Prediction of therapeutic effect of cognitive behavioral therapy for anxiety and obsessive-compulsive disorder

• Project/Area Number: 19K03309
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 10030:Clinical psychology-related
• Research Institution: Chiba University
• Principal Investigator: 平野 好幸 千葉大学, 子どものこころの発達教育研究センター, 教授 (50386843)
• Project Period (FY): 2019-04-01 – 2025-03-31
• Project Status: Granted (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 認知行動療法 / 不安症 / 強迫症 / MRI / 認知機能検査 / fMRI / 拡散テンソル / 治療効果予測 / 脳画像

Outline of Research at the Start

不安症や強迫症などの精神疾患に対する認知行動療法は、薬物療法に劣らない治療効果を発揮するが、提供できる医療機関や治療者の数は限られている。そこで、認知行動療法が奏効する可能性が高いと判断される患者に優先的に提供していくためには、治療反応性が高いと予測することが有効である。本研究では、認知行動療法の治療効果を、認知機能検査とMRI脳機能・形態画像により、従来より高い確率で予測できる因子を探索する。

Outline of Annual Research Achievements

認知行動療法は、患者の認知や行動をより適応的なものへと変容させていくことを援助する治療法であり、うつ病、社交不安症等の不安症、および強迫症などに対して薬物療法に劣らない治療効果を発揮することがわかっている。しかしながら、本邦の医療現場において、認知行動療法を希望する患者全員に提供できる医療機関や治療者の数は依然として限られている。そこで、認知行動療法が奏効する可能性が高いと判断される患者に優先的に認知行動療法を提供していくために、あらかじめ治療反応性を予測する手法を確立することを目的とした。本年度は、認知行動療法を受ける予定の不安症9名、強迫症7名、健常対照者30名をリクルートし、症状評価、MRI検査、認知機能検査を実施し、認知行動療法を完遂した患者には、治療後の症状評価を行った。また、認知行動療法の治療効果予測の候補因子の探索のため、社交不安症を対象とした認知行動療法の治療効果と関連する安静時脳機能結合を探索した。MVPAによる解析により抽出された左視床と右前頭極・下前頭回間を結ぶ安静時脳機能結合が社交不安症の重症度変化と有意に相関していたことから、個人認知療法の有効性を示す指標となる可能性が示された。本結果は、2023年12月に国際学術誌Frontiers in Psychiatryに受理・掲載された。また、強迫症に関しては、30名の患者を対象にしたMVPA解析により、CBT施行前のrsfMRIにおいて後頭皮質を中心とする機能的結合性と、Y-BOCSの変化量に相関が認められた。このクラスターを元にSeed to Voxel解析により得られた7つの脳機能結合をBorutaにより選択された特徴量により認知行動療法の治療予測モデルを評価した結果、比較的良好な性能を示した（AUC=0.77）。本結果は、日本認知療法・認知行動療法学会で報告された。

Current Status of Research Progress

3: Progress in research has been slightly delayed.

Reason

研究開始初期の新型コロナウイルス感染症の蔓延にともない、認知行動療法を受ける不安症と強迫症患者のリクルートが遅れたため。

Strategy for Future Research Activity

患者と健常対照者のリクルートと症状評価、MRI検査、認知機能検査を引き続き行うとともに、前年度までに得られた各種MRI画像と心理指標と治療効果との関連性を調べるためのデータ整備を行うとともに、集積したデータを用いて解析を進める。

Research Products

• [Int'l Joint Research] Amsterdam UMC/Levvel, Acad. Cent. for Child Adol. Care/Radboud University Medical Center(オランダ)
• [Int'l Joint Research] University of Toronto/University of British Columbia/McMaster University(カナダ)
• [Int'l Joint Research] University of Cape Town/Stellenbosch University/BC Children’s Hospital(ブラジル)
• [Int'l Joint Research] University of Barcelona/CIBERSAM/Hospital Clinic de Barcelona(スペイン)
• [Int'l Joint Research] The National Institutes of Health/Stanford University/University of Southern California(米国)
• [Int'l Joint Research]
• [Int'l Joint Research] Amsterdam UMC/Acad. Cent. for Child Adol. Psychiatry/Radboud University(オランダ)
• [Int'l Joint Research] University of Toronto/University of British Columbia/McMaster University(カナダ)
• [Int'l Joint Research] University of Cape Town/Stellenbosch University(南アフリカ)
• [Int'l Joint Research] IDIBAPS/CIBERSAM/University of Barcelona(スペイン)
• [Int'l Joint Research] University of Southern California/University of California/Yale University(米国)
• [Int'l Joint Research]
• [Int'l Joint Research] Amsterdam UMC/Erasmus Medical Center/Acad. Cent. for Child Adol. Psychiat.(オランダ)
• [Int'l Joint Research] University of Toronto/University of British Columbia/Canada(カナダ)
• [Int'l Joint Research] University of Cape Town/Stellenbosch University(南アフリカ)
