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A Study on Blood Flow Rebalancing and Thrombosis Formation Caused by Patent Ductus Arteriosus

Research Project

Project/Area Number 19K04181
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 19010:Fluid engineering-related
Research InstitutionGifu National College of Technology

Principal Investigator

Yamamoto Takahisa  岐阜工業高等専門学校, その他部局等, 准教授 (10345960)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords数値流体力学解析 / 血行動態 / 流体構造連成解析 / 動脈管 / バイオ流体力学 / 医療画像処理 / 血流の可視化
Outline of Research at the Start

左心室低形成症候群患児に対し実施されている動脈管ステント内挿術において,動脈管開大により血栓が成長する症例が報告されている。同手術は動脈管(大動脈と肺動脈とを繋ぐ小さい管)にステントを挿入し,肺に過大流入する血液の一部を全身へと迂回(リバランス)させることにより,全身の血液循環のバランスを取るものであるが,動脈管開大により大動脈と肺動脈の拍動流が干渉し,血栓形成に至っているものと推察される。本研究では,大動脈-動脈管-肺動脈系の数値流体力学解析ならびに三次元PIV可視化実験を行い,動脈管ステントによる血流のリバランス特性を明らかにする。また,動脈管に生ずる血栓形成の予測技術の確立を目指す。

Outline of Final Research Achievements

Hypoplastic left heart patients have significant blood flow unbalance in the cardiovascular system; excess blood flows from the right ventricles to the lung. Patent Ductus Arteriosus (PDA) stenting prevents excess blood flow and shunts the blood flow to the aorta through PDA. This study elucidated the hemodynamics of the aorta-pulmonary artery system experimentally and numerically. This study carried out Particle Image Velocimetry measurement and Computational Fluid Dynamics analysis for three patient-specific models. The analysis clarified transient hemodynamics in the aorta-pulmonary artery system; pulmonary blood flow was shunt to the aorta at the peak systole and diastole. Q-criterion, which indicates the second-order invariant of turbulence flow, was generated in the PDA at the same period. This study found the influence of PDA morphology on transient hemodynamics. These flow characteristics are essential factors in thrombus formation in PDA.

Academic Significance and Societal Importance of the Research Achievements

本研究の特徴は,臨床的にしか検討されてこなかった大動脈-動脈管-肺動脈系の血行動態および血流リバランスを,工学的アプローチ(数値流体力学(CFD)解析,実症例のCTデータからの大動脈-動脈管-肺動脈系の生体模型の製作,PIV計測)により明らかにする点にある。これら工学的アプローチにより,動脈管開大による血流のリバランスメカニズム,動脈管径(PDAステントによる開大度合いに相当),拍動パラメータが動脈管まわりの血行動態に及ぼす影響を明らかにした。これら研究成果により,症例特有の血流リバランスを評価,予測することが可能となる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (10 results)

All 2022 2021 2019 Other

All Int'l Joint Research (2 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (7 results) (of which Int'l Joint Research: 4 results)

  • [Int'l Joint Research] Universiti Teknologi Malaysia/IJN-UTM Cardio. Eng. Centre(マレーシア)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] IJN-UTM Cardiovascular Eng. Centre(マレーシア)

    • Related Report
      2019 Research-status Report
  • [Journal Article] Pulsatile Flow Interaction between Aorta and Pulmonary Artery2022

    • Author(s)
      Takahisas Yamamoto, Takumi Ichihashi, Shu Ishida, Etsuji Nomura, Mohamad Ikhwan Kori, Kahar Osman
    • Journal Title

      Medicine and Health Sciences

      Volume: 18 Pages: 12-16

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Study of thrombus formation in patients with hypoplastic left heart using fibrinogen transportation2021

    • Author(s)
      Takumi Ichihashi, Shu Ishida, Takahisa Yamamoto, Kahar Osman
    • Organizer
      3rd international Biofluid Symposium 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Influence of Hypoplastics in Aorta - Patent Ductus Arteriosus - Pulmonary Artery System2021

    • Author(s)
      Takumi Ichihashi, Shu Ishida, Takahisa Yamamoto, Kahar Osman
    • Organizer
      Joint International Medical Devices and Technology Conference (iMEDiTEC)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pulsatile Flow Interaction between Aorta and Pulmonary Artery2021

    • Author(s)
      Takahisa Yamamoto, Takumi Ichihashi, Shu Ishida, Etsuji Nomura, Mohamad Ikhwan Kori, Kahar Osman
    • Organizer
      The International Joint Conference on Medical Engineering, Sciences & Technology (iMEDiST 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大動脈-肺動脈系における血行動態に関する研究:動脈管を介した血流リバランスの影響2021

    • Author(s)
      山本高久, 市橋匠, Mohamad Ikhwan Kori, Kahar Osman
    • Organizer
      日本機械学会第33回バイオエンジニアリング講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 左心低形成が大動脈-動脈管-肺動脈の血行動態に及ぼす影響2021

    • Author(s)
      市橋匠, 山本高久, Kahar Osman
    • Organizer
      日本機械学会東海支部学生発表会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 左心低形成が大動脈-動脈管-肺動脈の血行動態に及ぼす影響2021

    • Author(s)
      市橋匠、山本高久、Kahar Osman
    • Organizer
      日本機械学会東海支部第52回卒業研究発表会
    • Related Report
      2020 Research-status Report
  • [Presentation] Blood Flow Interaction in Aorta-Pulmonary Artery System2019

    • Author(s)
      Takahisa Yamamoto, Masaya Iinuma, Mohamad Ikhuwan, Kahar Bin Osman
    • Organizer
      International Conference on Biomedical Engineering 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2023-01-30  

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