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Development and verification of precision nutrition program sustaining maternal healthy eating habits before pregnancy, during pregnancy, and after childbirth

Research Project

Project/Area Number 19K02369
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionDepartment of Clinical Research, National Hospital Organization Kyoto Medical Center

Principal Investigator

Kanno Miwako  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (90795189)

Co-Investigator(Kenkyū-buntansha) 坂根 直樹  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究室長 (40335443)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords妊娠前 / 妊娠 / 産後 / 個別化栄養
Outline of Research at the Start

妊娠前、妊娠中、産後の食生活を支援する個別化された栄養プログラムを開発し、その効果を検証するのが本研究の目的である。妊婦の食事調査は食事頻度調査(FFQ)で行われてきたため、食事パターンしか明らかにならなかったが、本研究では具体的な料理やメニューが明らかとなる(妊婦の食事データベースの作成)。年齢、BMI、患者の嗜好、経済状態、体質によって個別化された栄養プログラムは学術的に独自性が高く、創造的であると考えられる。

Outline of Final Research Achievements

The goal of this study is to develop an individualized nutrition program to support dietary habits before, during, and after pregnancy. Using a dietary database of pregnant women, we conducted a dietary survey and genetic analysis to investigate the relationship with anemia during pregnancy and pregnancy outcomes. Anemia during pregnancy may reduce QOL and worsen pregnancy outcomes, and we were able to clarify the association between the dietary inflammatory index (DII), gestational diabetes, and SNPs related to iron metabolism obtained from the dietary survey and anemia during pregnancy. We found that guidance using an intermittent scanning continuous glucose monitor for diabetic patients improved blood glucose fluctuations when the number of scans was 12 or more. A simulation model was used to calculate the optimal ratio of nutrients for weight management and blood glucose manageme

Academic Significance and Societal Importance of the Research Achievements

妊娠前、妊娠中、産後の食生活を支援する個別化された栄養プログラムを開発することができた。妊娠後の体重管理には朝と晩の体重測定が役立つ可能性がある。これらの情報は個別化栄養プログラムの開発に役立つと考えられる。
これらのエビデンスは妊娠前、妊娠中、産後の食生活の管理に役立つ可能性が高い。これらの情報をヘルスケアアプリに搭載することで、若年世代にも役立つモバイルヘルスができることが期待される。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (22 results)

All 2023 2022 2021 2020 2019

All Journal Article (14 results) (of which Peer Reviewed: 9 results,  Open Access: 8 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (3 results)

  • [Journal Article] Association of a pro-inflammatory diet and gestational diabetes mellitus with maternal anemia and hemoglobin levels during pregnancy: a prospective observational case-control study2023

    • Author(s)
      Hayashi Ikuyo、Sakane Naoki、Suganuma Akiko、Nagai Narumi
    • Journal Title

      Nutrition Research

      Volume: 115 Pages: 38-46

    • DOI

      10.1016/j.nutres.2023.05.003

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The accuracy of the object detection and quantification of hospital meals by artificial intelligence: A pilot study2023

    • Author(s)
      村田 敬、坂根 直樹、小林 司、豊田 雅夫、廣田 勇士、三浦 順之助、森岡 宏介、平野 和保、鍛冶 亜由美、高橋 路子
    • Journal Title

      Journal of the Japan Innovative Diabetes Treatment

      Volume: 17 Issue: 1 Pages: 15-23

    • DOI

      10.34612/asindtj.17.1_15

    • ISSN
      2436-0058
    • Related Report
      2023 Annual Research Report
  • [Journal Article] 糖尿病診療にテクノロジーをどの様に利用するか 先進糖尿病テクノロジーを用いた糖尿病の個別化医療2023

    • Author(s)
      坂根 直樹
    • Journal Title

      糖尿病

      Volume: 66

    • Related Report
      2023 Annual Research Report
  • [Journal Article] 妊娠糖尿病患者の対面および遠隔栄養指導に対する満足度についてのパイロットスタディ2023

    • Author(s)
      田中 貴和, 田中 雅彰, 平野 和保, 坂根 直樹, 村田 敬
    • Journal Title

      日本先進糖尿病治療研究会雑誌

      Volume: 17 Pages: 136-136

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Optimization of nutritional strategies using a mechanistic computational model in prediabetes: Application to the J-DOIT1 study data2023

    • Author(s)
      Chen Julia H.、Fukasawa Momoko、Sakane Naoki、Suganuma Akiko、Kuzuya Hideshi、Pandey Shikhar、D’Alessandro Paul、Venkatapurapu Sai Phanindra、Dwivedi Gaurav
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 11 Pages: e0287069-e0287069

    • DOI

      10.1371/journal.pone.0287069

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Association of Social Networking Sites Use with Actual and Ideal Body Shapes, and Eating Behaviors in Healthy Young Japanese Women2023

    • Author(s)
      Yumen Yukina、Takayama Yumi、Hanzawa Fumiaki、Sakane Naoki、Nagai Narumi
    • Journal Title

      Nutrients

      Volume: 15 Issue: 7 Pages: 1589-1589

    • DOI

      10.3390/nu15071589

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Validation of questionnaire for assessing perceived benefits and barriers of vegetable consumption in Japanese adults2022

    • Author(s)
      Yaeko Kawaguchi, Junichiro Somei, Chikana Kawaguchi, Akiko Suganuma, Naoki Sakane
    • Journal Title

      Malaysian Journal of Nutrition

      Volume: 28 Issue: 1 Pages: 107-117

    • DOI

      10.31246/mjn-2021-0051

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters2021

    • Author(s)
      Nirengi Shinsuke、Taniguchi Hirokazu、Ishibashi Aya、Fujibayashi Mami、Akiyama Nao、Kotani Kazuhiko、Ishihara Kengo、Sakane Naoki
    • Journal Title