• [Int'l Joint Research] CIBERSAM/IDIBAPS/University of Barcelona(スペイン)
• [Int'l Joint Research] University of Southern California/University of California, Los Angeles/Harvard Medical School(米国)
• [Int'l Joint Research]
• [Int'l Joint Research] Vrije Universiteit Amsterdam/Radboud University/Leiden University Medical Center(オランダ)
• [Int'l Joint Research] University of Toronto/McGill University/McMaster University(カナダ)
• [Int'l Joint Research] University of Cape Town/Stellenbosch University(南アフリカ)
• [Int'l Joint Research] CIBERSAM/IDIBAPS/University of Barcelona(スペイン)
• [Int'l Joint Research] University of Southern California/University of California/Harvard Medical School(米国)
• [Int'l Joint Research]
• [Int'l Joint Research] Vrije Universteit Amsterdam/Radboud University/Max Planck Institute for Psycholinguist(オランダ)
• [Int'l Joint Research] University of Southern California/University of California/Harvard Medical School(米国)
• [Int'l Joint Research] Stellenbosch University/University of Cape Town(南アフリカ)
• [Int'l Joint Research] University of Barcelona/CIBERSAM/IDIBAPS(スペイン)
• [Int'l Joint Research] University of Toronto/University of Calgary/Joseph’s Healthcare(カナダ)
• [Int'l Joint Research]
• [Journal Article] White matter diffusion estimates in obsessive-compulsive disorder across 1653 individuals: machine learning findings from the ENIGMA OCD Working Group (2024)
  • Author(s): Kim Bo-Gyeom、他多数 Abe Yoshinari（３番目）
  • Journal Title: Molecular Psychiatry Volume: NA Issue: 4 Pages: 1063-1074
  • DOI: 10.1038/s41380-023-02392-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Individual cognitive therapy reduces frontal-thalamic resting-state functional connectivity in social anxiety disorder (2023)
  • Author(s): Kurita K, Obata T, Sutoh C, Matsuzawa D, Yoshinaga N, Kershaw J, Chhatkuli RB, Ota J, Shimizu E, Hirano Y.
  • Journal Title: Frontiers in Psychiatry Volume: 14 Pages: 1233564-1233564
  • DOI: 10.3389/fpsyt.2023.1233564
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Brain Morphometry Study with Across-Site Harmonization Using a ComBat-Generalized Additive Model in Children and Adolescents (2023)
  • Author(s): Shiohama T, Maikusa N, Kawaguchi M, Natsume J, Hirano Y, Saito K, Takanashi J, Levman J, Takahashi E, Matsumoto K, Yokota H, Hattori S, Tsujimura K, Sawada D, Uchida T, Takatani T, Fujii K, Naganawa S, Sato N, Hamada H.
  • Journal Title: Diagnostics Volume: 13 Issue: 17 Pages: 2774-2774
  • DOI: 10.3390/diagnostics13172774
  • Peer Reviewed / Open Access
• [Journal Article] Higher longitudinal brain white matter atrophy rate in aquaporin-4 IgG-positive NMOSD compared with healthy controls (2023)
  • Author(s): Masuda H, Mori M, Hirano S, Uzawa A, Uchida T, Muto M, Ohtani R, Aoki R, Hirano Y, Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI), Kuwabara S.
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 12631-12631
  • DOI: 10.1038/s41598-023-38893-1
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of eye communication training device for social anxiety disorder treatment: A single-arm pilot trial (2023)
  • Author(s): Matsumoto J, Hirano Y, Nakaguchi T, Tamura M, Nakamura N, Fukuda F, Sahara Y, Ikeda Y, Takiguchi N, Miyauchi M, Shimizu E.
