Inhibitor Febuxostat Exerts an Anti-Inflammatory Action and Protects against Diabetic Nephropathy Development in KK-Ay Obese Diabetic Mice:2019

    • Author(s)
      Mizuno Y, Yamamotoya T, Nakatsu Y, Ueda K, Matsunaga Y, Inoue MK, Sakoda H, Fujishiro M, Ono H, Kikuchi T, Takahashi M, Morii K, Sasaki Kg Masaki T, Asano T and Kushiyama A.
    • Journal Title

      Int J Mol Sci,

      Volume: 20 Pages: 1-12

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 筋肉細胞のミトコンドリア形態変化と酸化ストレス及びアクチンの関与2023

    • Author(s)
      馬場めぐみ、横山尚哉、 高橋雅弘、山室大介、櫛山暁史
    • Organizer
      第67回 日本薬学会関東支部大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 細胞における糖の違いによる炎症誘発効果の検討:2023

    • Author(s)
      内田彩友美、高橋雅弘、冨田結惟、天池律樹、櫛山暁史
    • Organizer
      第67回 日本薬学会関東支部大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 高血糖・小胞体ストレス応答が与えるSGLT2発現・膜輸送への影響2023

    • Author(s)
      横山尚哉、 馬場めぐみ、山室大介、高橋雅弘、櫛山暁史
    • Organizer
      第67回 日本薬学会関東支部大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 肥満糖尿病モデルマウスにおける運動療法の熱産生に対する効果2023

    • Author(s)
      山口創大、高橋雅弘、鍵山菜菜子、畑山竣吏、天池律樹、冨田結惟、内田彩友美、櫛山暁史、
    • Organizer
      日本薬学会第143年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] インスリン抵抗性におけるマクロファージのコレステロール合成系の意義の検討2023

    • Author(s)
      武井暁一、永島秀一、武井祥子、山室大介、若林徹治、岡崎啓明、海老原健a、石橋俊a
    • Organizer
      第55回日本動脈硬化学会総会・学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 様々な血糖変動指標と2型糖尿病腎症発症進展の関連2023

    • Author(s)
      藤坂紗彩、高橋雅弘、大塚美空、山之内美環、菊池貴子、櫛山暁史
    • Organizer
      第67回 日本薬学会関東支部大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] SGLT2阻害薬またはDPP4阻害薬開始後の肝線維化指標FIB-4 indexへの影響についての解析2023

    • Author(s)
      菊池貴子、櫛山暁史
    • Organizer
      第44回日本肥満学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] J774.1細胞における糖の違いによる炎症誘発効果の検討2023

    • Author(s)
      内田彩友美、高橋雅弘、冨田結惟、天池律樹、櫛山暁史
    • Organizer
      第67回 日本薬学会関東支部大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 32.細胞質内Ca2+濃度における小胞体ストレス応答のSGLT2の膜上発現量への影響2023

    • Author(s)
      横山尚哉、櫛山暁史、高橋雅弘、馬塲めぐみ
    • Organizer
      日本薬学会第143年会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Analysis of trends in food and nutrition intake and eating habits of younger generation in modern Japan using quantification of the tendency toward the basic ”Washoku" pattern and "Japanese Dietary Pattern2023

    • Author(s)
      Sakura Kushiyama, Minako Saito, Misaki Fuchigami, Eriko Yokoyama, Noriko Homma, Akifumi Kushiyama, Michiko Minami
    • Organizer
      国際栄養学会
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] J774.1マクロファージ様細胞における糖の違いによる代謝への影響2023

    • Author(s)
      内田 彩友美、高橋 雅弘、冨田 結惟、天池 律樹、鍵山 菜菜子、山口 創大、畑山 竣吏、野澤 玲子、櫛山 暁史
    • Organizer
      日本薬学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 細胞質内Ca2+濃度における小胞体ストレス応答のSGLT2の膜上発現量への影響2023

    • Author(s)
      横山 尚哉、櫛山 暁史、高橋 雅弘、馬塲 めぐみ
    • Organizer
      日本薬学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 筋肉細胞におけるROS産生増加によるミトコンドリア形態変化への影響2023

    • Author(s)
      馬塲 めぐみ、横山 尚哉、高橋 雅弘、櫛山 暁史
    • Organizer
      日本薬学会
    • Related Report
      2022 Research-status Report
  • [Presentation] 糖尿病網膜症のバイオマーカーと代謝への介入2023

    • Author(s)
      櫛山 暁史
    • Organizer
      日本薬学会
    • Related Report
      2022 Research-status Report
  • [Book] 季刊栄養教諭 食育読本2020

    • Author(s)
      南 道子
    • Total Pages
      8
    • Publisher
      全国学校栄養士協議会
    • Related Report
      2020 Research-status Report
  • [Book] わかりやすい栄養学 改訂6版2020

    • Author(s)
      伊藤順子、井上久美子、笠原賀子、小築康弘、小林実夏、小松渡、志田万里子、篠田粧子、南 道子、村上淳
    • Total Pages
      188
    • Publisher
      三共出版
    • ISBN
      9784787207920
    • Related Report
      2019 Research-status Report
  • [Book] 最新基礎栄養学2019

    • Author(s)
      南 道子、櫛山櫻、篠田粧子、大池秀明、西村直道、佐川まさの、阿部志磨子、江口昭彦、雨海照祥、原一雄
    • Total Pages
      194
    • Publisher
      医歯薬出版  第9版
    • ISBN
      9784263707470
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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