      Frontiers in Nutrition

      Volume: 8 Pages: 1-6

    • DOI

      10.3389/fnut.2021.657789

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of telephone support programme using telemonitoring on stage of change towards healthy eating and active exercise in people with prediabetes2021

    • Author(s)
      Sakane Naoki、Oshima Yoshitake、Kotani Kazuhiko、Suganuma Akiko、Takahashi Kaoru、Sato Juichi、Suzuki Sadao、Izumi Kazuo、Kato Masayuki、Noda Mitsuhiko、Kuzuya Hideshi
    • Journal Title

      Journal of Telemedicine and Telecare

      Volume: 27 Issue: 5 Pages: 307-313

    • DOI

      10.1177/1357633x211010981

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary Factors Associated With Dyslipidemia Traits in Individuals With Impaired Glucose Tolerance2021

    • Author(s)
      Sakane Naoki、Suganuma Akiko、Kuzuya Hideshi
    • Journal Title

      Journal of Endocrinology and Metabolism

      Volume: 11 Issue: 1 Pages: 22-27

    • DOI

      10.14740/jem721

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 単胎妊娠の日本人妊婦における妊娠前からの食事要因と正期産在胎不当過小児との関連の検討2020

    • Author(s)
      林 育代、山口 建, 住友 理浩, 湊 聡美, 鈴木 麻希, 住友 文, 能瀬 陽子, 高倉 健二, 坂根 直樹, 永井 成美
    • Journal Title

      小児保健研究

      Volume: 79 Pages: 267-278

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Postpartum hemorrhage is associated with neonatal body weight, pre-pregnancy body mass index, and maternal weight gain2020

    • Author(s)
      Yamamura S, Yamaguchi K, Hayashi I, Nagai N, Sakane N, Ikeda A, Takakura M, Emoto I, Ujita M, Kawasaki K, Abiko K, Takao Y, Takakura K, Konishi I
    • Journal Title

      Clinical and Experimental Obstetrics & Gynecology

      Volume: 47 Issue: 6 Pages: 920-920

    • DOI

      10.31083/j.ceog.2020.06.5365

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 日本人妊婦におけるPNPLA3遺伝子多型と妊娠後期食事中のn-6/n-3比が妊娠中の体重増加に与える影響2019

    • Author(s)
      湊 聡美, 二連木 晋輔, 林 育代, 山口 建, 高倉 賢二, 坂根 直樹, 永井 成美
    • Journal Title

      日本臨床栄養学会雑誌

      Volume: 41 Pages: 172-181

    • NAID

      40022142751

    • Related Report
      2019 Research-status Report
  • [Journal Article] Association between socioeconomic status and small‐for‐gestational‐age in Japan: A single center retrospective cohort study2019

    • Author(s)
      Hayashi Ikuyo、Takakura Kenji、Yamaguchi Ken、Sumitomo Masahiro、Suzuki Maki、Sumitomo Aya、Minato Satomi、Nose Yoko、Nagai Narumi、Sakane Naoki
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 46 Issue: 1 Pages: 110-118

    • DOI

      10.1111/jog.14069

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 医師から見た国内の臨床現場で求められるDTxとは2021

    • Author(s)
      坂根 直樹
    • Organizer
      第18回DIA日本年会2021
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] (第一報)薬局管理栄養士によるポーションコントロールプレートを使用した肥満改善2019

    • Author(s)
      橋詰 真子, 小山 芳明, 山内 惠子, 坂根 直樹
    • Organizer
      第40回日本肥満学会
    • Related Report
      2019 Research-status Report
  • [Presentation] (第二報)薬局管理栄養士によるポーションコントロールプレートを使用した肥満改善2019

    • Author(s)
      橋詰 真子, 小山 芳明, 山内 惠子, 坂根 直樹
    • Organizer
      第40回日本肥満学会
    • Related Report
      2019 Research-status Report
  • [Presentation] The study of Metabolic Improvement by Nutritional Intervention controlling Endogenous GIP (Mini Egg study): a randomized, double-blinded, cross-over study2019

    • Author(s)
      Naoki Sakane, Noriko Osaki, Hideto Takase, Junko Suzuki, Chika Suzukamo, Shinsuke Nirengi, Akiko Suganuma, Akira Shimotoyodome
    • Organizer
      79th Scientific Sessions, ADA
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 内臓脂肪を減らす食事2019

    • Author(s)
      坂根直樹
    • Organizer
      第40回日本肥満学会、第37回肥満治症治療学会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Book] ニュートリションケア2022年9月号 電話・オンラインを用いた栄養指導のスキルアップは? ヘルスケアアプリを用いた栄養指導の実際は? オンラインでの集団栄養指導はできるの?どのように行うの?2022

    • Author(s)
      坂根 直樹
    • Total Pages
      140
    • Publisher
      メディカ出版
    • ISBN
      9784840477857
    • Related Report
      2022 Research-status Report
  • [Book] 体脂肪や内臓脂肪が気になる人向けの栄養情報2020

    • Author(s)
      坂根直樹
    • Total Pages
      3
    • Publisher
      産業保健と看護 12巻2号
    • Related Report
      2019 Research-status Report
  • [Book] 間食をやめることができず、テレビの情報をうのみにするメタボリックシンドローム患者2019

    • Author(s)
      井上 奈緒美, 坂根 直樹
    • Total Pages
      6
    • Publisher
      Nutrition Care 12巻12号
    • Related Report
      2019 Research-status Report

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Published: 2019-04-18   Modified: 2025-01-30  

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