  • Journal Title: Journal of Affective Disorders Reports Volume: 14 Pages: 100626-100626
  • DOI: 10.1016/j.jadr.2023.100626
  • Peer Reviewed / Open Access
• [Journal Article] The functional connectome in obsessive-compulsive disorder: resting-state mega-analysis and machine learning classification for the ENIGMA-OCD consortium (2023)
  • Author(s): Bruin Willem B.、Abe Yoshinari、他多数
  • Journal Title: Molecular Psychiatry Volume: - Issue: 10 Pages: 4307-4319
  • DOI: 10.1038/s41380-023-02077-0
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Right Prefrontal Cortical Thickness Is Associated With Response to Cognitive Behavioral Therapy in Children With Obsessive-Compulsive Disorder (2023)
  • Author(s): Bertolin S, Alonso P, Martinez-Zalacain I, Hirano Y, Kuno M, Nakagawa A, Shimizu E, ENIGMA-OCD Working Group; C, Hamatani S, Takahashi J, Yoshida T, Thompson PM, van den Heuvel OA, Stein DJ, Soriano-Mas et al.
  • Journal Title: Journal of the American Academy of Child and Adolescent Psychiatry Volume: 62 Issue: 4 Pages: 403-412
  • DOI: 10.1016/j.jaac.2022.07.865
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Associations of medication with subcortical morphology across the lifespan in OCD: Results from the international ENIGMA Consortium (2022)
  • Author(s): Ivanov I, Boedhoe PSW, Hirano Y, Nakagawa A, Shimizu E, Thompson PM, Stein DJ, van den Heuvel OA, O'Neill J, ENIGMA-OCD Working Group et al.
  • Journal Title: Journal of Affective Disorders Volume: 318 Pages: 204-216
  • DOI: 10.1016/j.jad.2022.08.084
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Separating neuronal activity and systemic low-frequency oscillation related BOLD responses at nodes of the default mode network during resting-state fMRI with multiband excitation echo-planar imaging (2022)
  • Author(s): Tachibana T, Ikoma Y, Hirano Y, Kershaw J, Obata T
  • Journal Title: Frontiers in Neuroscience Volume: 16 Pages: 961686-961686
  • DOI: 10.3389/fnins.2022.961686
  • Peer Reviewed / Open Access
• [Journal Article] Super-resolution generative adversarial networks with static T2*WI-based subject-specific learning to improve spatial difference sensitivity in fMRI activation (2022)
  • Author(s): Ota J, Umehara K, Kershaw J, Kishimoto R, Hirano Y, Tachibana Y, Ohba H, Obata T
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 10319-10319
  • DOI: 10.1038/s41598-022-14421-5
  • Peer Reviewed / Open Access
• [Journal Article] The mediating effect of symptoms of posttraumatic stress disorder and depression on the relationship between personality traits and quality of life in emergency service workers (2022)
  • Author(s): Noda Y, Asano K, Shimizu E, Hirano Y.
  • Journal Title: Comprehensive Psychiatry Volume: 116 Pages: 152327-152327
  • DOI: 10.1016/j.comppsych.2022.152327
  • Peer Reviewed / Open Access
• [Journal Article] Effectiveness of school-based brief cognitive behavioral therapy with mindfulness in improving the mental health of adolescents in a Japanese school setting: A preliminary study (2022)
  • Author(s): Kato K, Matsumoto Y, Hirano Y.
  • Journal Title: Frontiers in Psychology Volume: 13 Pages: 895086-895086
  • DOI: 10.3389/fpsyg.2022.895086
  • Peer Reviewed / Open Access
• [Journal Article] 小児・青年期と成人期の社交不安症における脳画像研究 (2022)
  • Author(s): 栗田 幸平、平野 好幸
  • Journal Title: The Journal of Child & Brain Development Volume: 13 Issue: 1 Pages: 31-37
  • DOI: 10.34572/jcbd.13.1_31
  • ISSN: 2185-1417, 2435-8819
  • Peer Reviewed / Open Access
• [Journal Article] 強迫症における脳画像研究 (2022)
  • Author(s): 大田 淳子、平野 好幸
  • Journal Title: The Journal of Child & Brain Development Volume: 13 Issue: 1 Pages: 25-30
  • DOI: 10.34572/jcbd.13.1_25
  • ISSN: 2185-1417, 2435-8819
  • Open Access
• [Journal Article] 社交不安症に対する認知行動療法の効果 脳機能画像研究の知見から (2022)
  • Author(s): 平野好幸、薛陸景
  • Journal Title: 臨床精神医学 Volume: 51 Pages: 875-880
• [Journal Article] 恐怖症 (2022)
  • Author(s): 平野好幸
  • Journal Title: 日本医師会雑誌（精神疾患診療） Volume: 151
• [Journal Article] The thalamus and its subnuclei - a gateway to obsessive-compulsive disorder (2022)
  • Author(s): Weeland CJ, Hirano Y, Nakagawa A, Shimizu E, Takahashi J, ENIGMA OCD Working Group, Thompson PM, Stein DJ, van den Heuvel OA, Vriend C et al.
  • Journal Title: Translational Psychiatry Volume: 12 Issue: 1 Pages: 70-70
  • DOI: 10.1038/s41398-022-01823-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ventrolateral prefrontal hemodynamic responses in autism spectrum disorder with and without depression (2021)
  • Author(s): Ohtani T, Wakabayashi A, Sutoh C, Oshima F, Hirano Y, Shimizu E
  • Journal Title: PLoS One Volume: 16 Issue: 8 Pages: e0256780-e0256780
  • DOI: 10.1371/journal.pone.0256780
  • Peer Reviewed / Open Access
• [Journal Article] Reduced Brain Activation in Response to Social Cognition Tasks in Autism Spectrum Disorder with and without Depression (2021)
  • Author(s): Ohtani T, Matsuo K, Sutoh C, Oshima F, Hirano Y, Wakabayashi A, Shimizu E
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 17 Pages: 3015-3024
  • DOI: 10.2147/ndt.s327608
  • Peer Reviewed / Open Access
• [Journal Article] 安静時脳機能からみた精神疾患に対する認知行動療法の効果と機序 (2021)
  • Author(s): 栗田幸平、清水栄司、平野好幸
  • Journal Title: Precision Medicine Volume: 4 Pages: 1056-1059
  • Peer Reviewed
• [Journal Article] White matter microstructure and its relation to clinical features of obsessive?compulsive disorder: findings from the ENIGMA OCD Working Group (2021)
  • Author(s): Piras F, Piras F, Hirano Y, Nakagawa A, Shimizu E, Tahakashi J, ENIGMA OCD Working Group, Stein DJ, Jahanshad N, Thompson PM, van den Heuvel OA, Spalletta G et al.
  • Journal Title: Translational Psychiatry Volume: 11 Issue: 1 Pages: 173-173
  • DOI: 10.1038/s41398-021-01276-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders (2021)
  • Author(s): Writing Committee for the Attention-Deficit/Hyperactivity Disorder; Autism Spectrum Disorder; Bipolar Disorder; Major Depressive Disorder; Obsessive-Compulsive Disorder; and Schizophrenia ENIGMA Working Groups; Patel Y, Hirano Y, Nakagawa A, Shimizu E et al.
  • Journal Title: JAMA Psychiatry Volume: 78 Issue: 1 Pages: 47-63
  • DOI: 10.1001/jamapsychiatry.2020.2694
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuropsychological Comparison Between Patients with Social Anxiety and Healthy Controls: Weak Central Coherence and Visual Scanning Deficit (2020)
  • Author(s): Okawa S, Hamatani S, Hayashi Y, Arai H, Nihei M, Yoshida T, Takahashi J, Shimizu E, Hirano Y
  • Journal Title: Neuropsychiatric Disease and Treatment Volume: Volume 16 Pages: 2849-2855
  • DOI: 10.2147/ndt.s283950
  • Peer Reviewed / Open Access
• [Journal Article] Predictors of response to exposure and response prevention-based cognitive behavioral therapy for obsessive-compulsive disorder (2020)
  • Author(s): Hamatani S, Tsuchiyagaito A, Nihei M, Hayashi Y, Yoshida Y, Takahashi J, Okawa S, Arai H, Nagaoka M, Matsumoto K, Shimizu E, Hirano Y
  • Journal Title: BMC Psychiatry Volume: 20 Issue: 1 Pages: 433-433
  • DOI: 10.1186/s12888-020-02841-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structural neuroimaging biomarkers for obsessive-compulsive disorder in the ENIGMA-OCD consortium: medication matters (2020)
  • Author(s): Bruin W, Taylor L, Thomas R, Shock J, Zhutovsky P, Hirano Y, Nakagawa H, Shimizu, ENIGMA-OCD Working-Group, Thompson P, van den Heuvel O, Stein D, van Wingen G et al.
  • Journal Title: Translational Psychiatry Volume: 10 Issue: 1 Pages: 342-342
  • DOI: 10.1038/s41398-020-01013-y
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD); findings from the ENIGMA-ADHD, -ASD, and -OCD working groups (2020)
  • Author(s): Boedhoe PSW, van Rooij D, Hoogman M, Twisk JWR, Schmaal L, Hirano Y, Kuno M, Nakagawa A, Tsuchiyagaito A, Thompson PM, Stein DJ, Buitelaar J, Franke B, van den Heuvel OA et al.
  • Journal Title: American Journal of Psychiatry Volume: In press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] An overview of the first 5 years of the ENIGMA obsessive-compulsive disorder working group: The power of worldwide collaboration. (2020)
  • Author(s): van den Heuvel OA, Boedhoe PSW, Hirano Y, Thompson PM, Stein DJ et al.
  • Journal Title: Human Brain Mapping Volume: In press Issue: 1 Pages: 23-36
  • DOI: 10.1002/hbm.24972
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: A comparative study (2020)
  • Author(s): Fujioka T, Tsuchiya KJ, Saito M, Hirano Y, Matsuo M, Kikuchi M, Maegaki Y, Choi D, Kato S, Yoshida T, Yoshimura Y, Ooba S, Mizuno Y, Takiguchi S, Matsuzaki H, Tomoda A, Shudo K, Ninomiya M, Katayama T, Kosaka H
  • Journal Title: Molecular Autism Volume: In press
  • Peer Reviewed / Open Access
• [Journal Article] Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings from the ENIGMA Consortium (2019)
  • Author(s): Kong XZ, Boedhoe PSW, Hirano Y, Kuno M, Nakagawa A, Tsuchiyagaito A, Thompson PM, Stein DJ, van den Heuvel OA, Francks C et al.
  • Journal Title: Biological Psychiatry Volume: In press Issue: 12 Pages: 1022-1034
  • DOI: 10.1016/j.biopsych.2019.04.022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Prognosis Prediction Using Therapeutic Agreement of Video Conference?Delivered Cognitive Behavioral Therapy: Retrospective Secondary Analysis of a Single-Arm Pilot Trial (2019)
  • Author(s): Matsumoto Kazuki、Yoshida Tokiko、Hamatani Sayo、Sutoh Chihiro、Hirano Yoshiyuki、Shimizu Eiji
  • Journal Title: JMIR Mental Health Volume: 6 Issue: 11 Pages: e15747-e15747
  • DOI: 10.2196/15747
  • Peer Reviewed / Open Access
• [Journal Article] Insensitivity of the auditory mismatch negativity (MMN) in human classical fear conditioning and extinction (2019)
  • Author(s): Kurayama T, Matsuzawa D, Hirano Y, Shimizu E
  • Journal Title: Neuroreport Volume: 30 Issue: 7 Pages: 468-472
  • DOI: 10.1097/wnr.0000000000001221
  • Peer Reviewed
• [Journal Article] Alterations of mental defeat and cognitive flexibility during cognitive behavioral therapy in patients with major depressive disorder: a single-arm pilot study. (2019)
  • Author(s): Murata T, Hiramatsu Y, Yamada F, Seki Y, Nagata S, Shibuya T, Yokoo M, Noguchi R, Tanaka M, Oshiro K, Matsuzawa D, Hirano Y, Shimizu E.
  • Journal Title: BMC Research Notes Volume: 12 Issue: 1 Pages: 723-723
  • DOI: 10.1186/s13104-019-4758-2
  • Peer Reviewed / Open Access
• [Journal Article] Assessing subgroup differences in posttraumatic stress disorder among rescue workers in Japan using the impact of events scale-revised. (2019)
  • Author(s): Noda Y, Asano K, Shimizu E, Hirano Y.
  • Journal Title: Disaster Medicine and Public Health Preparedness Volume: 13 Issue: 3 Pages: 309-318
  • DOI: 10.1053/rvsc.2000.0420
  • Peer Reviewed
• [Journal Article] 認知行動療法と脳科学 (2019)
  • Author(s): 平野好幸
  • Journal Title: 行動科学 Volume: 2 Pages: 89-95
  • NAID: 40022319402
  • Peer Reviewed
• [Journal Article] Internet-Based Cognitive Behavioral Therapy via Videoconference for Patients With Bulimia Nervosa and Binge-Eating Disorder: Pilot Prospective Single-Arm Feasibility Trial (2019)
  • Author(s): Hamatani Sayo、Numata Noriko、Matsumoto Kazuki、Sutoh Chihiro、Ibuki Hanae、Oshiro Keiko、Tanaka Mari、Setsu Rikukage、Kawasaki Yohei、Hirano Yoshiyuki、Shimizu Eiji
  • Journal Title: JMIR Formative Research Volume: 3 Issue: 4 Pages: e15738-e15738
  • DOI: 10.2196/15738
  • Peer Reviewed / Open Access
• [Journal Article] Hemodynamic responses in prefrontal cortex and personality characteristics in patients with bulimic disorders: a near-infrared spectroscopy study. (2018)
  • Author(s): Numata N, Hirano Y, Sutoh C, Matsuzawa D, Takeda K, Setsu R, Shimizu E, Nakazato M.
  • Journal Title: Eat Weight Disord, in press Volume: - Issue: 1 Pages: 1-9
  • DOI: 10.1007/s40519-018-0500-7
  • Peer Reviewed
• [Journal Article] Reliability and validity of the Japanese version of the Obsessive-Compulsive Inventory-Revised (OCI-R). (2018)
  • Author(s): Koike H, Tsuchiyagaito A, Hirano Y, Oshima F, Asano K, Sugiura Y, Kobori O, Ishikawa R, Nishinaka H, Shimizu E, Nakagawa A.
  • Journal Title: Curr Psychol Volume: In press Issue: 1 Pages: 1-7
  • DOI: 10.1007/s12144-017-9741-2
  • Peer Reviewed / Open Access
• [Presentation] Neuroanatomical and Functional Features of Cerebellar and Subcortical Cortex in Major Depressive Disorder, Obsessive-Compulsive Disorder, and Social Anxiety Disorder. (2023)
  • Author(s): Kurita K, Hirano Y, Shimizu E, Kamashita R, Ohira I, Sudo Y, Kitagawa H.
  • Organizer: EABCT 2023 Congress
  • Int'l Joint Research
• [Presentation] Neuropsychological Studies on Cognitive Impairment in Psychiatric Disorders (2023)
  • Author(s): Maral S, Hirano Y.
  • Organizer: EABCT 2023 Congress
  • Int'l Joint Research
• [Presentation] Resting-State Functional MRI; Predicts Response to Cognitive Behavioral therapy in Pediatric Obsessive-Compulsive Disorder (2023)
  • Author(s): Isobe Y, Hirano Y, Kuno M, Ikemizu Y, Ota J, Matsumoto K, Shimizu E
  • Organizer: EABCT 2023 Congress
  • Int'l Joint Research
• [Presentation] Multimodal Functional and Structural Brain Connectivity analysis Focusing on Response to Cognitive Behavioral therapy For Obsessive-Compulsive Disorder: A Combined Resting-State FMRI and DTI Study (2023)
  • Author(s): Ikemizu Y, Hirano Y, Shimizu E, Ohta J, Chhatkuli RB, Kato N, Nakagawa A
  • Organizer: EABCT 2023 Congress
  • Int'l Joint Research
• [Presentation] 全般性不安症及び社交不安症の安静時脳機能の比較；感覚運動ネットワークと報酬応答の特徴 (2023)
  • Author(s): 長野智美、栗田幸平、清水栄司、平野好幸
  • Organizer: 第28回日本神経精神医学会学術集
• [Presentation] 強迫症に対する認知行動療法によるY-BOCSの変化に注目した、安静時脳機能結合の探索と予測モデル研究 (2023)
  • Author(s): 池水結輝, Ritu Bhusal Chhatkuli, 大田淳子, 磯部祐子, 吉田斎子, 松本浩史, 久能勝, 加藤奈子, 中川彰子, 清水栄司, 平野好幸
  • Organizer: 第23回日本認知療法・認知行動療法学会
• [Presentation] 健常者との対比からみえたAQP4+NMOSDの進行性大脳白質萎縮とその臨床的特徴 (2023)
  • Author(s): 枡田大生、森雅裕、平野成樹、鵜沢顕之、内田智彦、武藤真弓、大谷龍平、青木玲二、青山辰二、平野好幸、桑原聡
  • Organizer: 第35回日本神経免疫学会学術集会
• [Presentation] Progressive brain white matter atrophy in NMOSD: an MRI volumetric study (2023)
  • Author(s): Hiroki Masuda, Masahiro Mori, Shigeki Hirano, Akiyuki Uzawa, Tomohiko Uchida, Mayumi Muto, Ryohei Ohtani, Reiji Aoki, Yoshiyuki Hirano, Satoshi Kuwabara
  • Organizer: Sendai Conference 2023
• [Presentation] 社交不安症と閾値下社交不安の神経基盤の差異 (2023)
  • Author(s): 佐々木翼、大田淳子、野田義和、鎌下莉緒、吉田斎子、栗田幸平、Ritu Bhusal Chhatkuli、荒木謙太郎、大平育世、松本浩史、桝田喜正、清水栄司、平野好幸
  • Organizer: 第119回日本精神神経学会学術総会
  • Invited
• [Presentation] 閾値下社交不安の病態解明のための脳機能解析 (2023)
  • Author(s): 大田淳子、佐々木翼、Ritu Bhusal Chhatkuli、鎌下莉緒、吉田斎子、栗田幸平、荒木謙太郎、大平育世、大場久照、清水栄司、平野好幸
  • Organizer: 第15回日本不安症学会学術大会
• [Presentation] 強迫症の認知行動療法における、治療反応性に着目した安静時脳機能結合の探索 (2023)
  • Author(s): 池水結輝、大田淳子、Ritu Bhusal Chhatkuli、栗田幸平、佐々木翼、鎌下莉緒、磯部祐子、須藤佑輔、吉田斎子、松本浩史、桝田喜正、加藤奈子、中川彰子、清水栄司、平野好幸
  • Organizer: 第15回日本不安症学会学術大会
• [Presentation] 社交不安症、うつ病、強迫症と健常者のfALFFの差異に関する探索的研究 (2023)
  • Author(s): 和俊冰、栗田幸平、清水栄司、平野好幸
  • Organizer: 第15回日本不安症学会学術大会
• [Presentation] Effect of individual cognitive behavioral therapy for antidepressant-resistant social anxiety disorder in resting-state functional MRI (2022)
  • Author(s): Kurita K, Obata T, Sutoh C, Matsuzawa D, Yoshinaga N, Shimizu E
  • Organizer: 52nd European Association for Behavioural and Cognitive Therapies Congress
  • Int'l Joint Research
• [Presentation] 社交不安の特徴を考慮した脳活動パターンの探索的研究 (2022)
  • Author(s): 佐々木翼、大田淳子、野田義和、鎌下莉緒、吉田斎子、栗田幸平、ブーサル チャタクリ リトゥ、荒木謙太郎、大平育世、磯部祐子、長野 智美、松本浩史、桝田喜正、池水結輝、須藤佑輔、和俊冰、Sertap Maral、娜迪熱阿西木、北川等美、清水栄司、平野好幸
  • Organizer: 第49回日本脳科学会
• [Presentation] 閾値下社交不安の安静時脳機能結合に対する探索的検討 (2022)
  • Author(s): 佐々木翼、大田淳子、鎌下莉緒、吉田斎子、栗田幸平、Ritu Bhusal Chhatkuli、荒木謙太郎、大平育世、須藤千尋、清水栄司、平野好幸
  • Organizer: 第14回日本不安症学会学術大会
• [Presentation] 社交不安症に対する認知行動療法による安静時脳機能ネットワークの変化 (2021)
  • Author(s): 栗田幸平、小畠隆行、須藤千尋、松澤大輔、吉永尚紀、清水栄司、平野好幸
  • Organizer: 第13回日本不安症学会
• [Presentation] A Cutting-edge Concept for Outstanding Functional Resolution in fMRI (2020)
  • Author(s): Ota J, Umehara K, Tachibana Y, Hirano Y, Ohba H, Obata T, Higashi T
  • Organizer: RSNA 2020 106th Scientific Assembly and Annual Meeting
  • Int'l Joint Research
• [Presentation] Prefrontal cortical thickness is associated with response to cognitive-behavioral therapy in children with obsessive-compulsive disorder (2019)
  • Author(s): Soriano-Mas C, Bertolin S, Martinez-Zalacain I, Boedhoe PSW, Hirano Y, Thompson P, Menchon JM, Stein DJ, van den Heuve OA
  • Organizer: The First European Congress on Clinical Psychology and Psychological Treatment of EACLIPT
  • Int'l Joint Research
• [Presentation] Prefrontal cortical thickness is associated with response to cognitive-behavioural therapy in children and adolescents with OCD (2019)
  • Author(s): Bertolin Triquell S, Martinez-Zalacain I, Boedhoe PSW, Alonso P, Brennan BP, Fitzgerald KD, Hirano Y et al.
  • Organizer: 32nd European College of Neuropsychopharmacology (ECNP) Congress
  • Int'l Joint Research
• [Presentation] Comparison of Neuropsychological Function in Social Anxiety Disorder and Healthy Controls (2019)
  • Author(s): Okawa S, Hamatani S, Arai H, Nihei M, Yoshida T, Takahashi J, Hirano Y
  • Organizer: 9th World Congress of Behavioural and Cognitive Therapies
  • Int'l Joint Research
• [Presentation] Correlations between the Clinical Profiles and the Profile of the Wechsler Adult Intelligence Scale-III in Obsessive Compulsive Disorder. (2019)
  • Author(s): Hamatani S, Nihei M, Hayashi Y, Tsuchiyagaito A, Nakagawa A, Shimizu E, Hirano Y
  • Organizer: 9th World Congress of Behavioural and Cognitive Therapies
  • Int'l Joint Research
• [Presentation] Dependence of slice selection on cerebral blood flow signals during visual stimulation: a study using simultaneous ASL and bold measurement (2019)
  • Author(s): Ikoma Y, Hirano Y, Tachibana A, Tachibana Y, Murata K, Higashi T, Obata T
  • Organizer: 29th International Symposium on Cerebral Blood Flow, Metablism and Function
  • Int'l Joint Research
• [Presentation] ディープ ラーニングを用いた課題時fMRIの高精度化に向けた初期的検討 (2019)
  • Author(s): 大田淳子、立花泰彦、平野好幸、梅原健輔、影山肇、生駒洋子、大場久照、小畠隆行
  • Organizer: 第47回日本放射線技術学会秋季学術大会
• [Presentation] T2*WIを代替訓練データとして安静時fMRIを深層学習により高解像度化する手法の初期検討 (2019)
  • Author(s): 影山肇、立花泰彦、大田淳子、梅原健輔、平野好幸、小畠隆行、近藤啓介、志村一男
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] 視覚刺激時fMRI信号と脳血流変化の空間的時間的差異 (2019)
  • Author(s): 城谷良太、生駒洋子、平野好幸、立花泰彦、村田勝俊、東達也、小畠隆行、粟井和夫
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] 強迫症・不安症の認知行動療法の作用機序と治療効果予測：脳画像による検討 (2019)
  • Author(s): 平野好幸
  • Organizer: 第23回日本精神保健・予防学会学術集会
• [Remarks] 認知行動脳科学領域 | 研究案内 | 連合小児発達学研究科 千葉校
  • URL: https://www.cocoro.chiba-u.jp/rengochiba/research/research3.html
• [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター:
  • URL: https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html
• [Remarks] 社交不安症の患者に対する認知行動療法の治療効果を 安静時脳機能MRIで証明
  • URL: https://www.chiba-u.ac.jp/news/research-collab/0124_mri.html
• [Remarks] 研究内容 | 研究者の方へ | 千葉大学 子どものこころの発達教育研究センター
  • URL: https://www.m.chiba-u.ac.jp/class/rccmd/researcher/research.html